• 대한한의학방제학회지
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• 제13권1호
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• pp.85-101
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• 2005

Kamiondamtang(KODT) has been used in oriental medicine as stress by many medical practitioner for the study of KODT, we had fed mice divided to three groups(basal diet, hyperlipidemic diet, hyperlipidemic diet + KODT), and observed the change of weight, total cholesterol, triglyceride, SGOT, SGPT, HDL-cholesterol, LDL-cholesterol on the serum per every 7days for 6weeks. To help comparison with the results above, we had tested endothelial cells and liver. The results of this Study were obtained as fallows ; 1. Total cholesterol, triglyceride and LDL-cholesterol were decreased significantly by KODT. 2. HDL-cholesterol was increasd significantly by KODT. 3. SGOT was intended to decrease by KODT, 4. %W was decreased significantly by KODT. 5. In case of supplying KODT, WBC attatched on endothelial cells and vacuoles in muscular layer were not observed. 6. In case of supplying KODT, fatty degeneration was not observed in liver portal area.

• Asian Pacific Journal of Cancer Prevention
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• 제13권8호
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• pp.3989-3995
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• 2012

The aim of the present investigation was to evaluate the effect of A.nilotica extract against Dalton's ascitic lymphoma (DAL) induced solid and ascitic tumors in BALB/c mice. Experimental animals received A.nilotica extract (10 mg/kg.bw) intraperitoneally for 10 and 14 consecutive days before induction of solid and ascitic tumors, respectively. Treatment with A.nilotica extract significantly decreased the development of tumor and percentage increase in body weight when compared to DAL induced solid tumor control group, also increasing the life span, restoring the total white blood cell count and hemoglobin content and significantly decreasing the levels of serum aspartate transaminase (SGPT), alanine transaminase (SGOT), alkaline phosphatase (ALP), gamma glutamyl transferase (GGT) and nitric oxide (NO) when compared to DAL induced ascitic tumor controls. The treatment also reduced significantly the cellular glutathione (GSH) and nitric oxide levels in treated animals. Histopathological studies also confirmed protective influence. The outcome of the present work indicates that A.nilotica extract could be used as natural anticancer agent for human health.

• Advances in Traditional Medicine
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• 제7권4호
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• pp.372-378
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• 2007

A well known Ayurvedic formulation Ashokarista, used for menstrual disorders has been studied in a single blind randomised placebo controlled clinical trial for the treatment of menorrhagia and dysmenorrhoea. Dysmenorrhoea and menorrhagia patients who were taking Ashokarista (20 ml twice daily) for 10 menstrual cycles had an increase in haemoglobin level. Menorrhagia treated group has shown to reduce the erythrocyte sedimentation rate level that has been increased in the menorrhagia control group. The platelet count, total count and differential count were observed unchanged in the study. The Ashokarista did not affect the SGPT and SGOT level, which signify its lack of toxicity in hepatic function. The treated menorrhagic patients showed an increase in serum albumin content and decrease in blood clotting time, whereas the serum protein content was observed unchanged. There was a significant increase in both serum cholesterol and triglyceride level, which usually associated with the use of oral contraceptives. No major side effects were observed by the clinicians during the study.

• 혜화의학회지
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• 제13권1호
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• pp.81-88
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• 2004

As a long-term goal for the development of new prescriptions for hyperlipidemia, OBL was examined in the present study using a rat model in which the hyperlipidemia was induced. The major parameters related to lipid metabolism were investigated and the key findings are summarized below. 1. The body weight of hyperlipidemia-induced rats was increased by 50.6% compared to control group whereas the body weight of hyperlipidemia-induced rats with OBL injection showed 33.3% increases above the control group. 2. OBL-treated animals showed significant decreases in cholesterol levels compared to control group at the time point of 4 months after OBL injection. 3. OBL-treated animals showed significant decreases in T. cholesterol levels in comparison with the control group. 4. OBL-treated animals showed significant decreases in glucose levels compared to control group. 5. OBL-treated animal group showed decreases in SGOT and SGPT levels compared to control group, but its effects were not statistically significant. 6. Levels of HDL cholesterol were increased in OBL-treated animal group compared to the control, but the difference was statistically insignificant. 7. Levels of LDL cholesterol were decreased in OBL-treated animal group compared to the control group, but the difference was statistically insignificant.

