• Asian Pacific Journal of Cancer Prevention
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• v.13 no.11
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• pp.5439-5444
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• 2012

Objective: To explore the correlation of human papillomavious (HPV) infection with expression of p53 and proliferating cell nuclear antigen (PCNA) in patients with different ethnicity in Xinjiang, China. Methods: 166 biopsy specimens from 83 laryngeal squamous cell carcinomas (LSCC), 63 laryngeal papillomas (LP), and 20 laryngeal inflammatory polyps (LIP) were included in this study. HPV infection was determined by polymerase chain reaction (PCR) using specific types of HPV primers. Expression of p53 and PCNA was assessed using immunohistostaining. Results: The frequency of HPV 6/11 was higher in LP (33.3%) than in LSCC (9.6%) (P<0.0005), whereas the frequency of HPV 16/18 was higher in LSCC (37.3 %) than in LP (6.3%) (P<0.0005). Patients of the Han ethnic group with LSCC had a higher infection rate with HPV 6/11 or HPV 6/11 and HPV 16/18 coinfection than those of Uygur and Kazak ethnicity (P<0.05). Overexpression of p53 and PCNA were higher in LSCC (62.7%, 57.8%) than in LP (38%, 33.3%) (P<0.005, and P<0.005, respectively). That of p53 was not associated with lymph-node metastases and clinical stages, but overexpression of PCNA closely correlated with clinical stage. Conclusions: These results strongly implicate HPV6/11 infection in the carcinogenesis of LSCC and LP, respectively. There was a higher coincidence of increased malignancy of laryngeal tumors with overexpression of p53 and PCNA. Overexpression of p53 may serve as an early risk marker for malignant transformation in HPV infected cells while the overexpression of PCNA may serve as a late marker for progression of LSCC.

• World Technopolis Review
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• v.6 no.2
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• pp.148-158
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• 2017

Sejong City, which has been chosen as a new administrative capital of South Korea, has completed the first phase of its development plan with the construction of the facilities needed to accommodate central administrative organizations and the required accompanying population. Now, it is undergoing the second phase of development with a focus on strengthening the region's innovation capacity to catalyze endogenous development. The strategy for phase II is to establish a regional innovation system including building necessary infrastructure and attracting innovation agents such as universities, businesses, and research institutes. The first step for this is developing a research complex, tentatively named Tech Valley, that includes universities, research institutes, and businesses, and building infrastructure comprising a science complex, a knowledge industry center, and support facilities. Phase II of the city's development initiative includes the establishment of a joint university campus, which is to serve as a center to promote cooperation among industry actors, universities, and research institutes. The concept of a joint campus has been drawn from a need to enhance capacity for innovation and specialization in the region's industries and to maximize synergy among participating universities through the sharing of research equipment, facilities, and programs. The joint campus is expected to play a key role in creating an innovation system in the region by enhancing research capacity for strategic industries, cultivating highly skilled human resources, and leading industry-academia-research cooperation. In order to ensure the sustainable development of the new city, there is a growing need to have a main player in place that could lead the region's economic development. The joint campus will propel industrial specialization and serve as a catalyst to attract competent universities to the region. This paper will examine the concept, major functions, and the establishment and operation of the joint campus.

• Journal of Digital Convergence
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• v.13 no.10
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• pp.437-444
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• 2015

In this age of digital technology, we often experience overwhelming and inescapable feelings of weakness, vulnerability, loneliness and fear that propel us into a state of gloom or frustration. Poetry can also serve as a therapeutic medium for overcoming them because it provides unique opportunities for self-discovery and is a catalyst for healing and self-integration. This study examines the healing properties in English poetry. First, Poetry has expressed innermost feelings, which can serve as a catharsis the emotional release. Therefore it can nurture and strengthen the human capacity. Poetic language heals our soul and mind. Rhythm which comes in many forms and poetic form also are important components of the therapeutic value of poetry. So we can say English poetry can be used as a therapeutic means for healing and personal growth.

