• Proceedings of the Korea Concrete Institute Conference
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• 2004.11a
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• pp.97-100
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• 2004

Steel encased composite columns are widely used due to their excellent structural performance in terms of stiffness, strength, and ductility. However, experimental studies were usually for the columns having higher steel ratio $(3-4\%)$. There are two different design concepts for SRC columns. ACI-318 specifies the design strength of the column using the same concept of reinforced concrete columns. AISC-LRFD specifies the P-M diagram using the concept of steel column. In this paper, SRC columns have the steel ratio of $0.53\%\;and\;1.06\%$. From the test results, ACI-318 specifications showed better evaluation of SRC columns having low steel ratio. H beam and steel tube partially filled with concrete were embedded in concrete. Flexural tests showed considerably high ductility.

• Journal of the Korean GEO-environmental Society
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• v.14 no.1
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• pp.23-32
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• 2013

Currently, the west coast has focused on large-scale investment and development, such as harbor construction work and land reclamation projects, with soft ground grouting issues being the major concern. In addition, grouting for soft ground reinforcement is definitely considered that construction purpose, soil condition, construction situation, and construction costs. The SRC method, which is a high pressure injection method, can easily produce well-distributed strength regardless of soil characteristics and is environmentally friendly. Therefore in this study, the SRC method was applied to marine clay on the west coast where located Jeongok-ri, Seosin-myeon, Hwaseong-si, Gyeonggi-do, Korea as well as estimated of the ground reinforcement and the application on the site. The results of the application on the site by SRC method indicated age 28 day strength is $14,700{\sim}31,800kN/m^2$ which is satisfied the criterion of unconfined compressive strength that more than $5,333kN/m^2$. Therefore the result that the SRC method constructed marine clay on the west coast indicated the outstanding strength as well as excellent durability.

• Publications of The Korean Astronomical Society
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• v.30 no.2
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• pp.119-120
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• 2015

We report results of the measurement of the trigonometric parallax of an $H_2O$ maser source in IRAS 22555+6213 with the VLBI Exploration of Radio Astrometry (VERA). The annual parallax was determined to be $0.278{\pm}0.019$ mas, corresponding to a distance of $3.66^{+0.30}_{-0.26}kpc$. Our results confirm that IRAS 22555+6213 is located in the Perseus arm. We computed the peculiar motion of IRAS 22555+6213 to be ($U_{src}$, $V_{src}$, $W_{src}$) = ($0{\pm}1$, $-32{\pm}1$, $9{\pm}1$) $km\;s^{-1}$, where $U_{src}$, $V_{src}$, and $W_{src}$ are directed toward the Galactic center, in the direction of Galactic rotation and toward the Galactic north pole, respectively. IRAS 22555+6213, NGC7538 and Cepheus A lie along the same line of sight, and are within $2^{\circ}$ on the sky. Their parallax distances, with which we derived their absolute position in the Milky Way, show that IRAS 22555+6213 and NGC7538 are associated with the Perseus arm, while Cepheus A is located in the Local arm. We compared the kinematic distances of IRAS 22555+6213 derived with flat and non-flat rotation curve with its parallax distance and found the kinematic distance derived from the non-flat rotation assumption ($-32km\;s^{-1}$ lag) to be consistent with the parallax distance.

• Steel and Composite Structures
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• v.47 no.3
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• pp.423-436
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• 2023

In this research, we tested 10 simply supported concrete-encased composite columns under monotonic eccentric loads and investigated their shear behaviour. The specimens tested were two reinforced concrete specimens, three steel-reinforced concrete (SRC) specimens with an H-shaped steel section (also called a beam section), and five SRC specimens with a cruciform-shaped steel section (also called a column section). The experimental variables included the transverse steel shape's depth and the longitudinal steel flange's width. Experimental observations indicated the following. (1) The ultimate load-carrying capacity was controlled by web compression failure, defined as a situation where the concrete within the diagonal strut's upper end was crushed. (2) The composite effect was strong before the crushing of the concrete outside the steel shape. (3) We adjusted the softened strut-and-tie SRC (SST-SRC) model to yield more accurate strength predictions than those obtained using the strength superposition method. (4) The MSST-SRC model can more reasonably predict shear strength at an initial concrete softening load point. The rationality of the MSST-SRC model was inferred by experimentally observing shear behaviour, including concrete crushing and the point of sharp variation in the shear strain.

• Biomolecules & Therapeutics
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• v.29 no.1
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• pp.41-51
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• 2021

Src family kinases (SFKs), an important group of non-receptor tyrosine kinases, are suggested to be excessively activated during various types of tissue fibrosis. The present study investigated the effect of KF-1607, an orally active and a newly synthesized Src kinase inhibitor (SKI) with proposed low toxicity, in preventing the progression of renal interstitial fibrosis. Unilateral ureteral obstruction (UUO) surgery was performed in 6-week-old male C57BL/6 mice to induce renal interstitial fibrosis. Either KF-1607 (30 mg/kg, oral gavage) or PP2 (2 mg/kg, intraperitoneal injection), a common experimental SKI, was administered to mice for seven days, started one day prior to surgery. UUO injury-induced SFK expression, including Src, Fyn, and Lyn kinase. SFK inhibition by KF-1607 prevented the progression of tubular injury in UUO mice, as indicated by decreases in albuminuria, urinary KIM-1 excretion, and kidney NGAL protein expression. Renal tubulointerstitial fibrosis was attenuated in response to KF-1607, as shown by decreases in α-SMA, collagen I and IV protein expression, along with reduced Masson's trichrome and collagen-I staining in kidneys. KF-1607 also inhibited inflammation in the UUO kidney, as exhibited by reductions in F4/80 positive-staining and protein expression of p-NFκB and ICAM. Importantly, the observed effects of KF-1607 were similar to those of PP2. A new pan Src kinase inhibitor, KF-1607, is a potential pharmaceutical agent to prevent the progression of renal interstitial fibrosis.

