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Synthesis of L-3-[$^{123}I$]iodo-${\alpha}$-methyltyrosine and Biodistribution in 9L Glioma Bearing Rats (L-3-[$^{123}I$iodo-${\alpha}$-methyltyrosine 합성과 9L Glioma 이식 백서 분포조사)

  • Yang, Seung-Dae;Lim, Sang-Moo;Woo, Kwang-Sun;Chung, Wee-Sup;Chun, Kwon-Soo;Suh, Yong-Sup;Lim, Jong-Seok;Park, Hyon;Yun, Yong-Ki;Lee, Jong-Doo
    • The Korean Journal of Nuclear Medicine
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    • v.29 no.1
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    • pp.105-109
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    • 1995
  • L-3-[$^{123}I$]iodo-${\alpha}$-methyltyrosine([$^{123}I$] IMT) was synthesized by electrophilic radio-iodination using chloramine-T and Iodobead in phosphate buffered solution. And the biodistribution was examined in 9L glioma bearing rats. The radiosynthesis of [$^{123}I$]IMT with iodobead was simpler and higher in radiochemical yield(88%) than the method using chloramine-T(83%) as radioiodinating reagent. The highest yield was obtained from the reaction using 1 piece of Iodobead, $200{\mu}g$ ${\alpha}$-methyltyrosine in $100{\mu}l$ phosphate-buffered solution(pH 5.5) and the reaction was completed in 7min. 24 hours after the injection, the biodistribution in 9L glioma transplanted rats revealed the in vivo deiodination, the excretion via kidney, and 3 times higher uptake in the tumor than normal brain. These results suggest the promising clinical use of [$^{123}I$] IMT in the various malignancies.

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Effect of Selected Environmental Factors on the Production of Geosmin in Phormidium Sp. (Phormidium sp.의 Geosmin 생산에 미치는 환경요인의 영향)

  • 박대균;오희목;안치용;맹주선
    • Korean Journal of Microbiology
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    • v.36 no.1
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    • pp.52-57
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    • 2000
  • A method for quantitative and qualitative analysis of geosmin, odorant produced by several actinomycetes and cyanobacteria, was established and optimized. The effects of environmental conditions on the growth of Phormidium sp. NIVA-CYA7 were examined and the production and release of geosmin by the species was analyzed by using the purge and trap-gas chromatographic technique. One of the major advantages of the technique established in the present study is that the preparation of sample is simpler and purge time is shorter. Under the culture conditions (pH 7.9, $20^{\circ}C$, 120-140 $\mu$E/$m^2$/s and Z8 medium), Phormidium showed growth characteristics with a lag phase for 8 days and an exponential phase for 14 days followed by a stationary phase. Reduction of inorganic nitrogen concentrations in the culture medium from 250 to 100 or 25 $\mu$M brought no significant effect on the cell growth. However, the cell growth was significantly inhibited with decreasing concentrations of inorganic phosphorus from 25 to 10 or 2.5 $\mu$M. When the inorganic phosphorus concentration in the medium was lowered from 25 to 10 $\mu$M, the levels of geosmin in the organism expressed as percentages per unit TOC and chlorophyII-$\alpha$ increased by 35% and 68%, respectively. When the initial pH of the medium was 9.4, geosmin content was 0.0824 $\mu$g/mg C, which was 2-fold higher than that at pH 7.9 Consequently, the level of geosmin in Phormidium was found to vary with growth phases of the culture, external inorganic phosphorus concentration and external pH, while the release of geosmin was not significantly affected by the factors.

