• Structural Engineering and Mechanics
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• 제22권4호
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• pp.419-432
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• 2006

Experimental studies on the behaviors of box-shape steel reinforced concrete (SRC) composite beams were conducted. Seven 1:3 scale model composite beams were tested to failure. Each of the beams was simply supported at the ends and two concentrated loads were applied at the one-third span and two-thirds span respectively. Experimental results indicate that the flexural strength can be enhanced when the ratio of flexural reinforcements and flange thickness of the shape steel are increased; the shear strength is enhanced with increase of web thickness of the shape steel. Insignificant effects of concrete in the box-shape steel are found on improving the flexural strength and shear strength of the box-shape SRC composite beams, thus concrete inside the box-shape steel can be saved, and the weight of the SRC beams can be decreased. Shear studs can strengthen the connection and co-work effects between the shape steel and the concrete and enhance the shear strength, but stud design for the composite beams should be further improved. Formulas for flexural and shear strength of the composite beams are proposed, and the calculated results are in good agreement with the experimental results. In general, the box-shape SRC composite beam is a kind of ductile member, and suitable for extensive engineering application.

• Steel and Composite Structures
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• 제1권3호
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• pp.295-312
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• 2001

The purpose of this paper is to propose a new type of steel reinforced concrete (SRC) beam-column joints and to examine the structural performance of the proposed joints, which simplify the construction procedure of steel fabrication, welding works, concrete casting and joint strengthening. In the proposed beam-column joints, the steel element of columns forms continuously built-in crossing of H-sections (${\Box}$), with adjacent flanges of column being connected by horizontal stiffeners in a joint at the level of the beam flanges. In addition, simplified lateral reinforcement (${\Box}$) is adopted in a joint to confine the longitudinal reinforcing bars in columns. Experimental and analytical studies have been carried out to estimate the structural performance of the proposed joints. Twelve cruciform specimens and seven SRC beam-column subassemblage specimens were prepared and tested. The following can be concluded from this study: (1) SRC subassemblages with the proposed beam-column joints show adequate seismic performances which are superior to the demand of the current code; (2) The yield and ultimate strength capacities of the beam-to-column connections can be estimated by analysis based on the yield line theory; (3) The skeleton curves and the ultimate shear capacities of the beam-column joint panel are predicted with a fair degree of accuracy by considering a simple stress transfer mechanism.

• Steel and Composite Structures
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• 제18권3호
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• pp.623-639
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• 2015

Self-compacting Concrete (SCC) Filled Square steel Tubes (SCFST) was used to strengthen square RC columns. To establish the efficiency of this strengthening method, 17 columns were tested under axial compression loading including 3 RC columns without any strengthening (WRC), 1 RC column strengthened with concrete jacket (CRC), 13 RC columns strengthened with self-compacting concrete filled square steel tubes (SRC). The experimental results showed that the use of SCFST is interesting since the ductility and the bearing capacity of the RC columns are greatly improved. The improvement ratio is significantly affected by the nominal wall thickness of steel tubes (t), the strength grade of strengthening concrete (C), and the length-to-width ratio (L / B) of the specimens. In order to quantitatively analyze the effect of these test parameters on axial loading behavior of the SRC columns, three performance indices, enhancement ratio (ER), ductility index (DI), and confinement ratio (CR), were used. The strength of the SRC columns obtained from the experiments was then employed to verify the proposed mode referring to the relevant codes. It was found that codes DBJ13-51 could relatively predict the strength of the SRC columns accurately, and codes AIJ and BS5400 were relatively conservative.

