• The Journal of Korean Institute of Communications and Information Sciences
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• v.32 no.5B
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• pp.277-285
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• 2007

In this paper, we present a simulation model of Slammer worm propagation process which caused serious disruptions on Internet in the you of 2003 and analyze the process of Slammer by using NS-2. Recently introduced NS-2 modeling called "Detailed Network-Abstract Network Model" had enabled packet level analysis. However, it had deficiency of accommodating only small sized network. By extending the NS-2 DN-AN model to AN-AN model (Abstract Network-Abstract Network model), it is effectively simulated that the whole process from the initial infection to the total network congestion on hourly basis not only for the Korean network but also for the rest of the world networks. Furthermore, the progress of the propagation from Korean network to the other country was also simulated through the AN-AN model. 8,848 hosts in Korean network were infected in 290 second and 66,152 overseas hosts were infected in 308 second. Moreover, the scanning traffics of the worm at the Korean international gateway saturated the total bandwidth in 154 seconds for the inbound traffic and in 135 seconds for the outbound one.

• Molecules and Cells
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• v.42 no.9
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• pp.661-671
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• 2019

Adipose tissue-derived mesenchymal stem cells (ADSCs) are promising for regenerating degenerated intervertebral discs (IVDs), but the low efficiency of nucleus pulposus (NP)-specific differentiation limits their clinical applications. The Sonic hedgehog (Shh) signaling pathway is important in NP-specific differentiation of ADSCs, and Smoothened Agonist (SAG) is a highly specific and effective agonist of Shh signaling. In this study, we proposed a new differentiation strategy with the use of the small molecule SAG. The NP-specific differentiation and extracellular matrix (ECM) synthesis of ADSCs were measured in vitro, and the regenerative effects of SAG pretreated ADSCs in degenerated IVDs were verified in vivo. The results showed that the combination of SAG and transforming growth factor-${\beta}3$ ($TGF-{\beta}3$) is able to increase the ECM synthesis of ADSCs. In addition, the gene and protein expression levels of NP-specific markers were increased by treatment with SAG and $TGF-{\beta}3$. Furthermore, SAG pretreated ADSCs can also improve the disc height, water content, ECM content, and structure of degenerated IVDs in vivo. Our new differentiation scheme has high efficiency in inducing NP-specific differentiation of ADSCs and is promising for stem cell-based treatment of degenerated IVDs.

• Journal of the Korea institute for structural maintenance and inspection
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• v.23 no.6
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• pp.1-8
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• 2019

To resolve the conservative requirements for clear headed-bar spacing in KBC 2016 and ACI 318-08, two 2/3-scale exterior beam-column connections were tested under cyclic seismic loading. The seismic tests primarily explored the effect on their seismic performance of using (a) small clear spacings and (b) multiple layers of headed reinforcements in the beam. Also, the previous test data were thoroughly analyzed. It was concluded that the clear bar spacing of 2d_b or the use of two bar layers might be permitted for headed reinforcements embedded in exterior beam-column connections.

• The Korean Journal of Physiology and Pharmacology
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• v.24 no.2
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• pp.173-183
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• 2020

An in vitro model for ischemia/reperfusion injury has not been well-established. We hypothesized that this failure may be caused by serum deprivation, the use of glutamine-containing media, and absence of acidosis. Cell viability of H9c2 cells was significantly decreased by serum deprivation. In this condition, reperfusion damage was not observed even after simulating severe ischemia. However, when cells were cultured under 10% dialyzed FBS, cell viability was less affected compared to cells cultured under serum deprivation and reperfusion damage was observed after hypoxia for 24 h. Reperfusion damage after glucose or glutamine deprivation under hypoxia was not significantly different from that after hypoxia only. However, with both glucose and glutamine deprivation, reperfusion damage was significantly increased. After hypoxia with lactic acidosis, reperfusion damage was comparable with that after hypoxia with glucose and glutamine deprivation. Although high-passage H9c2 cells were more resistant to reperfusion damage than low-passage cells, reperfusion damage was observed especially after hypoxia and acidosis with glucose and glutamine deprivation. Cell death induced by reperfusion after hypoxia with acidosis was not prevented by apoptosis, autophagy, or necroptosis inhibitors, but significantly decreased by ferrostatin-1, a ferroptosis inhibitor, and deferoxamine, an iron chelator. These data suggested that in our SIR model, cell death due to reperfusion injury is likely to occur via ferroptosis, which is related with ischemia/reperfusion-induced cell death in vivo. In conclusion, we established an optimal reperfusion injury model, in which ferroptotic cell death occurred by hypoxia and acidosis with or without glucose/glutamine deprivation under 10% dialyzed FBS.

