• Title/Summary/Keyword: SIS

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Transdermal Delivery of Estradiol and Norethindrone Acetate: Effect of Vehicles and Pressure Sensitive Adhesive Matrix

  • Chun, Myung-Kwan;Choi, Hoo-Kyun
    • Journal of Pharmaceutical Investigation
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    • v.35 no.3
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    • pp.173-177
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    • 2005
  • Addition of 30% propylene glycol was required to maintain sink condition in the evaluation of percutaneous absorption of estradiol and norethindrone acetate. The permeability of estradiol was higher in silicone and SIS adhesives. However, estradiol was crystallized in silicone, SIS, and SBS adhesive matrix. The permeability ratio of estradiol or norethindrone acetate from acrylic pressure sensitive adhesives varied widely depending on the functional group of the acrylic adhesives. PEO grafting to acrylic adhesive seemed to change physicochemical property of acrylic adhesive and increased the permeability of estradiol and norethindrone acetate significantly. On the contrary, highly cross-linked enhancer compatible acrylic adhesive decreased the permeability of both estradiol and norethindrone acetate. $Span^{\circledR}$ 20 provided the highest enhancing effect on the permeability of both estradiol and norethindrone acetate followed by oleic acid and $Crovol^{\circledR}$ EP40. The permeability of the drugs from the developed system was comparable to that from commercial $Combitran^{\circledR}$, although significantly lower amount of estradiol and norethindrone acetate were loaded in the developed system.

특허 데이터를 활용한 정보통신 산업혁신체제의 역동성 분석

  • Kim, Jin-Yong;Jeong, Jae-Yong
    • Journal of Technology Innovation
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    • v.11 no.2
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    • pp.283-314
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    • 2003
  • The transformation of sector system in Information and Communications Technology (ICT), a prominent character in sector system, has been paid much attention in innovation theory with rapid change in information technologies and technological environment. In this context, we explore how Sectoral Innovation System (SIS) in ICT has been transformed since 1970 by employing US patent data and Proxy variables which measures the basic elements for SIS and its technological characteristics. By utilizing patent data, it is demonstrated that technological regimes, key links and Schumpeterian patterns of innovation in overall ICT sector have drastically transformed over the last three decades. We also reviewed how changes of knowledge bases and technological characteristics driving forces of dynamics in ICT help heterogeneous agents interact with environmental factors (Industrial structure and institutions), leading to industrial or economic growth and its dynamics in the historical perspective over ICT sector (Telecommunication, Computer and Semiconductor). Consequently, our research shows clearly that Schumpeterian patterns of innovation have shifted from Mark I to Mark II in ICT. Our study also provides a glimpse picture of dynamics patent data.

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Best Estimate Small Break LOCA Analysis for KNGR SIS Optimization

  • Song, Jin-Ho;Lim, Hong-Sik;Bae, Kyoo-Hwan;Lee, Joon
    • Proceedings of the Korean Nuclear Society Conference
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    • 1996.05b
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    • pp.417-422
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    • 1996
  • The KNGR has an advanced ECCS design feature which employs four mechanically-separated SI trains where each train consisting of one HPSI pump and one SIT injects ECC water directly into the reactor vessel downcomer annulus. To demonstrate that the KNGR ECCS design features meet the EPRI ALWR requirements of no core uncovery for a break of up to 6 inch diameter, small break LOCA cases with various break sizes were analyzed using a best-estimate analytical procedure. Two kinds of break locations are considered: cold leg and DVI line breaks. It was observed that the KNGR ECC design can tolerate a cold leg break of up to 10 inches with no core uncovery. However. since DVI line break with 6 inch diameter undergoes slight core uncovery. further investigation is required for KNGR SIS optimization.

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A Study on the Relationships between Human Dimensions and Interior Space of the Residence Yunkyungdang (주택 연경당 내부공간과 인체치수와의 상관성 분석 연구)

  • 최상헌
    • Korean Institute of Interior Design Journal
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    • no.4
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    • pp.5-9
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    • 1995
  • In this study, the relationships between the interior space of the upper class residence of Korean late Chosun dynasty and human dimensions based on their life styles of that era are analized. As an object of the study, the interior space of Yunkyungdant in Changduk palace is selected. The major analytical frame works of this study are : the analysis of Space-Human Body System, the analysis of Space-Objects-Human Body System, and the analy-sis of Space-Objects-Human Body System, and the analy-sis of Space-Objects-Life Activities of Human Body System. As a result, it was verified that there are certain quantitative relationships between the interior space of the residence and the human dimensions of Koreans lived up to their life styles and activities of Chosun dynasty era, specialized as 'Confucian life style'.

