• Asian Pacific Journal of Cancer Prevention
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• v.15 no.2
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• pp.605-610
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• 2014

Chronic liver diseases, including cancer, are characterized by inflammation and elevated serum ferritin (SF). However, the causal-relationship remains unclear. This study used primary rat hepatic stellate cells (HSC) as a model to investigate effects of physiological SF concentrations (10, 100 and 1000 pM) because HSCs play a central role in the development and progression of liver fibrosis. Physiological concentrations of SF, either horse SF or human serum, induced pro-inflammatory cytokine $IL1{\beta}$, IL6 and $TNF{\alpha}$ secretion in rat activated HSCs (all p<0.05). By contrast, treatment did not alter activation marker ${\alpha}SMA$ expression. The presence of SF markedly enhanced expression of Grp78 mRNA (p<0.01). Furthermore, transient knock down of Grp78 by endotoxin EGF-SubA abolished SF-induced $IL1{\beta}$ and $TNF{\alpha}$ secretion in activated HSCs (all p<0.05). In conclusion, our results showed that at physiological concentrations SF functions as a pro-inflammatory mediator in primary rat HSCs. We also provide a molecular basis for the action of SF and identified Grp78-associated ER stress pathways as a novel potential therapeutic target for resolution of fibrosis and possible prevention of liver cancer.

• Korean Journal of Materials Research
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• v.10 no.6
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• pp.450-455
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• 2000

For further scaling down of the silicon devices, the application of low dielectric constant materials instead of silicon oxide has been considered to reduce power consumption, crosstalk, and interconnection delay. In this paper, the effect of $O_2/SF_6$ plasma chemistry on the etching characteristics of polyimide-one of the promising low-k interlayer dielectrics-has been studied. The etch rate of polyimide decreases with the addition of $SF_6$ gas due to formation of nonvolatile fluorine compounds inhibiting reaction between oxygen and hydrocarbon polymer, while applying substrate bias enhances etching process through physical attack. However, addition of small amount of $SF_6$ is desirable for etching topography. $SiO_2$ hard mask for polyimide etching is effective under $O_2$plasma etching(selectivity~30), while $O_2/SF_6$ chemistry degrades etching selectivity down to 4. Based on the above results, $1-2\mu\textrm{m}$ L&S PI2610 patterns were successfully etched.

• Journal of the Korea institute for structural maintenance and inspection
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• v.13 no.1 s.53
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• pp.161-168
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• 2009

In this study, the concrete, in which the steel fiber(SF) with different volume-surface ratios and lengths was intermixed in High flowing Self-Compacting Concrete(HSCC), was produced to compare with steel fiber reinforced concrete as a part of plan to improve the workability and the quality of steel fiber reinforced concrete. As the result of experiment, the flowing and passing characteristics of HSCC intermixed with SF was highly improved as there was no fiber ball phenomenon due to the effect of high flowability and the viscosity, and in the identical range of compressive strength, it showed the tendency that the splitting and flexural strength was increasing as the length was getting longer regardless of volume-surface ratio when compared with HSCC which was intermixed with SF. It is estimated that in case of application of HSCC intermixed with steel fiber to work sites, it would be possible to improve the workability and the quality which would be better than that of steel fiber reinforced concrete which has been used.

• Korean Journal of Microbiology
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• v.37 no.4
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• pp.245-252
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• 2001

Erm proteins, MLS (macrolide-lincosamide-streptogramin B) resistance factor proteins, show high degree of amino acid sequence homology and comprise of a group of structurally homologous N-methyltransferases. On the basis of the recently determined structures of ErmC` and ErmAM, ErmSF was divided into two domains, N-terminal end catalytic domain and C-terminal end substrate binding domain and attempted to overexpress catalytic domain in E. coli using various pET expression systems. Three DNA fragments were used to express the catalytic domain: DNA fragment 1 encoding Met 1 through Glu 186, DNA fragment 2 encoding Arg 60 to Glu 186 and DNA fragment 3 encoding Arg 60 through Arg 240. Among the pET expression vectors used, pET 19b successfully expressed the DNA fragment 3 and pET23b succeeded in expression of DNA fragment 1 and 2. But the overexpressed catalytic domains existed as inclusion body, a insoluble aggregate. To assist the soluble expression of ErmSF catalytic domains, Coexpression of chaperone GroESL or Thioredoxin and lowering the incubation temperature to $22^{\circ}C$ were attempted, as did in the soluble expression of the whole ErmSF protein. Both strategies did not seem to be helpful. Solubilization with guanidine-HCl and renaturation with gradual removal of denaturant and partial digestion of overexpressed whole ErmSF protein (expressed to the level of 126 mg/ι culture as a soluble protein) with proteinase K, nonspecific proteinase are under way.