• BMB Reports
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• 제39권3호
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• pp.304-310
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• 2006

Transcription factor NF-E2-related factor 2 (Nrf2) regulates the induction of Phase II detoxifying enzymes and antioxidant enzymes in response to many cancer chemopreventive compounds. In this study, we investigated the role of receptor associated coactivator (RAC3) or steroid receptor coactivator-3 (SRC3) and other nuclear co-regulators including CBP/p300 (CREB-binding protein), CARM1 (Coactivator-associated arginine methyltransferase), PRMT1 (Protein arginine methyl-transferase 1), and p/CAF (p300/CBP-associated factor) in the transcriptional activation of a chimeric Gal4-Nrf2-Luciferase system containing the transactivation domain (TAD) of Nrf2 in HepG2 cells. The results indicated that RAC3 up-regulated the transactivation activity of Gal4-Nrf2-(1-370) in a dose-dependent manner. The enhancement of transactivation domain activity of Gal4-Nrf2-(1-370) by RAC3 was dampened in the presence of dominant negative mutants of RAC3. Next we studied the effects of other nuclear co-regulators including CBP/p300, CARM1, PRMT1 and p/CAF, and the results showed that they had different level of positive effects on this transactivation domain activity of Gal4-Nrf2-(1-370). But importantly, synergistic effects of these co-regulators in the presence of RAC3/SRC3 on the transactivation activity of Gal4-Nrf2-(1-370) were observed. In summary, our present study showed for the first time that the 160 RAC3/SRC3 is involved in the functional transactivation of TAD of Nrf2 and that the other nuclear co-regulators such as CBP/p300, CARM1, PRMT1 and p/CAF can also transcriptionally activate this TAD of Nrf2 and that they could further enhance the transactivation activity mediated by RAC3/SRC3.

• BMB Reports
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• 제48권3호
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• pp.184-189
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• 2015

Src homology 2-containing protein tyrosine phosphatase 2 (SHP-2) is known to protect neurons from neurodegeneration during ischemia/reperfusion injury. We recently reported that ROS-mediated oxidative stress promotes phosphorylation of endogenous SHP-2 in astrocytes and complex formation between caveolin-1 and SHP-2 in response to oxidative stress. To examine the region of SHP-2 participating in complex formation with caveolin-1, we generated three deletion mutant constructs and six point mutation constructs of SHP-2. Compared with wild-type SHP-2, binding of the N-SH2 domain deletion mutant of SHP-2 to p-caveolin-1 was reduced greatly, using flow cytometric competitive binding assays and surface plasmon resonance (SPR). Moreover, deletion of the N-SH2 domain of SHP-2 affected $H_2O_2$-mediated ERK phosphorylation and Src phosphorylation at Tyr 419 in primary astrocytes, suggesting that N-SH2 domain of SHP-2 is responsible for the binding of caveolin-1 and contributes to the regulation of Src phosphorylation and activation following ROS-induced oxidative stress in brain astrocytes.

• Journal of Welding and Joining
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• 제14권3호
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• pp.48-57
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• 1996

A study was made to examine the characteristics of base metal and stress relief cracking(SRC) of heat affected zone(HAZ) for HY-100 and Cu-bearing HSLA-100 steels. The Gleeble thermal/mechanical simulator was used to simulate the SRC/HAZ. The details of mechanical properties of base plate and SRC tested specimens were studied by impact test, optical microscopy and scanning electron microscopy. The specimens were aged at $650^{\circ}C$ for HSLA-100 steel and at $660^{\circ}C$ for HY-100 steel and thermal cycled from $1350^{\circ}C$ to $25^{\circ}C$ with a cooling time of $\Delta$t_${800^{circ}C/500^{circ}C}$=21sec. corresponds to the heat input of 30kJ/cm. The thermal cycled specimens were stressed to a predetermined level of 248~600MPa and then reheated to the stress relief temperatures of $570~620^{\circ}C$. The time to failure$(t_f)$ at a given stress level was used as a measure of SRC susceptibility. The strength, elongation and impact toughness of base plate were greater in HSLA-100 steel than in HY-100 steel. The time to failure was decreased with increasing temperature and/or stress. HSLA-100 steel was more susceptible to stress relief cracking than HY-100 steel under same conditions. It is thought to be resulted from the precipitation of $\varepsilon$-Cu phase by dynamic self diffusion of solute atoms. By the precipitation of $\varepsilon$-Cu phase, the differential strengthening of grain interior relative to grain boundary may be greater in the Cu-bearing HSLA-100 steel than in HY-100 steel. Therefore, greater strain concentration at grain boundary of HSLA-100 steel results in the increased SRC susceptibility. The activation energies for SRC of HSLA-100 steel are 103.9kcal/mal for 387MPa and 87.6kcal/mol for 437MPa and that of HY-100 steel is 129.2kcal/mol for 437MPa.

