• BMB Reports
• /
• 제46권1호
• /
• pp.17-24
• /
• 2013

Transcutaneous immunization refers to the topical application of antigens onto the epidermis. Transcutaneous immunization targeting the Langerhans cells of the skin has received much attention due to its safe, needle-free, and noninvasive antigen delivery. The skin has important immunological functions with unique roles for antigen-presenting cells such as epidermal Langerhans cells and dermal dendritic cells. In recent years, novel vaccine delivery strategies have continually been developed; however, transcutaneous immunization has not yet been fully exploited due to the penetration barrier represented by the stratum corneum, which inhibits the transport of antigens and adjuvants. Herein we review recent achievements in transcutaneous immunization, focusing on the various strategies for the enhancement of antigen delivery and vaccination efficacy.

• Macromolecular Research
• /
• 제11권1호
• /
• pp.19-24
• /
• 2003

Polymeric gene delivery system attracts profound attention as it shows less toxicity, versatility, and reasonable gene expression efficiency. Terplex system, a synthetic biopolymeric gene delivery system consisting of stearyl poly-L-lysine (stearyl-PLL) and low density lipoprotein (LDL) was evaluated for its body distribution of gene expression of exogenously administered pDNA after tail-vein injection in mice. Kidney and spleen are two major organs with highest gene expression, whereas liver and heart showed marginal gene expression among the organs examined. Hemolytic effect of the terplex system was evaluated using human red blood cells, where terplex system did not cause significant hemolysis at the concentrations above the experimental ranges, although unmodified PLL or stearyl-PLL without LDL did. Serum stability of terplex system against enzymatic degradation was also significantly enhanced, presumably due to the steric stabilization from the polymers. Based on these findings and along with its high in vitro transfection efficiency, terplex system could serve as a safe and efficient polymeric gene delivery system with many applications for the in vivo gene therapy.

• Journal of Dairy Science and Biotechnology
• /
• 제38권4호
• /
• pp.189-196
• /
• 2020

Milk proteins, such as casein and whey protein, exhibit significant potential as natural emulsifiers for the preparation and stabilization of emulsion-based delivery systems. This can be attributed to their unique functional properties, such as the amphiphilic nature, GRAS (generally recognized as safe) status, high nutritional value, and viscoelastic film-forming ability around oil droplets. In addition, milk protein has been used as a coating material in emulsion-based delivery systems to protect bioactive compounds during food processing and storage owing to its unique functional properties. These properties include the ability to bind lipophilic bioactive compounds and antioxidant activity. In this review, we present the use of milk proteins as emulsifiers for the formation of emulsions and food applications of milk protein-stabilized emulsion delivery systems.

• 한국포장학회지
• /
• 제23권2호
• /
• pp.103-108
• /
• 2017

The amount of delivered parcels have been increasing according to the change and expansion of consumption pattern through e-commerce, and they are required to minimize breakout or failure under the delivery. In this study, we measured and analyzed the distribution environment data (vibration and impact) occurred in the packaging, which were prepared with 5 types by the weight and dimension, distributed from Seoul to Busan in Korea by 2 parcel delivery service companies through e-commerce order. Date showed the parcels had 3-5 times of drop impact and 0.3-0.7 m of drop height on average, and 0.8 Grms of vibration acceleration from equivalent equation to the vertical direction. The significant gap in service quality was not found between 2 parcel delivery service companies. This study is expected to be useful for designing the suitable packaging in order to enhance safe transportation of the delivered packaging, and furthermore useful for developing Korean testing method for Field-to-Lab simulation.

• 한국디지털정책학회:학술대회논문집
• /
• 한국디지털정책학회 2004년도 International Conference on Digital Policy & Management
• /
• pp.435-448
• /
• 2004

While Internet promises ubiquitous access, it also creates a fundamental challenge to the traditional ownership toward digital assets traded in e-commerce market. Sharing digital information freely through shared networks leads to many untapped business opportunities, but uncontrolled digital asset transaction undermines many electronic business models. Thus, in this Internet age, proper protection and safe delivery of Intellectual Property (IP) and its representation as digital assets would be a crucial ingredient of building trust in upcoming e-business environment. In this paper, we give a general structural diagram of Intellectual Property Management and Protection (IPMP) and implement an IPMP prototype based on the RSA encryption algorithm and XrML (eXtensible rights Markup Language) WORK tags to show how proper protection and safe delivery of the intellectual property is achieved. This study concludes that IPMP mechanism may contribute significantly to the volume and quality of e-commerce market.

• Safety and Health at Work
• /
• 제11권4호
• /
• pp.533-536
• /
• 2020

Strengthening of the health system is a safety imperative, especially in a crisis as caused by the ongoing COVID-19 pandemic. While there is a need for enhancing the number and skill sets of the public health professionals, especially the frontline workers, it will be prudent to use the digital health technologies, including artificial intelligence, in enhancing the capacity of the healthcare professional education and delivery. However, it has to be ensured that an ethical and safe approach is adopted to develop and use digital health technology and, ethically appropriate training is imparted, to enhance the capacity of the human resources for health, leading to an overall health system strengthening.