• 전기의세계
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• v.29 no.6
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• pp.339-343
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• 1980

본고의 내용은 다음과 같다. 1. $SF_{6}$가스의 개요특성 2. 절연파괴특성과 시험조건 3. 각종불순물의 영향 4. 수분의 대책

• ETRI Journal
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• v.21 no.3
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• pp.16-21
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• 1999

After etching Al-Cu alloy films using SiCl4/Cl_2/He/CHF3 mixed gas plasma, the corrosion phenomenon at the grain boundary of the etched surface and a passivation layer on the etched surface with an SF6 plasma treatment subsequent to the etching were studied. In Al-Cu alloy system, corrosion occurs rapidly on the etched surface by residual chlorine atoms, and it occurs dominantly at the grain boundaries rather than the crystalline surfaces. To prevent corrosion, the SF6 gas plasma treatment subsequent to etching was carried out. The passivation layer is composed of fluorine-related compounds on the etched Al-Cu surface after the SF6 treatment, and it suppresses effectively corrosion on the surface as the SF6 treatment pressure increases. Corrosion could be suppressed successfully with the SF6 treatment at a total pressure of 300 mTorr. To investigate the reason why corrosion could be suppressed with the SF6 treatment, behaviors of chlorine and fluorine were studied by various analysis techniques. It was also found that the residual chlorine incorporated at the grain boundary of the etched surface accelerated corrosion and could not be removed after the SF6 plasma treatment.

• Information Systems Review
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• v.10 no.1
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• pp.193-211
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• 2008

Effective Training has been recognized as one of the most important success factors for enterprise resource planning (ERP) system operations. However, both ERP system vendors and user companies have failed to provide an effective training method for users because practical business process cases cannot be formalized. Also, incomplete testing by ERP system vendors results in insufficient and ineffective user training. This paper suggests a scenario framework for ERP testing and training (SF-ETT). SF-ETT is constructed by expanding the practice-based ERP testing scenario construction framework designed for unERPII. SF-ETT contains concrete business process entities that users understand actually and provides practice definition, notation, and architecture.

• Journal of the Microelectronics and Packaging Society
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• v.8 no.3
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• pp.63-67
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• 2001

Up to now, most studies about Pt-etching have been focused on physical sputtering mechanism with Cl-based plasma, while only a limited results are available for etching characteristics with fluorine-based plasma. In this study, etch characteristics of Pt thin film with $Cl_2$/Ar and $SF_{6}$/Ar Ar gas chemistries have been studied with ECR plasma etching system. It is confirmed that $SF_{6}$/Ar Ar plasma chemistry could make volatile etch-products through the reaction with Pt thin film. Also the improvement in etch rate, etch profile and surface roughness is obtained due to the formation of volatile platinum fluoride compounds.

• Structural Engineering and Mechanics
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• v.91 no.2
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• pp.177-195
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• 2024

This research plans to investigate the simultaneous impact of bamboo fibers (BF) and steel fibers (SF) on the mechanical and spalling characteristics of ultra-high-performance concrete (UHPC) exposed to high temperatures (HT). To this aim, 25 mixtures were made and assessed. BF was added at five contents of 0, 2.5, 5, 7.5 and 10 kg/m³. Additionally, SF was used at five weight contents: 0%, 1%, 2%, 3% and 4%. Specimens were exposed to temperatures ranging between 25℃ and 800℃. Thus, com-pressive, tensile, and flexural strengths, elastic moduli, mass loss, and permeability were measured. Experiments revealed that the simultaneous use of low BF and SF contents could totally prevent spalling of UHPC, but the use of either SF or BF alone could not prevent spalling at high levels of fibers. Besides, the synergetic positive impact of BF and SF on the spalling resistance of UHPC was by reason of the rise of BF' permeability and the bridging role of SF at HT. Moreover, it was concluded that the use of SF could moderate the adverse influence of BF on the compressive resistance of UHPC.

• Korean Journal of Materials Research
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• v.4 no.3
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• pp.312-318
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• 1994

In this paper the breakdown and dielectric characteristics of purified transformer oil dissolved with $SF_6$ Gas are investigated with a few decade MHz frequency voltage. The results are as follows. 1) High frequency current is a approximately proportional to the square root of high frequency voltage in purified transformer oil. 2) As frequency increase breakdown voltage decrease inversely proportional to the square root of frequency and the high frequency breakdown voltage is lower about 35 percentage than that of AC 3) The breakdown voltage of high frequency has a little increase with the pressure increase of dissolved $SF_6$, Air and Ar Gas. 4) As voltage freguency increases the value of the dielectric loss tangent has increased almost exponentially and the dielectric constant ($\varepsilon$) has tended to decrease with a slope[0.6% MHz]. 5) When dissolved with $SF_6$ Gas, oil electrical characteristics has more increased about 25% than in Air or Ar gas with high voltage frequency.