• 한국정보처리학회:학술대회논문집
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• 한국정보처리학회 2004년도 춘계학술발표대회
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• pp.625-628
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• 2004

GVM(General Virtual Machine)은 무선 단말기 상에서 동적인 응용프로그램을 실행할 수 있는 가상 기계(Virtual Machine) 플랫폼이다. 가상 기계를 이용한 응용프로그램의 실행은 플랫폼 독립적인 실행이 가능하며 또한 효과적인 다운로드 솔루션을 통한 동적인 실행이 가능하다. GVM은 SGS 파일을 다운로드 받아 실행되는 시스템이므로, 성능의 저하없이 실행되기 위해서는 효율적인 최적화와 실행 시스템이 요구된다. 본 논문은 SGS 파일이 시스템 리소스의 제한이 큰 무선 단말기 상에서 보다 효율적으로 실행되기 위해서 SAL 코드에 대한 최적화를 수행하였다. SAL 코드 최적화 단계를 수행한 GS 파일은 부분적으로 SGS 파일의 최적화를 가져와 전체 SGS 파일의 크기를 줄이고, 실행될 때 수행 속도 면에서 좀 더 빠른 실행 속도를 가지게 된다. 존재하는 최적화 방법론에 관한 연구를 통하여 SAL 코드의 특성을 고려한 최적화 방법론을 제시하고, 최적화된 SAL 코드를 생성하기 위한 코드 최적화기에 관하여 설계하고 구현하였다.

• BMB Reports
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• 제55권12호
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• pp.577-586
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• 2022

Stress granules (SGs) are stress-induced subcellular compartments, which carry out a particular function to cope with stress. These granules protect cells from stress-related damage and cell death through dynamic sequestration of numerous ribonucleoproteins (RNPs) and signaling proteins, thereby promoting cell survival under both physiological and pathological condition. During tumorigenesis, cancer cells are repeatedly exposed to diverse stress stimuli from the tumor microenvironment, and the dynamics of SGs is often modulated due to the alteration of gene expression patterns in cancer cells, leading to tumor progression as well as resistance to anticancer treatment. In this mini review, we provide a brief discussion about our current understanding of the fundamental roles of SGs during physiological stress and the effect of dysregulated SGs on cancer cell fitness and cancer therapy.

• Reproductive and Developmental Biology
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• 제34권3호
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• pp.213-216
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• 2010

This study was carried out between November 2008 and October 2009 in the experimental farm of Chunnam National University to investigate the effect of feeding of Sudangrass silage on the reproductive performance of Hanwoo cows. Two diets, rice straw or Sudangrass silage separately from concentrate were fed 19 Hanwoo cows. In control group (=CON), cows (n=9) were fed 5 kg (/head) rice straw and 3 kg (/head) commercial diet. In Sudangrass silage group (=SGS), cows (n=10) were fed 12.5 kg (/head) Sudangrass silage and 1 kg (/head) commercial diet. 1. Days to post-partum insemination were $78.8{\pm}25.3$ days for CON and $84.7{\pm}24.6$ days for SGS group and days to post-partum conception in CON or SGS were $90.1{\pm}24.1$ and $87.7{\pm}26.8$ days, respectively. 2. Post-partum conception rates for first service in CON or SGS was 66.7% and 90.0%, respectively, and caving interval was $375.1{\pm}46.7$ days for CON and $370.2{\pm}34.4$ days for SGS group. 3. Body Condition Scores of Hanwoo cows at artificial insemination was 5.36 for CON group and 4.93 for SGS group.

