• 제목/요약/키워드: Safety Estimation

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일부 동물성 한약재의 독성과 안전성등급화 - 봉독, 사독, 반묘와 오공을 중심으로 - (Toxicity and safety classification of 4 animal medicines - Focusing on venoms from bee, snake, blister beetle and scolopendrid -)

  • 박영철;이선동
    • 대한예방한의학회지
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    • 제20권1호
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    • pp.125-144
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    • 2016
  • Objectives : About 13% of the medicines used by traditional korean medicines(TKM), are called animal medicines and are derived from non-herbal sources such as animals and insects. However, the clinical use of these preparations from animal medicines is often based on tradition and belief, rather than on evidence of toxicity and efficacy. As a result, animal medicines containing toxin have caused serious problems from injecting patients with venom. Here, various venoms frequently used as TKM were reviewed in terms of their instinct toxity and tried to estimate their safety classification. Methods : The estimation of safety classification was based on human equivalent dose(HED)-based MOS (margin of safety) and clinical dose applied for patients. Results and Conclusions : Except that of snake venom due to no clinical dose, they were evaluated as class 3 for bee venom, class 4 for cantharidin, toxin from blister beetle, and class 1 for venom from scolopendrid. In conclusion, animal medicines showed a wide range of safety classification from class 1 to class 4. This wide range is estimated to result from extremely limited applications of each venom for patients because of their strong toxicity. However, it should be cautious for application in clinics since animal medicines can produce anaphylactic reactions particularly after veinous administration even with a tiny amount of venom.

신생사업장 재해율 및 재해발생형태 분석 (Estimation of Occupational Accident Rate about Start-up Establishment and Analysis of Characteristics about Occurrence)

  • 김영선;구권호;최성원;권오준
    • 한국안전학회지
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    • 제27권4호
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    • pp.83-89
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    • 2012
  • In order for start-up establishment to enter the business market, it has to get over the first mover advantage of the existing establishment. As a result, its working condition deteriorates and a great deal of occupational accidents take place. Based on 2009 standard, the occupational accident rate of start-up establishment is 1.28%, which is two times higher than existing establishment and the gap between manufacturing and service industry has been getting wide. For the characteristic of injured person in start-up establishment, it is showed that the occupancy rate of women and people with less than 30 age starting out in a career is high and the occupancy rate of occupational accident for holiday and night work is high. Therefore, the act for occupational accident prevention is needed in the early period of business and underprivileged group for occupational accident.

열차제어시스템 SIL할당 및 입증에 관한 연구 (A Study on the SIL Allocation and Demonstration for Train Control System)

  • 신덕호;백종현;이강미;이재호
    • 한국철도학회:학술대회논문집
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    • 한국철도학회 2009년도 춘계학술대회 논문집
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    • pp.855-859
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    • 2009
  • In this paper, we introduce the estimation method by Risk or SIL(Safety Integrity Level) for the criterion of safety assurance and summarize each application method and target. IEC 62278(EN 50126) which is international standard for the specification and verification of the railway system RAMS indicate a criterion of safety assurance. Especially, it recommend the safety verification by continuous verification as the order of requirement establishment, design, manufacture, installation, operation, and maintenance for the equipment not easy to quantify the operation environment. In this paper, we study the SIL requirement allocation method relating to internal new system development and existing system improvement by analysing SIL recommendations which were used to understand SIL for a train control equipment in 1990s in IRSE and theoretically their allocation background. This paper help the safety management of Korea train control system to develope the quantitative management procedure as international level by analyzing the SIL requirement allocation by operation agency and the right SIL verification procedure by manufacture and indicating the example to assure safety because it is necessary for improvement and localization for the Korea train control system having highly dependence on aboard technology.

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상용프로그램을 이용한 강판의 비선형 거동에 대한 신뢰성해석 (Reliability Analysis for Nonlinear Behavior of Steel Plate using Commercial Structural Software)

  • 박석재;김요숙;신영수
    • 한국전산구조공학회:학술대회논문집
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    • 한국전산구조공학회 2001년도 가을 학술발표회 논문집
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    • pp.425-431
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    • 2001
  • In order to take account of the statistical properties of probability variables used in the structural analysis, the conventional approach using the safety factor based on past experience usually estimated the safety of a structure. The real structures could only be analyzed with the error in estimation of loads, material characters and the dimensions of the members. But the errors should be considered systematically in the structural analysis. Structural safety could not precisely be appraised by the traditional structural design concept. Recently, new approach based on the probability concept has been applied to the assessment of structural safety using the reliability concept. In this study, safety of structures will estimated by the reliability analysis with commercial structural software that has the tools of nonlinear elastic-plastic 3-D analysis. Experimental test result is compared to results from this research and Coan/sup 1)/ In this paper, AFOSM(Advanced First-Order Second Moment method) is applied with von Mises, Tresca and Mohr-Coulomb failure criterions. The reliability index β and probability of failure P/sub f/ can be obtained by following this practical procedure as judgement a safety of structures and necessity of reinforcing.

