• 대한기계학회논문집
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• 제18권5호
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• pp.1134-1143
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• 1994

A study of adiabatic shear band formation and propagation of 4340 steel was done using the stepped speciment which was subjected to high velocity impact. The high velocity impact was performed on compression Hopkinson bar impact machine. After the controlled impact, the specimen was prepared for visual inspection. Numerical simulation was also performed with same geometrical dimension using explicit time integration finite element code. Experimental results were then compared with the numerical prediction. It was found that the numerical prediction is quite accurate, average thickness of adiabatic shear band is about $10{\mu}m$, the macro crack around shoulder is due to folding, and the deformation control ring is effective to freeze the propagation of adiabatic shear band.

• 한국응용곤충학회지
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• 제42권2호
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• pp.91-100
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• 2003

경북농업기술원 약용작물 전시포에서 약용작물 기생선충을 조사하던 중 Helicotylenchus clarkei Sher, 1966와 Rotylenchus usitatus Van den Berg et Heyns, 1974 등 2종이 우리나라 미기록종으로 확인되어 보고한다. 이로서 국내에는 총 8종의 Helicotylenchus와 총 9종의 Rotylenchus가 기록외었으며 각 종에 대한 분류검색표를 첨부하였다.

• Asian Pacific Journal of Cancer Prevention
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• 제15권7호
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• pp.2987-2991
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• 2014

Connexin 43 is an important gap junction protein in vertebrates and is known for its tumor suppressive properties. Cx43 is abundantly expressed in the human intestinal epithelial cells and muscularis mucosae. To explore the role of Cx43 in the genesis of human colon cancer, we performed the expression analysis of Cx43 in 80 cases of histopathologically confirmed and clinically diagnosed human colon cancer samples and adjacent control tissue and assessed correlations with clinicopathological variables. Western blotting using anti-Cx43 antibody indicated that the expression of Cx43 was significantly down regulated (75%) in the cancer samples as compared to the adjacent control samples. Moreover, immunohistochemical analysis of the tissue samples confirmed the down regulation of the Cx43 in the intestinal epithelial cells. Cx43 down regulation showed significant association (p<0.05) with the histological type and tumor invasion properties of the cancer. Our data demonstrated that loss of Cx43 may be an important event in colon carcinogenesis and tumor progression, providing significant insights about the tumor suppressive properties of the Cx43 and its potential as a diagnostic marker for colon cancer.

• Journal of Forest and Environmental Science
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• 제28권1호
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• pp.8-11
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• 2012

The Kashmir Himalaya, known for its indigenous and endemic flora, also provides home to a large number of exotic plants, which exhibit a wide taxonomical and distributional stretch. Although, some preliminary studies have been carried out in the region on some aspects of its exotic flora, the inventorization and documentation of its exotic have received a little or negligible attention. There is a lot of scope of these exotic plant species in Kashmir valley, but lack of authentic identification has been as a big hurdle in their scientific management. It is in this backdrop that the present floristic study was carried out to identify, inventorize, document and characterize the exotic plant species grown in the Valley. The present study has revealed that Kashmir Valley grows 317 exotic plant species, which belong to 209 genera in 85 families. Dicotyledons are the largest group, represented by 252 species in 163 genera and 67 families. Monocotyledons comprise 52 species in 37 genera and 13 families. Gymnosperms are the smallest group, with 13 species distributed in 9 genera and 5 families. Asteraceae is the largest family containing 33 exotic species.

• Asian-Australasian Journal of Animal Sciences
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• 제26권9호
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• pp.1347-1358
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• 2013

Membrane technology has revolutionized the dairy sector. Different types of membranes are used in the industry for various purposes like extending the shelf life of milk without exposure to heat treatment, standardization of the major components of milk for tailoring new products as well increasing yield and quality of the dairy products, and concentrating, fractionation and purification of milk components especially valuable milk proteins in their natural state. In the cheese industry, membranes increase the yield and quality of cheese and control the whey volume, by concentrating the cheese milk. With the advancement of newer technology in membrane processes, it is possible to recover growth factor from whey. With the introduction of superior quality membranes as well as newer technology, the major limitation of membranes, fouling or blockage has been overcome to a greater extent.

• 논리연구
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• 제17권1호
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• pp.71-109
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• 2014

셔어는 타르스키의 논리적 귀결 정의가 개념적으로나 외연적으로 적합한 설명이라고 믿는다. 셔어는 모스토프스키의 동형 구조 내의 불변적인 것으로서 일반화된 양화사 개념, 그리고 자신의 모형 이론에 근거해서 그 믿음을 정당화하려 하였다. 이 글에서 나는 타르스키의 정의를 정당화하려는 셔어의 시도는 반만 성공한 것임을 보이려 한다. 나는 논리적인 것이 동형 구조 내의 불변적인 것이라는 셔어의 생각은 논리적 귀결의 형식적 특징을 보이기에 충분하다는 점을 인정한다. 반면 나는 용어의 의미에 대한 셔어의 생각은 외연이 빈 술어의 문제를 제대로 다루기에는 아주 부적합해서, 결국 셔어는 논리적으로 필연적인 진리들과 그 밖의 진리들을 구별하는 데 실패하였다고 생각한다.