• Geomechanics and Engineering
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• 제16권3호
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• pp.273-284
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• 2018

A detailed understanding of the mechanical behaviors for crushed coal rocks after grouting is a key for construction in the broken zones of mining engineering. In this research, experiments of grouting into the crushed coal rock using independently developed test equipment for solving the problem of sampling of crushed coal rocks have been carried out. The application of uniaxial compression was used to approximately simulate the ground stress in real engineering. In combination with the analysis of crack evolution and failure modes for the grouted specimens, the influences of different crushed degrees of coal rock (CDCR) and solidified grout strength (SGS) on the mechanical behavior of grouted specimens under uniaxial compression were investigated. The research demonstrated that first, the UCS of grouted specimens decreased with the decrease in the CDCR at constant SGS (except for the SGS of 12.3 MPa). However, the UCS of grouted specimens for constant CDCR increased when the SGS increased; optimum solidification strengths for grouts between 19.3 and 23.0 MPa were obtained. The elastic moduli of the grouted specimens with different CDCR generally increased with increasing SGS, and the peak axial strain showed a slightly nonlinear decrease with increasing SGS. The supporting effect of the skeleton structure produced by the solidified grouts was increasingly obvious with increasing CDCR and SGS. The possible evolution of internal cracks for the grouted specimens was classified into three stages: (1) cracks initiating along the interfaces between the coal blocks and solidified grouts; (2) cracks initiating and propagating in coal blocks; and (3) cracks continually propagating successively in the interfaces, the coal blocks, and the solidified grouts near the coal blocks. Finally, after the propagation and coalescence of internal cracks through the entire specimens, there were two main failure modes for the failed grouted specimens. These modes included the inclined shear failure occurring in the more crushed coal rock and the splitting failure occurring in the less crushed coal rock. Both modes were different from the single failure mode along the fissure for the fractured coal rock after grouting solidification. However, compared to the brittle failure of intact coal rock, grouting into the different crushed degree coal rocks resulted in ductile deformation after the peak strength for the grouted specimens was attained.

• 대한기계학회논문집B
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• 제24권11호
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• pp.1523-1534
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• 2000

The performance of a number of existing dynamic subgrid-scale(SGS) models is evaluated in large-eddy simulations(LES) of two prototype transitional and turbulent shear flows, a planar jet and a channel flow. The dynamic SGS models applied include the dynamic Smagorinsky model(DSM);Germano et al. 1991, Lully 1992), the dynamic tow-component model(DTM; Akhavan et al. 2000), the dynamic mixed model(DMM;Zang et al, 1993). and the dynamic two-parameter model(DTPM; Salvetti & Banerjee 1995). The results are compared with those for DNS for their evaluation. The LES results demonstrate the superior performance of DTM with use of a sharp cutoff filter and DMM with use of a box filter, as compared to their respect counterpart DSM, in predicting the mean statistics, spectra and large-scale structure of the flow, Such features of DTM and DMM derive from the construction of the models in which tow separate terms are included to represent the SGS interactions; a Smagorinsky edd-viscosity term to account for the non-local interactions, and a local-interaction term to account for the nonlinear dynamics between the resolved and subgrid scales in the vicinity of the LES cutoff. As well, overall the SGS models using a sharp cutoff filter are more successful than those using a box filter in capturing the statistics and structure of the flow. Finally, DTPM is found to be compatible or inferior to DMM.

• Journal of Microbiology and Biotechnology
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• 제22권9호
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• pp.1271-1278
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• 2012

Genetic fusion of two proteins frequently induces beneficial effects to the proteins, such as increased solubility, besides the combination of two protein functions. Here, we study the effects of the bacterial surface layer protein SgsE from Geobacillus stearothermophilus NRS 2004/3a on the folding of a C-terminally fused enhanced green fluorescent protein (EGFP) moiety. Although GFPs are generally unable to adopt a functional confirmation in the bacterial periplasm of Escherichia coli cells, we observed periplasmic fluorescence from a chimera of a 150-amino-acid N-terminal truncation of SgsE and EGFP. Based on this finding, unfolding and refolding kinetics of different S-layer-EGFP chimeras, a maltose binding protein-EGFP chimera, and sole EGFP were monitored using green fluorescence as indicator for the folded protein state. Calculated apparent rate constants for unfolding and refolding indicated different folding pathways for EGFP depending on the fusion partner used, and a clearly stabilizing effect was observed for the SgsE_C fusion moiety. Thermal stability, as determined by differential scanning calorimetry, and unfolding equilibria were found to be independent of the fused partner. We conclude that the stabilizing effect SgsE_C exerts on EGFP is due to a reduction of degrees of freedom for folding of EGFP in the fused state.

