• Korean Journal of Cleft Lip And Palate
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• v.10 no.2
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• pp.81-88
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• 2007

Cleft lip and palate (CLP) is one of the most prevalent congenital craniofacial anomalies. It has a significantly greater incidence of dental abnormalities in number, size, shape, and eruption of the teeth. Knout-out mouse model can identify several genes which play an important role in tooth agenesis. Since disruption of these genes has been confirmed to result in tooth agenesis in humans, CLP associated with hypodontia may be the best models for isolated tooth agenesis. According to the studies of dental abnormalities in CLP, the severity of dental defect is known to be influenced by the CLP phenotype. The cumulative data obtained from mouse and human genetic studies indicated that MSX1, PAX9 and AXIN2 are considered as candidate genes in non-syndromic hypodontia, while Shh, Pitx2, Irf6, p63 and EDA pathway genes are involved in syndromic one. We expect that genetic approach of CLP can offer the basis for tooth regeneration and be a new target in hypodontia therapy.

• Journal of Institute of Control, Robotics and Systems
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• v.6 no.9
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• pp.768-776
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• 2000

A robust high-speed motion controller is proposed. The proposed controller consists of the proximate time optimal servomechai는 (PTOD) for high-speed motion, disturbance observer (DOB) for robustness, friction compensator, and saturation handling element, In the proposed controller, DOB basically provides the chance to apply PTOS to non-double integrator systems by drastically reducing disturbances as well as unwanted signals due to difference between real system and the double integrator model. But, in DOB-based systems, if control input is saturated due to control input PTOS and/or DOB, overall system stability cannot be guaranteed. To solve this problem, ribust stability, when the control input is saturated. Eventually, a simple saturation handling element is inserted to maintain internal stability of overall system. Also, we explain the our two saturation handling methods, Additional Saturation Element (ASE_ and Self Adjusting Saturation (SAS), are the equivalent solutions of the saturation problem to maintain internal stability. The stability and performance of the proposed controller are verified through numerical simulations and experiments using a precision linear motor system.

• Asian-Australasian Journal of Animal Sciences
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• v.27 no.3
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• pp.303-309
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• 2014

The increasing importance of meat quality has implications for animal breeding programs. Research has revealed much about the genetic background of pigs, and many studies have revealed the importance of various genetic factors. Since meat quality is a complex trait which is affected by many factors, consideration of the overall phenotype is very useful to study meat quality. For integrating the phenotypes, we used principle component analysis (PCA). The significant SNPs refer to results of the GRAMMAR method against PC1, PC2 and PC3 of 14 meat quality traits of 181 Duroc pigs. The Genome-wide association study (GWAS) found 26 potential SNPs affecting various meat quality traits. The loci identified are located in or near 23 genes. The SNPs associated with meat quality are in or near five genes (ANK1, BMP6, SHH, PIP4K2A, and FOXN2) and have been reported previously. Twenty-five of the significant SNPs also located in meat quality-related QTL regions, these result supported the QTL effect indirectly. Each single gene typically affects multiple traits. Therefore, it is a useful approach to use integrated traits for the various traits at the same time. This innovative approach using integrated traits could be applied on other GWAS of complex-traits including meat-quality, and the results will contribute to improving meat-quality of pork.

• Journal of the Institute of Electronics Engineers of Korea TC
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• v.43 no.12 s.354
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• pp.68-74
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• 2006

The MANET(Mobile Ad Hoc Network) is an independent network that is oranized by only Mobile Hosts. MANET guarantees the mobility of the node and does not need a backbone network or a base station. Recently, there is a strong demand to connect MANET to the Internet. For the interconnection between MANET and Internet, Mobile hosts of MANET must have global IP address. The well known scheme of the address configuration for MANET is SAA(Stateless Address Autoconfiguration). SAA configurated IP address by node itself. The advantage of SAA is not requiring any server for address configuration. However the SAA has problems of unstable and inefficient interconnection on the AD Hoc Network. To solve this problem we propose a method that assigns an IPv6 Global address to the node through the Internet Gateway. The format of assigned IPv6 address is also defined. The simulation result demonstrates that the proposed method can support the host for fast getting of global IPv6 Address and Mobile IPv6 efficiently.