• Asian Pacific Journal of Cancer Prevention
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• 제15권15호
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• pp.6397-6403
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• 2014

Background: Aberrant promoter hypermethylation has been recognized in human breast carcinogenesis as a frequent molecular alteration associated with the loss of expression of a number of key regulatory genes and may serve as a biomarker. The E-cadherin gene (CDH1), mapping at chromosome 16q22, is an intercellular adhesion molecule in epithelial cells, which plays an important role in establishing and maintaining intercellular connections. The aim of our study was to assess the methylation pattern of CDH1 and to correlate it with the expression of E-cadherin, clinicopathological parameters and hormone receptor status in breast cancer patients of Kashmir. Materials and Methods: Methylation specific PCR (MSP) was used to determine the methylation status of CDH1 in 128 invasive ductal carcinomas (IDCs) paired with the corresponding normal tissue samples. Immunohistochemistry was used to study the expression of E-cadherin, ER and PR. Results: CDH1 hypermethylation was detected in 57.8% of cases and 14.8% of normal adjacent controls. Reduced levels of E-cadherin protein were observed in 71.9% of our samples. Loss of E-cadherin expression was significantly associated with the CDH1 promoter region methylation (p<0.05, OR=3.48, CI: 1.55-7.79). Hypermethylation of CDH1 was significantly associated with age at diagnosis (p=0.030), tumor size (p=0.008), tumor grade (p=0.024) and rate of node positivity or metastasis (p=0.043). Conclusions: Our preliminary findings suggest that abnormal CDH1 methylation occurs in high frequencies in infiltrating breast cancers associated with a decrease in E-cadherin expression. We found significant differences in tumor-related CDH1 gene methylation patterns relevant to tumor grade, tumor size, nodal involvement and age at diagnosis of breast tumors, which could be extended in future to provide diagnostic and prognostic information.

• 상하수도학회지
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• 제34권6호
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• pp.503-512
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• 2020

Identifying the water circulation status is one of the indispensable processes for watershed management in an urban area. Recently, various water circulation models have been developed to simulate the water circulation, but it takes a lot of time and cost to make a water circulation model that could adapt the characteristics of the watershed. This paper aims to develop a water circulation state estimation model that could easily calculate the status of water circulation in an urban watershed by using multiple linear regression analysis. The study watershed is a watershed in Seoul that applied the impermeable area ratio in 1962 and 2000. And, It was divided into 73 watersheds in order to consider changes in water circulation status according to the urban characteristic factors. The input data of the SHER(Similar Hydrologic Element Response) model, a water circulation model, were used as data for the urban characteristic factors of each watershed. A total of seven factors were considered as urban characteristic factors. Those factors included annual precipitation, watershed area, average land-surface slope, impervious surface ratio, coefficient of saturated permeability, hydraulic gradient of groundwater surface, and length of contact line with downstream block. With significance probabilities (or p-values) of 0.05 and below, all five models showed significant results in estimating the water circulation status such as the surface runoff rate and the evapotranspiration rate. The model that was applied all seven urban characteristics factors, can calculate the most similar results such as the existing water circulation model. The water circulation estimation model developed in this study is not only useful to simply estimate the water circulation status of ungauged watersheds but can also provide data for parameter calibration and validation.

• Animal Bioscience
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• 제37권3호
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• pp.522-535
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• 2024

Objective: Transition period is considered from 3 weeks prepartum to 3 weeks postpartum, characterized with dramatic events (endocrine, metabolic, and physiological) leading to occurrence of production diseases (negative energy balance/ketosis, milk fever etc). The objectives of our study were to analyze the periodic concentration of serum beta-hydroxy butyric acid (BHBA), glucose and oxidative markers along with identification, and validation of the putative markers of negative energy balance in buffaloes using in-silico and quantitative real time-polymerase chain reaction (qRT-PCR) assay. Methods: Out of 20 potential markers of ketosis identified by in-silico analysis, two were selected and analyzed by qRT-PCR technique (upregulated; acetyl serotonin o-methyl transferase like and down regulated; guanylate cyclase activator 1B). Additional two sets of genes (carnitine palmotyl transferase A; upregulated and Insulin growth factor; downregulated) that have a role of hepatic fatty acid oxidation to maintain energy demands via gluconeogenesis were also validated. Extracted cDNA (complementary deoxyribonucleic acid) from the blood of the buffaloes were used for validation of selected genes via qRTPCR. Concentrations of BHBA, glucose and oxidative stress markers were identified with their respective optimized protocols. Results: The analysis of qRT-PCR gave similar trends as shown by in-silico analysis throughout the transition period. Significant changes (p<0.05) in the levels of BHBA, glucose and oxidative stress markers throughout this period were observed. This study provides validation from in-silico and qRT-PCR assays for potential markers to be used for earliest diagnosis of negative energy balance in buffaloes. Conclusion: Apart from conventional diagnostic methods, this study improves the understanding of putative biomarkers at the molecular level which helps to unfold their role in normal immune function, fat synthesis/metabolism and oxidative stress pathways. Therefore, provides an opportunity to discover more accurate and sensitive diagnostic aids.

• Kyungpook Mathematical Journal
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• 제55권3호
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• pp.689-694
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• 2015

In this paper we consider the class of polynomials of the type $p(z)=z^s(a_0+{\Sigma}_{j={\mu}}^{n-s}ajz^j)$, $1{\leq}{\mu}{\leq}n-s$, $0{\leq}s{\leq}n-1$ having some zeros at origin and rest of zeros on or outside the boundary of a prescribed disk, and obtain the generalization of well known results.