• Toxicological Research
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• 제17권
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• pp.323-327
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• 2001

March 19, 1999, the renovation qf the runway of the Bo-Fai ai1field in Hua Hin, Prachubk-erikhan, Thailand, unearthed chemicals which were left over from the project "anch Hand Operation" held during the Vietnam war era. The chemical mixtures were analyzed by the US EPA, the Department oj Medical Sciences (DMSc), Ministry oj Public Health (MoPH) and the Pollution Control Department (PCD), the Ministry oj Science Technology and Environment (MOSTE) of Thailand, The samples were found to contain several defoliants used in the operation. They were 2,4-D, 2,4,5-T, Dicamba, Cocydelic acid, and Dioxins. Due to the complexity of the issue, the multiplicity of possible health effects, and the socio-economic implications for imports and exports, the Thai Society of Toxicology submitted a proposal to request World Health Organization (WHO), Geneva. The assistance is for the area of chemical safety and called for immediate action to explore the magnitude qf risk involved with Dioxins. In this paper we present our approach to health risk assessment which takes into an account the epidemiological studies of high-risk group exposed to the Ranch Hand operation. Dioxins are endocrine disruption chemicals which public concerns are developed due to presumption that a hazard exists (www.eva.gov/dioxins/html) for which current methodologies are deemed insufficient. The recent concepts of how oxidative stress toxicants may affect health end points and biomarkers of exposure of exposed individuals are discussed. While research activities are undergoing, The Thai Society of Toxicology do not anticipate significant risk to local residents and the environment due to our concurrence with opinion from the international experts invited by the World Health Organization proposed to the local experts at a workshop in Bangkok.n Bangkok.

• 한국발생생물학회지:발생과생식
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• 제14권2호
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• pp.43-50
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• 2010

최근에 체세포 리프로그래밍 기법을 사용하여 체세포에 몇 가지 전사인자(리프로그래밍 인자)를 넣어줌으로써 유도만능줄기세포(induced pluripotent stem cell, iPS)를 만드는데 성공하였다. 유도만능줄기세포는 배아줄기세포와 유사하게 자가재생 할 수 있는 능력이 있으며, 신체의 모든 타입의 세포로 분화할 수 있는 특징을 가지고 있다. 배아줄기세포와는 달리 면역거부반응이 없다는 점과 윤리적인 문제로부터 자유롭다는 장점이 있어 2006년 Yamanaka 팀이 유도만능줄기세포에 관해 처음 보고한 이후로 이 분야 연구의 급속한 발전이 이루어지고 있다. 하지만 안전성의 문제점 때문에 세포치료제로 사용되기 위해서는 리프로그래밍 인자의 도입 방법 및 새로운 리프로그래밍 인자의 발굴 등 몇 가지 해결해야 할 점들이 남아 있다. 본 종설에서는 유도만능줄기세포를 만드는데 사용된 몇 가지 리프로그래밍 인자에 대해 보고된 연구 내용을 리프로그래밍 인자가 존재하는 세포인 배아줄기세포 및 난자와 배아에서 정리하고자 하며, 리프로그래밍 인자의 연구에 관한 방향에 대해 논의하고자 한다.

• The Korean Journal of Pain
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• 제29권3호
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• pp.153-157
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• 2016

Tapentadol is a novel oral analgesic with a dual mode of action as an agonist of the ${\mu}$-opioid receptor (MOR), and as a norepinephrine reuptake inhibitor (NRI) all in a single molecule. Immediate release (IR) tapentadol shows its analgesic effect quickly, at around 30 minutes. Its MOR agonistic action produces acute nociceptive pain relief; its role as an NRI brings about chronic neuropathic pain relief. Absorption is rapid, with a mean maximal serum concentration at 1.25-1.5 h after oral intake. It is present primarily in the form of conjugated metabolites after glucuronidation, and excretes rapidly and completely via the kidneys. The most common adverse reactions are nausea, dizziness, vomiting, and somnolence. Constipation is more common in use of the ER formulation. Precautions against concomitant use of central nervous system depressants, including sedatives, hypnotics, tranquilizers, general anesthetics, phenothiazines, other opioids, and alcohol, or use of tapentadol within 14 days of the cessation of monoamine oxidase inhibitors, are advised. The safety and efficacy have not been established for use during pregnancy, labor, and delivery, or for nursing mothers, pediatric patients less than 18 years of age, and cases of severe renal impairment and severe hepatic impairment. The major concerns for tapentadol are abuse, addiction, seeking behavior, withdrawal, and physical dependence. The presumed problem for use of tapentadol is to control the ratio of MOR agonist and NRI. In conclusion, tapentadol produces both nociceptive and neuropathic pain relief, but with worries about abuse and dependence.

