• Proceeding of Spring/Autumn Annual Conference of KHA
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• 2003.11a
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• pp.145-149
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• 2003

This study is to investigate residents' living satisfaction with high-rise mixed-use apartment complexes built in the structures of the reinforced concrete constructing and the steel framed reinforced concrete construction. The results of this study were obtained as follows: 1. Residents expressed below average satisfaction (below 3.0) with the common-area landscape and environmentally-friendly factors, children's playground and its facilities, community service for residents' by the management offices and the plan of utility. 2.According to the satisfaction of sound environment, residents of SRC group expressed above average satisfaction; it can be concluded that problems of causing noise around the residential area of the SRC and S groups were well solved in this study. However, satisfaction with the freshness of indoor air, humidity, and smell in the living quarters was rated low by the residents of SRC group. 3. High-rise mixed-use apartment complexes should accomodate families's life cycle, design an environmentally-friendly resting place in harmony with city life, and provide various communal programs for residents.

• Korean Journal of Pharmacognosy
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• v.35 no.3 s.138
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• pp.244-249
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• 2004

The effects of hesperetin and naringenin on $NF-{\kappa}B$ activation were investigated in normal rat kidney cells transformed by temperature sensitive Rous Sarcoma Virus (tsNRK). The flavonoids, naringenin and hesperetin, significantly reduced v-Src-induced $NF-{\kappa}B$ activation as well as phosphorylation of Akt and GSK-3 in tsNRK cells, whereas these compounds did not effect on platelet-derived growth factor (PDGF)-induced $NF-{\kappa}B$ activation in $NIH3T3{\gamma}l$ cells. In addition, the DNA binding activity of SP-I was also reduced but that of AP-1 was not affected by the compounds. Our study suggests that Src-induced $NF-{\kappa}B$ activation could occur via Akt-GSK-3 pathway without $IkB{\alpha}$ degradation and that naringenin and hesperetin could be used in the treatment of cancer through the inhibition of $NF-{\kappa}B$ activation.

• Journal of the Computational Structural Engineering Institute of Korea
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• v.26 no.5
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• pp.335-342
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• 2013

Since the seriousness of environmental pollution came to the fore recently, various efforts have been made globally for the reduction of the environmental load. In particular, in the field of construction, an industry responsible for a considerable amount of pollution, studies have been actively conducted to reduce $CO_2$ emissions and energy consumption. However, most conventional research about pollution as it relates to construction is focused on the maintenance stages where $CO_2$ emissions are the greatest. Research related to the design stage is in its infancy, as it has only been conducted thus far on steel buildings and RC buildings. In fact, in order to achieve environmentally friendly construction considering the Life Cycle Assessment(LCA), the building design should be derived to reduce the $CO_2$ emissions from the early building design stage, and structural engineers should be able to suggest a design plan considering its environmental friendliness. In this study, optimal structural design method for steel reinforced concrete(SRC) columns considering $CO_2$ emissions is presented. The trends of $CO_2$ emissions in SRC columns according to the variations of steel shapes, concrete strengths and loads are investigated.

• Journal of the Korea institute for structural maintenance and inspection
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• v.18 no.3
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• pp.40-48
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• 2014

In this study, experimental research was carried out to evaluate and improve the seismic performance of reinforced concrete beam-column joint regions using strengthening materials (embedded CFRP rod and CFRP sheet) in existing reinforced concrete building. Therefore it was constructed and tested six specimens retrofitting the beam-column joint regions using such retrofitting materials. Specimens, designed by retrofitting the beam-column joint regions of existing reinforced concrete building, were showed the stable failure mode and increase of load-carrying capacity due to the effect of crack control at the times of initial loading and confinement of retrofitting materials during testing. Specimens RBCJ-SRC2, designed by the retrofitting of CFRP Rod and CFRP Sheet in reinforecd beam-column joint regions were increased its maximum load carrying capacity by 1.97 times and its energy dissipation capacity by 2.08 times in comparison with standard specimen RBCJ for a displacement ductility of 4 and 7. Also, specimens RBCJ-SRC2 were increased its maximum load carrying capacity by 1.09~1.11 times in comparison with specimen RBCJ-SR series. And Specimens RBCJ-CS, RBCJ-SR series, RBCJ-SRC2 were increased its energy dissipation capacity by 1.10~2.30 times in comparison with standard specimen RBCJ for a displacement ductility of 5, 6.

