Browse > Article
http://dx.doi.org/10.14775/ksmpe.2019.18.2.044

A Study on the Fabrication of 3D Scaffolds Using the Solid Freeform Method  

Choi, Do-Hyun (Department of Mechanical & Automotive Engineering, Inje University)
Kim, Hyun-Chul (Department of Electronic IT Mechanical & Automotive Engineering, Inje University)
Publication Information
Journal of the Korean Society of Manufacturing Process Engineers / v.18, no.2, 2019 , pp. 44-51 More about this Journal
Abstract
With the goal of tissue regeneration for organs damaged through an accident or a disease, research on tissue engineering has been conducted to produce 3-D scaffolds that can support the cells in the attachment and growth for the cell proliferation and differentiation. A scaffold requires a suitable pore size and porosity to increase the nutrient circulation or oxygen supply for the attachment and growth of cells. The existing production methods such as solvent-casting particulate leaching, phase separation, and fiber bonding have certain disadvantages. With these methods, it is difficult to obtain a free desired shape. In addition, certain pore sizes and interconnectivities among the pores may not be guaranteed. To solve these problems, this study has fabricated a scaffold with a 3-D shaped nose using Alginate, which is a natural polymer obtained through Fused Deposition Modeling (FDM), one of the CAD/CAM-based Solid Freeform Fabrication (SFF) methods.
Keywords
Scaffold; Solid Freeform Fabrication; Hydrogel; Tissue Engineering;
Citations & Related Records
연도 인용수 순위
  • Reference
1 Stock, U. A. and Vacanti, J. P., "Tissue Engineering: Current State and Prospects," Annual Review of Medicine, Vol. 52, pp. 443-451, 2001.   DOI
2 Fuchs, J. R., Nasseri, B. A. and Vacanti, J. P., “Tissue engineering: A 21st century solution,” Annals of Thoracic Surgery, Vol. 72, No. 2, pp. 577-591, 2001.   DOI
3 Catherine, K. K and Peter, X. M., "Ionically crosslinked alginate hydrogels as scaffolds for tissue engineering: Part 1. Structure, gelation rate and mechanical properties," Biomaterials, Vol. 22, pp. 511-512, 2001.   DOI
4 Cho, E. C., Kim, J. W. and Alberto, F., “Highly Responsive Hydrogel Scaffolds Formed by Three-Dimensional Organization of Microgel Nanoparticles,” NANO LETTERS, Vol. 8, No. 1, pp. 168-172, 2008.   DOI
5 Jessica, M., Williams, Adebisi, A. and Rachel, M. S., et al., "Bone tissue engineering using polycaprolactone scaffolds fabricated via selective laser sintering," Biomaterials, Vol. 26, pp. 4817-4827, 2005.   DOI
6 Salerno, A., et al., “Design of porous polymeric scaffolds by gas foaming of heterogeneous blends,” Journal of Materials Science: Materials in Medicine, Vol. 20, No. 10, pp. 2043-2051, 2009.   DOI
7 Salerno, A., Iannace, S. and Netti, P. A., “Open-pore biodegradable foams prepared via gas foaming and microparticulate templating,” Macromolecular Bioscience, Vol. 8, No. 7, pp. 655-664, 2008.   DOI
8 Lee, S. H., Jo, A. R., Choi, G. P., et al, “Fabrication of 3D Alginate Scaffold with Interconnected Pores using Wire-Network Molding Technique,” Tissue Engineering and Regenerative Medicine, Vol. 10, No. 2, pp. 53-59, 2013.   DOI
9 Cartmell, S., “Controlled Release Scaffolds for Bone Tissue Engineering,” Journal of Pharmaceutical Sciences, Vol. 98, No. 2, pp. 430-441, 2009.   DOI
10 Jeanie, L. D. and David, J. M., "Hydrogels for tissue engineering: scaffold design variables and applications," Biomaterials, Vol. 24, pp. 4337-4351, 2003.   DOI
11 Choi, S. W., Moon, S. K., Chu, J. Y., et al, “Alginate Hydrogel Embedding Poly(D,L-lactided-co-glycolide) Porous Scaffold Disks for Cartilage Tissue Engineering,” Macromolecular Research, Vol. 20, No. 5, pp. 447-452, 2012.   DOI
12 Cao, N., "Fabrication of alginate hydrogel scaffolds and cell viability in calcium-crosslinked alginate hydrogel," University of Saskatchewan, pp. 6-12, 2011.
13 Ramay, H. R. R. and Zhang, M., “Biphasic calcium phosphate nanocomposite porous scaffolds for load-bearing bone tissue engineering,” Biomaterials, Vol. 25, No. 21, pp. 5171-5180, 2004.   DOI
14 Cardea, S., Pisanti, P. and Reverchon, E., “Generation of chitosan nanoporous structures for tissue engineering applications using a supercritical fluid assisted process,” Journal of Supercritical Fluids, Vol. 54, No. 3, pp. 290-295, 2010.   DOI
15 Goto, E., et al., “A rolled sheet of collagen gel with cultured Schwann cells: Model of nerve conduit to enhance neurite growth,” Journal of Bioscience and Bioengineering, Vol. 109, No. 5, pp. 512-518, 2010.   DOI