• Korean Journal of Remote Sensing
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• v.23 no.2
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• pp.89-101
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• 2007

This paper investigates the effects of the fusion of multifrequency (C and L bands) polarimetric SAR data in land-cover classification. NASA JPL AIRSAR C and L bands data were used to supervised classification in an agricultural area to simulate the integration of ALOS PALSAR and Radarsat-2 SAR data to be available. Several scattering features derived from target decomposition based on eigen value/vector analysis were used as input for a support vector machines classifier and then the posteriori probabilities for each frequency SAR data were integrated by applying a probabilistic ratio model as a decision level fusion methodology. From the case study results, L band data had the proper amount of penetration power and showed better classification accuracy improvement (about 22%) over C band data which did not have enough penetration. When all frequency data were fused for the classification, a significant improvement of about 10% in overall classification accuracy was achieved thanks to an increase of discrimination capability for each class, compared with the case of L band Shh data.

• Development and Reproduction
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• v.25 no.4
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• pp.279-291
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• 2021

Hair loss is one of the most common chronic diseases, with a detrimental effect on a patient's psychosocial life. Hair loss results from damage to the hair follicle (HF) and/or hair regeneration cycle. Various damaging factors, such as hereditary, inflammation, and aging, impair hair regeneration by inhibiting the activation of hair follicle stem cells (HFSCs) and dermal papilla cells (DPCs). Formyl peptide receptor 2 (FPR2) regulates the inflammatory response and the activity of various types of stem cells, and has recently been reported to have a protective effect on hair loss. Given that stem cell activity is the driving force for hair regeneration, we hypothesized that FPR2 influences hair regeneration by mediating HFSC activity. To prove this hypothesis, we investigated the role of FPR2 in hair regeneration using Fpr2 knockout (KO) mice. Fpr2 KO mice were found to have excessive hair loss and abnormal HF structures and skin layer construction compared to wild-type (WT) mice. The levels of Sonic hedgehog (Shh) and β-catenin, which promote HF regeneration, were significantly decreased, and the expression of bone morphogenetic protein (Bmp)2/4, an inhibitor of the anagen phase, was significantly increased in Fpr2 KO mice compared to WT mice. The proliferation of HFSCs and DPCs was significantly lower in Fpr2 KO mice than in WT mice. These findings demonstrate that FPR2 impacts signaling molecules that regulate HF regeneration, and is involved in the proliferation of HFSCs and DPCs, exerting a protective effect on hair loss.

• Proceedings of the International Union of Geodesy And Geophysics Korea Journal of Geophysical Research Conference
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• 2003.05a
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• pp.14-14
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• 2003

SAR (Synthetic Aperture Radar) is an imaging radar which can scan and image Earth System targets without solar illumination. Most Earth observation Shh systems operate in X-, C-, S-, L-, and P-band frequencies, where the shortest wavelength is approximately 1.5 cm. This means that most opaque objects in the SAR signal path become transparent and SAR systems can image the planetary surface targets without sunlight and through rain, snow and/or even volcanic ash clouds. Most conventional SAR systems in operation, including the Canada's RADARSAT-1, operate in one frequency and in one polarization. This has resulted in black and with images, with which we are familiar now. However, with the launching of ENVTSAT on March 1 2002, the ASAR system onboard the ENVISAT can image Earth's surface targets with selected polarimetric signals, HH+VV, HH+VH, and VV+HV. In 2004, Canadian Space Agency will launch RADARSAT-II, which is C-band, fully polarimetric HH+VV+VH+HV. Almost same time, the NASDA of Japan will launch ALOS (Advanced land Observation Satellite) which will carry L-band PALSAR system, which is again fully polarimetric. This means that we will have at least three fully polarimetric space-borne SAR system fur civilian operation in less than one year. Are we then ready for this new all weather Earth Observation technology\ulcorner Actual imaging process of a fully polarimetric SAR system is not easy to explain. But, most Earth system scientists, including geologists, are familiar with polarization microscopes and other polarization effects in nature. The spatial resolution of the new generation of SAR systems have also been steadily increased, almost to the limit of highest optical resolution. In this talk some new applications how they are used for Earth system observation purpose.