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실제 선로조건에 따른 DMT 화차의 탈선안전도 평가 (The Derailment Safety Estimation of DMT Freight for Real Track Condition)

  • 손명선;엄범규;이희성
    • 한국소음진동공학회논문집
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    • 제21권7호
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    • pp.637-642
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    • 2011
  • The DMT freight is judged that economic performance is good because can increase cargoes than existing freight. However, the existing freight cars, each with a different balance to the body structure is bogie because the vibrations may occur. Thus, by minimizing vibration over the existing freight securing the safety of the driving if you will not have major problems in cargoes. In this study, multi-body dynamic analysis tool, VI-Rail using the actually Gyeongbu Railroad line and an empty, full freight condition include curve radius, track irregularity, The DMT freight of the derailed wagons were assessed for safety analysis. Full and empty freight conditions for parity in the Gyeongbu Railroad line(Dongdaegoo${\leftrightarrow}$Kyungsan) derailment safety analysis, such as derailment coefficient and the wheel unloaded, echoing the curve and the orbit is affected by the irregularity was found. Full freight condition than the empty conditions showed a significant derailment safety. Overall, the limits of derailment coefficient(Q/P = 0.8) and wheel unload decrement limits(${\triangle}P/P$ = 0.6) is less safe with me confirmed that the derailment safety.

변형률-수명 평가기법을 이용한 Al/CFRP 하이브리드 적층 복합재의 피로수명 측정 (The Estimation of Fatigue Life for Al/CFRP Hybrid Laminated Composites using the Strain-Life Method)

  • 양성진;권오헌;전상구
    • 한국안전학회지
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    • 제36권3호
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    • pp.7-14
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    • 2021
  • Hybrid laminated Al/carbon-fiber-reinforced plastic (CFRP) composites are attracting considerable attention from industries such as aerospace and automobiles owing to their excellent specific strength and specific rigidity. However, when this material is used to fabricate high-pressure fuel storage containers subjected to repeated fatigue loads, fatigue life evaluation for the working load is regulated as an important criterion for operational safety and ease of maintenance. Among the existing evaluation methods for these vessels, the burst test and the hydraulic repeat test require expensive facilities. Thus, the present study aims to develop an improved fatigue life test for Al/CFRP laminated hybrid composites. The test specimen was manufactured using a curved mold considering the shape of a type III high-pressure storage container. The strain-life method was used for fatigue life evaluation, and the life was predicted based on the transition life. The results indicate that the more complex the CFRP stacking sequence, the longer is the transition life. This test method is expected to be useful for ensuring the fatigue safety and economy of hybrid laminate composites.

재난대응 의사결정 지원을 위한 시설물 중요도·위험도·피해액 산정 인벤토리 구축 방안 연구 (Development Plan of Facility Importance, Risk, and Damage Estimation Inventory Construction for Assisting Disaster Response Decision-Making)

  • 최수영;강수명;조윤원;오은호;박재우;김길호
    • 한국지리정보학회지
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    • 제19권1호
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    • pp.167-179
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    • 2016
  • 최근 범지구적으로 증가하는 이상기후에 의해 SOC 시설물 안전이 지속적으로 위협받고 있다. 재난대응을 위해서는 피난 대피 경로 제시 등과 같은 신속한 의사결정이 필요하며 이는 재난 재해 정보 및 SOC 시설물 정보가 융 복합된 시공간적 정보가 활용되어야 한다. 이러한 정보는 정부 및 유관기관에서 분산적으로 수집되고 있어, 통합적 관리가 이루어지지 않고 있는 실정이다. 신속한 재난대응을 위해서는 분산 수집 관리되고 있는 재난 재해 정보의 통합관리와 SOC 시설물에 대한 안전도와 피해도 등의 정보 생성이 필요하다. 또한 재난 재해 정보 특성상 시공간적 융합이 필요하기 때문에, 관련 정보를 통합한 재해대응 의사결정 지원을 위한 인벤토리 구축이 필요하다. 본 연구에서는 신속한 재난대응의사결정 지원을 위한 시설물 중요도 위험도 피해액 인벤토리 구축 방안을 제시한다. 본 연구를 통해 분산 관리 되고 있는 재난 재해 및 SOC 시설물 관련 데이터를 수집하여 표준화 하고, 시설물의 중요도 위험도 피해액 산정에 필요한 통합 정보를 제공 할 수 있다. 향후 제안된 시스템을 통해 선제적 재난 대응을 위한 의사결정 도구로 활용할 수 있을 것으로 판단된다.

