• Title/Summary/Keyword: SL-175

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Molecular Docking Analysis of Protein Phosphatase 1D (PPM1D) Receptor with SL-175, SL-176 and CDC5L

  • Madhavan, Thirumurthy
    • Journal of Integrative Natural Science
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    • v.11 no.1
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    • pp.25-29
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    • 2018
  • Protein phosphatase manganese dependent 1D (PPM1D), a Ser/Thr protein phosphatise, play major role in the cancer tumorigenesis of various tumors including neuroblastoma, pancreatic adenocarcinoma, medulloblastoma, breast cancer, prostate cancer and ovarian cancer. Hence, analysis on the structural features required for the formation of PPM1D-inhibitor complex becomes essential. In this study, we have performed molecular docking of SL-175 and -176 and protein-protein docking of CDC5L with PPM1D. On analysing the docked complexes, we have identified the important residues involved in the formation of protein-ligand complex. Research concentrating on these residues could be helpful in understanding the pathophysiology of various tumors related to PPM1D.

Feeding Habits of Sebastes inermis in the Eelgrass (Zostera marina) Bed in Kwangyang Bay (광양만 잘피밭에 서식하는 볼낙(Sebastes inermis)의 식성)

  • HUH Sung-Hoi;KWAK Seok Nam
    • Korean Journal of Fisheries and Aquatic Sciences
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    • v.31 no.2
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    • pp.168-175
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    • 1998
  • Feeding habits of Sebastes inermis collected from the eelgrass bed in Kwangyang Bay from January 1994 to December 1994 were studied. S. inermis ($1\~9\;cm\;SL$) was a carnivore which mainly consumed amphipods (gammarid amphipods and caprellid amphipods) and copepods. Its diets included small quantities of caridean shrimps, crabs, gastropods, and fishes. It showed ontogenetic changes in feeding habits. In an initial stage, copepods were major food organisms. However, amphipods were heavily selected as the body size of S. inermis increases. Although consumption of copepods increased during spring, amphipods were major prey organisms for all seasons.

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Fluctuations in Phenolic Content and Antioxidant Capacity of Green Vegetable Juices during Refrigerated Storage

  • Kim, Seong Yeong
    • Preventive Nutrition and Food Science
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    • v.20 no.3
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    • pp.169-175
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    • 2015
  • Shinseoncho and kale were made into green vegetable juices by building block [shinsenocho branch (SB), shinsenocho leaf (SL), kale branch (KB), and kale leaf (KL)]. Fluctuations in their phenolic contents and antioxidant capacities were analyzed during refrigerated storage at $4^{\circ}C$ for 28 days. Total polyphenolic contents of leaf parts showed a decreasing tendency after 4 days (SL) or 7 days (KL), whereas branch parts showed fluctuating values during the entire storage period. The 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulphonic acid) (ABTS) radical scavenging capacity was rapidly decreased in SB and in SL at 28 days (P<0.001), whereas KL showed a slightly increasing tendency after 14 days. For the 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging capacity, SL showed a sharp fall at 28 days (P<0.001), and KL showed a decreasing tendency after 14 days (P<0.001). SB showed a steady decrease during the entire storage period and KB indicated a nearly zero (0.97%) at 28 days. Pearson's coefficients for the correlation between antioxidant capacities measured by the ABTS and DPPH assays, and the total polyphenolic contents were determined. The results showed that the ABTS assay (r=0.934, P<0.001) was more strongly positively correlated with the total phenolic contents than the DPPH assay (r=0.630, P<0.001). In conclusion, when considering all building blocks, green vegetable juices, including kale and shinseoncho may have kept antioxidant capacities for up to 14 days under refrigeration, and the ABTS assay better reflects a positive correlation with the total phenolic contents when compared to the DPPH assay.

Feeding habits of juvenile Acanthopagrus schlegeli in the eelgrass(Zostera marina) bed in Kwangyang Bay (광양만 잘피밭에 서식하는 감성돔(Acanthopagrus schlegeli) 유어의 식성)

  • Huh, Sung-Hoi;Kwak, Seok-Nam
    • Korean Journal of Ichthyology
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    • v.10 no.2
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    • pp.168-175
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    • 1998
  • Feeding habits of juvenile Acanthopagrus schlegeli collected from the eelgrass bed in Kwangyang Bay were studied. A. schlegeli (1~7cm SL) was a carnivore which consumed mainly amphipods (gammarid and caprellid amphipods), crabs and shrimps. Its diets included small quantities of gastropods, polychaetes, hydroids, tanaids, copepods and isopods. A. schlegeli showed ontogenetic changes in feeding habits. Small individuals preyed mainly on gammarid amphipods, gastropods and polychaetes. However, crabs and shrimps were heavily selected with increasing fish size.

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Feeding habits of yellowfin goby, Acanthogobius flavimanus in the tidal flat of Sangnae-ri, Suncheon, Korea (순천 상내리 갯벌역에 출현하는 문절망둑 (Acanthogobius flavimanus)의 식성)

  • PARK, Jong-Hyeok;JEONG, Jae-Mook;KIM, Hyeon-Ji;YE, Sang-Jin;BAECK, Gun-Wook
    • Journal of the Korean Society of Fisheries and Ocean Technology
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    • v.52 no.2
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    • pp.169-175
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    • 2016
  • The feeding habits of yellowfin goby (Acanthogobius flavimanus) were studied based on the examination of stomach contents of 171 specimens collected from September 2013 to August 2014 in the tidal flat of Sangnae-ri, Suncheon, Korea. The size of A. flavimanus ranged from 10.6 to 18.3 cm in standard length (SL). A. flavimanus mainly consumed amphipods (especially Corophium sp.). Its diet also included shrimps, crabs, fishes and polychaetes. Ontogenetic changes in diet composition of A. flavimanus were evident. The portion of amphipods and polychaetes was inversely proprotional to the increase in fish size whereas it was directly proportional to the increase in the consumption of shrimps and crabs increased.