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Development of an Interactive Graphic-Aided Decision Su, pp.rt System for Designing Inspection Plans (검사시스템 설계를 위한 컴퓨터 그래픽에 근거한 대화형 의사결정 지원시스템의 개발)

  • 신완선;조원양
    • Journal of Korean Society for Quality Management
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    • v.25 no.4
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    • pp.168-184
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    • 1997
  • The primary objective of this paper is to develop an interactive computer graphic aided decision su, pp.rt system for the design of inspection plans for complex production systems. This research first develops a computer simulator, called Simulator for Inspection Systems(SIS), in order to represent the production system as a network model. The simulator elicits fundamental information about the system from the decision maker(DM) in an interactive manner. A decision su, pp.rt system is then proposed by combining SIS and Compromise Programming. The system simulates a set of possible inspection strategies implicitly, observes all the important measurements about the inspection system, and employs the compromise programming a, pp.oach to help the DM determine the best compromising allocation of inspection effort considering his/her preferences. Finally, the performance of the proposed system is evaluated using two test cases. The pros and cons of the system are also discussed.

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Design of mandrel in tube drawing process for automotive steering input shaft (자동차용 SIS 인발 공정에서의 맨드렐 형상 설계)

  • Kim S. W.;Lee Y. S.;Kwon Y. N.;Lee J. W.;Lee J. H.
    • Proceedings of the Korean Society for Technology of Plasticity Conference
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    • 2005.10a
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    • pp.198-201
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    • 2005
  • Monobloc technology Provides a homogeneous material along the complete tubular shaft without any discontinuity between the interconnecting tube and the stems as is found when the tubes and stems have been Joined by welding. Cold tube drawing is a technique that can be applied for manufacturing of those monobloc tubular shafts with several advantages such as high productivity and cost reduction. The present study is concerned with the investigation about the process parameters related with tool configuration. In order to obtain successfully formed SIS(Steering Input Shaft) without any defects, advanced design of mandrel is presented and analyzed by the FEM and ductile fracture criterion in this paper.

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THE DESIGN OF QUASI-OPTICS FOR DUAL-CHANNEL SIS RECEIVER (100GHz/150GHz 대역용 이중채널 SIS수신기의 준광학계 설계)

  • 박종애;한석태;김광동;김효령;정현수;김태성;이창훈;조세형;양종만
    • Journal of Astronomy and Space Sciences
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    • v.14 no.1
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    • pp.67-79
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    • 1997
  • We have designed the quasi optics of the dual channel receiver to observe the radio sources with 100GHz-band and 150GHz-band simultaneously. We introduced the general quasi optics and the relation between the Gaussian beam and thin lens approximation. We determined the parameters of the quasi optic components to match the beam waist at cassegrain focus with that of feed horn well.

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Delayed Parallel Interference Cancellation for GPS C/A Code Receivers

  • Glennon, Eamonn P.;Bryant, Roderick C.;Dempster, Andrew G.
    • Proceedings of the Korean Institute of Navigation and Port Research Conference
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    • v.2
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    • pp.261-266
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    • 2006
  • A number of different techniques are available to mitigate the problem of cross correlations caused by the limited dynamic range of the 10-bit Gold codes in the GPS C/A code. These techniques include successive-interference cancellation (SIC) and parallel-interference cancellation (PIC), where the strong signals are subtracted at IF prior to attempting to detect the weak signals. In this paper, a variation of these techniques is proposed whereby the subtraction process is delayed until after the correlation process, although still employing a pure reconstructed C/A code signal to permit prediction of the cross correlation process. The paper provides details on the method as well as showing the results obtained when the method was implemented using a software GPS receiver. The benefits of this approach are also described, as is the application of the method to the cancellation of CW interference.

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