• Asian Pacific Journal of Cancer Prevention
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• v.14 no.10
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• pp.5735-5740
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• 2013

Background: A number of studies have investigated the association between increased pretreatment serum C-reactive protein (CRP) levels and the prognosis of gastric cancer. However, due to the inconsistent results, whether the serum CRP level can be a prognostic factor in primary gastric cancer remains controversial. Methods: We searched Medline, PubMed, Embase and the Cochrane Central Register of Controlled Trials for relevant high-quality reports. A meta-analysis was carried out using the included studies to assess the association between pretreatment serum CRP level and overall survival (OS) in patients with gastric cancer. Correlation analyses were conducted to evaluate the relationship between serum CRP and tumor characteristics such as tumor node metastasis (TNM) stage and recurrence. Results: Twelve reports involving 2,597 patients with gastric cancer were included. Primary meta-analysis indicated a significant association between elevated CRP level and poor OS (HR 1.77, 95% CI 1.56-2.00). Subgroup analyses showed no single factor could alter the primary results when we divided the included studies by "number of patients", "max follow-up period", "TNM stage", "treatment" and "cut-off value". Correlation analyses showed that serum CRP level was significantly related to TNM stage (OR 2.96, 95% CI 2.22-3.93) and tumor recurrence (OR 1.81, 95% CI 1.21-2.71). Conclusions: We demonstrated that increased pretreatment serum CRP level (${\geq}10mg/L$) was significantly associated with poor prognosis in gastric cancer patients, either in early or advanced stages.

• Proceedings of the Korean Institute of Information and Commucation Sciences Conference
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• 2008.05a
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• pp.129-132
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• 2008

The generally six-port phase correlator is comprised of a wilkinson power divider and three $90^{\circ}$ hybrid coupler, got bandwidth performance of less than 10%. in this paper, the six-port phase correlator using two section power divider has 33% bandwidth and external matching hybrid coupler has 15% bandwidth was designed with the center frequency of 2.5GHz. Analysis of the simulation result indicates that RF port and LO port got frequency bandwidth of 13%. Insert loss performance of fabricated six-port phase correlator is incremented, but bandwidth resembles simulation result. And phase tolerance within bandwidth is less than $90^{\circ}$.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.32 no.8B
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• pp.529-538
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• 2007

In this paper, we have analyzed a simulation model of Slammer worm propagation process which caused serious disruptions on the Internet in the year of 2003 by using NS-2. Previously we had presented and analyzed Abstract Network to Abstract Network(AN-AN) model being modified from the Detailed Network to Abstract Network(DN-AN) of NS-2. However, packet analysis in AN-AN model had a problem of taking 240 hours to simulate the initial 300 seconds of infection. We have reduced the AN-AN model to save the simulation time and analyzed total 3.5 hours of the network congestions within 107 hours. Moreover, we have derived optimal quarantine rate of 0.0022 considering service outage of network devices caused by the heavy infected traffics, which was not taken into consideration in previous works. As the result of simulation, Although the inbound traffic at the Korean international gateway was back in normal conditions at 4,787 second, due to the revese direction saturation was maintained until 12,600 seconds, the service outage was persisted for 3.5 hours.

