• 생명과학회지
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• 제12권3호
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• pp.332-339
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• 2002

옻나무(Rhus verniciflua Stokes)로부터 간섬유화에 따른 간독성의 경감기전을 추구할 목적으로 ethyl acetate 분획에서 분리한 fustin 및 sulfuretin을 실험동물에 투여하고서 혈액학적 변화 및 간장 중 활성산소에 미치는 영향 검토한 결과 담도결찰하여 간섬유화를 유도한 군에서는 AST, ALT, SDH, ${\gamma}$-GT활성 및 total bilirubin의 양이 현저히 증가되던 것이 옻나무의 메탄을 엑스(250 mg/kg), 에틸아세테이트 엑스(250 mg/kg), fustin(10 mg/kg) 및 sulfuretin(10 mg/kg)을 2주간 각각 경구투여 하므로서 유의성 있게 억제되었다. Hydroxyproline양 및 MDA 농도에서도 간섬유화를 유도하므로서 현저히 증가되던 것이 옻나무의 분획 및 sulfuretin과 fustin의 투여로서 각각 약 60% 및 47%정도 감소되었다. 간섬유화를 유도한 cytosolic계 효소인 xanthine oxidase 및 aldehyde oxidase의 활성이 현저히 증가되었으며 한편 superoxide dismutase, glutathione peroxidase 및 catalase은 간섬유화의 유도로 감소되었으나 옻나무의 분획(메탄올, 에틸아세테이트) 및 성분(fustin, sulfuretin)의 투여로서 조절되었다.

• Journal of Ginseng Research
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• 제27권1호
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• pp.1-10
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• 2003

In present study, we examined whether or not the pretreatment of Korean Red Ginseng (KRG) could protect hepatotoxicity induced by carbon tetrachloride (CCl$_4$) and D-galatosamine (GalN). For this study, we not only tested activity of various plasma enzymes (AST, ALT, SDH, LDH), which are used as indicators of liver disease, but also checked the change of liver components such as lipid, glutathione and cytochromes content, and several liver enzyme activity. Pretreatment of KRG for two weeks significantly reduced the elevated plasma enzyme activities induced by CCl$_4$ and GalN. Pretreatment of KRG also restored the hepatic enzymes, malonedialdehyde formation, and depletion of reduced glutathione content induced by CCl$_4$ and GalN to near normal level. However, ${\gamma}$-glutamylcysteine synthetase activity was lot affected by KRG. These results suggest that KRG shows the hepatoprotective effect by reducing lipid peroxidation, by reducing the activity of free radical generating enzymes, and by preserving the hepatic glutathione.

• ETRI Journal
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• 제34권6호
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• pp.816-826
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• 2012

Self-healing Ethernet rings show promise for realizing the SONET/SDH-grade resilience in Carrier Ethernet infrastructures. However, when a ring is faulty, high-priority protection messages are processed in less time than low-priority data frames are processed. In this situation, any delayed data frames either being queued or traveling through long ring spans will cause the ring nodes to generate incorrect forwarding information. As a result, the data frames spread in the wrong direction, causing the ring to become unstable. To solve this problem, we propose four schemes, that is, dual flush, flush delay timer setting, purge triggering, and priority setting, and evaluate their protection performance under various traffic conditions on a ring based on the Ethernet ring protection (ERP) method. In addition, we develop an absorbing Markov chain model of the ERP protocol to observe how traffic congestion can impact the protection performance of the proposed priority setting scheme. Based on our observations, we propose a more reliable priority setting scheme, which guarantees faultless protection, even in a congested ring.

• The Korean Journal of Physiology
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• 제28권2호
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• pp.113-122
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• 1994

The present study was carried out to characterize the functional properties of spinomesencephalic tract (SMT) neurons in the lumbar spinal cord of urethane anesthetized rats. Extracellular single unit recordings were made from neurons antidromically activated by stimulation of the midbrain area, including the deep layers of superior colliculus, periaqueductal gray and midbrain reticular formation. Recording sites were located in laminae I-VII of spinal cord segments of L2-L5. Receptive field properties and responses to calibrated mechanical stimulation were studied in 78 SMT cells. Mean conduction velocity of SMT neurons was $19.1{\pm}1.04\;m/sec$. SMT units were classified according to their response profiles into four groups: wide dynamic range (58%), deep/tap (23%), high threshold (9%) and low threshold (3%). A simple excitatory receptive field was found for most SMT neurons recorded in superficial dorsal horn (SDH). Large complex inhibitory and/or excitatory receptive fields were found for cells in lateral reticulated area which usually showed long after-discharge. Most of SMT cells received inputs from $A{\delta}$ and C afferent fiber types. These results suggest that sensory neurons in the rat SMT may have different functional roles according to their location in the spinal cord in integrating and processing sensory inputs including noxious mechanical stimuli.

• Asian Pacific Journal of Cancer Prevention
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• 제17권8호
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• pp.3741-3745
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• 2016

Background: This study was carried out to examine breast cancer risk and its fertility predictors in women aged ${\geq}35$. Materials and Methods: This cross-sectional study was conducted on 560 healthy women referred to health centers of Tabriz-Iran, 2013-2014. Five-year and lifetime risk of developing breast cancer were determined using the Gail model. General linear modeling was applied to determine breast cancer predictors. Results: The mean age of the subjects was 42.7 (SD: 7.7) years. Mean 5-year and lifetime risks of developing breast cancer were determined to be 0.6% (SD: 0.2%) and 8.9% (SD: 2.5%), respectively. Variables of family history of breast cancer, age, age at menarche, parity, age at first childbirth, breastfeeding history, frequency of breastfeeding, method of contraception, marital status and education were all found to be predictors of breast cancer risk. Conclusions: According to the results of this study, screening programs based on the Gail model should be implemented for Iranian people who have a high risk for breast cancer in order to facilitate early detection and better plan for possible malignancies.