• Journal of Animal Science and Technology
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• 제59권4호
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• pp.8.1-8.17
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• 2017

Growth promoters have been widely used as a strategy to improve productivity, and great benefits have been observed throughout the meat production chain. However, the prohibition of growth promoters in several countries, as well as consumer rejection, has led industry and the academy to search for alternatives. For decades, the inclusion of phytochemicals in animal feed has been proposed as a replacement for traditional growth promoters. However, there are many concerns about the application of phytochemicals and their impact on the various links in the meat production chain (productive performance, carcass and meat quality). Therefore, the effects of these feed additives are reviewed in this article, along with their potential safety and consumer benefits, to understand the current state of their use. In summary, the replacement of traditional growth promoters in experiments with broilers yielded benefits in all aspects of the meat production chain, such as improvements in productive performance and carcass and meat quality. Although the effects in pigs have been similar to those observed in broilers, fewer studies have been carried out in pigs, and there is a need to define the types of phytochemicals to be used and the appropriate stages for adding such compounds. In regard to ruminant diets, few studies have been conducted, and their results have been inconclusive. Therefore, it is necessary to propose more in vivo studies to determine other strategies for phytochemical inclusion in the production phases and to select the appropriate types of compounds. It is also necessary to define the variables that will best elucidate the mechanism(s) of action that will enable the future replacement of synthetic growth promoters with phytochemical feed additives.

• Journal of Microbiology and Biotechnology
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• 제24권6호
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• pp.803-811
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• 2014

Concerns over drug-resistant bacteria have stimulated interest in developing alternative methods to control bacterial infections. Endolysin, a phage-encoded enzyme that breaks down bacterial peptidoglycan at the terminal stage of the phage reproduction cycle, is reported to be effective for the control of bacterial pathogenic bacteria. Bioinformatic analysis of the SPN9CC bacteriophage genome revealed a gene that encodes an endolysin with a domain structure similar to those of the endolysins produced by the P1 and P22 coliphages. The SPN9CC endolysin was purified with a C-terminal oligo-histidine tag. The endolysin was relatively stable and active over a broad temperature range (from $24^{\circ}C$ to $65^{\circ}C$). It showed maximal activity at $50^{\circ}C$, and its optimum pH range was from pH 7.5 to 8.5. The SPN9CC endolysin showed antimicrobial activity against only gram-negative bacteria and functioned by cutting the glycosidic bond of peptidoglycan. Interestingly, the SPN9CC endolysin could lyse intact gram-negative bacteria in the absence of EDTA as an outer membrane permeabilizer. The exogenous lytic activity of the SPN9CC endolysin makes it a potential therapeutic agent against gram-negative bacteria.

• Journal of Biosystems Engineering
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• 제41권2호
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• pp.93-97
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• 2016

Purpose: Grain slurry diet are described as food obtained from ground grain paste. They serve as highly nutritious food for both adults and infants in Nigeria because of their immense nutritive and economical value. However, the production of these grain slurry diets is confronted with challenges that have hampered their commercialization. This study examines the trends and constraints of grain slurry food processing in Kaduna State. Methods: A survey was conducted using a structured questionnaire to elicit information from 192 selected processors, including both men and women. The survey was structured in line with the study objectives. The information was collated and synopsized into frequency distribution. Results: These findings revealed that 80% of the respondents processed between 1.0 tons and 13.0 tons of grain slurry per month. More than 90% of the processors processed grain slurry into koko, kunu, agidi, and pito. Accordingly, 80% of the interviewed processors indicated that sieving is one of the major constraints. Furthermore, inadequate modern machinery required to perform this operation makes it highly discouraging. One of the major challenges faced by the grain slurry producers in Nigeria is the lack of processing machinery for most operations (39.1%), followed by the tedious processing nature (27.1%), high labor cost (18.1%), and lack of market (9.4%). The traditional method of grain slurry processing was more popular than using modern equipment, except milling (96.5%), which is the only mechanized unit operation in grain slurry processing. Conclusion: Grain slurry processing and marketing were found to be profitable. However, these limitations could extremely reduce the level of grain slurry production, processing, and economic returns, thereby affecting the general wellbeing of the processors. The study also raised concerns about the safety and hygiene associated with traditionally processed grain slurry diets in the investigated areas.