• Journal of the Korea Concrete Institute
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• v.21 no.1
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• pp.37-45
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• 2009

An objective of this study is to evaluate the structural performance of the weak axis SRC column-RC beam joints by experiments. Although one of common joint types is the connection with standard hooks, it has been required to examine its safety and to settle problems of the joint among practical engineers. Specimen types are classified into two categories, namely the type of standard hook and the type of shape improvement. The first one is consisted of three specimens which are reference type, development length modification type, and development length supplement type. Three specimens for shape improvement were made with variations on the arrangement of longitudinal reinforcements and the development length. Test results based on cyclic loadings were discussed with load-deflection curves, maximum strengths, strength degradations beyond the maximum. It was found that the standard hook types showed premature failures and consequent strength degradations due to splitting of joint concrete. However, satisfactory performance was obtained with the shape improvement type with wing-plate welding. No premature failures and strength degradations were detected with the specimens.

• Steel and Composite Structures
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• v.46 no.2
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• pp.221-236
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• 2023

In order to study the seismic response of the main plant of steel reinforced concrete (SRC) structure of the CAP1400 nuclear power plant under the influence of different high-mode vibration, the 1/7 model structure was manufactured and its dynamic characteristics was tested. Secondly, the finite element model of SRC frame-bent structure was established, the seismic response was analyzed by mode-superposition response spectrum method. Taking the combination result of the 500 vibration modes as the standard, the error of the base reactions, inter-story drift, bending moment and shear of different modes were calculated. Then, based on the results, the influence of high-mode vibration on the seismic response of the SRC frame-bent structure of the main plant was analyzed. The results show that when the 34 vibration modes were intercepted, the mass participation coefficient of the vertical and horizontal vibration mode was above 90%, which can meet the requirements of design code. There is a large error between the seismic response calculated by the 34 and 500 vibration modes, and the error decreases as the number of modes increases. When 60 modes were selected, the error can be reduced to about 1%. The error of the maximum bottom moment of the bottom column appeared in the position of the bent column. Finally, according to the characteristics of the seismic influence coefficient αj of each mode, the mode contribution coefficient γj•Xji was defined to reflect the contribution of each mode to the seismic action.

• Proceedings of the IEEK Conference
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• 2005.11a
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• pp.93-96
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• 2005

We propose a computationally efficient sphere decoding (SD) algorithm with smart radius control (SRC). As a baseline algorithm for SD, we consider the modified Schnorr-Euchner (SE) algorithm [1] (hereafter, called as the MSE algorithm). In principle, the radius after zero-forcing decision feedback equalization (ZF-DFE) estimation can be reduced further if we select a new lattice vector closer to the received signal vector than the lattice vector corresponding to the ZF-DFE estimate does. In our case, we obtain such a better lattice vector by performing a sequence of alternating one-dimensional searches, starting from the ZF-DFE estimate. We then develop a novel SRC algorithm that adopts adaptively the additional radius reduction process according to the estimated signal-to-noise-power ratio (SNR) after ZF-DFE estimation. In addition, we analyze the effect of detection ordering on the complexity for SD. Column-norm ordering of the channel matrix and optimal ordering [1] are considered here. From our analyses, we see that SRC can reduce greatly the complexity for SD and the degree of complexity reduction gets significant as the SNR decreases, irrespective of detection ordering schemes used.

