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http://dx.doi.org/10.7317/pk.2014.38.1.93

Effect of Drug Eluting Uniformity for Biodegradable Stent by Solid Freeform Fabrication  

Cheong, Sin Young (Nano Convergence & Manufacturing Systems Research Division, Korea Institute of Machinery & Materials (KIMM))
Kim, Yang Eun (Nano Convergence & Manufacturing Systems Research Division, Korea Institute of Machinery & Materials (KIMM))
Koh, Young Joo (Medical Devices Research, R&D Center, Samyang Biopharmaceuticals Corporation)
Shin, Wang Soo (Medical Devices Research, R&D Center, Samyang Biopharmaceuticals Corporation)
Lee, Jun Hee (Nano Convergence & Manufacturing Systems Research Division, Korea Institute of Machinery & Materials (KIMM))
Kim, Wan Doo (Nano Convergence & Manufacturing Systems Research Division, Korea Institute of Machinery & Materials (KIMM))
Yoo, Young Eun (Nano Convergence & Manufacturing Systems Research Division, Korea Institute of Machinery & Materials (KIMM))
Park, Su A (Nano Convergence & Manufacturing Systems Research Division, Korea Institute of Machinery & Materials (KIMM))
Publication Information
Polymer(Korea) / v.38, no.1, 2014 , pp. 93-97 More about this Journal
Abstract
Biodegradable drug-eluting stent has dual functions of supporting the lumen and treating internal tumor preventing the restenosis by releasing drug. In this study, the polycaprolactone (PCL) based three dimensional (3D) mesh loaded with paclitaxel (PTX) was presented by rapid prototyping (RP) technique of solid freeform fabrication (SFF) for biodegradable drug-eluting stent application. PCL has many advantageous properties such as good biocompatibility, good mechanical properties, and good drug permeability. PTX is widely used in the cancer treatment by inhibiting tumor cell proliferation. Analytical methods of HPLC and NMR were used for simultaneous quantification of PTX. Scanning electron microscopy (SEM) was performed to observe the architecture and morphologies of 3D mesh. The cytotoxicity assay results indicated released PTX's biological activity. This study provided that PCL based 3D mesh loaded with PTX by RP technique has great potential for biodegradable drug-eluting stent application.
Keywords
drug-eluting stent; polycaprolactone (PCL); paclitaxel (PTX); rapid prototyping (RP); solid freeform fabrication (SFF);
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