• Journal of the Korean Home Economics Association
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• v.42 no.6
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• pp.1-12
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• 2004

This study investigates residents' living satisfaction with high-rise, mixed-use apartments built in the structures of reinforced concrete construction(RC) and with steel framed, reinforced concrete construction(SRC). The following study results were obtained: 1) Residents expressed below average satisfaction (below 3.0) with the common-area landscape and environmentally-friendly factors, children's playground and its facilities, community service for residents' by the management offices and utility plan. 2) According to the satisfaction of sound environment, residents of the SRC group expressed above average satisfaction. It can be concluded that noise problems around the residential area of the SRC group was well solved in this study. However, the residents of the SRC group expressed low satisfaction with the freshness of indoor air, humidity, and smell in the living quarters. 3) High-rise, mixed-use apartments should accommodate a familial life cycle, be designed as an environmentally friendly resting place in harmony with city life, and provide various communal programs for residents.

• Journal of Korean Neurosurgical Society
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• v.55 no.5
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• pp.255-260
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• 2014

Objective : The purpose of this study was to compare the radiological and neurological outcomes between two atlantoaxial fusion method for atlantoaxial stabilization; C1 lateral mass-C2 pedicle screws (screw-rod constructs, SRC) versus C1-2 transarticular screws (TAS). Methods : Forty-one patients in whom atlantoaxial instability was treated with atlantoaxial fixation by SRC group (27 patients, from March 2005 to May 2011) or TAS group (14 patients, from May 2000 to December 2005) were retrospectively reviewed. Numeric rating scale (NRS) for pain assessment, Oswestry disability index (ODI), and Frankel grade were also checked for neurological outcome. In radiologic outcome assessment, proper screw position and fusion rate were checked. Perioperative parameters such as blood loss during operation, operation time, and radiation exposure time were also reviewed. Results : The improvement of NRS and ODI were not different between both groups significantly. Good to excellent response in Frankel grade is shown similarly in both groups. Proper screw position and fusion rate were also observed similarly between two groups. Total bleeding amount during operation is lesser in SRC group than TAS group, but not significantly (p=0.06). Operation time and X-ray exposure time were shorter in SRC group than in TAS group (all p<0.001). Conclusion : Both TAS and SRC could be selected as safe and effective treatment options for C1-2 instability. But the perioperative result, which is technical demanding and X-ray exposure might be expected better in SRC group compared to TAS group.

• Magazine of the Korea Concrete Institute
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• v.13 no.6
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• pp.60-66
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• 2001

• Molecules and Cells
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• v.42 no.11
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• pp.810-819
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• 2019

For physiological or pathological understanding of bone disease caused by abnormal behavior of osteoclasts (OCs), functional studies of molecules that regulate the generation and action of OCs are required. In a microarray approach, we found the suppression of tumorigenicity 5 (ST5) gene is upregulated by receptor activator of nuclear $factor-{\kappa}B$ ligand (RANKL), the OC differentiation factor. Although the roles of ST5 in cancer and ${\beta}-cells$ have been reported, the function of ST5 in bone cells has not yet been investigated. Knockdown of ST5 by siRNA reduced OC differentiation from primary precursors. Moreover, ST5 downregulation decreased expression of NFATc1, a key transcription factor for osteoclastogenesis. In contrast, overexpression of ST5 resulted in the opposite phenotype of ST5 knockdown. In immunocytochemistry experiments, the ST5 protein is colocalized with Src in RANKL-committed cells. In addition, ST5 enhanced activation of Src and Syk, a Src substrate, in response to RANKL. ST5 reduction caused a decrease in RANKL-evoked calcium oscillation and inhibited translocation of NFATc1 into the nucleus. Taken together, these findings provide the first evidence of ST5 involvement in positive regulation of osteoclastogenesis via Src/Syk/calcium signaling.

• BMB Reports
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• v.48 no.3
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• pp.184-189
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• 2015

Src homology 2-containing protein tyrosine phosphatase 2 (SHP-2) is known to protect neurons from neurodegeneration during ischemia/reperfusion injury. We recently reported that ROS-mediated oxidative stress promotes phosphorylation of endogenous SHP-2 in astrocytes and complex formation between caveolin-1 and SHP-2 in response to oxidative stress. To examine the region of SHP-2 participating in complex formation with caveolin-1, we generated three deletion mutant constructs and six point mutation constructs of SHP-2. Compared with wild-type SHP-2, binding of the N-SH2 domain deletion mutant of SHP-2 to p-caveolin-1 was reduced greatly, using flow cytometric competitive binding assays and surface plasmon resonance (SPR). Moreover, deletion of the N-SH2 domain of SHP-2 affected $H_2O_2$-mediated ERK phosphorylation and Src phosphorylation at Tyr 419 in primary astrocytes, suggesting that N-SH2 domain of SHP-2 is responsible for the binding of caveolin-1 and contributes to the regulation of Src phosphorylation and activation following ROS-induced oxidative stress in brain astrocytes.