• Archives of Pharmacal Research
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• v.20 no.5
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• pp.480-485
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• 1997

The absorption profile of phenytoin Na emulsion were examined compared to that of phenytoin suspension after oral administration in the rat. The corn oil-in-water emulsion, particle size of $184{\pm}$57.8 nm, was prepared using a microfludizer, and phenytoin Na added by shaft homogenizer. The phenytoin emulsion or suspension, 100 mg/kg, were intubated intragastrically using oral dosing needle and blood samples were withdrawn via an indwelling cannula from the conscious rat. Plasma concentrations of phenytoin were measured with HPLC using phenacetin as an internal standard. The plasma concentration versus time data were fitted to a one compartment open model and the pharmacokinetic parameters were calculated using the computer program, Boomer. The phenytoin plasma concentrations from the emulsion at each observed time were about 1.5-2 times higher than those from the suspension, significantly at time of 5, 6 and 7 hr after administration. The absorption $(k_a)$ and elimination rate constant $(k_e)$ were not altered significantly, however the AUC increased from 65.6 to $106.7{\mu}ghr/ml$ after phenytoin suspension or emulsion oral administration, respectively. From an equilibrium dialysis study, the diffusion rate constant $(k_{IE})$ was considerably higher from the phenytoin Na emulsion $(0.0439 hr{-1})$ than phenytoin suspension $(0.0014 hr{-1})$.

• Journal of Environmental Science International
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• v.15 no.12
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• pp.1193-1197
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• 2006

This study was to examine the variations of chromosome number and the ranges of variety in the suspension culture of ginseng (Panax ginseng C. A. Meyer) callus cell, and the effect of plant hormones for the chromosome aberration. Plant hormones added with MS medium in the suspension culture were 2,4-D, kinetin, and 2,4-D+kinetin and concentration of the plant hormones were $1000{\mu}M$ and $0.1\;{\mu}M$ respectively. As a result of these experiment the following conclusion has been obtained. Media contained with 2,4-D+kinetin in $10{\mu}M$ concentration was very effective in the suspension culture result from 26.4% mitosis frequency, and found the various variation of chromosome number. Variety of chromosome number was diversed ($9\sim110$), espicially frequency of hypohaploid and hyperhaploid cells were very higher than hyperdiploid cells. In this experiments, it is suggested that $10{\mu}M$ 2,4-D+kinetin added with medium in the suspension culture of ginseng callus was effect in the variations of chromosome number.

• Proceedings of the KSME Conference
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• 2004.11a
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• pp.1505-1509
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• 2004

The suspension of hardened red blood cells (RBCs) differs from the suspension of normal RBCs with respect to their rheological behavior. The deformability of normal and hardened RBCs (obtained by heating blood at $49^{\circ}C$ or by incubating RBCs in a solution of hydrogen peroxide) was measured with a slit diffractometer and RBC suspension viscosity was measured with a rotational viscometer. The peroxide-treated RBCs showed a significant decrease of the deformability and their suspension viscosity increased over a range of shear rates. The suspension viscosity of the heated RBCs, however, where the deformability is even lower than that of the peroxide-treated RBCs, was slightly higher than that of the normal RBC suspension in the high shear rates. The present study found that not all rigid cells cause an increase of blood viscosity at high shear rate, and therefore that decreased membrane deformability is not predictive of high-shear blood viscosity.

• Proceedings of the Korean Society of Machine Tool Engineers Conference
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• 1997.04a
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• pp.113-118
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• 1997

This paper presents the dimensional synthesis and kinematic analysis of the RSCS-SSP motion generating spatial mechanism using the displacement matrix method. This type of spatial mechanisms is used for the Mcpherson suspension in small automobiles. It is modeled for the wheel bump/rebound and steering motion. First, the suspension is modeled as a multiloop spatial rigid body guidance mechanism for the two major motions. Then the design equations for SSP, RS, and SC strut links are applied to synthesize an RSCS-SSP for up to three prescribed positions for the steering motiom from the suspension design specification. Thus a RSCS-SSP mechanism which is synthesized is also analyzed for the displacement during the steering motion.

• Transactions of the Korean Society for Noise and Vibration Engineering
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• v.17 no.5 s.122
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• pp.464-471
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• 2007

This paper presents a maneuver analysis of a full-vehicle featuring electrorheological(ER) suspension and ER brake. In order to achieve this goal, an ER damper and an ER valve pressure modulator are devised to construct ER suspension and ER brake systems, respectively. After formulating the governing equations of the ER damper and ER valve pressure modulator, they are designed and manufactured for a middle-sized passenger vehicle, and their field-dependent characteristics are experimentally evaluated. The governing equation of motion for the full-vehicle is then established and integrated with the governing equations of the ER suspension and ER brake. Subsequently, a sky-hook controller for the ER suspension and a sliding mode controller for the ER brake are formulated and implemented. Control performances such as vertical displacement and braking distance of vehicle are evaluated under various driving conditions through computer simulations.