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The Development of Confocal Microscopy Using the Amplified Double-compound Flexure Guide (레버 증폭 구조의 플렉서를 이용한 공초점 현미경의 개발)

  • Lee, Sang-Won;Kim, Wi-Han;Jung, Young-Dae;Park, Min-Kyu;Kim, Jee-Hyun;Lee, Sang-In;Lee, Ho
    • Korean Journal of Optics and Photonics
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    • v.22 no.1
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    • pp.46-52
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    • 2011
  • A confocal microscope was developed utilizing a scanning sample stage based on a home-built double-compound flexure guide. A scanning sample stage with nano-scale resolution consisted of a double leaf spring based flexure, a displacement amplifying lever, a Piezo-electric Transducer(PZT) actuator and capacitance sensors. The performance of the two-axis stage was analyzed using a commercial finite element method program prior to the implementation. A single line laser was employed as the light source along with the Photo Multiplier Tube(PMT) that served as the detector. The performance of the developed confocal microscope was evaluated with a mouse ear skin imaging test. The designed scanning stage enabled us to build the confocal microscope without the two optical scanning mirror modules that are essential in the conventional laser scanning confocal microscope. The elimination of the scanning mirror modules makes the optical design of the confocal microscope simpler and more compact than the conventional system.

Optimal design of a nonparametric Shewhart-Lepage control chart (비모수적 Shewhart-Lepage 관리도의 최적 설계)

  • Lee, Sungmin;Lee, Jaeheon
    • Journal of the Korean Data and Information Science Society
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    • v.28 no.2
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    • pp.339-348
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    • 2017
  • One of the major issues of statistical process control for variables data is monitoring both the mean and the standard deviation. The traditional approach to monitor these parameters is to simultaneously use two seperate control charts. However there have been some works on developing a single chart using a single plotting statistic for joint monitoring, and it is claimed that they are simpler and may be more appealing than the traditonal one from a practical point of view. When using these control charts for variables data, estimating in-control parameters and checking the normality assumption are the very important step. Nonparametric Shewhart-Lepage chart, proposed by Mukherjee and Chakraborti (2012), is an attractive option, because this chart uses only a single control statistic, and does not require the in-control parameters and the underlying continuous distribution. In this paper, we introduce the Shewhart-Lepage chart, and propose the design procedure to find the optimal diagnosis limits when the location and the scale parameters change simultaneously. We also compare the efficiency of the proposed method with that of Mukherjee and Chakraborti (2012).

An Enhanced DESYNC Scheme for Simple TDMA Systems in Single-Hop Wireless Ad-Hoc Networks (단일홉 무선 애드혹 네트워크에서 단순 TDMA 시스템을 위한 DESYNC 알고리즘 개선 방안)

  • Hyun, Sanghyun;Lee, Jeyul;Yang, Dongmin
    • KIPS Transactions on Computer and Communication Systems
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    • v.3 no.9
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    • pp.293-300
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    • 2014
  • TDMA(Time Division Multiple Access) is a channel access scheme for shared medium networks. The shared frequency is divided into multiple time slots, some of which are assigned to a user for communication. Techniques for TDMA can be categorized into two classes: synchronous and asynchronous. Synchronization is not suitable for small scale networks because it is complicated and requires additional equipments. In contrast, in DESYNC, a biologically-inspired algorithm, the synchronization can be easily achieved without a global clock or other infrastructure overhead. However, DESYNC spends a great deal of time to complete synchronization and does not guarantee the maximum time to synch completion. In this paper, we propose a lightweight synchronization scheme, C-DESYNC, which counts the number of participating nodes with GP (Global Packet) signal including the information about the starting time of a period. The proposed algorithm is mush simpler than the existing synchronization TDMA techniques in terms of cost-effective method and guarantees the maximum time to synch completion. Our simulation results show that C-DESYNC guarantees the completion of the synchronization process within only 3 periods regardless of the number of nodes.