• Journal of the Korea Furniture Society
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• v.20 no.1
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• pp.21-30
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• 2009

This research is conducted on temporary street furniture, which is one of the significant factors that comprise the street landscape in modem cities. The primary purpose of this research is to present the guidance on direction of planning by examining the design and installation types of construction and screen fences usually established at construction sites for buildings, roads, parks and etc. The results are as follows: 1. The construction and screen fences at construction sites of urban areas used to be a mere tentative facility to prevent noise and safety accidents but have now incremented their roles to serve not only as a functional but also as an aesthetic element with a city view and harmonization with other elements taken into consideration. In particular, it is noticeable that, based on its unique feature of tentativeness, its role has developed to serve as street furniture that adds variability to the modem city. 2. There are two different types of screen fences: blackout type and transparent type. The transparent screen turns out to be used a lot at the construction site of building a skyscraper or differentiated building in downtown city area or in places where there are buildings of similar types and shapes located along the street in the vicinity of the construction site. 3. The actual cases of adopting the tentative construction and screen fences all at the same time as a single unit have been found in historically and culturally significant architectures with the screen design used to demonstrate the view after completion of construction or the characteristics of the architecture.

• Journal of architectural history
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• v.14 no.3 s.43
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• pp.7-21
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• 2005

This paper is an attempt to find/make an entrance to John Hejduk's architecture. Based explicitly on both Karl Popper's model of knowledge production called 'conjecture and refutation' and Harold Bloom's theory of poetry called 'revisionism', this paper, in order to produce a new problem, mainly deals with an existing knowledge as an object to refute, that is, Michael Hays' interpretation of Wall House by Jacques Lacan's notion of the gaze, Hejduk's a pivotal architectural finding. The arguments underlying this paper are two: First, Hejduk, just like this paper, follows Popper's model and Bloom's theory in conducting his own architectural research. Secondly, he takes what might be called artist's attitude when absorbing previous knowledge and producing new one. These two arguments are made in the first part and then served as a basic propositions for further arguments. In the process of criticizing the way in which Hays explicates Hejduk's Wall House, this paper reaches two main arguments. First, Lacan's notion of the gaze is not proper specifically for the explication of it. However, it may be useful and even promising when dealing with other works such as Subject/Object and House of the Inhabitant Who Refused to Participate. Secondly, Freud's notion of 'uncanny', arguably Hejduk's strong architectural orientation, may serve much better as a main gate among possibly many ones in trying to open his architecture. It is considered that this might also serve as an important clue to solving mysticism remaining yet untouched in his architecture.

• Journal of Educational Research in Mathematics
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• v.11 no.1
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• pp.157-177
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• 2001

Modern society's technological and economical changes require high-level education that involve critical thinking, problem solving, and communication with others. Thus, today's perspective of mathematics and mathematics learning recognizes a potential symbolic relationship between concrete and abstract mathematics. If the problems engage students' interests and aspiration, mathematical problems can serve as a source of their motivation. In addition, if the problems stimulate students'thinking, mathematical problems can also serve as a source of meaning and understanding. From these perspectives, the purpose of my study is to prove that mathematical modeling tasks can provide opportunities for students to attach meanings to mathematical calculations and procedures, and to manipulate symbols so that they may draw out the meanings out of the conclusion to which the symbolic manipulations lead. The review of related literature regarding mathematical modeling and model are performed as a theoretical study. I especially concentrated on the study results of Freudenthal, Fischbein, Lesh, Disessea, Blum, and Niss's model systems. We also investigate the emphasis of mathematising, the classified method of mathematical modeling, and the cognitive nature of mathematical model. And We investigate the purposes of model construction and the instructive meaning of mathematical modeling. In conclusion, we have presented the methods that promote students' effective model construction ability. First, the teaching and the learning begins with problems that reflect reality. Second, if students face problems that have too much or not enough information, they will construct useful models in the process of justifying important conjecture by attempting diverse models. Lastly, the teachers must understand the modeling cycle of the students and evaluate the effectiveness of the models that the students have constructed from their classroom observations, case study, and interaction between the learner and the teacher.

• The KIPS Transactions:PartB
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• v.17B no.6
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• pp.413-420
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• 2010

In this paper, we propose a scheme for dynamic allocating network bandwidth based on the playback buffer levels of the clients in a distributed mobile multimedia system. In this scheme, the amount of bandwidth allocated to serve a video request depends on the buffer level of the requesting client. If the buffer level of a client is low or high temporarily, more or less bandwidth will be allocated to serve it with an objective to make it more adaptive to the playback situation of this client. By employing the playback buffer level based bandwidth allocation policy, fair services can also be provided to the clients. In order to support high quality video playbacks, video frames must be transported to the client prior to their playback times. The main objectives in this bandwidth allocation scheme are to enhance the quality of service and performance of individual video playback such as to minimize the number of dropped video frames and at the same time to provide fair services to all the concurrent video requests. The performance of the proposed scheme is compared with that of other static bandwidth allocation scheme through extensive simulation experiments, resulting in the 4-9% lower ratio of frames dropped according to the buffer level.

