• 폴리머
• /
• 제38권1호
• /
• pp.93-97
• /
• 2014

약물방출 고분자 코팅 스텐트는 수술후 재협착을 획기적으로 줄였지만, 약물방출이 균일한 구조체를 제작하는 것이 어렵고 체내에 구조체를 영구적으로 남겨야 하는 부담을 여전히 가지고 있다. 이를 해결하는 방안으로 생분해성 고분자로 스텐트를 제작하는 방법들이 활발하게 연구되고 있다. 본 연구에서는 조형가공기술(solid freeform fabrication, SFF)의 하나인 쾌속조형기법(rapid prototyping technique)의 3차원 플로팅(3D plotting) 기술을 이용하여 파크리탁셀(PTX) 약물을 함유한 폴리카프로락톤(PCL) 3차원 구조체를 제작하였고, 생분해성 PCL 고분자로부터 PTX의 방출거동과 스텐트 제작 가능성을 고찰하였다. 약물을 포함한 구조체의 표면특성을 SEM으로 확인한 결과 굴곡이 자연스럽고 매끄러운 표면을 가지고 있었다. FTIR을 통해서 약물이 성공적으로 구조체에 포함되었음을 확인하였고, NMR과 HPLC를 통해서 PCL 구조체 중의 PCL함량과 PTX의 서서히 방출됨을 확인되었다. 또한 세포실험을 통해 구조체에서 방출된 약물이 생물학적으로 활성을 유지하고 있으며, 반복제작된 구조체에서도 균일한 활성의 약물이 방출됨을 확인하였다. 이와같은 쾌속조형기법을 이용하여 약물을 포함하는 구조체를 제작하고 분석함으로써, 생분해성 고분자 스텐트로서의 적용가능성을 제시하였다.

• 한국정밀공학회:학술대회논문집
• /
• 한국정밀공학회 2007년도 추계학술대회 논문집
• /
• pp.533-534
• /
• 2007

• 한국정밀공학회:학술대회논문집
• /
• 한국정밀공학회 2007년도 추계학술대회 논문집
• /
• pp.543-544
• /
• 2007

• 한국정밀공학회:학술대회논문집
• /
• 한국정밀공학회 2007년도 추계학술대회 논문집
• /
• pp.529-530
• /
• 2007

• 대한기계학회:학술대회논문집
• /
• 대한기계학회 2005년도 창립60주년 기념 추계 학술대회
• /
• pp.211.2-211.2
• /
• 2005

• 한국정밀공학회:학술대회논문집
• /
• 한국정밀공학회 2006년도 추계학술대회 논문집
• /
• pp.15-16
• /
• 2006

• 대한전자공학회:학술대회논문집
• /
• 대한전자공학회 2002년도 ITC-CSCC -3
• /
• pp.2027-2030
• /
• 2002

SFFS(Solid Freeform Fabrication System) is commercializing to rapid prototyping concept in world- wide some corporations including the U.S.A, have much technological problems yet and need new mode for agile solid freeform fabrication as well as prototyping. In this paper, we design an algorithm that the cutting path of laser beam, on the SFFS, is controlled with constant speed. The designed algorithm fer constant-speed path control is implemented and experimented in the CAFL$\^$VM/ (Computer Aided Fabrication of Lamination for Various Material) system, the new SffS which is developed in this paper. Finally, the ceramic, new material developed in this paper, cut and fabricated. The dimensional accuracy and mechanical stability of the 3D object is confirmed through the experiment, also.

• 한국기계가공학회지
• /
• 제18권2호
• /
• pp.44-51
• /
• 2019

With the goal of tissue regeneration for organs damaged through an accident or a disease, research on tissue engineering has been conducted to produce 3-D scaffolds that can support the cells in the attachment and growth for the cell proliferation and differentiation. A scaffold requires a suitable pore size and porosity to increase the nutrient circulation or oxygen supply for the attachment and growth of cells. The existing production methods such as solvent-casting particulate leaching, phase separation, and fiber bonding have certain disadvantages. With these methods, it is difficult to obtain a free desired shape. In addition, certain pore sizes and interconnectivities among the pores may not be guaranteed. To solve these problems, this study has fabricated a scaffold with a 3-D shaped nose using Alginate, which is a natural polymer obtained through Fused Deposition Modeling (FDM), one of the CAD/CAM-based Solid Freeform Fabrication (SFF) methods.

• 한국정밀공학회:학술대회논문집
• /
• 한국정밀공학회 2004년도 추계학술대회 논문집
• /
• pp.1299-1302
• /
• 2004

A real object duplication system (RODS), including three dimensional (3D) scanner and solid freeform fabrication system (SFFS), is a device to make three-dimensional objects directly from the drawing or photo data. A Selective Multi-Laser Sintering (SMLS) process designed in this paper is by which computer images received using 3D scanner are built up from polymer powder on building room of large size using dual laser at industrial type SFF system. Using the process can rapidly produce real object duplication components of industrial type such as cylinder, engine block, chassis of automobile, etc. In this paper, the industrial type SFF system using SMLS process is manufactured and the system is satisfied with high precision and high speed processing technique. To research characteristics of each part for theindustrial type SFF system, a structure and thermal analysis and test of each part is carried out. Also, to achievement of high performance for industrial type SFF system, design and fabrication for the structure, heater, nitrogen supply, laser and control part are carried out.

• 대한기계학회:학술대회논문집
• /
• 대한기계학회 2007년도 춘계학술대회A
• /
• pp.1404-1409
• /
• 2007

Polymers for laser sintering were needed in order to fabricate the articles with the three-dimensional duplication equipment of SLS (selective laser sintering) process. The thermal properties, particle size, distribution, and shape of polymer powder had a close relation with the processibility of laser sintering. In this study, we prepared new polymer powders with uniform size and higher bulk density by wet process. Wet process consists of several finely-controlled steps such as dissolution, nucleation, propagation and crystallization. Several additives were added to improve the thermal, rheological, and flow properties.