• Journal of Pharmaceutical Investigation
• /
• 제32권3호
• /
• pp.153-159
• /
• 2002

Gene therapy is fundamentally a sophisticated drug delivery technology to cure a disease by the transfer of genetic material to modify living cells. In other words, the gene is used as a therapeutic drug much like a chemical compound is employed in chemotherapy. Currently almost 600 clinical trials are underway worldwide since the first clinical trials carried out in 1990 to treat adenosine deaminase deficiency using retroviral vectors. Despite the great progress still is there no gene therapy product being approved as a new drug. This is partly due to a lack of an ideal gene delivery system that is safe and can provide stable, optimal level production of the therapeutic proteins in the cell. This review covers the current status of several different biological and physico-chemical agents that are being developed as gene delivery vehicles. Although gene therapy promises great hopes toward the cure of a broad spectrum of genetic and acquired diseases, the success of gene therapy heavily asks for the development of vector systems for safe and efficient application in humans.

• 한국포장학회지
• /
• 제25권2호
• /
• pp.23-29
• /
• 2019

The volume of parcel delivery is steadily increasing with the rapid growth of the global online e-commerce market. However, a large amount of packaging materials used for these parcel delivery is finally causing environmental problems as waste. The rapid increase of these packaging waste has been making many countries to research ways to reduce the generation of distribution packaging waste. In this study, we have measured the empty space ratio for 131 packagings of parcel delivery purchased through the several domestic online stores in order to investigate the present situation in connection with the degree of excessive or overpack in korean parcel delivery packagings, so that 64 packagings were exceeded 50% in the empty space ratio. And we have suggested ways to reduce the generation of distribution packaging waste raised by e-commerce-based parcel delivery through analyzing the previous research and case studies ; one is to optimize and minimize the packaging design by safe transit test(field-to-lab test), another is to develop a reusable & returnable transport packaging and system applicable in the domestic supply chain, the other is to regulate directly with a policy.

• 한국안전학회지
• /
• 제37권1호
• /
• pp.70-77
• /
• 2022

The total number of Korean restaurants using delivery applications has substantially increased from 7.6% in 2018 to 11.2% in 2019. In 2020, the gross sales in the food delivery service market reached approximately 17 trillion won; this amount is virtually six times that in 2017 (i.e., 2 trillion won). Meanwhile, the annual average death toll of motorcycle riders increased by 3.5%, whereas the number of deaths due to other traffic accidents decreased by 8.2%. Consequently, the foregoing has become a critical social problem. Despite the continuing increase in the number of delivery riders due to the rapid expansion of the delivery industry, no appropriate safety management system has been established. Moreover, the government is experiencing difficulties in assessing the exact situation because of the absence of competent authority. In this study, fundamental data on the characteristics of delivery work and motorcycle accidents were collected through surveys and interviews; then, the influencing factors of traffic accidents were analyzed. Different influencing factors were identified: work experience as a rider; number of deliveries; whether to accept delivery requests in transit; manner of accepting delivery requests; and traffic law violations, such as speeding (for faster delivery) and running a red light. Because the motorcycle delivery industry has a relatively low job-entry barrier (i.e., special qualifications are not required), the riding skills of riders must be improved, and delivery companies must be technically developed to achieve a safe working environment. The results of this study can be utilized as fundamental data for system development or structural improvement of the delivery industry.

• 대한간호학회지
• /
• 제6권1호
• /
• pp.51-59
• /
• 1976

Contemporary nursing is concerned with meeting patients physical psychological and secio-economical needs and with helping persons to sore their own problems. At the time of confinement and delivery, women often have physical and psychological disco- mort related to fear, tension or anxiety. Pain related to these causes varies with the individual woman. Effective nursing care to meet individual needs during labor and delivery is important if nurses are to understand and relieve woman's physical and psychological pain. A questionnaire prepared for the purpose by the investigator was administered to 162 women in two general hospitals, one in Seoul and one in TaeGu, during August 1 and September 20, 1975 and to the 13 delivery-room nurses who cared for them. It was hoped that the study would contribute to comprehensive nursing care during labor and delivery and to improve maternal and child health. 1. The sample of mothers ranged in age from 18 to 39; the majority were from 25 to 29 years old (54.3%). Most of them were housewives (87.6%). Sixty-three percent had high school or higher education. They had a range of one to seven deliveries. Sixty-one percent were primiparas Most had some prenatal care (87.6%). 2. The age of the group of nurses ranged from 22 to 39. Ten were 22 or 23. Five of the 13 had from six to ten months experience in the de]ivory room. Twelve were single and ten had a religious affiliation. 3. Both primiparas and multiparas thought equally that physical and psychological care, nursing skills and attitudes were important during labor and delivery, but did not relate basic nursing care directly to normal delivery. Need for nursing care was rated more highly by primiparas (2.83-3.48) than by multiparas (2.51-3.17) (p〈0.05). 4. There was no difference in need for nursing care according to the educational level of the women nor according to whether they had a religious affiliation or not (p〉0.05). 5. There was no difference in the reported nursing care given regarding of the educational preparation of the nurses (p〉 0.05). 6. There the reported nursing needs of the women and the reported nursing care given were compared, physical and psychological nursing care directed toward protecting the mother and fetus and a safe do]ivory were considered important by both groups. Neither group related simple nursing care directly to protection of the mother and fetus or to a safe delivery. The women rated highly their needs for nourishment (3.05) and having a relative with them (2.90) for emotional support but there was little evidence (2.39) that the nurses provided care to meet these needs (p〈0.05). In conclusion, the nursing needs of the women during the three stages of labor and the nursing care given were generally similar. The women had more psychological needs than physical needs but in comparison, nurses gave a little more physical than psychological care. The results point up the need to make adjustments in labor and delivery room nursing care the nurse should Prepared to pay more attention and bigger consideration in psychological comfort care than physical care.