• Journal of the Ergonomics Society of Korea
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• v.31 no.1
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• pp.7-13
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• 2012

Objective: This paper discussed the characteristics of service design process by comparing with product design process. Background: Service design has different design outcomes, project participants, and design constraints than product design. Method: The comparison took two perspectives: one was shorter-term, design process of a service, and the other was longer-term, process of service development. Results: It was discussed that service design process is similar in overall, but has four differences. First, the role of design is required earlier and longer in the process, which means service designers need to participate from the begging of the project to service operation. Thus service designers are required to have holistic viewpoint of the project. Second, service design requires many design expertise thus collaboration needs to be well defined and managed throughout the process. Third, since service provider has limited resources, regulations, and market competition, some service features cannot be provided. Service designers are required to know both customers' needs and functional constraints. Last, service design is highly coupled with service operation. Designing and providing service happens at the same time and evolves over time. Conclusion: Consequently it was asserted that the role of designers in service design is essential for success. In specific, the role of service design architect, who manages design process and design outcomes, is a new and important role in service design project.

• Biomolecules & Therapeutics
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• v.13 no.2
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• pp.113-117
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• 2005

Organosulfur compounds have been shown to exert an anti-cancer activity. In an attempt to develop novel chemopreventive and anti-cancer agents for liver cancer, we synthesized allylthiopyridazine derivatives. We have previously shown that allylthiopyridazine derivatives exert inhibitory effects on proliferation, invasion and migration of SK-Hep-1 hepatocarcinoma cells in vitro. The in vivo anti-tumor effect of 3-methvl-6-allylthiopy-ridazine, named as K6, was also reported. In this study, we further investigated the preclinical anti-cancer efficacy of K6 for hepatocarcinoma using nude mice xenografted with Hep-G2 hepatocellular carcinoma cells. K6(20-100 mg/kg, orally administered everyday for 30 days) markedly decreased the tumor volume of Hep-G2 cell-transplanted nude mice as evidenced by ultrasonographic and plethysmogranhic analyses. The inhibitory effect on tumor volume was lower than that exerted by doxorubicin (2 mg/kg), intravenously injected) which was used as a positive control. This study shows that K6 efficiently suppresses xenograft tumor growth, revealing K6 as apotential anti-cancer agent for suppressing in vivo progression of liver cancer. Given that hepatocarcinoma is among the most prevalent and lethal malignancies and there is no effective treatment to date, our study may contribute to the potential drug development for liver cancer.

• Proceedings of the Korean Institute of Navigation and Port Research Conference
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• 2014.06a
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• pp.46-48
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• 2014

The port of Incheon is very famous of strong current and many curved fairway with exist of many islands around the fairway. Therefore the max size of calling vessel is restricted in 50K DWT with 13.0m draft. However in the near future, half cargo loaded VLCC will call SK energy Dolphin berth for discharging of crude oil. In this connection, this study will evaluate the safety of passing for Dongsudo-fairway by using the shiphandling simulation data that was produced by familiarized training & education for Incheon port pilots about VLCC's maneuvering characters and the fairway of Incheon port.

• Proceedings of the Korean Society of Dyers and Finishers Conference
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• 2012.03a
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• pp.97-97
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• 2012

비스코스 레이온 소재는 목재 펄프를 원료로 한 재생섬유로서 Drape성과 반발성은 탁월하나, 습식 방사에 따른 분자 구조적 불안정성으로 소비자가 일반 세탁 시 수축발생으로 종종 Dry Cleaning을 해야 하는 문제점들이 있음. 본 연구에서는 이와 같은 레이온의 단점을 극복하고 신축성 발현 및 형태안정성을 부여하기 위해 Rayon DTY사와 Spun T/R 40's를 개발하고 다양한 조직의 환편물을 제작하였으며, 기존의 레이온 제품 대비 수축률 등 형태안정성과 신축특성이 발현될 수 있는 염색가공 공정 조건을 설정하였음. 먼저 전처리시 균일하고 안정적인 수축이 발생하도록 하여 최종 생산품의 형태안정성과 신축성이 유지 될 수 있는 최적의 조건을 설정하였음. 전처리는 저온 축소 후 고온에서 정련하는 공정이 환편물의 조직에 관계없이 우수하였으며, 비교적 견뢰도가 우수하다고 판단되는 시판 분산염료 및 반응성염료를 사용하여 Polyester/Rayon의 2욕 2단 염색을 진행하였음. 또한 시제품의 품위를 높이기 위해 레이온 섬유의 고유한 특성을 부여할 수 있는 유연처방을 사용하여 총 13종의 환편물을 개발할 수 있었으며, 이렇게 개발된 원단은 형태안정성 -2.5~1.0%, 신장회복률 83% 이상, 필링성 4-5급의 결과를 나타내었음.

• Proceedings of the Korean Geotechical Society Conference
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• 2006.03a
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• pp.208-218
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• 2006

It is very important to evaluate predictable problems diversely such as stability of a tunnel and structures when tunnel is inevitably constructed in the area where is adjacent to a structure and low overburden. Double electrified railway design on the third section of Donghae-Nambu line studied in this paper has some problems mentioned above. So more careful works are required before construction. In this study, ground surrounding is composed of faults, fault zone and set back about 13m from a Buddhist temple located on the upper part of the tunnel. From these conditions, this case study presents proper methods considering ground condition, effects of blasting and civil petitions. It is tried to make the tunnel and Buddhist temple stable by analytical technique and analysis of existing cases. And design considering stability of tunnel and adjacent structure during operation is carried out as well. Especially, environmentally friendly railway tunnel which is appropriate to the local condition and surroundings is designed by minimizing noise and vibration that is able to occur during construction and train service. From now on, this study is helpful to better design in the case of tunnel design which has to consider civil petition.