A General Formula for Calculating the Value of Transverse Moment of Inertia by Observing the Roll Motion of Ships (횡요상태 관측에 의한 선체 횡관성모멘트 값의 도출을 위한 일반식)

  • Choi, Soon-Man
    • Journal of the Korean Society of Marine Environment & Safety
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    • v.21 no.5
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    • pp.538-542
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    • 2015
  • The transverse moment of inertia is an indispensable factor in analyzing the roll motion characteristics of ships and the calculating method needs to be based on the more reasonable theories when deciding the value as the results and reliability of analysis could be much affected by the correctness. However, the mass distribution and shape of hulls are quite complicated and give much difficulties in case of calculating the value directly from the ship design data, furthermore even acquiring the detailed design data for calculation is almost impossible. Therefore some simpler ways are practically adopted in the assumption that the gyradius of roll moment can be decided by a given ratio and hull width. It is well known that the responses of the free roll decay are varied according to the value of roll moment in view of roll period and amplitude decay ratio, so that the general formula to get the moment value can be derived also from the observation of roll decay responses. This study presents how the roll period and decay ratio are interrelated each other from the roll motion characteristics with suggesting a general formula to be able to calculate roll moment from it. Finally, the obtained general formula has been applied to a ship data to check the resultant characteristics through analyzing graphs and showed that the roll moment becomes more accurate when rolling period and decay ratio are considered together in calculation.

Comparison Study of the Impact Response Characteristics of Fixed Cylindrical Offshore Structures Considering Seawater Fluid Region (해수유체영역을 고려한 고정식 실린더형 해양구조물의 충격응답특성 비교연구)

  • Lee, Kangsu;Hong, Keyyong
    • Journal of Advanced Marine Engineering and Technology
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    • v.39 no.4
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    • pp.489-494
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    • 2015
  • This research focused on minimizing the response of fixed cylindrical offshore structures to a ship impact considering the seawater fluid part. A collision between a ship and offshore structure is generally a complex problem and it is often impractical to perform rigorous finite element analyses to include all the effects and sequences during the collision. The structural behavior of a fixed cylindrical type offshore substructure with a seawater fluid part has a simpler response and small deformation due to the dissipation of impact energy. Upon applying the impact force of a ship to the cylindrical structure, the maximum acceleration, internal energy, and plastic strain are calculated for each load cases using Ls-dyna finite element software. In the maximum cases 2.0 m/s velocity, the response result for the structure was carried out to compare between having a fluid region and no fluid region. Fluid-structure interaction analysis was performed using the ALE method, which make it possible to apply a fluid region on the impact problem. The case of a fixed cylindrical type offshore structure without a seawater fluid part can be a more conservative design.

Study on the stress distribution depending on the bone type and implant abutment connection by finite element analysis (지대주 연결 형태와 골질에 따른 저작압이 임프란트 주위골내 응력분포에 미치는 영향)

  • Park, Hyun-Soo;Lim, Sung-Bin;Chung, Chin-Hyung;Hong, Ki-Seok
    • Journal of Periodontal and Implant Science
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    • v.36 no.2
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    • pp.531-554
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    • 2006
  • Oral implants must fulfill certain criteria arising from special demands of function, which include biocompatibility, adequate mechanical strength, optimum soft and hard tissue integration, and transmission of functional forces to bone within physiological limits. And one of the critical elements influencing the long-term uncompromise functioning of oral implants is load distribution at the implant- bone interface, Factors that affect the load transfer at the bone-implant interface include the type of loading, material properties of the implant and prosthesis, implant geometry, surface structure, quality and quantity of the surrounding bone, and nature of the bone-implant interface. To understand the biomechanical behavior of dental implants, validation of stress and strain measurements is required. The finite element analysis (FEA) has been applied to the dental implant field to predict stress distribution patterns in the implant-bone interface by comparison of various implant designs. This method offers the advantage of solving complex structural problems by dividing them into smaller and simpler interrelated sections by using mathematical techniques. The purpose of this study was to evaluate the stresses induced around the implants in bone using FEA, A 3D FEA computer software (SOLIDWORKS 2004, DASSO SYSTEM, France) was used for the analysis of clinical simulations. Two types (external and internal) of implants of 4.1 mm diameter, 12.0 mm length were buried in 4 types of bone modeled. Vertical and oblique forces of lOON were applied on the center of the abutment, and the values of von Mises equivalent stress at the implant-bone interface were computed. The results showed that von Mises stresses at the marginal. bone were higher under oblique load than under vertical load, and the stresses were higher at the lingual marginal bone than at the buccal marginal bone under oblique load. Under vertical and oblique load, the stress in type I, II, III bone was found to be the highest at the marginal bone and the lowest at the bone around apical portions of implant. Higher stresses occurred at the top of the crestal region and lower stresses occurred near the tip of the implant with greater thickness of the cortical shell while high stresses surrounded the fixture apex for type N. The stresses in the crestal region were higher in Model 2 than in Model 1, the stresses near the tip of the implant were higher in Model 1 than Model 2, and Model 2 showed more effective stress distribution than Model.