Research on rapid source term estimation in nuclear accident emergency decision for pressurized water reactor based on Bayesian network

  • Wu, Guohua;Tong, Jiejuan;Zhang, Liguo;Yuan, Diping;Xiao, Yiqing
    • Nuclear Engineering and Technology
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    • 제53권8호
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    • pp.2534-2546
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    • 2021
  • Nuclear emergency preparedness and response is an essential part to ensure the safety of nuclear power plant (NPP). Key support technologies of nuclear emergency decision-making usually consist of accident diagnosis, source term estimation, accident consequence assessment, and protective action recommendation. Source term estimation is almost the most difficult part among them. For example, bad communication, incomplete information, as well as complicated accident scenario make it hard to determine the reactor status and estimate the source term timely in the Fukushima accident. Subsequently, it leads to the hard decision on how to take appropriate emergency response actions. Hence, this paper aims to develop a method for rapid source term estimation to support nuclear emergency decision making in pressurized water reactor NPP. The method aims to make our knowledge on NPP provide better support nuclear emergency. Firstly, this paper studies how to build a Bayesian network model for the NPP based on professional knowledge and engineering knowledge. This paper presents a method transforming the PRA model (event trees and fault trees) into a corresponding Bayesian network model. To solve the problem that some physical phenomena which are modeled as pivotal events in level 2 PRA, cannot find sensors associated directly with their occurrence, a weighted assignment approach based on expert assessment is proposed in this paper. Secondly, the monitoring data of NPP are provided to the Bayesian network model, the real-time status of pivotal events and initiating events can be determined based on the junction tree algorithm. Thirdly, since PRA knowledge can link the accident sequences to the possible release categories, the proposed method is capable to find the most likely release category for the candidate accidents scenarios, namely the source term. The probabilities of possible accident sequences and the source term are calculated. Finally, the prototype software is checked against several sets of accident scenario data which are generated by the simulator of AP1000-NPP, including large loss of coolant accident, loss of main feedwater, main steam line break, and steam generator tube rupture. The results show that the proposed method for rapid source term estimation under nuclear emergency decision making is promising.

부유사 확산예측 모형의 신뢰도 평가에 관한 연구 (Reliability Evaluation of the Estimation of Suspended Sediment Dispersion)

  • 탁대호;정연진;전은주;양준용
    • 해양환경안전학회지
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    • 제28권6호
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    • pp.890-898
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    • 2022
  • 해상공사에서 발생하는 부유사는 해수의 탁도를 증가시키고 광량을 감소시켜 해양생물에 악영향을 미치므로 해양환경영향평가에서 중요한 요소이다. 하지만 평가에 적용되는 인자에 대한 공식적인 자료의 부족과 평가자의 능력에 따라 그 영향이 달리 평가되고 있다. 따라서 본 연구에서는 해역이용영향평가센터에서 검토한 3년간(2012-2014)의 매립, 준설, 외곽시설물 설치 등 총 58건 사업에 대한 부유사 확산 평가에 대한 실태를 진단하고 개선방안을 제시하였다. 개선방안 제시를 위해 4가지의 평가지표(격자체계의 적정성, 원단위의 적정성, 대표입경 및 침강속도의 적정성)를 적용하였다. 각 항목별 신뢰도에 평균점수 분석결과, 격자체계는 25점, 원단위는 60점, 대표입경은 34점 그리고 침강속도는 17점으로 평가항목에 대한 개선방안이 필요한 것으로 나타났다. 본 연구에서는 부유사 확산 평가상태에 대한 진단 및 신뢰도 평가 결과를 활용하여 부유사 확산예측에 대한 개선방안을 제안하였다. 먼저, 부유사 발생원단위 및 대표입경별 침강속도에 대한 공신력 있는 값이 가이드라인을 통해 제공해야 한다. 그리고 실무에선 신뢰성 향상을 위해 격자체계의 적정성과 결과의 검증을 철저히 해야 한다.

Estimation of Hydrodynamic Coefficients from Sea Trials Using a System Identification Method

  • Kim, Daewon;Benedict, Knud;Paschen, Mathias
    • 해양환경안전학회지
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    • 제23권3호
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    • pp.258-265
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    • 2017
  • This paper validates a system identification method using mathematical optimization using sea trial measurement data as a benchmark. A fast time simulation tool, SIMOPT, and a Rheinmetall Defence mathematical model have been adopted to conduct initial hydrodynamic coefficient estimation and simulate ship modelling. Calibration for the environmental effect of sea trial measurement and sensitivity analysis have been carried out to enable a simple and efficient optimization process. The optimization process consists of three steps, and each step controls different coefficients according to the corresponding manoeuvre. Optimization result of Step 1, an optimization for coefficient on x-axis, was similar compared to values applying an empirical regression formulae by Clarke and Norrbin, which is used for SIMOPT. Results of Steps 2 and 3, which are for linear coefficients and nonlinear coefficients, respectively, was differ from the calculation results of the method by Clarke and Norrbin. A comparison for ship trajectory of simulation results from the benchmark and optimization results indicated that the suggested stepwise optimization method enables a coefficient tuning in a mathematical way.