• Genomics & Informatics
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• 제12권2호
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• pp.50-57
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• 2014

We present a new next-generation sequencing-based method to identify somatic mutations of lung cancer. It is a comprehensive mutation profiling protocol to detect somatic mutations in 30 genes found frequently in lung adenocarcinoma. The total length of the target regions is 107 kb, and a capture assay was designed to cover 99% of it. This method exhibited about 97% mean coverage at $30{\times}$ sequencing depth and 42% average specificity when sequencing of more than 3.25 Gb was carried out for the normal sample. We discovered 513 variations from targeted exome sequencing of lung cancer cells, which is 3.9-fold higher than in the normal sample. The variations in cancer cells included previously reported somatic mutations in the COSMIC database, such as variations in TP53, KRAS, and STK11 of sample H-23 and in EGFR of sample H-1650, especially with more than $1,000{\times}$ coverage. Among the somatic mutations, up to 91% of single nucleotide polymorphisms from the two cancer samples were validated by DNA microarray-based genotyping. Our results demonstrated the feasibility of high-throughput mutation profiling with lung adenocarcinoma samples, and the profiling method can be used as a robust and effective protocol for somatic variant screening.

• 천문학회보
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• 제37권2호
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• pp.176.2-176.2
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• 2012

다목적실용위성 3호의 태양전지판은 위성의 -Z축 방향에 고정되어 있는 방식으로 사용되고 있다. 이로 인해 위성이 임무수행을 위한 자세기동을 하게 되면 태양전지판의 태양입사각 변화에 따라 전력생산량이 변하게 되고 이를 예측하여 최대 방전률(DOD : Depth of Discharge)을 넘지 않는 제한조건 내에서 임무 계획을 수행해야 한다. 전력생산량 및 전력소비량을 예측하기 위해서는 전력 모의실험을 수행해야 하며 이를 위해 위성의 자세 및 위치정보, 임무를 고려한 Mission Profile, 태양입사각, 초기 방전률 값을 생성해야 한다. 본 논문은 태양입사각 계산을 위해 위성의 임무(영상 촬영, 지상국 교신)를 반영한 자세 및 위치 정보를 생성하고, 이 결과를 태양입사각 계산 로직에 적용하여 태양입사각을 생성한 결과를 정리하였다. 생성된 결과의 타당성을 검토하기 위해 상용 툴인 STK를 이용하여 비교를 수행하였다. 또한, 전력 모의실험에 사용된 Mission Profile은 위성 운용에 안정성을 높이며 복잡한 임무 시나리오에 적용이 용이하도록 운용 Margin을 고려하여 생성하였다. 본 논문에서 제시한 방안을 실제 수행된 임무 시나리오에 적용하여 전력 모의실험을 수행하였으며, 그 결과를 임무 수행 후 획득된 위성 Telemetry를 이용한 실측값과 비교하여 전력 모의 실험 결과에 대한 타당성을 검증하였다. 실제 초기 운영결과 제한된 전력 허용 범위 내에서 적용이 가능함을 확인할 수 있었다.

• 대한기계학회논문집
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• 제13권4호
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• pp.689-696
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• 1989

본 실험에서는 종래와는 달리 먼저 입출구 부분에서 입자분포 측정장치를 이용하여 실험함으로써 여러 가지 입자크기에 대하여 동시에 효율을 구할 수 있는 장치를 구성하고 앞에서 열거한 여러 가지 실험인자중 레이놀즈수와 S/W를 변화시키면 서 일단 슬릿 임팩터(one-stage slit impactor)의 효율을 .root.Stk에 따라 구하여 일단 임팩터 뿐만 아니라 다단 임팩터(multistage impactor)에 대한 설계기초자료를 마련하 고자 한다.

• Journal of Astronomy and Space Sciences
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• 제39권3호
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• pp.109-116
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• 2022

The small-scale magnetospheric and ionospheric plasma experiment (SNIPE) is a mission initiated by the Korea Astronomy and Space Science Institute (KASI) in 2017 and comprises four 6U-sized nano-satellites (Korea Astronomy and Space Science Institute Satellite-1, KASISat-1) flying in formations. The main goal of the SNIPE mission is to investigate the space environment in low Earth orbit at 500-km. Because Iridium & GPS Board (IGB) is installed on the KASISat-1, a communication simulation is required to analyze the contact number and the duration. In this study, communication simulations between the Iridium satellite network and KASISat-1 are performed using STK Pro (System Tool Kit Pro Ver 11.2) from the AGI (Analytical Graphics, Inc.). The contact number and durations were analyzed by each orbit and date. The analysis shows that the average access number per day is 38.714 times, with an average of 2.533 times per orbit for a week. Furthermore, on average, the Iridium satellite communication is linked for 70.597 min daily. Moreover, 4.625 min is the average duration of an individual orbit.