• Genomics & Informatics
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• v.5 no.4
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• pp.174-178
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• 2007

The earliest stages of mammalian embryogenesis are governed by the activity of maternally inherited transcripts and proteins. Cytoplasmic polyadenylation of selected maternal mRNA has been reported to be a major control mechanism of delayed translation during preimplantation embryogenesis in mice. The presence of cis-elements required for cytoplasmic polyadenylation (e.g., CPE) can serve as a useful tag in the screening of maternal genes partaking in key functions in the transcriptionally dormant egg and early embryo. However, due to its relative simplicity, UA-rich sequences satisfying the canonical rule of known CPE consensus sequences are often found in the 3'-UTR of maternal transcripts that do not actually undergo cytoplasmic polyadenylation. In this study, we developed a method to confirm the validity of candidate CPE sequences in a given gene by a multiplex comparison of 3'-UTR sequences between mammalian homologs. We found that genes undergoing cytoplasmic polyadenylation tend to create a conserved block around the CPE, while CPE-like sequences in the 3'-UTR of genes lacking cytoplasmic polyadenylation do not exhibit such conservation between species. Through this cross-species comparison, we also identified an alternative CPE in the 3'-UTR of tissue-type plasminogen activator (tPA), which is more likely to serve as a functional element. We suggest that verification of CPEs based on sequence conservation can provide a convenient tool for mass screening of factors governing the earliest processes of mammalian embryogenesis.

• Journal of the Korean Society of Fashion and Beauty
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• v.1 no.1 s.1
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• pp.65-78
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• 2003

This research is to provide practical help in learning hair and makeup illustration skills by presenting techniques for hair and makeup drawing; to serve efficient illustration education; and to enhance the status of beauty and contribute to artistic development. Hair style and makeup techniques include graphical one, pattern-centered one, one using pattern paper, simplifying one and mood one expressing image. Of them, this research made the illustrations to use cosmetics, color pencils and pastel based on the graphical technique. for each design of the illustrations, ethnic, sexy, natural, romantic and gorgeous images, which were considered to be appropriate to the graphical technique, were chosen by the researcher out of hair and makeup styles that appeared in the fashion magazines including Vogue, Gap, Mode et Mode from 2000 through 2001. In particular, they were chosen with focusing on basic styles. The summaries below were found with the experience of making illustrations. Various techniques and skills are required to express the ideas of hair and makeup styles. Of them, the graphical technique is very useful as the primary step to learn various techniques and improve drawing skills. First, the graphical technique may enable not only expressing what is desired to draw as is, but also accurately representing hair and makeup designs so as to convey objective expression. In this regard, it is a proper way to achieve its inherent purpose as conveyance of messages. Second, more accurate styling of hair and makeup is available through graphical expression, which helps understand related practical techniques. In addition, makeup illustration, which is expressed through direct makeup products and instruments, may serve skill improvement since such direct use provides the feeling of real makeup. Third, the graphical technique as a basic drawing skill may unrestrictedly show the artist's expression ability. Fourth, although artistic merits implying individuality and creativity should be shared through illustrations that express the artist's ideas or emotions, the graphical technique is the easiest method to beginners who just started learning of illustration, in that it enables expression without highly advanced skills.

• Journal of Korean Library and Information Science Society
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• v.45 no.3
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• pp.119-139
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• 2014

The objective of this study is to establish and propose a construction plan for a new main library in a metropolitan city. The case to be discussed in this paper is the new library of Busan. Library Law revised in 2007 requires each metropolitan cities and provinces to designate a public library as the representative regional main library or to build a new one. The city of Busan has been enthusiastic to build a new main library that can serve as a representative public library for the citizen. This new public library will serve as a community center, an intellectual archive, and the policy hub for the regional information services. In this paper, the strategy for the new Busan central metropolitan library will be discussed. It will strive to illustrate elements to be considered for the planning of a regional central library as other citied and provinces may refer to for their own regional central libraries.