• The Plant Pathology Journal
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• v.30 no.1
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• pp.43-50
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• 2014

Microorganisms have many roles in nature. They may act as decomposers that obtain nutrients from dead materials, while some are pathogens that cause diseases in animals, insects, and plants. Some are symbionts that enhance plant growth, such as arbuscular mycorrhizae and nitrogen fixation bacteria. However, roles of plant pathogens and diseases in natural ecosystems are still poorly understood. Thus, the current study addressed this deficiency by investigating possible roles of plant diseases in natural ecosystems, particularly, their positive effects on arthropod diversity. In this study, the model system was the oak tree (Quercus spp.) and the canker disease caused by Annulohypoxylon truncatum, and its effects on arthropod diversity. The oak tree site contained 44 oak trees; 31 had canker disease symptoms while 13 were disease-free. A total of 370 individual arthropods were detected at the site during the survey period. The arthropods belonged to 25 species, 17 families, and seven orders. Interestingly, the cankered trees had significantly higher biodiversity and richness compared with the canker-free trees. This study clearly demonstrated that arthropod diversity was supported by the oak tree canker disease.

• Journal of Haehwa Medicine
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• v.4 no.2
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• pp.273-297
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• 1996

Hexane fraction of Oldenlandiae diffusae Herba(ODH) which was being used for the treatment of caner in oriental medicine showed the best cytotoxicity against L1210 and A549 in the solvent fractions. Antitumor substance isolated from hexane fraction of ODH was identified as ursolic acid(UA) by photometric analysis. IC50 of UA against cancer cells as SNU-1, HCT15, XF498, SK-MEL2 and A549 was $13{\mu}g/m{\ell}$, $15{\mu}g/m{\ell}$, $12{\mu}g/m{\ell}$, $9{\mu}g/m{\ell}$ and $11{\mu}g/m{\ell}$ respectively. It significantly inhibited the metastasis to lungs and kidneys from pulmonary colonization assay and study on histological changes of organs and showed the enhancing effect on B cell dosage-dependently by FACS analysis. T/C % of UA against S-180 cells was 171 % and its cytotoxicity against SNU-1 iant was confirmed from the morphological changes by elctronic microscopes such as SEM and TEM that it induced undulated membrane 4 hr after UA treatment, and the breakdown of cell membrane and nucleus 24 hr after UA treatment.

• Journal of the Korean Solar Energy Society
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• v.38 no.1
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• pp.13-24
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• 2018

As part of the "Carbon free Island 2030" policy, the local government of Jeju Island is currently working to reduce carbon through renewable energy supply. However, renewable energy is difficult to predict due to intermittent characteristics. If the share of renewable energy increase, it is difficult to plan of supply of electricity to grid due to that characteristic of renewable. In this paper analyze the fluctuation rate and the capacity credit of wind power and PV to find out how much wind power and PV contribute to supply of electricity of power system in Jeju. As a result mean value of variation rate of wind power and PV is about 3%, 5% and capacity credit is about 10% and 2% respectively.

• Archives of Pharmacal Research
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• v.29 no.6
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• pp.503-507
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• 2006

Flavonoids are known as natural anti-inflammatory agents. In this investigation, an anti-inflammatory potential of new topical preparation (SK Ato $Formula^{\circledR}$) containing flavonoid mixtures from Scutellaria baicalensis Georgi roots and Ginkgo biloba L. leaves with an extract of Gentiana scabra Bunge roots was evaluated in an animal model of chronic skin inflammation. Multiple 12-O-tetradecanoylphorbol-13-acetate treatments for 7 consecutive days on ICR mouse ear provoked a chronic type of skin inflammation: dermal edema, epidermal hyperplasia and infiltration of inflammatory cells. When topically applied in this model, this row formulation $(5-20\;{\mu}L/ear/treatment)$ reduced these responses. Furthermore, it inhibited prostaglandin $E_2$ generation (17.1-33.3%) and suppressed the expression of proinflammatory genes, cyclooxygenase-2 and $interleulin-1{\beta}$ in the skin lesion. Although the potency of inhibition was lower than that of prednisolone, all these results suggest that Ato $Formula^{\circledR}$ may be beneficial for treating chronic skin inflammatory disorders such as atopic dermatitis.

• IE interfaces
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• v.13 no.4
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• pp.619-626
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• 2000

In this paper, we place the focus on suggesting a method of forecasting demand for PCS resale service with survey data in Korea. It is important for the service provider to forecast the diffusion process when designing marketing strategies and analyzing the costs and benefits. For the reason, we conduct a survey of three groups composed of non-subscribers, cellular subscribers, and PCS subscribers in order to forecast the demand according to several possible scenarios and business strategies. We consider the survey item that is measured by multiple point scales in response to a question if he would subscribe to the mobile telephone service in the future. We propose a method to forecast the size of market potential by classifying each individual into the two extreme groups, that is, yes or no. Then, by integrating survey data and historical data, we forecast the demand for PCS resale service that varies according to scenarios and strategies. From the results, we can find several implications for the provider of PCS resale service.