A Study on Enclosed Mast Characteristics for Radar Cross-Section Reduction (레이더반사면적 감소를 위한 폐위형 마스트 특성 연구)

  • Kwon, Hyun-Wung;Hong, Suk-Yoon;Hwang, Joon-Tae;Jeong, Seung-Jin;Kim, Jong-Chul;Song, Jee-Hun
    • Journal of the Korean Society of Marine Environment & Safety
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    • v.23 no.6
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    • pp.746-753
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    • 2017
  • Radar Cross Section (RCS) is a factor directly related to survivability, and a design to reduce the presence of this factor is needed. The upper structure, guns, radar and so on are related to warship RCS, but radar RCS reduction is difficult because of complex shapes involved. In this paper, an enclosed mast, which is one modern method for reducing radar RCS, and the characteristics of an applied Frequency Selected Surface (FSS) are analyzed. The RCS reduction ability of an enclosed mast has been confirmed by comparing RCS analysis results for a general radar with that of an enclosed mast for available frequency according to FSS shape. The characteristics of the enclosed mast have also been studied by analyzing the elevation angle and slope of the mast. General radar RCS was high because of its complex shape, but low RCS was shown for the enclosed mast model, which had a simpler shape.

The Effects of Active Movement Myofascial Decompression Therapy and Static Myofascial Decompression Therapy on Range of Motion, Muscle Strength, Functional Movement in Young Adults. (젊은 성인에서 능동 움직임을 결합한 근막감압치료 적용과 정적 적용이 관절가동범위, 근력, 기능적 움직임에 미치는 영향)

  • Lee, Jee-Hyun;Kim, Tae-Hyeon;Kang, Si-Yun;Kum, Do-Gun;Lee, Sung-Yeon;Do, Kwang-Sun;Kim, Chang-Sook;Bae, Ju-Han;Park, Jun-Hyuck;Kim, Jae-Eun
    • Journal of The Korean Society of Integrative Medicine
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    • v.9 no.3
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    • pp.165-173
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    • 2021
  • Purpose : Myofascial decompression is frequently mentioned as a method applied to cupping. The purpose of this study is to evaluate and compare active range of motion (AROM), muscle strength, and functional movement by applying myofascial decompression to the hamstrings. Methods : This study evaluated AROM, muscle strength, and functional movement by applying active movement myofascial decompression and static myofascial decompression to the dominant leg, respectively, in a crossover design conducted with normal adults (n=21) in their average 20s enrolled at G University in G city, Gyeongsangbuk-do. Active movement myofascial decompression was implemented for five minutes at a rate of 100 bpm to make the beats in flexion and extension respectively. Static myofascial decompression was only performed for five minutes while at rest. All of these interventions were performed at a cupping depth of two mm. After a one-week washout period, static was applied again to compare the same dependent variables. Results : Regarding AROM and muscle strength, both groups showed significant differences in the before and after results (p<.05). However, in the Functional Reach Aspect and Single Leg Hop test, the active movement myofascial decompression group showed better results. There was no statistical difference between the Active movement myofascial decompression group and Static myofascial decompression group in any dependent variable (p<.05). Conclusion : As a result of this experiment, both active movement myofascial decompression and static myofascial decompression had a positive effect on dependent variable. Therefore this study is meaningful in that it is easier and simpler to see the effect on flexibility, muscle strength, and functional movement just by implementing movement myofascial decompression.