• 한국콘크리트학회:학술대회논문집
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• 한국콘크리트학회 2001년도 가을 학술발표회 논문집
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• pp.297-302
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• 2001

SRC pier at KTE 6-1 construction area is a very important structure. Precise control of quality is needed. This pier has 3.50m$\times$3.73m section and 38.20m length. So this structure must be treated as mass concrete and thermal crack caused by hydration heat should be controled. In this project belite cement concrete is used to control the thermal crack. As a result of adapting belite cement concrete perfect control is achieved. Finally, hydration heat FEM analysis of horizontal element is executed for Ordinary Portland Cement concrete and belite cement concrete. In comparison of two results, it is confirmed that using low heat portland cement concrete is necessary.

• 한국주거학회:학술대회논문집
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• 한국주거학회 2003년도 정기총회 및 추계학술대회
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• pp.145-149
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• 2003

This study is to investigate residents' living satisfaction with high-rise mixed-use apartment complexes built in the structures of the reinforced concrete constructing and the steel framed reinforced concrete construction. The results of this study were obtained as follows: 1. Residents expressed below average satisfaction (below 3.0) with the common-area landscape and environmentally-friendly factors, children's playground and its facilities, community service for residents' by the management offices and the plan of utility. 2.According to the satisfaction of sound environment, residents of SRC group expressed above average satisfaction; it can be concluded that problems of causing noise around the residential area of the SRC and S groups were well solved in this study. However, satisfaction with the freshness of indoor air, humidity, and smell in the living quarters was rated low by the residents of SRC group. 3. High-rise mixed-use apartment complexes should accomodate families's life cycle, design an environmentally-friendly resting place in harmony with city life, and provide various communal programs for residents.

• 전력전자학회:학술대회논문집
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• 전력전자학회 2012년도 전력전자학술대회 논문집
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• pp.349-350
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• 2012

본 논문에서는 직렬공진 컨버터를 이용한 3kW급 차량탑재형 배터리 충전기의 최적설계 방법을 제안한다. 제안한 충전기의 부스트컨버터는 역률보상과 동시에 배터리의 전압 또는 전류제어를 수행하여 절연부 직렬공진컨버터(SRC)를 고정주파수에서 동작시킴으로서 전부하 영역에서 스위치와 다이오드의 ZCS 턴온과 턴오프가 성취되고 모든 소자 정격을 최소화 할 수 있다. 또한 공진소자 공차에 따라 공진주파수가 변동되도 기존 방식과 달리 출력전압 변동이 거의 없고 하드스위칭 전류를 작게 할 수 있는 최적설계방법을 제시한다. 3kW 시작품을 통해 제안한 방식의 타당성을 검증하였다.

• Archives of Pharmacal Research
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• 제16권2호
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• pp.114-117
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• 1993

Ginsenosides present in the roots of panax ginseng C.A. Meyer were shown to induce a stimulatory effect on the overexpressed cellular chicken c-src protein tyrossine kinase in NH3T3 cells. Among 4 ginsenosides studied $(G-Rb_2,\;G-Rc,\;G-Re\;and\;G-Rg_1),\;G-Rg_1$ showed the most stimulatory effect at $16.7\mu{g/ml}$ ginsenoside concentration increasing the activity by 2-4 times. Inhibitors of either protein synthesis or RNA synthesis blocked the activation of c-src proein tyrosine kinase. These results suggest that the csrc kinase activation apprars to involve an increase in the amount of protein of the kinase by transcriptional control mechanism rather than an increase in the kinase activity.