• Natural Product Sciences
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• 제13권1호
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• pp.61-67
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• 2007

The ethanolic extract of Bacopa monnieri Linn. aerial parts were studied far its hepatoprotective effect on $CCl_4-induced$ hepatotoxic rats. The extract was found to decrease significantly $CCl_4-induced$ elevation of SGOT, SGPT, ALP, bilirubin and total cholesterol. But, it increased HDL-cholesterol level and liver weight with respect to $CCl_4$ toxic rats. The extract was also found to decrease significantly the $CCl_4-induced$ elevation of lipid peroxidation and increase the activity of antioxidant enzymes (SOD and CAT) and GSH level in the liver of extract treated rats when compared with $CCl_4$ induced rats. Histopatholosical profiles showed that the extract had significant protective effect against $CCl_4-induced$ liver injury, which corroborates the above findings. Hence it may be possible that the mechanism of hepatoprotection of the extract is due to its antioxidant effect.

• 한국임상수의학회지
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• 제11권1호
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• pp.407-417
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• 1994

Present experiments were undertaken for the purpose of clarifying the effect of repeated halothane anesthesia on the liver and kidney function. Nine mongrel dogs were divided into three groups. The group one dogs were anesthesized once(control group) and the other two groups twice and trice respectively on 10th day of previous anesthesia experimental groups. Hematological examinations and blood chemical assays were undertaken during the period from one hour to 10 days after the anesthesia. From these experiments fellowing results were obtained; 1. No significant changes of erythrocyte count were recognized in both the control and experimental groups after the halothane anesthesia. 2. The total leukocyte counts of experimental groups showed significant decrease on one hour and subsequent increases after the anesthesia. 3. No significant changes were observed in SGOT, SGPT, ALP, BUN and serum glucose values in both the control and experimental groups. 4. The total serum protein values showed a tendency to decrease on the first hour of halothane anesthesia in both the control and experimental groups. From these results it may be concluded that the repeated halothane anesthesia done 10th day of previous anesthesia do not affect the liver and kidney function in dogs.

• Parasites, Hosts and Diseases
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• 제31권1호
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• pp.71-74
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• 1993

복통과 담석을 주소로 서울시립 보라매병원에 입원한 43세 여자 환자가 수술 후 담석증을 동반한 담도회충증으로 진단되었다. 환자는 어릴 때부터 '횟배'를 자주 앓아왔으며 입원 20일 전부터 식후 복통과 오심 및 구토 증세를 나타내었고 개인병원에서 시행한 초음파 검사에서 담석이 발견되어 수술을 받기 위해 입원하였다. 입원 당시 간기능 검사상 SGOT 및 SGPT는 다소 증가되어 있었고 대변검사에서 기생충의 충란은 검출되지 않았다. 환자는 담석증 진단 하에 담낭절제술을 시행받았다. 수술 전 담도조영 검사상 좌측 간내 담도는 막혀 있었으며 수술 후 어느 정도 호전되었으나 잔존 오니 (sludge)로 여전히 막혀있는 상태였다 광학현미경 검사상 담낭은 만성 담낭염의 소견을 보였고 오니에서는 심하게 변성된 회충의 충체와 비교적 잘 보존된 충란이 함께 관찰되었다. 이 환자의 경우 담석 형성은 담관 내로 기어 들어간 회충이 오랜 기간 경과하면서 변성되어 담석의 핵 (nidus)으로 작용하였을 것으로 추측되었다. 이 환자는 최근 5년 동안 국내 문헌상 매우 드물게 발견되는 담도 회충증의 증례이었다.