• Animal cells and systems
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• v.6 no.1
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• pp.1-12
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• 2002

A role of Src family protein Tyrosine kinases (SFK) as mediators of receptor-ligand initiated responses is well established. Well documented, but less well understood is the role of SFK in cellular reaction to stresses. Evidence from the wide variety of experimental systems indicates that SFK mediate responses to all major classes of stress, including oxidation, DNA damage, mechanical impacts, and protein denaturing. SFK may be activated by stresses directly or via regulatory circuits whose identity is not yet fully understood. Depending on the cell type and the nature of activating stimulus, SFK may activate known downstream signaling cascades leading to cell survival, proliferation, cytoskeletal rearrangement, and apoptosis; the identity of these cascades is discussed. As in the case of receptor-initiated signaling, roles of individual SFK in various stress response may be redundant or non-redundant. Although signals generated by different stresses are generally transduced via distinct SFK pathways, these pathways may overlap or exhibit crosstalk. In some cell types stress-induced activation of SFK promotes survival and inhibits apoptosis, whereas the opposite may be true for other cell types. Stress responses constitute a new and rapidly developing area of SFK-mediated signaling.

• Journal of Korean Ophthalmic Optics Society
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• v.21 no.1
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• pp.69-76
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• 2016

Purpose: The study was conducted to determine that photoreceptors of mouse having pigment in RPE(retinal pigment epithelium) can be damaged by blue-light and apoptosis of specific cells among photoreceptors are induced by blue-light, and to assist the investigation of AMD(Age-related macular degeneration) mechanisms and development of AMD drugs. Methods: C57Black mice were injured by irradiating $2800{\pm}10lux$ of 463 nm LED for 6 hours after 24 hours dark adaptation and eyes were enucleated 1, 3, 7 days. Damage of retina induced by blue-light was determined by western blotting GFAP(Glial fibrillary acidic protein) expression. In the light-injured retina, cell death of photoreceptors was determined by TUNEL(Terminal deoxynucleotidyl transferase dUTP nick end labeling) assay. ERK(Extracellular signal-regulated kinases), JNK, and SRC(sarcoma) expression were assessed by western blotting to determine regulated pathway. Blue light-injured retina were immunostained with antibodies against Opsin and Rhodopsin as markers of photoreceptors to compared the damage cone cells with rod cells. Results: After 1, 3 and 7 days from exposure to blue-light, thickness of retina was more decreased than control, and more decreased at nuclear layer than at outer plexiform layer and GFAP expression was increased day 1 after blue-light injured. While phosphorylated ERK and SRC protein expressions at day 1 were increased after blue-light injured, phosphorylated c-JUN was decreased. Fluorescence intensity analysis showed that markers of cone and rod cells were decreased after blue-light injured and Opsin was more decreased than Rhodopsin. Conclusions: The study suggests possibilities that the blue-light promotes retinal damage and causes apoptotic cell death via ERK and SRC pathway in mouse retina, and blue-light retinal damage is more induced cone cells apoptosis than rod cells directly.

• Animal cells and systems
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• v.13 no.4
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• pp.391-397
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• 2009

The house dust mite (Dermatophagoides pteronissinus) is an important factor in triggering allergic diseases. The function of eosinophils, particularly in the production of cytokine or chemokine, is critical in understanding the pathogenesis of inflammatory diseases. In this study, we examined whether D. pteronissinus extract (DpE) induces the expression of monocyte chemotactic protein 1 (MCP-1)/CCL2, IL-8/CXCL8, and IL-6 that mediate in the infiltration and activation of immune cells and in its signaling mechanism in the human eosinophilic cell line, EoL-1. DpE increased the mRNA and protein expression of MCP-1, IL-8, and IL-6 in a time- and dose-dependent course in EoL-1 cells. In our experiments using signal-specific inhibitors, we found that the increased expression of MCP-1, IL-8, and IL-6 due to DpE is associated with Src family tyrosine kinase and protein kinase C $\delta$ (PKC $\delta$). In addition, the activation of extracellular signal-regulated kinase (ERK) is required for MCP-1 and IL-8 expression while p38 mitogen-activated protein kinase (MAPK) is involved in IL-6 expression. DpE induced the phosphorylation of ERK and p38 MAPK. PP2, an inhibitor of Src family tyrosine kinase, and rottlerin, an inhibitor of PKC $\delta$, blocked the activation of ERK and p38 MAPK. DpE induces the activation of ERK and p38 MAPK via Src family tyrosine kinase and PKC $\delta$ for MCP-1, IL-8, or IL-6 production. Increased cytokine release due to the house dust mite and the characterization of its signal transduction may be valuable in understanding the eosinophil-related pathogenic mechanism of inflammatory diseases.