• The Korea Genome Conference
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• 2005.09a
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• pp.34-34
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• 2005

• BMB Reports
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• v.43 no.11
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• pp.720-725
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• 2010

The small ubiquitin-like modifier (SUMO) proteins have been implicated in the pathology of a number of diseases, including neurodegenerative diseases. The conjugation machinery for SUMOylation consists of a number of proteins which are redox sensitive. Here, under oxidative stress ($100{\mu}M$ hydrogen peroxide), antioxidant ($100{\mu}M$ ascorbate) or control conditions 169 proteins were identified by electospray ionisation fourier transform ion cyclotron resonance mass spectrometry. The majority of these proteins (70%) were found to contain SUMOylation consensus sequences. From the remaining proteins a small number (12%) were found to contain possible SUMO interacting motifs. The proteins identified included DNA and RNA binding proteins, structural proteins and proteasomal proteins. Several of the proteins identified under oxidative stress conditions had previously been identified as SUMOylated proteins, thus validating the method presented.

• Proceedings of the Korean Society for Language and Information Conference
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• 2007.11a
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• pp.155-162
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• 2007

In this study, we explore the polysemy of da3 through the ontological conceptual structure found in SUMO. First, we divide several different senses for da3, clustering physical event senses and metaphorical event senses. In here, we only focus on physical event senses of da3. From the physical event senses of da3, we divide them into two main categories: 1) hit and 2) pump. We then use SUMO ontological concepts to identify these physical senses. Finally, we can observe the common patterns of the "hit" sense group and the "pump" sense group for da3.

• International Journal of Contents
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• v.16 no.1
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• pp.1-9
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• 2020

Recently, the number of traffic accidents on trunk roads tends to decrease due to the performance improvement of passenger vehicles. In the commuter rush hour of morning and evening, vehicles via residential road increases without going along trunk roads. Therefore, there are many traffic accidents of pedestrians (or bicycles) and vehicles on residential roads. In order to safeguard residents against traffic accidents, traffic calming devices (TCD), such as chicane, speed hump, and school zone, etc. have been introduced. Investigating these effects repeatedly is not easy since many times and efforts are required, such as observed at the place actually. In this paper, the effects of TCDs in residential areas, such as noise, speed, and emission of a vehicle, using Simulation of Urban Mobility (SUMO) are examined. As a result, it is found that it is possible to reduce the speed of the vehicle by TCD, and the level of noise at the location behind TCD becomes higher than the level of noise at the location of TCD implemented.

• BMB Reports
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• v.52 no.2
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• pp.113-118
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• 2019

The small ubiquitin-related modification molecule (SUMO), one of the post-translational modification molecules, is involved in a variety of cellular functions where it regulates protein activity and stability, transcription, and cell cycling. Modulation of protein SUMOylation or deSUMOylation modification has been associated with regulation of carcinogenesis in breast cancer. In the dynamic processes of SUMOylation and deSUMOylation in a variety of cancers, SUMO proteases (SENPs), reverse SUMOylation by isopeptidase activity and SENPs are mostly elevated, and are related to poor patient prognosis. Although underlying mechanisms have been suggested for how SENPs participate in breast cancer tumorigenesis, such as through regulation of target protein transactivation, cancer cell survival, cell cycle, or other post-translational modification-related machinery recruitment, the effect of SENP isoform-specific inhibitors on the progression of breast cancer have not been well evaluated. This review will introduce the functions of SENP1 and SENP2 and the underlying signaling pathways in breast cancer for use in discovery of new biomarkers for diagnosis or therapeutic targets for treatment.

• Proceedings of the Korean Society of Potoscience Conference
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• 2005.06a
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• pp.36-36
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• 2005

• Animal cells and systems
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• v.11 no.1
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• pp.39-50
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• 2007

Tau plays a role in numerous neuronal processes, such as vesicle transport, microtubule-plasma membrane interaction and intracellular localization of proteins. SUMO (Small Ubiquitin-like Modifier) modification (SUMOylation) appears to regulate diverse cellular processes including nuclear transport, signal transduction, apoptosis, autophagy, cell cycle control, ubiquitin-dependent degradation, as well as gene transcription. We noticed that putative SUMOylation site is localized at $^{340}K$ of $Tau(^{339}VKSE^{342})$ with the consensus sequence information (${\Phi}KxE$ ; where ${\Phi}$ represents L, I, V or F and x is any amino acid). In this report, we demonstrated that $^{340}K$ of Tau is the SUMOylation site and that a point mutant of Tau S214E (an analog of the phospho $^{214}S$ Tau) promotes its SUMOylation at $^{340}K$ and its nuclear or nuclear vicinity localization, by co-immunoprecipitation and confocal microscopy analysis. Further, we demonstrate that the Tau S214E (neither Tau S214A nor Tau K340R) mutant increases its protein stability. However, the SUMOylation at $^{340}K$ of Tau did not influence cell survival, as determined by FACS analysis. Therefore, our results suggested that the phosphorylation of Tau on $^{214}S$ residue promotes its SUMOylation on $^{340}K$ residue and nuclear vicinity localization, and increases its stability, without influencing cell survival.

• The Journal of the Convergence on Culture Technology
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• v.5 no.1
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• pp.429-434
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• 2019

There are several high technologies applied to the driving cars such as self-driving car and connected car for safe and convenient driving. VANET provides useful information such as route selection and gas price by communicating nearby cars and RSUs. VANET prefers CCN rather than traditional TCP/IP stack because CCN offers inherent multicast communication for sharing traffic information as well as traditional unicast. When all participating node rebroadcasts the Interest packets in a Vehicular CCN, the network may suffer from Broadcast Storm Problem. In order to mitigate the effect of the problem and to improve the Data packet transmission, not all but some selected nodes have to rebroadcast the packet. This paper simulates car movements using SUMO and evaluates data transmission performance using ns-3. According to the simulation results, when some selected nodes rebroadcast the Interest packets, the transmission performance improves 10% to 25% depending on the number of requesting nodes.

• 대한약리학회:학술대회논문집
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• 2006.11a
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• pp.48-48
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• 2006

• BMB Reports
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• v.45 no.6
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• pp.342-347
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• 2012

Plant mitochondria possess alternative respiratory pathways mediated by the type II NAD(P)H dehydrogenases and alternative oxidases. Here, E3 SUMO ligase was shown to regulate alternative respiratory pathways and to participate in the maintenance of carbon and nitrogen balance in Arabidopsis. The transcript abundance of the type II NAD(P)H dehydrogenases NDA2 and NDB2 and alternative oxidases AOX1a and AOX1d genes was low in siz1-2 mutants compared to that in wild-type. The addition of nitrate or ammonium resulted in a decrease or an increase in the expression of the same gene families, respectively, in both wild-type and siz1-2 mutants. The amount of free sugar (glucose, fructose and sucrose) was lower in siz1-2 mutants than that in wild-type. These results indicate that low nitrate reductase activity due to the AtSIZ1 mutation is correlated with an overall decrease in alternative respiration and with a low carbohydrate content to maintain the carbon to nitrogen ratio in siz1-2 mutants.