• 동의생리병리학회지
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• 제19권6호
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• pp.1629-1635
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• 2005

Hyperlipidemia is caused by high dietary intake of cholesterol and saturated fats, and is known as a major risk factor for atherosclerosis. In the oriental medicine, Cheunggansoyo-san (CGSYS) has been used for supplementing hematopoietic function and for treating cardiovascular disorders. In the present study, CGSYS was administered into hyperlipidemic mice. Increases in body weight and cholesterol levels induced by hyperlipidemic diets for 6 weeks were significantly inhibited by CGSYS administration. Serum levels of glucose, triglyceride, SGOT, and SGPT values were all decreased by CGSYS treatment compared with hyperlipidemic dietary mice. Moreover, CGSYS decreased LDL-cholesterol, but increased HDL-cholesterol levels in hyperlipidemic mice. Thus, the present results suggest that CGSYS appears to De effective for down-regulating risk factors of hyperlipidemia.

• 한국응용약물학회:학술대회논문집
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• 한국응용약물학회 1993년도 제2회 신약개발 연구발표회 초록집
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• pp.163-163
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• 1993

대상환자는 모두 23명이였으여, 이중 12명은 fluconazole을, 11명은 nystatin을 투여받았다. 두 군사이에 연령, 남여비, 기저질환, 진균감염의 위험요소는 차이가 없었다. 투약기간은 fluconazole군(F)이 24일, nystatin군(N)이 23일이였다. 중도탈락은 3례로 F중 MRSA ？혈증 1례, N중 오심, 구토 1례외 Stevens-Johnson증후군 1례였다. 평가가능한 20례중, F 11례중 8례와, N 9례중 4례에서 진균감염중의 예방에 성공하였고, F 3례와 N 5례는 실패하였다. 실패한 F 3례는 코의 피부조직에서 aspergillus가 중명된 1례와 경험적으로 amphotericin을 투여한 2례였고, N 5례는 혈액배양에서 Candida tropicalis가 분리된 1례와 경험적 amphotericin을 받은 4례였다. 진균의 colonization은 F중 3균주는 치료중 소실되었으나, 2례는 증가하였다. N은 1균주가 소실된 반면, 3례는 증가하였다. Colonization이 증가한 F 2례는 C. albicans와 Trichosporon beigelli가 대변에서 분리된 경우이고. M 3례는 대변에서 C. albicans가 분리된 1례, 구강에서 aspergillus가 분리된 1례, 혈액배양에서 C. tropicalis가 분해된 1례였다. 부작용은 오심 구토가 F중 1례, N중 2례 였으며, 이중 N의 1례는 증상이 심하여 투약을 중지하였다. 간기능 검사상 SGOT/SGPT의 상승은 F 12중 3례, N 11중 2례에서 관찰되었으나, 두 군사이에 통계학적으로 유의한 차이는 없었다.

• Journal of Chest Surgery
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• 제14권2호
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• pp.144-152
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• 1981

The effect of cardiopulmonary bypass procedures on the blood components were studied through the measurements of several serum enzymes, SGOT, SGPT, CPK and LDH with its isozymes in the patients who had surgery for their heart diseases. They wre 85 patients: 40 Males and 45 Females. Their ages ranged widely between one and fifty-six. They were divided into 5 groups: Group I.patent ductus arteriosus without extracorporeal circulation, Group II-atrial septal defect, Group III-ventricular septal defect, Group IV-tetralogy of Fallot, and Group V-valve replacement. Generally serum enzymes revealed the increased values after surgery and the tendency returning toward preoperative levels. With the high total serum LDH levels seen uniformly after operation which persisted long in patients with replaced valves, the changes of LDH-isozymes were further analyzed. The isozymes, especially LDI and LDs increased their activities postoperatively, and the other fractions varied little. And $LD_1$/$LD_2$ ratios also showed similar rises and falls while the elevated values lasted longer in the patients with cardiac valve replacement. The significant values of LDH-isozymes in predicting the hemolysis occuring after extracorporeal circulation and in following the patients whose valves were replaced have been further discussed with the special stress placed on the $LD_1$/$LD_2$ratios.