Effect of Lime Materials Application on Reducing Injury of Simulated Acid Rain in Soybean (콩의 산성비 피해경감을 위한 석회물질의 시용효과)

  • Kim, Bok-Jin;Back, Jun-Ho;Kim, Heung-Gyu
    • Korean Journal of Environmental Agriculture
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    • v.16 no.2
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    • pp.175-180
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    • 1997
  • This experiment was conducted to find out the effects of lime materials application on reducing injury of simulated acid rain(SAR) in soybean grown in pot contained with sandy loam. Six treatments including control, slaked lime(SL), 1% and 2% lime water(LW) and composite treatments with SL+LW were applied. Slaked lime was applied to soil in pot before planting, and lime water was applied to leaves a day prior to the spray of SAR(pH 2.7) and normal rain(pH 6.0), and these were sprayed at 2-day intervals. Growth, yield and yield components, foliar injury rate, chrolophyll content and photosynthetic activity in leaves, content of mineral nutrients in plant and soil chemical properties were analyzed and investigated. These results obtained are summarized as follows : Seed yield of all lime treatment was reduced by SAR compared with control. But seed yield of all lime treatment was increased with treatment of lime material in soil and on leaves. After 15 and 45 times spray of SAR, all lime treatments were effective in injury reducing visible injury of leaves compared with none treatment. Chlorophyll content in leaves was highest in plants treated with slaked lime+ 1% lime water and photosynthetic activity was highest with treatment of slaked lime. Concentration of total nitrogen, phosphate, and sulfur in soybean plant were increased by the spray of SAR. Concentration of total nitrogen, potassium and calcium in soybean plant were increased with treatment of slaked lime into soil. By treatments of SAR, soil pH was decreased, and total nitrogen and sulfur concentration in soil were increased. However, available phosphate and exchangeable cations in soil such as calcium, magnesium and potassium were reduced. Soil pH, calcium and silicate concentration were increased with treatment of slaked lime into soil.

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Enzymatic Synthesis of Structured Lipids Containing Conjugated Linoleic Acid from Extracted Corn and Peanut Oil (추출된 옥수수유와 땅콩유로부터 Conjugated Linoleic Acid를 함유한 재구성지질의 효소적 합성 및 분석)

  • 김남숙;이기택
    • Journal of the Korean Society of Food Science and Nutrition
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    • v.33 no.6
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    • pp.1000-1005
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    • 2004
  • Structured lipids (SLs) were synthesized by acidolysis of crude oils (corn and peanut oil) and conjugated linoleic acid (CLA) with a molar ratio of 1:3 (extracted oil:CLA) in a shaking water bath. The reaction was performed for various reaction time (1, 2, 3, 6 and 24 hr) at 55$^{\circ}C$ with 175 rpm catalyzed by sn -1,3 specific IM 60 lipase from Rhizomucor miehei. The content of the incorporated CLA increased with the prolonged reaction time, showing 7.5∼9.3 ㏖% in the synthesized SL triacylglycerol molecules from the extracted corn and peanut oil. However, total tocopherol content in SLs decreased up to about 20% compared to the content in extracted oils. Among the CLA isomers, 6.3∼7.5 ㏖% of cis 9,trans 11- and trans 10,cis 12-CLA known as physiologically active compounds are contained in corn and peanut SLs.

Status of RDA Researches on Weed Control for Rice Nurserybed (농진청(農振廳)의 못자리 잡초방제(雜草防除) 연구(硏究) 현황(現況))

  • Kim, S.C.;Chung, G.S.;Kim, D.S.
    • Korean Journal of Weed Science
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    • v.5 no.2
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    • pp.175-186
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    • 1985
  • Research situation and recent research activities of the RDA of Korea were reviewed and summarized for rice nurserybed. Sixty five percent of total 784 weed research items were carried out as rice research while only 6 percent was belonged to nurserybed within rice research. The floristic composition based on the degree of dominance significantly affected by herbicide properties, type of nurserybed and seeding itself. Herbicidal phytotoxicity of currently used several herbicides was greatly dependent upon the covering, absorption, germination, and irrigation regimes. The new safening agent "CGA 123 407" (4,6-dichloro-2-phenyl-pyrimidine) permited the safe application of pretilachlor (2-chloro-2',6-diethyl-N-(2-propoxyethyl) acetanilide) as a pre-emergence herbicide without reducing herbicidal efficacy. Several new herbicides, pyrazolate (4-(2,4-dichlorobenzoyl)-1,3-dimethylpyrazol-5-yl-p-toluenesulphonate), SL-49 (1,3-dimethyl-4-(2,4-dichlorobenzoyl)-5-phenacyloxy-pyrazole) MY-93 (S(1-methyl-1-phenethyl)-piperidine-1-carbathioate) and DPX-84 ((methyl 2- ((4,6-dimethoxypyrimidin-2-yl) amino-carbonyl) aminosulfonylmethyl)) benzolate)) performed satisfactorily in terms of safety and herbicidal efficacy for both surface covered and surface pressed nurserybed after herbicide application and thus expected very significant contributions not only for all kind of nurserybeds but also for direct seeding.

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