• Transactions of the Korean Society for Noise and Vibration Engineering
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• v.27 no.1
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• pp.65-71
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• 2017

This work presents a comparative work on the ride comfort of a quarter car suspension system between two different magneto-rheological (MR) dampers; one is conventional type without bypass hole and the other is featured by several bypass holes in the piston. As a first step, two different MR dampers are designed on the basis of the governing equation and manufactured with same geometric dimensions except the bypass holes. After investigating the field-dependent damping properties, two dampers are installed to the quarter car suspension system. The suspension model is then derived and a sky-hook controller is implemented to identify vibration control performance under random road. It is shown that the suspension system with MR damper featured by the bypass holes can provide much better ride quality than the case without the bypass holes. This is validated via experimental implementation.

• Journal of Biosystems Engineering
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• v.37 no.3
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• pp.148-154
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• 2012

Purpose: In order to improve road-friendliness of heavy vehicles, a fuzzy hybrid control strategy consisting of a hybrid control strategy and a fuzzy logic control module is proposed. The performance of the proposed strategy should be effectively evaluated using a hardware-in-the-loop (HIL) simulation model of a semi-active suspension system based on the fuzzy hybrid control strategy prior to real vehicle implementations. Methods: A hardware-in-the-loop (HIL) simulation system was synthesized by utilizing a self-developed electronic control unit (ECU), a PCI-1711 multi-functional data acquisition board as well as the previously developed quarter-car simulation model. Road-friendliness of a semi-active suspension system controlled by the proposed control strategy was simulated via the HIL system using Dynamic Load Coefficient (DLC) and Dynamic Load Stress Factor (DLSF) criteria. Results: Compared to a passive suspension, a semi-active suspension system based on the fuzzy hybrid control strategy reduced the DLC and DLSF values. Conclusions: The proposed control strategy of semi-active suspension systems can be employed to improve road-friendliness of road vehicles.

• Transactions of the Korean Society of Automotive Engineers
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• v.19 no.2
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• pp.57-65
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• 2011

In this paper, a hydropneumatic modeling and dynamic analysis of a heavy truck semi-active cabin air suspension system is presented. Semi-active cabin air suspension system improves driver's ride comfort by controlling the damping characteristics in accordance with driving situation. So it can reduce vibration between truck frame and cabin. Semi-active cabin air suspension system is consist of air spring, leveling valve and CDC shock absorber, and full cabin system are mathematically modelled using AMESim software. Simulation results of components and full cabin system are compared with experimental data of components and test results of a cabin using 6 axis simulation table. It is found that the simulation results are in good agreements with test results, and the hydropneumatic model can be used well to predict dynamic characterics of heavy truck semi-active cabin air suspension system.

• Journal of the Korean Society for Advanced Composite Structures
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• v.6 no.4
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• pp.24-29
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• 2015

Bridge construction cost estimates have generally been conducted by using historial unit-price(per meter or square meter). The traditional estimating method based on unit-price references can never completely reflect the specialty of cable supported bridge. In this paper, we have developed the system for supporting the approximate construction cost and the quantity estimation based on 3D model information in the pre-project planning phase of 3-span continuous suspension bridge with 2-pylons. First of all, we'd analyzed the design information (such as structural design report, blueprint and quantity) and the real cost data from the existing suspension bridges and derived the design variables of the bridges. We developed the BIM wizard that generates a suspension bridge model parametrically based on derived design variables. The principle material quantities of suspension bridge are calculated directly from 3-dimensional bridge model built by using the BIM wizard. We have established the system that the construction cost can be estimated more specific than the traditional estimating method.

• Journal of the Earthquake Engineering Society of Korea
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• v.1 no.3
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• pp.45-58
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• 1997

An analysis algorithm and a computer program have been developed to clarify the geometrically nonlinear response characteristics of a suspension bridge subject to the support excitation. The Finite Element procedures are utilized for the application to a self-anchored suspension bridge or to a mono-duo cable suspension bridge. The propagation of earthquake wave is simulated by taking a record as the input at the left anchorage of the bridge, and addign appropriate time delay to the other inputs for the purpose of considering the multi-support effects. According to the application for a mono-duo self-anchored suspension bridge, it has been found that the effects of nonlinear behavior and multi-support excitation are notable for this relatively short-spanned suspension bridge.