• Journal of Digestive Cancer Research
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• v.4 no.1
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• pp.1-9
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• 2016

The abundance of multi-drug resistance ATPase binding cassette and deranged self-renewal pathways shown in cancer stem cells (CSCs) played a crucial role in tumorigenesis, tumor resistance, tumor recurrence, and tumor metastasis. Therefore, elucidation of CSCs biology can improve diagnosis, enable targeted treatment, and guide the follow up of GI cancer patients. In order to achieve chemoquiescence, seizing cancer through complete ablation of CSCs, CSCs are rational targets for the design of interventions that will enhance responsiveness to traditional therapeutic strategies and contribute in the prevention of local recurrence as well as metastasis. However, current cancer treatment strategies fail to either detect or differentiate the CSCs from their non-tumorigenic progenies mostly due to the absence of specific biomarkers and potent agents to kill CSCs. Recent advances in knowledge of CSCs enable to produce several candidates to ablate CSCs in gastrointestinal (GI) cancers, especially cancers originated from inflammation-driven mutagenesis such as Barrett's esophagus (BE), Helicobacter pylori-associated gastric cancer, and colitis-associated cancer (CAC). Our research teams elucidated through revisiting old drugs that proton pump inhibitor (PPI) and potassium competitive acid blocker (p-CAB) beyond authentic acid suppression, chloroquine for autophage inhibition, sonic hedgehog (SHH) inhibitors, and Wnt/β-catenin/NOTCH inhibitor can ablate CSCs specifically and efficiently. Furthermore, nanoformulations of these molecules could provide an additional advantage for more selective targeting of the pathways existing in CSCs just like current molecular targeted therapeutics and sustained action, while normal stem cells intact. In this review article, the novel approach specifically to ablate CSCs existing in GI cancers will be introduced with the introduction of explored mode of action.

• The Journal of Korean Institute of Electromagnetic Engineering and Science
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• v.16 no.9 s.100
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• pp.903-908
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• 2005

In this paper, in order to consider SAR(Specific Absorption Rate) problem at the beginning stage of a handset development, we investigated the Shh value change by using simulation method according to various EMI(Electromagnetic Interference) paint patterns on front case of a handset and folding angles. First, we made some experiments with EMI paint pattern on front case of a handset, and obtained results showed that different patterns of EMI paint had different SAR values. Among the simulation results on SAR value according to EMI paint patterns, the hairpin pattern showed the best performance, i.e. the decrease efficiency of $8.04\%$ and completely removed pattern showed the decrease efficiency of $5.94\%$. Orignal pattern was set as the reference and the folding angle was $150^{\circ}$. Second, simulation was carried out with changing folding angle from $150^{\circ}$ to $140^{\circ}$ and $160^{\circ}$. Simulation results for the modeled handset showed that SAR value was decreased with increasing the folding angle. When the folding angle was $160^{\circ}$ and with original pattern, we got the SAR value of about 1,61 W/kg. When we applied hairpin pattern with the folding angle of $160^{\circ}$, we got the lowest SAR value of about 1.45 W/kg.

• Reproductive and Developmental Biology
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• v.30 no.2
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• pp.143-156
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• 2006

Major characteristics of embryonic stem cells (ESCs) are sustaining of sternness and pluripotency by self-renewal. In this report, transcriptional profiles of the molecules in the developmentally important signaling pathways including Wnt, BMP4, $TGF-\beta$, RTK, Hh, Notch, and JAK/STAT signaling pathways were investigated to understand the self-renewal of mouse ESCs (mESCs), J1 line, and compared with the NIH3T3 cell line and mouse embryonic fibroblast (MEF) cells as controls. In the Wnt signaling pathway, the expression of Wnt3 was seen widely in mESCs, suggesting that the ligand may be an important regulator for self-renewal in mESCs. In the Hh signaling pathway, the expression of Gli and N-myc were observed extensively in mESCs, whereas the expression levels of in a Shh was low, suggesting that intracellular molecules may be essential for the self-renewal of mESCs. IGF-I, IGF-II, IGF-IR and IGF-IIR of RTK signaling showed a lower expression in mESCs, these molecules related to embryo development may be restrained in mESCs. The expression levels of the Delta and HESS in Notch signaling were enriched in mESCs. The expression of the molecules related to BMP and JAK-STAT signaling pathways were similar or at a slightly lower level in mESCs compared to those in MEF and NIH3T3 cells. It is suggested that the observed differences in gene expression profiles among the signaling pathways may contribute to the self-renewal and differentiation of mESCs in a signaling-specific manner.