• Asian-Australasian Journal of Animal Sciences
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• v.30 no.7
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• pp.985-993
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• 2017

Objective: The objective of this study was to evaluate increasing doses of a novel microbial phytase (Cibenza Phytaverse, Novus International, St. Charles, MO, USA) on standardized total tract digestibility (STTD) of P in canola meal (CM), corn, corn-derived distiller's dried grains with solubles (DDGS), rice bran (RB), sorghum, soybean meal (SBM), sunflower meal (SFM), and wheat. Methods: Two cohorts of 36 pigs each (initial body weight = $78.5{\pm}3.7kg$) were randomly assigned to 2 rooms, each housing 36 pigs, and then allotted to 6 diets with 6 replicates per diet in a randomized complete block design. Test ingredient was the only dietary source of P and diets contained 6 concentrations of phytase (0, 125, 250, 500, 1,000, or 2,000 phytase units [FTU]/kg) with 0.4% of $TiO_2$ as a digestibility marker. Feeding schedule for each ingredient was 5 d acclimation, 5 d fecal collection, and 4 d washout. The STTD of P increased (linear or exponential $p{\leq}0.001$) with the inclusion of phytase for all ingredients. Results: Basal STTD of P was 37.6% for CM, 37.6% for corn, 68.6% for DDGS, 10.3% for RB, 41.2% for sorghum, 36.7% for SBM, 26.2% for SFM, and 55.1% for wheat. The efficiency of this novel phytase to hydrolyze phytate is best described with a broken-line model for corn, an exponential model for CM, RB, SBM, SFM, and wheat, and a linear model for DDGS and sorghum. Based on best-fit model the phytase dose (FTU/kg) needed for highest STTD of P (%), respectively, was 735 for 64.3% in CM, 550 for 69.4% in corn, 160 for 55.5% in SBM, 1,219 for 57.8% in SFM, and 881 for 64.0% in wheat, whereas a maximum response was not obtained for sorghum, DDGS and RB within the evaluated phytase range of 0 to 2,000 FTU/kg. These differences in the phytase concentration needed to maximize the STTD of P clearly indicate that the enzyme does not have the same hydrolysis efficiency among the evaluated ingredients. Conclusion: Variations in enzyme efficacy to release P from phytate in various feedstuffs need to be taken into consideration when determining the matrix value for phytase in a mixed diet, which likely depends on the type and inclusion concentration of ingredients used in mixed diets for pigs. The use of a fixed P matrix value across different diet types for a given phytase concentration is discouraged as it may result in inaccurate diet formulation.

• Journal of dental hygiene science
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• v.12 no.3
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• pp.253-258
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• 2012

Dental amalgam is an alloy composed of a mixture of approximately equal parts of elemental liquid mercury and an alloy powder. Amalgam has been the most popular and effective restorative material used in dentistry. Despite the long history and popularity of dental amalgam as a restorative material, there have been periodic concerns regarding the potential adverse health effects arising from exposure to mercury in amalgam. Since children are more at risk for mercury toxicity, we aimed to assess the association between dental amalgam filling and urinary mercury concentration in children. 581 of elementary school children in grades 1st4th were conveniently recruited from two schools located in Daegu city, Korea. To obtain dental caries experience states, oral examination were conducted using the full term for DFS index, number of amalgam filling surfaces and the type of filling materials. A questionnaire was used to collect information about general characteristics and the frequencies of tooth brushing, gum chewing and fish/seafood consumption. The statistical analysis was done using the SPSS 18.0 program. The mean urinary mercury concentration in children having more surfaces was highest. As a results Urinary mercury concentration of children who have 79 teeth of amalgam filling and more than 10 is higher than without amalgam filling. The number of amalgam filling surface is closely related with urinary mercury concentration.