• 산업경영시스템학회지
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• 제39권3호
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• pp.1-9
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• 2016

NSS (Navigation satellite system) provides the information for determining the position, velocity and time of users in real time using satellite-networking, and is classified into GNSS (Global NSS) and RNSS (Regional NSS). Although GNSS services for global users, the exactitude of provided information is dissatisfied with the degree required in modern systems such as unmanned system, autonomous navigation system for aircraft, ship and others, air-traffic control system. Especially, due to concern about the monopoly status of the countries operating it, some other countries have already considered establishing RNSS. The RNSS services for users within a specific area, however, it not only gives more precise information than those from GNSS, but also can be operated independently from the NSS of other countries. Thus, for Korean RNSS, this paper suggests the methodology to design the satellite constellation considering the regional features of Korean Peninsula. It intends to determine the orbits and the arrangement of navigation satellites for minimizing PDOP (Position dilution of precision). PGA (Parallel Genetic Algorithm) geared to solve this nonlinear optimization problem is proposed and STK (System tool kit) software is used for simulating their space flight. The PGA is composed of several GAs and iterates the process that they search the solution for a problem during the pre-specified generations, and then mutually exchange the superior solutions investigated by each GA. Numerical experiments were performed with increasing from four to seven satellites for Korean RNSS. When the RNSS was established by seven satellites, the time ratio that PDOP was measured to less than 5 (i.e. better than 'Good' level on the meaning of the PDOP value) was found to 94.3% and PDOP was always kept at 10 or less (i.e. better than 'Moderate' level).

• Journal of Astronomy and Space Sciences
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• 제25권3호
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• pp.283-290
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• 2008

이 논문에서는 간섭계 구성의 기본이 되는 위성 간 상대위치 추정에 관한 알고리즘을 개발하고 검증하였다. 편대위성 간 상대위치 추정을 실시간으로 수행하기 위해 확장칼만필터 (EKF, Extended Kalman Filter)와 Unscented 칼만필터 (UKF, Unscented Kalman Filter) 를 사용하였다. 칼만 필터를 이용한 상태벡터 (state-vector)의 갱신(update)을 위한 관측 데이터는 시뮬레이션을 통해 얻어진 GPS 위성 신호의 단일차분 (Single Difference)에 대한 값을 사용하였다. 이 연구에서 개발한 알고리즘으로 추정된 편대위성 간 상대위치는 확장칼만필터와 Unscented 칼만필터 모두 참 값으로 가정한 STK(Satellite Tool Kit) 의 시뮬레이션된 관측 값에 대해 ${\pm}1m$ 이내의 오차로 수렴함을 확인하였다. 또한 두 종류의 칼만필터를 이용하여 상대위치 결정을 수행함으로써 비선 형성을 가지는 경우 Unscented 칼만필터의 성능이 상대적으로 우수함을 확인할 수 있었다.

• Journal of Astronomy and Space Sciences
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• 제34권2호
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• pp.139-151
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• 2017

This paper presents an overview of deep space orbit determination software (DSODS), as well as validation and verification results on its event prediction capabilities. DSODS was developed in the MATLAB object-oriented programming environment to support the Korea Pathfinder Lunar Orbiter (KPLO) mission. DSODS has three major capabilities: celestial event prediction for spacecraft, orbit determination with deep space network (DSN) tracking data, and DSN tracking data simulation. To achieve its functionality requirements, DSODS consists of four modules: orbit propagation (OP), event prediction (EP), data simulation (DS), and orbit determination (OD) modules. This paper explains the highest-level data flows between modules in event prediction, orbit determination, and tracking data simulation processes. Furthermore, to address the event prediction capability of DSODS, this paper introduces OP and EP modules. The role of the OP module is to handle time and coordinate system conversions, to propagate spacecraft trajectories, and to handle the ephemerides of spacecraft and celestial bodies. Currently, the OP module utilizes the General Mission Analysis Tool (GMAT) as a third-party software component for high-fidelity deep space propagation, as well as time and coordinate system conversions. The role of the EP module is to predict celestial events, including eclipses, and ground station visibilities, and this paper presents the functionality requirements of the EP module. The validation and verification results show that, for most cases, event prediction errors were less than 10 millisec when compared with flight proven mission analysis tools such as GMAT and Systems Tool Kit (STK). Thus, we conclude that DSODS is capable of predicting events for the KPLO in real mission applications.