• 한국콘텐츠학회논문지
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• 제7권1호
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• pp.184-189
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• 2007

우리나라는 도로교통사고로 인한 사회적 비용이 연간 약 15조원에 달하며 국내총생산(GDP)의 2.15%를 차지한다. 교통사고로 하루 평균 약 20명이 사망하고, 그 피해액의 규모가 약 70억원에 이른다. 구체적으로 2005년 7월에 나온 OECD 교통사고 국제비교(2003년 통계를 기준)에 따르면 우리나라는 해당 년도 1년 동안 7,212명이 교통사고로 사망했으며 이는 인구 10만명당 교통사고 사망자가 OECD 26개국 가운데 26위, 어린이 10만명당 교통사고 사망자는 25개국 가운데 25위, 노인 10만명당 교통사고 사망자는 25개국 가운데 25위 등으로 선진국의 경우와는 대조를 보이고 있다. 그동안 정부에서는 교통사고를 줄이기 위한 여러 가지 교통정책을 시행하였고 획기적인 진전이 있었으나 일반 국민들이 느끼는 교통안전에 대한 무관심은 턱없이 부족하다. 본 연구에서는 광주.전남지역에서 발생한 교통사고 현황을 전남지방경찰청의 자료를 이용하여 분석하고 적절한 교통안전대책을 제시하고자 한다.

• Journal of Microbiology and Biotechnology
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• 제25권12호
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• pp.2043-2048
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• 2015

Bacillus thuringiensis microbial insecticide products have been applied worldwide. Although a few cases of B. thuringiensis foodborne illness have been reported, little is known about the toxigenic properties of B. thuringiensis isolates. The aims of this study were to estimate the pathogenic potential of B. thuringiensis selected from microbial insecticide products, based on its possession of toxin genes and production of enterotoxins. Fifty-two B. thuringiensis strains selected from four kinds of microbial insecticide products were analyzed. PCR assay for detection of toxin genes and immunoassay for detection of enterotoxins were performed. The hemolysin BL complex as a major enterotoxin was produced by 17 (32.7%), whereas the non-hemolytic enterotoxin complex was detected in 1 (1.9%) of 52 B. thuringiensis strains. However, cytK, entFM, and ces genes were not detected in any of the tested B. thuringiensis strains. The potential risk of food poisoning by B. thuringiensis along with concerns over B. thuringiensis microbial insecticide products has gained attention recently. Thus, microbial insecticide products based on B. thuringiensis should be carefully controlled.

• 한국IT서비스학회지
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• 제19권5호
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• pp.33-47
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• 2020

In recent years, due to the demand for operating efficiency and cost reduction of industrial facilities, remote access via the Internet is expanding. the control network accelerates from network separation to network connection due to the development of IIoT (Industrial Internet of Things) technology. Transition of control network is a new opportunity, but concerns about cybersecurity are also growing. Therefore, manufacturers must reflect security compliance and standards in consideration of the Internet connection environment, and enterprises must newly recognize the connection area of the control network as a security management target. In this study, the core target of the control system security threat is defined as the network boundary, and issues regarding the security architecture configuration for the boundary and the role & responsibility of the working organization are covered. Enterprises do not integrate the design organization with the operation organization after go-live, and are not consistently reflecting security considerations from design to operation. At this point, the expansion of the control network is a big transition that calls for the establishment of a responsible organization and reinforcement of the role of the network boundary area where there is a concern about lack of management. Thus, through the organization of the facility network and the analysis of the roles between each organization, an static perspective and difference in perception were derived. In addition, standards and guidelines required for reinforcing network boundary security were studied to address essential operational standards that required the Internet connection of the control network. This study will help establish a network boundary management system that should be considered at the enterprise level in the future.

• 한국응용과학기술학회지
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• 제29권2호
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• pp.317-322
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• 2012

미세 조직은 SEM, FT-IR 스펙트라, 인장특성, 그리고 [NCO]/[OH]의 mole %, 입도분석에 의해 측정하였다. 친환경적인 NATM에 관한 관심이 고조됨에 따라 스테인레스같은 금속코팅에 더욱더 중요한 열경화 무용제 수지를 합성 하였다. 이 수지는 일반적 도료와 비교하여 매우 강도가 강하고 내구성이 매우 좋다. 폴리우레탄 수지는 폴리올, IPDI, 실리콘 계면활성제, 촉매, 충전제로 구성된다. 폴리우레탄 화합물은 가교제가 첨가된 수지가 가교제가 첨가되지 않은 수지보다 물성이 우수함을 나타냈다. 견고한 폴리우레탄 도료의 기계적 특성은 [NCO]/[OH]와 가교제가 증가함에 따라 강도가 증가하였다. 합성한 도료의 물성 향상은 스테인레스 산업뿐만 아니라 다양한 산업에서 폴리우레탄 고분자 수지가 강구조물의 보수보강에 많은 응용이 기대된다.