• 대한기계학회논문집B
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• 제35권2호
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• pp.169-178
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• 2011

격자볼츠만 방법(LBM)을 이용하여 난류 경계층에서의 오염물질 확산에 대하여 수치계산을 수행 하였다. 난류 경계층 내의 유동을 모사하기 위하여 격자볼츠만 방법에 Smagorinsky 아격자 모델을 적용한 LB-SGS 모델을 사용하였으며, 오염물질의 확산을 모사하기 위하여 Passive-scalar 방법을 적용하였다. LB-SGS 모델의 신뢰성 검증을 위하여 Fackrell & Robins(1982)과 Raupach & Legg(1983)의 실험 조건과 동일한 조건하에서 수치계산을 수행하였고, 수치계산으로 얻어진 농도 분포를 실험값과 비교하였다. 이 결과로부터 LB-SGS 모델이 난류 경계층 내에서의 오염물질의 농도분포를 예측하는데 적합한 모델임을 알 수 있었다.

• 터널과지하공간
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• 제16권2호
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• pp.135-145
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• 2006

본 연구에서는 조건부 모사 기법 중 순차 가우시안 시뮬레이션(SGS)과 순차 지시 시뮬레이션(SIS)을 이용하여 터널설계 시 미시추구간의 암반등급(RMR)을 예측하여 보았다. 총 30개의 시추공자료 가운데 25개의 시추공자료를 이용하여 순차 가우시안 시뮬레이션과 순차 지시 시뮬레이션을 수행하였으며, 나머지 5개의 시추공에서의 실제 암반등급과 예측 암반등급을 비교하여 보았다. 그 결과 조건부 모사 기법은 암반등급의 공간적 분포특성을 비교적 잘 예측할 수 있고, 예측의 불확실성을 정량적으로 평가할 수 있는 효과적인 방법임을 확인할 수 있었다. 따라서 조건부 모사 기법의 결과는 미시추구간의 암반등급을 예측하는데 있어서 유용한 정보를 제공 해 줄 수 있을 것으로 판단된다.

• 한국항공우주학회지
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• 제30권7호
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• pp.68-80
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• 2002

최신 마이크로프로세서에서 성능 최적화된 수치 코드를 작성하는 접근법을 제시하였다. 국소화로 지칭한 이 코드 최적화 방법은 모든 최신 마이크로프로세서에서 채용되는 2차 캐시의 사용을 최대화하고 시스템의 주기억장치에 대한 접근을 최소화하는 개념이다. 본 연구에서는 유체역학 문제의 해결을 위한 LU-SGS 해법을 3 단계에 걸쳐 국소화 하였으며, 요즈음 널리 이용되고 있는 여러 가지 마이크로프로세서들에 대해 시험을 수행하였다. 국소 최적화 개념의 시험 결과는, 컴퓨터 시스템에 따라서는, 같은 컴퓨터에서 완전히 동일한 해를 기본 알고리즘에 비해 7.35배까지 빨리 얻을 수 있는 주목할 만한 성능을 보여 주었다.

• Journal of Genetic Medicine
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• 제17권1호
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• pp.43-46
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• 2020

The Shprintzen-Goldberg syndrome (SGS) is an extremely rare genetic disorder caused by heterozygous variant in SKI. SGS is characterized by neurodevelopmental impairment with skeletal anomaly. Recognition of SGS is sometimes quite challenging in practice because it has diverse clinical features involving skeletal, neurological, and cardiovascular system. Here we report a case of a 6-month-old boy who initially presented with developmental delay and marfanoid facial features including prominent forehead, hypertelorism, high arched palate and retrognathia. He showed motor developmental delay since birth and could not control his head at the time of first evaluation. His height was above 2 standard deviation score. Arachnodactyly, hypermobility of joints, skin laxity, and pectus excavatum were also noted. Sequencing for FBN1 was negative, however, a novel missense variant, c.350G>A in SKI was identified by sequential whole exome sequencing. To our knowledge, this is the first case with SGS with phenotypic features of SGS overlapping with those of the Marfan syndrome, diagnosed by next generation sequencing in Korea.