• Radiation Oncology Journal
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• v.28 no.4
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• pp.224-230
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• 2010

Purpose: We designed the aft-multiple-slit (AMS) system to reduce scatter in cone-beam computed tomography (CBCT). As a preliminary study, we performed a Monte Carlo N-Particle Transport Code (MCNP) simulation to verify the effectiveness of this system. Materials and Methods: The MCNPX code was used to build the AMS geometry. An AMS is an equi-angled arc to consider beam divergence. The scatter-reduced projection images were compared with the primary images only and the primary plus scatter radiation images with and without AMS to evaluate the effectiveness of scatter reduction. To obtain the full 2 dimensional (2D) projection image, the whole AMS system was moved to obtain closed septa of the AMS after the first image acquisition. Results: The primary radiation with and without AMS is identical to all the slit widths, but the profiles of the primary plus scattered radiation varied according to the slit widths in the 2D projection image. The average scatter reduction factors were 29%, 15%, 9%, and 8% when the slit widths were 5 mm, 10 mm, 15 mm, and 20 mm, respectively. Conclusion: We have evaluated the scatter reduction effect of the AMS in CBCT imaging using the Monte Carlo (MC) simulations. A preliminary study based on the MCNP simulations showed a mount of scatter reduction with the proposed system.

• Molecules and Cells
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• v.25 no.3
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• pp.390-396
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• 2008

Calreticulin (CRT) is one of the major $Ca^{2+}$ binding chaperone proteins of the endoplasmic reticulum (ER) and an unusual luminal ER protein. Postnatally elevated expression of CRT leads to impaired development of the cardiac conductive system and may be responsible for the pathology of complete heart block. In this study, the molecular mechanisms that affect $Ca^{2+}$-dependent signal cascades were investigated using CRT-overexpressing cardiomyocytes. In particular, we asked whether calreticulin plays a critical role in the activation of $Ca^{2+}$-dependent apoptosis. In the cells overexpressing CRT, the intracellular calcium concentration was significantly increased and the activity of PKC and level of SECAR2a mRNA were reduced. Phosphorylation of Akt and ERKs decreased compared to control. In addition the activity of the anti-apoptotic factor, Bcl-2, was decreased and the activities of pro-apoptotic factor, Bax, p53 and caspase 8 were increased, leading to a dramatic augmentation of caspase 3 activity. Our results suggest that enhanced CRT expression in mature cardiomyocytes disrupts intracellular calcium regulation, leading to calcium-dependent apoptosis.

• Molecules and Cells
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• v.24 no.2
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• pp.200-209
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• 2007

We generated gene expression data from the tissues of 50 gastric cancer patients, and applied meta-analysis and gene set analysis to this data and three other stomach cancer gene expression data sets to define the gene expression changes in gastric tumors. By meta-analysis we identified genes consistently changed in gastric carcinomas, while gene set analysis revealed consistently changed biological themes. Genes and gene sets involved in digestion, fatty acid metabolism, and ion transport were consistently down-regulated in gastric carcinomas, while those involved in cellular proliferation, cell cycle, and DNA replication were consistently up-regulated. We also found significant differences between the genes and gene sets expressed in diffuse and intestinal type gastric carcinoma. By gene set analysis of cytogenetic bands, we identified many chromosomal regions with possible gross chromosomal changes (amplifications or deletions). Similar analysis of transcription factor binding sites (TFBSs), revealed transcription factors that may have caused the observed gene expression changes in gastric carcinomas, and we confirmed the overexpression of one of these, E2F1, in many gastric carcinomas by tissue array and immunohistochemistry. We have incorporated the results of our meta- and gene set analyses into a web accessible database (http://human-genome.kribb.re.kr/stomach/).

• Korean Journal of Food Science and Technology
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• v.34 no.5
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• pp.931-934
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• 2002

To establish the optimal conditions for increasing oil yields from grape seed, extraction solvent, extraction time, and temperature were examined. Using grinding, grinding and roasting, grinding and steaming, and grinding, roasting, and steaming methods. Pressing extraction method resulted in 34.0% oil yield. Grinding and roasting, grinding and steaming, and grinding, roasting, and steaming gave 64.3, 63.0, and 65.6% yield, respectively. Ether solvent treatment resulted in 77.4 and 80.9% recoveries after 24 and 48 h static, respectively. The results of sensory evaluation revealed, oils extracted under optimal condition showed the best flavor, aroma, and whor, followed by grinding, grinding and roasting, grinding, roasting, and steaming, and grinding and steaming. Taking these results together, the optimal methods for oils extraction from grape seed were as follows: grape seed ${\rightarrow}$ washing ${\rightarrow}$ drying ${\rightarrow}$ roasting ($95{\sim}100^{\circ}C$ for 20 min) ${\rightarrow}$ cooling (room temperature) grinding ${\rightarrow}$ (0.5 mm>) ${\rightarrow}$ steaming ($0.8{\sim}0.9\;kg{\cdot}f/cm^2$ for 10 min) ${\rightarrow}$ pressing ($1st\;400\;kg/cm^2\;for\;2{\sim}3\;min,\;2^{nd}\;550{\sim}600\;/cm^2$ for 10 min, $3^{rd}\;700kg/cm^2$ for 60 min) ${\rightarrow}$ oils (yield $;85{\sim}90%$).

