• Title/Summary/Keyword: STEM education

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Efficacy and Safety of First Line Vincristine with Doxorubicin, Bleomycin and Dacarbazine (ABOD) for Hodgkin's Lymphoma: a Single Institute Experience

  • Ozdemir, Nuriye;Dogan, Mutlu;Sendur, Mehmet Ali Nahit;Yazici, Ozan;Abali, Huseyin;Yazilitas, Dogan;Akinci, Muhammed Bulent;Aksoy, Sercan;Zengi, Nurullah
    • Asian Pacific Journal of Cancer Prevention
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    • v.15 no.20
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    • pp.8715-8718
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    • 2014
  • Background: ABVD (doxorubicin, bleomycin, vinblastine (Vb) and dacarbazine) is the standard regimen in Hodgkin's lymphoma (HL).Vincristine (O) is a mitotic spindle agent like Vb. We aimed to evaluate the efficacy and safety of O as a part of ABOD in HL. Materials and Methods: Patients who had ABOD were enrolled. Stage I-II HL were evaluated for unfavorable risk factors according to NCCN. National Cancer Institute Common Toxicity Criteria was used for toxicity. Results: Seventy-nine HL patients in our center between 2003 and 2007 were evaluated retrospectively. Median follow-up was 54 months. Most of the patients were male in their third decade. Median ABOD cycles were 6 (2-8). Primary refractory disease rate was 17.7% whereas it was 5.1% for early relapse and 5.1% for late relapse disease. Response rates were as 82.3% for complete response, 11.4% for partial response, 5.1% for stable disease and 1.3% for progressive disease. Half of relapsed patients had autologous stem cell transplantation. Estimated 5-year failure-free survival was 71% and significantly longer in early stage patients without risk factors, bulky disease or radiotherapy (RT) (p=0.05, p<0.0001, p=0.02; respectively). Estimated 5-year overall survival was 74% and significantly longer in those who had no RT (p=0.001). Dose modification rate was 5.1% and chemotherapy delay rate was 19%. There were no toxicity-related deaths. Conclusions: ABOD seems to be effective with managable toxicity in HL, even in those with poor prognostic factors.

The Chemical Constituents of the Stem Barks of Fraxinus rhynchophylla (물푸레나무(Fraxinus rhynchophylla) 수피의 추출성분)

  • Yang, Eun-Ju;Lee, Dong-Geun;Lee, Jong-Won;Kim, Yae-Sil;Lim, Sun-Ha;Song, Kyung-Sik
    • Applied Biological Chemistry
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    • v.50 no.4
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    • pp.348-351
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    • 2007
  • The stem barks of Fraxinus rhynchophylla was extracted with 95% EtOH, and the concentrated extract was successively partitioned with $CH_2Cl_2$, n-BuOH, and $H_2O$ in order to investigate the major phytochemicals. From the $CH_2Cl_2$ soluble fraction, a sterol (1) was isolated through the repeated silica gel column chromatographies. Three additional compounds (2-4) were isolated from the n-BuOH soluble fraction through silica gel, RP-18, and Sephadex LH-20 column chromatographies. Their chemical structures were elucidated as daucosterol $(1;{\beta}-sitosterol-3-O-{\beta}-D-glucopyranoside)$, caffeic acid (2), 6,8-dihydroxy-7-methoxycoumarin (3), and coniferaldehyde glucoside (4) by comparing their spectral data with those in the literatures. All isolates (1-4) were the first to be isolated from F. rhynchophylla.

Incidences and Causal Agents of Postharvest Fruit Rots in Kiwifruits in Korea (우리나라 참다래 저장병 발병율과 병원균)

  • Koh, Young-Jln;Lee, Jae-Goon;Hur, Jae-Seoun;Jung, Jae-Sung
    • Research in Plant Disease
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    • v.9 no.4
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    • pp.196-200
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    • 2003
  • Sixteen hundred fruits were randomly collected from 16 kiwifruit (Actinidia deliciosa) orchards in Jeonnam, Gyeongnam and Jejn provinces in Korea in 2000 and incidences of postharvest fruit rots were examined. The overall disease incidence was 32% and varied much with locations of orchards ranging from 5 to 68%. The percentages of kiwifruits showing internal, external, and both internal and external symptoms were 21.9%, 4.9%, and 5.2%, respectively. Several fungi were isolated from rotten fruits; Botryosphaeria dothidea, Diaporthe actinidiae and Botrytis cinerea were the major pathogens with the average isolation rates of 83.3%, 11.9% and 1.4%, respectively. Based on the symptoms on kiwifruits and the characteristics, the postharvest fruit rots caused by B. dothidea and D. actinidiae are suggested to be named as ripe rots and stem-end rots, respectively.