• Asian Pacific Journal of Cancer Prevention
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• 제14권10호
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• pp.5609-5614
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• 2013

Background: Colorectal cancer is the third most common cancer in both men and women in the world and the second leading cause of cancer-related deaths. The incidence of colorectal cancer has increased in Iran in the past three decades and is now considered as a serious problem for our society. This cancer has two types hereditary and non-hereditary, 80% of cases being the latter. Considering that the relationship between SNPs with diseases is a concern, many researchers believed that they offer valuable markers for identifying genes responsible for susceptibility to common diseases. In some cases, they are direct causes of human disease. One SNP can increase risk of cancer, but when considering the rate of overlap and frequency of DNA repair pathways, it might be expected that SNP alone cannot affect the final result of cancer, although several SNPs together can exert a significant influence. Therefore identification of these SNPs is very important. The most important loci which include mutations are: MLH1, MSH2, PMS2, APC, MUTYH, SMAD7, STK11, $XRCC_3$, $DNMT_1$, MTHFR, Exo1, $XRCC_1$ and VDR. Presence of SNPs in these genes decreases or increases risk of colorectal cancer. Materials and Methods: In this article we reviewed the Genes and SNPs associated with non-hereditary and hereditary of colorectal cancer that recently were reported from candidate gene y, meta-analysis and GWAS studies. Results: As with other cancers, colorectal cancer is associated with SNPs in gene loci. Generally, by exploring SNPs, it is feasible to predict the risk of developing colorectal cancer and thus establishing proper preventive measures. Conclusions: SNPs of genes associated with colorectal cancer can be used as a marker SNP panel as a potential tool for improving cancer diagnosis and treatment planning.

• 한국항공우주학회지
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• 제43권2호
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• pp.141-148
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• 2015

본 논문에서는 각각 독립적으로 설계된 태양동기궤도 위성에 위성군 개념을 적용하여 다중 위성의 효율적인 운영에 대한 방법론을 제시한다. 이를 위해 태양동기궤도 설계 관점을 단순히 지방시나 태양동기성을 유지하는 것에 국한하지 않고, 지상국과 영상목표물의 교신 및 관측시간등을 고려하여 위성운영의 효율성을 높이고자 한다. 위성의 효율적인 운영을 위해 위성과 단일 목표물을 고려한 새로운 운영요소(Operation Parameter)를 정의하고, 이를 이용하여 위성의 운영효율성을 판단할 수 있는 운영효율성 지표(Figure of Merit)를 정의한다. 상용 소프트웨어인 MATLAB과 STK의 연동을 통해 비선형 시뮬레이션 기반의 수치최적화 기법을 적용하여 사용자의 요구사항을 만족하는 임무궤도를 재설계함으로써 본 연구의 적용가능성을 확인하였다.

• 산업경영시스템학회지
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• 제41권1호
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• pp.39-49
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• 2018

In the satellite operation phase, a ground station should continuously monitor the status of the satellite and sends out a tasking order, and a satellite should transmit data acquired in the space to the Earth. Therefore, the communication between the satellites and the ground stations is essential. However, a satellite and a ground station located in a specific region on Earth can be connected for a limited time because the satellite is continuously orbiting the Earth, and the communication between satellites and ground stations is only possible on a one-to-one basis. That is, one satellite can not communicate with plural ground stations, and one ground station can communicate with plural satellites concurrently. For such reasons, the efficiency of the communication schedule directly affects the utilization of the satellites. Thus, in this research, considering aforementioned unique situations of spacial communication, the mixed integer programming (MIP) model for the optimal communication planning between multiple satellites and multiple ground stations (MS-MG) is proposed. Furthermore, some numerical experiments are performed to verify and validate the mathematical model. The practical example for them is constructed based on the information of existing satellites and ground stations. The communicable time slots between them were obtained by STK (System Tool Kit), which is a well known professional software for space flight simulation. In the MIP model for the MS-MG problems, the objective function is also considered the minimization of communication cost, and ILOG CPLEX software searches the optimal schedule. Furthermore, it is confirmed that this study can be applied to the location selection of the ground stations.