• Journal of Integrative Natural Science
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• v.10 no.3
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• pp.125-130
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• 2017

Glucagon like pepide-2, one of the GLPs, is involved in various metabolic functions in the gastrointestinal tract. It plays a major role in the regulation of mucosal epithelium and the intestinal crypt cell proliferation. Because of their therapeutic importance towards the diseases in the gastrointestinal tract, it becomes necessary to study their interaction with its receptor, GLP-2R. In this study, we have developed protein-protein docking complexes of GLP-2 - GLP-2 receptor. Homology models of GLP-2 are developed, and a reliable model out of the predicted models was selected after model validation. The model was bound with the receptor, to study the important interactions of the complex. This study could be useful in developing novel and potent drugs for the diseases related with GLP-2.

• Journal of Integrative Natural Science
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• v.10 no.3
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• pp.137-140
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• 2017

Diabetes mellitus has become a major growing public health problem worldwide. More than 90% of all diabetes cases are classified as type 2 diabetes (T2D), which is also known as non-insulin dependent diabetes. Protein tyrosine phosphatase 1B (PTP1B) plays an important role in the negative regulation of insulin signal transduction pathway and has emerged as novel therapeutic strategy for the treatment of type 2 diabetes. PTP1B inhibitors enhance the sensibility of insulin receptor (IR) and have favorable curing effect for insulin resistance-related diseases. Recently twelve anti-diabetic xanthones were isolated from the bark of Garcinia xanthochymus. Hence, in the present study, molecular docking was carried out for these twelve xanthones. The objective of this work is to study the interaction of the newly isolated xanthones with PTP1B. The docking results showed that xanthones have good interactions and has better docking score with PTP1B and suggest LYS120 and ASP181 are the important residues involved in interaction between PTP1B enzyme and the xanthones.

• Journal of Integrative Natural Science
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• v.11 no.1
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• pp.25-29
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• 2018

Protein phosphatase manganese dependent 1D (PPM1D), a Ser/Thr protein phosphatise, play major role in the cancer tumorigenesis of various tumors including neuroblastoma, pancreatic adenocarcinoma, medulloblastoma, breast cancer, prostate cancer and ovarian cancer. Hence, analysis on the structural features required for the formation of PPM1D-inhibitor complex becomes essential. In this study, we have performed molecular docking of SL-175 and -176 and protein-protein docking of CDC5L with PPM1D. On analysing the docked complexes, we have identified the important residues involved in the formation of protein-ligand complex. Research concentrating on these residues could be helpful in understanding the pathophysiology of various tumors related to PPM1D.

• Journal of Integrative Natural Science
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• v.11 no.1
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• pp.9-13
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• 2018

KiSS1-derived peptide receptor, a GPCR protein, binds with the hormone Kisspeptin plays a major role in the neuroendocrine regulation of reproduction. It is important in the onset of puberty and triggers the release of gonadotrophin-releasing hormone. It is a potential drug target for the disorders related to GnRH, hence, analysing the structural features of the receptor becomes important. The three dimensional of the receptor modelled in a previous study was utilised. In this study, we have analysed the protein - protein interaction of the receptor with Kisspeptin 10 and 15. The study revealed the important residues which are involved in the interaction. The result of this study could be helpful in understanding the mechanism of Kiss1 receptor activation and the pathophysiology of the disorders related to the receptor.

• Journal of Integrative Natural Science
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• v.11 no.1
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• pp.19-24
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• 2018

CRFR is involved in the pathophysiology of various disorders including depression, stress, anxiety, post-traumatic stress disorder, and addiction. The discovery of novel and structurally diverse CRF1 receptor inhibitors becomes essential. In this study, we have performed molecular docking of CRF1R with the derivatives of 8-substituted-2-aryl-5-alkylaminoquinolines as CRF1R inhibitors. The antagonist molecules were optimized and docked into the binding site of the receptor. On analysing the docked complexes we have identified that the residues HIS214, THR215, ARG227, ARG1008, LYS1060 and ASP1061 are important in forming hydrogen bond with the inhibitors. Further studies on these residues could reveal important structural features required for the formation of CRF1R-inhibitor complex and thus in the discovery of novel and potent inhibitors.