Limitation of Light Energy Utilization in the Fallen Stems of Opunttia bigelovii without CO2 and Water Absorption (지상에 떨어진 Opunttia bigelovii 선인장의 줄기에 있어서 광에너지의 이용한계)

  • Chang, Nam-Kee
    • The Korean Journal of Ecology
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    • v.3 no.1_2
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    • pp.31-39
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    • 1980
  • Light energy utilization was investigated in the fallen stems of Opuntia bigelovii. Threshold time for the decreasing steady state of acid accumulation in the palisade tissue of Opuntia stems was 4 hours under 1,000 $\mu Em^{-2}sec^{-1}$ of PAR at $75^{\circ}C$, while stomatal closing throughout the stem stage was illustrated by 256.0-310.4 sec $\textrm{cm}^{-1}$ of stem diffusive resistance and 0.20g $day^{-1}$ of the water loss rate as cuticular resistance. The acid loss rate in the stems per 4 hours was related to tissue water contents and a few acid loss rate could be recognized at the water content rage of 56.4%~46.8%. Endogenous oscillation of tissue acidity due to the diurnal rhythmic phenomena depended on the tissue water content was found in the Opuntia stems with stomatal closing during the normal day/night cycle. The survival rate of 1 segment to survive 2 years old cactus was 22.7% in desert environments. Such a compensation photosynthesis which utilizes light energy and maintains the reassimilation of endogenous gases was interpreted as conceptual model.

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A Study on the Framework of Comparing New Cybersecurity Workforce Development Policy Based on the ATE Programs of U.S. (미국 ATE 정책 기반의 신규 사이버보안 인력양성 정책 비교 프레임워크 연구)

  • Hong, Soonjwa
    • Journal of the Korea Institute of Information Security & Cryptology
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    • v.28 no.1
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    • pp.249-267
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    • 2018
  • The US cybersecurity workforce policy is being pursued comprehensively and systematically, based on the NICE established initiated in 2010. Security Technologies, one of the eight areas of Advanced Technology Education(ATE) of the National Science Foundation(NSF) included in the STEM. This policy has been comprehensively promoted in conjunction with NICE, and this security technology field is operated with five detailed programs. In this paper, we examine in detail five cybersecurity workforce development programs supported by ATE, and compare them with the current status cultivation of cybersecurity workforce in Korea. After finding out the problems and improvements by comparison with the current situation of cybersecurity workforce development in Korea, we propose several implementations of nation-wide strategies for cultivating new cybersecurity workforce in Korea.

A Study on A Cabinet Maker, Kim Byeung-Soo in Korean Western Gyeongnam Province - Development of a Large Round Table with Bosang Flower Pattern for a Contemporary Meeting Room - (서부경남의 소목장연구 II - 대한민국 김병수 명장의 교육과정의 제작기법을 응용한 현대화/회의실용 대형 원형 보상화문 탁자 개발 -)

  • Moon, Sun-Ok
    • Journal of the Korea Furniture Society
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    • v.27 no.4
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    • pp.325-334
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    • 2016
  • This study explores developing a large round table with Bosang flower pattern for a contemporary meeting room made by a cabinet maker, Kim Byeung-soo, who has built the traditional Korean furniture in Korean Western Gyeongnam Province since after his elementary school. He uses the post finger joint from one of the middle level of his education process based on the traditional Korean technique, develops it into flower stem joint, and adds flower patterns' carving decoration called Bosang flower patterns. Hence, the table makes the table be strong, useful, and beautiful. Therefore, the modernized round table will be able to make the people access more easily and to make more demand on the traditional Korean furniture and the adopted furniture than ever.

