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The Diagnostic Accuracy of Preoperative Tstaging of Gastric Cancer Using EUS and CT (위암에서 EUS 및 CT에 의한 T-병기의 정확도)

  • Kim, Ki-Han;Kim, Min-Chan;Choi, Seok-Reyol;Jung, Ghap-Joong;Kim, Hyung-Ho
    • Journal of Gastric Cancer
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    • v.3 no.4
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    • pp.182-185
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    • 2003
  • Purpose: Preoperative staging of gastric cancer is crucial because the treatment modality and the prognosis depend upon the stage of gastric cancer. Current treatment modalities for early gastric cancer have focused on the quality of life. Endoscopic ultrasonography (EUS) and abdominal computed tomography (CT) are commonly used diagnostic tools to evaluate the invasiveness (T stage) of the primary tumor. The purpose of this paper is to evaluate the sensitivity and the specificity of preoperative EUS and CT in comparison with postoperative pathology. Materials and Methods: From October 2001 to October 2002, EUS and abdominal CT were performed simultaneously on 75 patients who underwent radical gastric surgery for the treatment of gastric cancer. Through analyzing the clinical T stage and the pathologic T stage, We evaluated the diagnostic sensitivities and specificities of endoscopic ultrasonography and abdominal computed tomography. Results: The male-to-female sex ratio was 1 : 0.6 (males: 47, females: 28). The mean age was 55.4 years in males (range: $28\~81$) and 54.4 years in females (range: $23\∼77$). The clinical T stage based on EUS included 22 T1mm, 7 T1sm, 22 T2, and 24 T3. The clinical T stage based on CT included 20 Tx, 23 T2, and 32 T3. The permanent pathologic report confirmed 23 T1mm, 10 T1sm, 17 T2, 24 T3, and 1 T4. The sensitivity and specificity of EUS were $84.2\%\;and\;94.7\%$, respectively. However, the sensitivity and specificity of abdominal CT were $53.3\%\;and\;77.0\%$, respectively. Conclusion: Our data suggest that EUS is a very useful diagnostic tool for evaluating the T stage of gastric cancer because EUS has higher specificity than abdominal CT. Therefore, EUS may have a significant role as a preoperative diagnostic modality in patients undergoing minimally invasive surgery.

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Trend in Research and Development Related to Motors and Permanent Magnets for Solving Rare-earth Resources Problem (희토류 자원문제 해결을 위한 모터 및 영구자석 연구개발 동향)

  • Lee, J.G.;Yu, J.H.;Kim, H.J.;Jang, T.S.
    • Journal of the Korean Magnetics Society
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    • v.22 no.2
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    • pp.58-65
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    • 2012
  • Since Nd-Fe-B magnet was first synthesized in 1983, many new applications have emerged in the past two decades. With regard to motor market, it will expand because of strong energy saving requirements from the automobile and electric application markets. Especially, permanent magnet motors for hybrid and electric vehicles are drawing great attention and the usage of Nd-Fe-B magnets will increase all the more hereafter. There is, however, a serious problem as motors in such eco-friendly cars are said to operate in high temperatures of about $200^{\circ}C$. Nd-Fe-B magnet has a drawback of dramatically decreasing coercive force with the rise of temperature. In order to improve this aspect. the best way is to add dysprosium (Dy) into the magnet. So, Dy has become an essential element for Nd-Fe-B high-performance magnet as it helps to maintain coercive force even at high temperatures. On the other hand, the rare earth resources in the earth crust are eccentrically-located and its majority is produced in China. There is a need to reduce its usage as, especially compared to light rare earth elements as neodymium (Nd) and samarium (Sm), heavy rare earth elements including Dy are unevenly distributed to a dramatic degree, their output low, and their prices are about 10 times that of Nd. The present article includes a summary of the trend in research and development of motors and permanent magnets to solve rare-earth resources problem.

A Method of Developing a Ground Layer with Risk of Ground Subsidence based on the 3D Ground Modeling (3차원 지반모델링 기반의 지반함몰 위험 지반 레이어 개발 방법)

