• 대한장애인치과학회지
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• 제6권2호
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• pp.84-93
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• 2010

The developmental disorder(intellectual disorder(ID) and autism spectrum disorder(ASD)) can severely impair a patient's ability to communicate and socialize. So they require physical management techniques, pharmacologic agents, and general anesthesia more than the normal at the dental clinic. The behavior therapy is a kind of the psychotherapy and is applied to the patient with behavioral problems. Seoul Dental Hospital for Disabled(SDHD) set up the Dental Behavior Clinic for the patients with developmental disorder and treated 32 patients with ID or ASD, blind. 18 patients were treated according to the ordinary plans, 14 patients stopped the treatment by different reasons. The various results of the treatment were produced by the kind or severity of the diseases, age and cooperation of the patients and the caregivers. Especially, the behavior therapist helped to figure out the characteristics of the patients and to make individualized treatment plans. In the future, it will be necessary to treat more patients and to make the dental behavior therapy objectify. And through the dental behavior therapy, it will be expected that the patients will become more cooperative to the dental clinic and can receive regular check-up peacefully, reducing the frequency of the general anesthesia.

• 대한장애인치과학회지
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• 제8권1호
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• pp.1-9
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• 2012

Mobile oral exam at the facilities for the disabled in Seoul is to improve the oral health of the disabled who can hardly approach dental clinic. We analyzed 1609 oral exam records at 24 facilities (11 special-education schools, 10 living facilities, 2 mental hospitals, 1 health care facility for the elderly) in 2011. The purpose of this study is to figure out the oral health state of the disabled in facilities in Seoul and to compare with the non-disabled in National Survey 2010 and 2008. 1. Special-education school : DMFT index of age 15 is 5.4 which is higher than 3.6 (DMFT index of age 15) of National Survey in 2010. 2. Living facility : DMFT index of ages 35~44 is 8.4 which is higher than 5.2 (DMFT index of ages 35 ~44) of National Survey in 2008. DT rate is higher (31.3% vs 19.2%) and MT rate is lower (7.6% vs 15.5%). 3. Mental hospital : DMFT index of ages 35~44 is 11.3 which is higher than 5.2 (DMFT indext of age 35~44) of National Survey in 2008. DT rate is significantly higher (50.7% vs 19.2%) and FT rate is lower (35.1% vs 65.3%). 4. Health care facility for the elderly : DMFT index of ages 65~74 is 7.1 which is slightly lower than 8.7 (DMFT index of ages 65~74) of National Survey in 2008. The number of existing natural teeth is similar (16 vs 18).

• BMB Reports
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• 제44권5호
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• pp.298-305
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• 2011

Most intracellular reactive oxygen species (ROS), especially superoxide anion ($O_2^{{\bullet}_-}$) that is converted from oxygen, are overproduced by excessive electron leakage from the mitochondrial respiratory chain. Intracellular oxidative stress that damages cellular components can contribute to lifestyle-related diseases such as diabetes and arteriosclerosis, and age-related diseases such as cancer and neuronal degenerative diseases. We have previously demonstrated that the excessive mitochondrial $O_2^{{\bullet}_-}$ production caused by SDHC mutations (G71E in C. elegans, I71E in Drosophila and V69E in mouse) results in premature death in C. elegans and Drosophila, cancer in mouse embryonic fibroblast cells and infertility in transgenic mice. SDHC is a subunit of mitochondrial complex II. In humans, it has been reported that mutations in SDHB, SDHC or SDHD often result in inherited head and neck paragangliomas (PGLs). Recently, we established Tet-mev-1 conditional transgenic mice using our uniquely developed Tet-On/Off system, which equilibrates transgene expression to endogenous levels. These mice experienced mitochondrial respiratory chain dysfunction that resulted in $O_2^{{\bullet}_-}$ overproduction. The mitochondrial oxidative stress caused excessive apoptosis leading to low birth weight and growth retardation in the neonatal developmental phase in Tet-mev-1 mice. Here, we briefly describe the relationships between mitochondrial $O_2^{{\bullet}_-}$ and aging phenomena in mev-1 animal models