• Journal of Electrical Engineering and Technology
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• v.13 no.4
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• pp.1578-1585
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• 2018

This work investigates two different motor drive technologies, switched reluctance motor (SRM) and induction motor (IM). They are designed optimally to meet the desired performances for electric scooters. The comparison of both motors is described in terms of performances and material cost. With the similar constraint, induction motor performs slightly better than switched reluctance motor. But this must be traded-off with higher weight and cost. Both drive systems are, however, suitable for electric scooter application. Finally, the range simulations are conducted on a European urban driving cycle, ECE15 driving cycle and a more realistic cycle, Bangkok driving cycle. The e-scooter ranges are varied from 36 to 109 km depending on driving cycle, motor technology and number of passengers.

• Journal of Electrical Engineering and Technology
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• v.13 no.5
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• pp.1996-2003
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• 2018

In this paper, the design and characteristic analysis of a novel single-phase hybrid switched reluctance motor (HSRM) for the purpose of replacing the universal motor in commercial blenders are presented. The proposed motor is easy to manufacture due to its simple yet robust structure with minimized power switches and no torque dead-zone. Moreover, the proposed HSRM is able to deliver a high starting torque as a requirement for blending hard food or even ice. The stator has permanent magnets (PMs) mounted on its inner surface and the rotor has a wide pole arc and salient poles that contribute to its high starting torque profile and the elimination of the torque dead-zone. Finite element method (FEM) is used to analyze the characteristic of the proposed motor. Finally, the prototype is manufactured and its performance is verified through experiments.

• Proceedings of the KIEE Conference
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• 2005.07b
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• pp.1291-1293
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• 2005

Switched reluctance motors have the advantage a high torque/weight ratio, as the large reluctance torque is made by salient poles of both stator and rotor, and a high reliability. On the other hand, the switched reluctance motors have the disadvantage of a large ripple torque which is made by salient poles. So the application for the industrial fields have been limited to special cases. This paper describes the design of a 12/8 switched reluctance motor using a enemy layer method of the asymmetry rotor. The design is focussed to reduce the torque ripple and radial force in the demanded value. The three dimension finite element analysis method(3D-FEM) was used for decides a enemy layer angle of the asymmetry rotor. This paper presents modifications of the rotor pole shape which reduces the torque ripple.

• Journal of Integrative Natural Science
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• v.9 no.1
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• pp.23-27
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• 2016

Hepatitis B virus is the leading source of liver disorders and is a global health problem and needs advancements in its treatment against increasing problems. Recently five vanitaracin derivatives were isolated from the fungus Talaromyces species which have anti-Hepatitis B virus activity. Hence, in the present study, molecular docking was carried out with five vanitaracin derivatives isolated from Talaromyces species and three known inhibitors.The objective of this work is to study the interaction of newly isolated compounds and compare its interaction with known inhibitors. The docking results revealed that vanitaracin derivatives have good interactions and has better docking score with the Hepatitis B virus and suggest SER2, SER4 and ASP30 are important residues involved in interaction with the inhibitors. These result authenticates vanitaracin derivatives contributes to inhibitory activity of Hepatitis B virus to treat liver disorders.

• Economic and Environmental Geology
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• v.49 no.2
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• pp.89-95
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• 2016

Mo isotope, one of highly redox-sensitive isotopes, has been shown to be useful tracers of geochemical processes. Many studies for Mo isotope have documented with the help of recently developed analysis tools, but it has not yet been documented in the Korea. In this study, we introduce two-stage column separation method of Mo using column tube (BioRad PolyPrep(R) column, 10 ml) and anion exchange resin (BioRad Resin AG(R) 1-X8, 200-400 mesh). Mo isotope ratios in the solid SRMs (BHVO-2, SDO-1, PACS-2) and liquid SRM (IAPSO) were measured on MC-ICP-MS (Multi-collector Inductively Coupled Plasma Mass Spectrometer) and then compared with reference Mo isotope ratios. Mo isotope ratios in our study overlap with reference Mo isotope ratios within analytical error.