  • Kang, Junggoo;Kang, Jaemo;Parh, Junhwan;Mun, Duhwan
    • Journal of the Korean GEO-environmental Society
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    • v.22 no.12
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    • pp.33-40
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    • 2021
  • The deterioration of underground facilities, disturbance of the ground due to underground development activities, and changes in ground water can cause ground subsidence accidents in the urban areas. The investigation on the geotechnical and hydraulic factors affecting the ground subsidence accident is very significant to predict the ground subsidence risk in advance. In this study, an analysis DB was constructed through 3D ground modeling to utilize the currently operating geotechnical survey information DB and ground water behavior information for risk prediction. Additionally, using these results, the relationship between the actual ground subsidence occurrence history and ground conditions and ground water level changes was confirmed. Furthermore, the methodology used to visualize the risk of ground subsidence was presented by reconstructing the engineering characteristics of the soil presented according to the Unified Soil Classification System (USCS) in the existing geotechnical survey information into the internal erosion sensitivity of the soil, Based on the result, it was confirmed that the ground in the area where the ground subsidence occurred consists of more than 40% of sand (SM, SC, SP, SW) vulnerable to internal erosion. In addition, the effect of the occurrence frequency of ground subsidence due to the change in ground water level is also confirmed.

A Study on Compaction Characteristics of Surplus Soils in Mountainous Areas in Busan, GyungNam Province (부산 경남지역 산지 현장 발생토의 다짐특성 연구)

  • Jung-Uk Kang;Gi-Ju Noh;Tae-Hyung Kim;In-Gon Joo
    • Journal of the Korean Geosynthetics Society
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    • v.22 no.2
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    • pp.63-70
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    • 2023
  • Most of the industrial complexes and housing complexes in Busan and Gyeongnam were constructed by developing mountainous areas, except for some landfill areas. During the development process, the surplus soil for site development was mainly used as the embankment material. In the field, however, even if the material of the material changes during the embankment work for site development, for convenience reasons such as construction period and site conditions, the material property test and compaction test are not additionally conducted for the embankment material, and quality control is conducted. In this study, physical property tests and compaction tests were conducted on surplus soils in mountainous areas in Busan, GyungNam Province and then regression analysis was performed on the data. In addition, a comparative analysis was conducted along with existing studies in Korea. The surplus soils at the sites in Busan and Gyeongnam were mainly weathered soils of granites, and were classified into clayey sand (SC) and silty sand (SM). As a result of regression analysis of the compaction characteristics according to the content of coarse and fine soils, the correlation between them was very high. Using the relational formula as a result of this study, it will be very useful for compaction management of the surplus soils in the field.

Effects of Glycogen Supercompensation in Fast and Slow Muscles on Maximal Running Time of Endurance-trained Rats (단련한 흰쥐의 속근 및 지근에 Glycogen 과저장이 운동 지구력에 미치는 영향)

  • Yeoun, Dong-Soo;Hwang, Soo-Kwan;Kim, In-Sook;Ko, Seong-Kyeong;Nam, Taick-Sang;Kang, Doo-Hee
    • The Korean Journal of Physiology
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    • v.22 no.1
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    • pp.63-77
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    • 1988
  • This study was carried out to investigate relationships between maximal running time (MRT) and glycogen supercompensation in fast twitch white fibers (white vastus, WV), fast twitch red fibers (red vastus, RV) and slow twitch red fibers (soleus muscle, SM) of endurance-trained rats. Male rats of a Sprague-Dawley strain were divided into the trained groups and untrained groups. Untrained groups were acquired to run on the treadmill 10 minutes for 3 days and remained rest and maintained with mixed diet for 4 weeks. For last 10 days of resting period, the untrained rats were divided into 3 groups i.e. mixed diet (untrained control), high and low carbohydrate (CHO) diet groups. And each group was subdivided into 2 groups, one group was tested for the MRT and the other was sacrificed to measure the blood glucose, blood lactate, glycogen contents of liver and muscles. The experimental groups were trained on treadmill by a modified method of Constable et al. (1984) maintained with mixed diet for 4 weeks. After measurement of MRT of this group, they were also divided into high and low CHO groups and fed with these diet for 2 days and MRT of each group was measured again to see the effect of high or low CHO feeding on the MRT. Each group was maintained with the same diet for next 2 days during which some of the rats were sacrificed at given time intervals for the measurements of blood glucose and lactate, liver and the muscles glycogen. The results were summarized as follows; 1) In the untrained group, there were no significant differences between subgroups in MRT, glycogen conent of SM, RV and WV. But blood glucose concentration and glycogen content of liver of low CHO group were significantly lower than those of mixed diet group. 2) The MRT and glycogen content of SM, RV and WV of trained mixed diet group were significantly increased compared to those of untrained mixed diet group, but there was no significant difference in glycogen content of liver. 3) MRT of trained mixed, high CHO and low CHO groups were $137{\pm}9.8,\;176{\pm}9.8\;and\;129{\pm}7.3\;min$ respectively with the significant difference between them. 4) There were no differences in blood lactate concentrations between the trained high and low CHO groups immediately after maximal running and during recovery period. 5) Glycogen contents in RV and SM of trained high CHO group were significantly increased, and glycogen contents in RV, WV and liver of trained low CHO group were significantly decreased compared to those of trained mixed diet group. 6) Immediately after maximal running, the blood glucose concentrations of trained high CHO and low CHO groups were $73{\pm}4.0\;and\;67{\pm}6.9mg%$ respecitively. The blood glucose of the trained high CHO group was fully recovered within one hour by feeding. But blood glucose concentration of low CHO group was slowly recovered up to $114{\pm}4.1mg%$ after two hours of feeding and maintained. Those values were still significantly lower than that of trained mixed diet group. The synthetic rates of glycogen in liver and muscles during the recovery period followed the similar time course of the blood glucose recoveries in each group. These results suggest that an increase in MRT of trained high CHO group was attributed to the glycogen supercompensation in slow twitch muscle fibers. And a decrease in MRT of trained low CHO may be due to decreased glycogen contents of liver and muscles. The results also suggest that glycogen supercompensation was more evident in slow twitch red fibers of endurance-trained rats and blood glucose is one of the limiting factors of glycogen synthesis.