• Journal of the Korea Fashion and Costume Design Association
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• v.10 no.2
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• pp.125-138
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• 2008

For physical and hand property evaluation of fabrics, the knitted fabrics from 11 types of machines knitting fancy yarns, boucle (M1), knot (M2), snarl (M3), and slub (M4), tamtam (M5), tubular (M6), fur 1 (M7), bead (M8), fur 2 (M9), fur 3 (M10), and ladder (M11) yarns, were prepared with 7-10 G plain stitch. Washing test and pilling test had also been carried out. For hand properties by objective sensibility evaluation, 17 items of sir mechanical properties using KES-FB (Kawabata Evaluation System) had been measured. Then hand values of knitted fabrics were calculated with a calculation formula, namely KN-402-KT. Finally the total hand values were obtained through KN-301-WINTER. As a result of physical properties and objective evaluation for machines knitting fancy fabrics, most of them shrank in the direction of wale and course after the washing test, in which their shrinkage rate had a maximum of 3.5%. Therefore, the washing test indicated that the shrinkage ratio of knitted fabrics had a minor change. The results of the pilling test are mostly 4-5th grade, and all of the machines knitting fancy fabrics showed good results in the pilling resistance. In hand properties and objective sensibility evaluation, twisted fancy yarns, such as boucle (M1), knot (M2), snarl (M3), and slub (M4), were superior to bonding rigidity (B) and shear rigidity (G). The surface property between course and wale differs in all samples and course direction is tougher than wale direction. FUKURAMI (fullness and softness) of all samples have high values, besides NUMERI (smoothness) of tamtam (M5) and boucle (M1), which were rather good. Most samples except fur 1 (M7) had low KOSHI (stiffness) value. The total hand value (THV) of twisted yarns was low. This study proves that manufacturers, who plan knitting yarn products and knit fashion, can apply these data to develop machines knitting yarns and knits that fit the consumers' demands.

• Geomechanics and Engineering
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• v.20 no.1
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• pp.75-86
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• 2020

This study aims to simulate the stabilization process of fibrous peat samples using end-bearing Cement Deep Mixing (CDM) columns by three area improvement ratios of 13.1% (TS-2), 19.6% (TS-3) and 26.2% (TS-3). It also focuses on the determination of approximate stress distribution between CDM columns and untreated fibrous peat soil. First, fibrous peat samples were mechanically stabilized using CDM columns of different area improvement ratio. Further, the ultimate bearing capacity of a rectangular foundation rested on the stabilized peat was calculated in stress-controlled condition. Then, this process was simulated via a FEM-based model using Plaxis 3-D foundation and the numerical modelling results were compared with experimental findings. In the numerical modelling stage, the behaviour of fibrous peat was simulated based on hardening soil (HS) model and Mohr-Coulomb (MC) model, while embedded pile element was utilized for CDM columns. The results indicated that in case of untreated peat HS model could predict the behaviour of fibrous peat better than MC model. The comparison between experimental and numerical investigations showed that the stress distribution between soil (S) and CDM columns (C) were 81%C-19%S (TS-2), 83%C-17%S (TS-3) and 89%C-11%S (TS-4), respectively. This implies that when the area improvement ratio is increased, the share of the CDM columns from final load was increased. Finally, the calculated bearing capacity factors were compared with results on the account of empirical design methods.

• Journal of the Korean Society for Railway
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• v.14 no.2
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• pp.151-159
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• 2011

This study performed an experimental study for air-tightness performance evaluation of concrete tube structures with joints. The test specimens consist of a continuous concrete tube, a concrete tube with a joint in the middle, and a segmented concrete tube. The test is performed in such a way that the inner pressure of the tube is dropped down to 0.1atm and the increase of the pressure is monitored with time. An equivalent air permeability is then calculated based on the test results. The results show that, as expected, a structure with more joints or bonds tends to be less air-tight. A sensitivity study shows that the system air-tightness performance level becomes higher as either the diameter or the thickness of the tube increases. Moreover, the increase in the diameter or the thickness of the tube makes an effort to enhance the air-tightness more effective.