• Journal of Arbitration Studies
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• v.14 no.1
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• pp.345-376
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• 2004

Die staatliche Gerichtsbarkeit und die Schiedsgerichtsbarkeit haben es gemeinsam, dass sie eine Institution der Entscheidung von priyatrechtlichen Streitigkeiten sind und dass ihre Entscheidungen auf ein rechtmaessiges Verfahren beruhen muessen. Auf der anderen Seite aber unterscheiden sick die beiden Institutionen wesentlich dadurch, dass die Schiedsgerichtsbarkeit auf einer rechtsgesch$\"{a}$ftlichen Parteihandlung, n$\"{a}$imlich einer Schiedsvereinbarung beruht, w$\"{a}$hrend das Prozessvefahren vol den staatllchen Gerichten seine Legitimation in der Staatshoheit hat. Wegen der vertraglichen Basis der Schiedsgerichtsbarkeit k$\"{o}$nnen die Parteien in der Schiedsgerichtsbarkeit $\"{u}$ber das Verfahren verf$\"{u}$gen, und beim Fehlen der Parteivereinbarung f$\"{u}$hrt das Schiedsgericht nach freiem Ermessen das Verfahren durch. Damit das Schiedsvefahren nicht zu einem quasi-Konventionalprozess wird und die Garantie der rechtsstaatlichen Prinzipien nicht ausser acht gelassen wird und ein geordnetes Schiedsverfahren zu gewahrleisten ist, braucht das Schiedsgericht einen Massstab seines Ermessens. Die Regelungen der Zivilprozessordnung sind dabei in erster Lime in Erw$\"{a}$gung zu ziehen, weil sie sick auf die rechtm$\"{a}$ssige Erledigung der Streitigkeiten richten. Die Zivilprozessordnung hat nicht zuletzt einen grossen Einfluss auf das Schiedsverfahren, sei os durch die Ausiibung der Zwangsgewalt des staatlichen Gerichts bei der Beweisaufnahme odor sei es durch das Anerkennungs- und Vollstreckbarerklarungsverfahren des Schiedsspruchs. Obwohl der Zivilprozess md das Schiedsverfahren sich im wesentlichen unterscheiden lassen, sind sie miteinander eng verbunden. Die staatlichen Gerichte haben nicht nor die Pflicht, im Wege der Aufhebungsklage md des YollstreckbarerldErungsverfahrens die Schiedsgerichtsbarkeit zu kontrollieren, sondern auch die Aufgabe, bei der Entscheidung des Schiedsgerichts mitzuwirken. Die Schiedsgerichtsbarkeit ist vol allem bei der Beweisaufnahme auf dieMitwirkung des staatlichen Gerichts angewiesen. Das ergibt sich aus dom Gewaltmonopol des Staates. Bei der Mitwirkung des staatlichen Gerichts spielt die Zivilprozessordnung eine entscheidende Rolle, weil das Gericht die Beweisaufnahme nach der Zivilprozessordnung durchzufiihren hat. Fiir die anderung der Zivilprozessordnung im Jahr 2002 muss man daher auch in der Schiedsgrichtsbarkeit Aufrnerksarnkeit zeigen. Vor allem lassen sich die eventuelle, alternative subjektive Klagenhaufung, die Rechtzeitigkeit des Vorbinggens, die St$\"{a}$rkung der Vorbereitung der miindlichen Verhandlung, der Zeugenbeweis md die Vorlegungspflicht der Urkunden sowie die Abanderungslrlage auch auf das Schiedsverfahren anwenden nd damit kann man die EffektivitEt des SchiedsverfEhrens vertiefen und erh$\"{o}$hen.