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Protective Effects of Ginkgolide B on Reperfusion of the Isolated Perfused Guinea Pig Heart (Ginkgolide B의 Guinea Pig 적출 심장에 대한 허혈 유발후 Reperfusion시의 보호 작용에 관한 연구)

  • Kwon, Kwang-il;Lee, Young-sin;Lee, Jae-heung
    • Korean Journal of Clinical Pharmacy
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    • v.3 no.2
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    • pp.147-155
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    • 1993
  • The cardiac effects of PAF antagonist Ginkgolide B(BN 52051) have been investigated on the isolated perfused guinea pig hearts maintained at the constant hydrostatic perfusion pressure of 80 cm water. PDE(Phosphodiesterase) inhibitor KR-30289 was used as a positive control to see the positive inotropic effects on the perfused hearts. In this expriments, Ginkgolide $B(10^{-5}-SM)$ showed negative inotropic effects by decreasing of LVP, LVDP, LV dp/dt, HR and RPP(Rate Pressure Product). Ginkgolide B also decreased the number of extrasystole by $51.9\%(from\;23.75\pm9.22/min\;to\;11.43\pm435/min)$ induced by global ischemia and reperfusion. The rate, [-dp/dt]/[+dp/dt] increased in preischemia but decreased in postischemia. 1n the separated study the injection of 1ml of Ginkgolide B$(10^{-4M})$ on the isolated heart, increased coronary flow(CF) by $11.8\%(from\;7.5\pm7.65ml/min\;to\;8.5\pm0.29ml/min)$ and decreased the number of extrasystole by $47.6\%(from\;21\pm5.92/min\;to\;11\pm5.27/min)$. In conclusion, Ginkgolide B showed antiarrhythmic and protective effects by decreasing the number of extrasystole and by increasing the coronary flow, respectively.

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Behavior of Initiation and Propagation of Fatigue Crack under Periodic Overstressing (In the case of Fatigue Limit Stresses) (과대, 과소 응력하에서의 피로크랙 발생거동 (피로한도 응력을 중심으로))

  • 송남홍;원시태
    • Transactions of the Korean Society of Mechanical Engineers
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    • v.15 no.6
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    • pp.1839-1851
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    • 1991
  • Fatigue crack behavior is studied through the two-level rotary bending test with the deep non-through radial holed notch specimens of low carbon steels(SM22C). The main factors investigated are the effects of the damage zone size around crack tip and phenomena of closing or opening of the crack tip. Obtained results are summarized as follows. Fatigue crack behavior in second level stressing slightly lower than fatigue limit is closely related to the size of damage zone produced by the first level stress higher than fatigue limit and to the phenomena of crack closing and opening for the second level stress. The non-propagating crack limit condition depends upon the crack length l$_{1}$ propagated under the first level stress and the magnitude of second level stress .sigma.$_{2}$ lower than the fatigue limit. The non-propagating crack limit condition is expressed by following eq. $\sigma_2^{6.1}{\times}l_{1}=7.35{\times}10^{6}[(kg_{f}mm^{6.1}(mm)]$

A Numerical Study on Characteristics of Dam-break Wave Propagation through an Idealized Urban Area (가상의 도시지역을 관통하는 댐 붕괴파의 전파특성에 관한 수치적 연구)