Management of Diabetic Foot Problems (당뇨병성 족부병변의 관리)

  • Park, Yoon-Jeong;Yun, So-Young
    • Physical Therapy Korea
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    • v.5 no.2
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    • pp.98-105
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    • 1998
  • The purposes of this article are to review the pathogenesis, prevention, and management of amputation due to diabetes mel1itus complications, and to report one case who had lost his toes due to diabetes mellitus. A primary cause for hospital admission of the patient was foot ulcer. Since many amputations in diabetic patients are precipitated by such ulcers, a program for active prevention and optimal treatment of diabetic foot lesions might decrease the risk of amputation. Diabetic foot ulcers and, ultimately, amputation can stem from a variety of pathways. The combination of peripheral neuropathy, peripheral vascular disease and infections is the harbinger of the final cataclysmic events of gangrene and amputation. As the physical therapist is often involved in the treatment of diabetic patients, the therapist should be aware of the followings: the patient's type of diabetes and the severity of the diabetes, the complications of the disease, the effects of exercise, the importance of wearing proper shoes and education to patients about appropriate diabetic foot care.

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The Role of Human Factors in Expert System (전문가시스템 개발에 있어서의 인간공학의 역할)

  • 서창교
    • The Journal of Information Systems
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    • v.1
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    • pp.95-109
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    • 1992
  • A number of success story about various application areas including manufacturing, accounting, finance, education, and engineering are reported. MIS professionals predicted that expert systems would improve the productivity enormously. However, the expert system revolution has not happened yet. Although not reported in the open society widely, there are failure stories of expert systems. Most of problems concerning expert system failure stem from the non-technical issues such as cognitive and psychological problems rather than the technical issues. We hypothesize that human factor principle enables designers to handle most of these non-technical problems elegantly and to improve the performance and acceptance of the expert systems. Major reasons for expert system failure and needs of human factors are discussed. Human factor guidelines to expert system make the prospects of the expert systems with human factors clear and understandable.

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The Understanding of Kindergarten Children about the Transition to Elementary School (초등학교 입학에 대한 유아의 이해)

  • Lee, Kyung-Soon
    • Korean Journal of Child Studies
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    • v.27 no.6
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    • pp.235-248
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    • 2006
  • Using qualitative methods of interviewing, documentation, and participant observation, this study explored kindergarten children's understanding on their transition into elementary school. Phenomenologically, results showed that children understood that the transition into elementary school means thrownness (Geworfenheit) and projection (Entwurf). When children answered the question about why they want to go to elementary school, their responses demonstrated an understanding of the inevitability (thrownness) of transition. That is, they understood that entering elementary school was an unavoidable step for growing up. They expected(projected) that they would enjoy new activities and opportunities in elementary school. While they felt anxious about stem teachers and difficult studies, they looked forward to intellectual development, various indoor activities, outdoor exercises, and multi-layered encounters.

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Scutellaria krasevii Kom. & I. Schischk. ex Juz. (Lamiaceae): a new record species from Mongolia

  • BAZARRAGCHAA, Badamtsetseg;BATDELGER, Gantuya;SHAGDAR, Darijmaa;PAEK, Woon Kee;LEE, Joongku
    • Korean Journal of Plant Taxonomy
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    • v.49 no.2
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    • pp.198-201
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    • 2019
  • We report Scutellaria krasevii Kom. & I. Schischk. ex Juz. (subfamily Scutellarioideae, family Lamiaceae) as a new recorded species of Mongolia. This species is morphologically similar to S. galericulata but can be differentiated by the presence of comparatively thick and triangular-cordate leaves having a heteromerously deep-crenate margin, a densely reclinate pubescent stem, and a densely pubescent corolla. A taxonomic description, a key to the genus in Mongolia, habit photographs, and scanning electron photomicrographs of nutlets are provided for species identification. We also present a table for a comparison of the diagnostic characteristics with those of related species. This species grows along the banks of the Unit river, Khutag-Undur soum, Bulgan province, Mongolia, approximately 2,300 km far away from the type locality in Russia.