• Korean Journal of Clinical Pharmacy
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• v.29 no.4
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• pp.238-246
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• 2019

Background: In South Korea, as an aged society, an understanding of dementia and its risk factors is important from clinical and healthcare policy perspectives. Relationship between cognitive impairment and body weight or weight changes have been reported, but these were contradictory. We have evaluated the association between weight changes and cognitive decline using national level longitudinal data. Methods: Data from the Korean Longitudinal Study of Ageing from 2006 to 2012 were used. Association between weight changes and decline in cognitive function as measured by K-MMSE (the Korean version of the Mini-mental state examination) score was assessed by multivariate logistic regression. Weight changes were calculated from 1st wave and 3rd wave survey data, and classified into five groups as stable, increases, decreases of >10%, or 5%-10%. Results: About 37% of the total participants (n=4,512) were 65 years or older. These participants made up the largest proportion of the groups with weight change exceeding 10%. Multivariate logistic regression analyses revealed that weight changes exceeding 10% (10% increase vs stable, adjusted OR [aOR] 1.47, 95% confidence interval (CI) 1.11-1.95; 10% decrease vs stable, aOR 1.44, 95% CI 1.11-1.88) were significant predictive factors for decline in cognitive function. In subgroup analyses, the association between weight changes and cognitive decline was significant in males aged over 65 years and in normal BMI groups. Conclusion: Weight changes, both increases and decreases exceeding 10% of baseline, were significantly associated with declines in cognitive function among older adults in South Korea.

• The Journal of Korean Academy of Prosthodontics
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• v.39 no.5
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• pp.463-476
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• 2001

Since the treatment of edentulous patients with osseointegrated implant was first introduced more than 30 years ago, implant therapy has become one of the most important dental treatment modalities today. Based on the previous experience and knowledge, $Br{\aa}nemark\;Novum^{(R)}$ protocol was introduced with the concept of simplifying surgical and prosthetic technique and reducing healing time recently. This protocol recommends the installation of three 5mm wide diameter futures in anterior mandible and the prefabricated titanium bars for superstructure fabrication. This study was designed to analyze the stress distribution at fixture and superstructure area according to changes of fixture number, diameter and superstructure materials. Four 3-dimensional finite element models were fabricated. Model 1 - 5 standard fixtures (13mm long and 3.75mm in diameter) & superstructure consisted of type IV gold alloy and resin Model 2- 3 wide diameter fixtures (13mm long and 5.0mm in diameter) & superstructure consisted of type IV gold alloy and resin Model 3-3 wide diameter fixtures (13mm long and 5.0mm in diameter) & superstructure consisted of titanium and resin Model 4-3 wide diameter fixtures (13mm long and 5.0mm in diameter) & superstructure consisted of titanium and porcelain A 150N occlusal force was applied on the 1st molar of each model in 3 directions - vertical($90^{\circ}$), horizontal($0^{\circ}$) and oblique($120^{\circ}$). After analyzing the stresses and displacements, following results were obtained. 1. There were no significant difference in stress distribution among experimental models. 2. Model 2, 3, 4 showed less amount of compressive stress than that of model 1. However, tensile stress was similar. 3. Veneer material with a high modulus of elasticity demonstrated less stress accumulation in the superstructure. Within the limites of this study, $Br{\aa}nemark\;Novum^{(R)}$ protocol demonstrated comparable biomechanical properties to conventional protocol.

• Journal of Korean Society of Forest Science
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• v.102 no.2
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• pp.305-308
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• 2013

This study was conducted to describe the external morphology of Platypus-koryoensis Murayama in immature stage, to determine each instar based on larvae head-capsule, and to measure individual and local variations in the number of mycangia of adult. Egg of P. koryoensis, had oval shape and lengths of the major and minor axis were $0.67{\pm}0.051$ mm and $0.41{\pm}0.053$ mm, respectively. Body colour of $5^{th}$ instar was gloss white with well-developed mandible. Larvae of P. koryoensis grew up to $5^{th}$ instar and each instar was clearly classified by head capsule width. Head capsule width for $1^{st}$, $2^{nd}$, $3^{rd}$, $4^{th}$, and $5^{th}$ instar larvae were $0.35{\pm}0.004$ mm, $0.45{\pm}0.010$ mm, $0.67{\pm}0.039$ mm, $0.94{\pm}0.069$ mm and, $1.12{\pm}0.007$ mm, respectively. The colour of pupa was pale yellow and its length was $4.64{\pm}0.044$ mm. The number of mycangia per female had individual variations from 5 to 12 and 83% of the adults had from 6 to 8 mycangia. There was no significant difference in number of mycangia collected from between Namyangju region and Honchen region.