  • Jeong, Woo-Chang;Song, Jai-Woo
    • Proceedings of the Korea Water Resources Association Conference
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    • 2009.05a
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    • pp.550-554
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    • 2009
  • 본 연구에서는 댐 붕괴시 발생하는 홍수파가 건물군으로 이루어진 가상의 도시지역을 관통하면서 이동될 경우 시간에 따라 변화되는 특성을 수치적으로 분석하였다. 분석에 적용된 수치모형은 2차원 유한체적법과 불연속 흐름을 모의하기 위해 시간과 공간상으로 1차 정확도를 가진 HLLC 기법을 적용한 모형이다. 본 연구에서 적용된 가상의 도시지역은 Soares-Frazao와 Zech(2008)에 의해 수행된 수리모형실험에 근거하여 세 가지 case에 대해 구성하였다. 첫 번째 case(Case 1)는 25개의 건물로 구성된 정방형의 도시지역이 흐름에 직각으로 배열되어 있는 경우이며, 두 번째와 세 번째 case는 각각 흐름에 대해 $22.5^{\circ}$(Case 2)와 $45^{\circ}$(Case 3)로 경사진 경우이다. 세 경우에 대해 시간에 따른 홍수파의 변화양상을 수치적으로 분석하였으며, 첫 번째와 두번째 case에 대해 모의된 수위변화결과를 수리모형실험결과와 비교하여 모형의 적용성을 검증하였다. 검증결과 수치모형을 통해 계산된 수위변화는 수리모형실험결과와 비교적 일치하는 결과를 얻었다. 또한 본 연구에서는 도시지역의 조도계수(Manning계수: 0.01,015,$0.025sm^{-1/3}$)와 비구조적 격자시스템을 구성하는 격자수(T1: 19759개 요소, T2: 193859)에 따른 홍수파의 변화양상을 분석하였다.

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Molecular Analysis of Intraspecific Variations of the Indonesian Cochliobolus heterostrophus

  • Gafur, Abdul;Mujim, Subli;Aeny, Titik Nur;Tjahjono, Budi;Suwanto, Antonius
    • Mycobiology
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    • v.31 no.1
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    • pp.19-22
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    • 2003
  • The primary objective of the current research was to detect genetic variations within the Indonesian isolates of Cochliobolus heterostrophus collected from ecologically different places of the country at molecular level using PCR-RFLP analyses. The primer pair of NS3 and NS6 produced amplification fragment in all of the isolates tested. A single fragment of estimated 907 bp was observed in the PCR product pattern. RFLP analysis of the PCR product employing three restriction enzymes, HaeIII, HhaI, and RsaI, respectively, did not reveal intraspecific variations within the fungus. Similarly, nucleotide sequences of portion of small subunit of the ribosomal DNA gene of two of the isolates collected showed no appreciable differences, indicating the absence of genetic diversities among the isolates tested. A phylogenetic tree was constructed and the Indonesian C. heterostrophus, represented by SM-1 isolate, was found to be phylogenetically located near C. sativus, a closely related species.

Capsular serogrouping and antimicrobial drug susceptibility of Pasteurella multocida isolated from Youngnam swine herds (영남지방 돼지에서 분리한 Pasteurella multocida의 협막혈청형 및 항균제 감수성 조사)

  • Cho, Gil-jae;Kim, Bong-hwan;Tak, Ryun-bin
    • Korean Journal of Veterinary Research
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    • v.29 no.4
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    • pp.487-492
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    • 1989
  • The capsular serogroupes and drug susceptibility of 111 isolates of Pasteurella multocida from pigs with atrophic rhinitis and pneumonic lesions were investigated. Of the 111 P multocida isolates, 42 were from lung lesions, 47 from nasal turbinate lesions and the remaining 22 from the nasal swabs. P multocida isolates were typed for capsular serogroupes A by hyaluronidase inhibition of capsule and D by acriflavine auto-agglutination. Most isolates(64.9%) were type A, 23.4% were type D and the remaining 11.7% were untypable. Resistance to triple sulfa(97.3%) was most frequent, followed by resistance to tiamulin(71.2%), tylosin(56.8%), streptomycin(36.9%), and neomycin(36.0%). The majority of the organisms were susceptible in order of prevalence to baytril(100%), ampicillin(98.2%), linsmycin(97.3%), colistin(97.3%), cephalothin(94.6%), gentamicin(93.7%), amikacin(92.3%), tetracycline(91.9%), trimethoprim/sulfamethoxazole(91.0%), and kanamycin(90.1%). No differences in drug resistance in relation to capsular serogroupes of P multocida and the origin of lesions were noted. A high prevalence of multiple drug resistance was observed and the most common resistant patterns were Sss, Tm, Ty(12.6%) and Sm, Sss, Tm, Ty(8.1%) patterns.

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