• 대한의생명과학회지
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• 제12권3호
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• pp.233-240
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• 2006

We investigated enzyme activity and histochemical changes in hind limb of mouse treated with 6-aminonicotinamide (6-AN). The activity of aspartate aminotransferase, alanine aminotransferase and creatine phosphokinase in 6-AN treated group were significantly higher than those of the control and pair-fed groups. Also, the activity of lactic dehydrogenase in 6-AN treated group was the highest among the three groups, whereas that of the pair-fed group were higher than that of the control group. In the 6-AN treated group, oxidative histochemical stains, nicotinamide adenine dinucleotide reductase (NADH), succinyl dehydrogenase (SDH) showed increased scattered fibers in 6-AN treated subsarcolemma. Cytochrome c oxidase (COX) stain showed decreased up to 85% in 6-AN treated fibers. These results demonstrate that 6-AN antagonizes cell metabolism and induces the morphological deformity like the other mitochondrial muscle diseases. Therefore, we suppose that these data would be useful indexes for disclosing the mechanism of mitochondrial muscle disease.

• Asian Pacific Journal of Cancer Prevention
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• 제14권11호
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• pp.6669-6672
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• 2013

Colon cancer (CRC) is a serious health problem throughout the world. Development of novel drugs without side effects for this cancer is crucial. Luteolin (LUT), a bioflavonoid, has many beneficial effects such as antioxidant, anti-inflammatory and anti-proliferative potential. was a potent chemical carcinogen used for the induction of colon cancer. Colon carcinogenesis was initiated by intraperitoneal injection of azoxymethane (AOM) to mice at the dose of 15 mg/body kg weight in Balb/C mice for 3 weeks. Mice were treated with LUT at the dose of 1.2 mg/body kg weight orally. Mitochondrial enzymes such as isocitrate dehydrogenase (ICDH), ${\alpha}$-keto dehydrogenase (${\alpha}$-KDH), succinate dehydrogenase (SDH) and the activities of respiratory chain enzymes NADH dehydrogenase and cytochrome c oxidase were found to be elevated in AOM-treated animals. Treatment with LUT decreased the activities of all the parameters significantly. Hence, LUT might be a potent anticancer agent against colorectal cancer.

• Applied Microscopy
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• 제24권2호
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• pp.26-36
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• 1994

To investigate the effects of mercuric chloride ($HgCl_2$) on the differentiation in the cerebral neuron of chick embryo 7 days, the ultrastructural changes in nerve cells injected with a various doses of mercuric chloride were observed with transmission electron microscope. The enzyme activity of the some dehydrogenases, and adenosine triphophate (ATP) were also analyzed. The results obtained are as follows; The ultrastructural changes in 1.0mg-injected group, the nuclear envelope were irregular, and the RER, Golgi complexes and mitochondria were not well developed. In 2.0mg-injected group, the nuclear envelope were partly destroyed or detached, and mitochondria were decreased in number and their cristae were destroyed, too. The RER and Golgi complexes were less developed than those of the normal groups. In general, the activities of dehydrogenases were declined by increasing the dose of mercuric chloride. Lactate dehydrogenase (LDH) activity fatted to below 85% of the normal group in 1.0mg-injected group, and 69% in 2.0mg-injected group. Malate dehydrogenase (MDH) activity was decreased greatly to 76% in 2.0mg-injected group. Succinate dehydrogenase (SDH) activity fatted to 85% in 1.0mg-injected group, and 74% in 2.0mg-injected group. ATP content in 1.0mg-injected group was almost near to the normal level, but it was increased significantly in 2.0mg-injected group.

• 한국통신학회논문지
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• 제34권9B호
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• pp.883-891
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• 2009

고속 네트워크 장비에 네트워크프로세서의 사용이 보편화되고 라우팅 기능과 패컷처리 기능을 분리하는 분산형 시스템 구조가 이용됨에 따라 대용량의 트래픽을 매우 빠르게 처리하는 향상된 성능을 보일 수 있으나, 제어평면과 데이터 평면 사이에 추가 메시지 교환이 필요하여 시스템 내부 통신 지연이 증가하는 문제가 발생한다. 본 논문에서 제안한 구조는 이더넷 프로텍션 스위칭 기술에 필요한 패킷 처리 기능 블록들을 효율적으로 배치하여 설계함으로써, 메시지 교환에 따른 지연의 증가에도 불구하고 단일 링크의 장애 발생 시 50 msec급 수준의 빠른 절체 성능을 보인다. 이에 따라 높은 신뢰성과 수십 기가비트의 광대역 전송이 요구되는 캐리어 이더넷 시스템에 적합한 선형 프로텍션 스위칭 기술의 설계 및 구현 방안을 제공할 수 있다.

• 한국정보처리학회논문지
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• 제5권12호
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• pp.3230-3243
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• 1998

액세스망 기술 분야는 초고속 정보통신 서비스를 제공하기 위하여 유·무선 전달 매체 처리기술, 액세스망 구성 방식 기술, 기존 인프라를 이용하는 고도의 DSL기술 등이 복합되어 사업자의 망 구축 여건에 따라 다양한 형태로 실현되고 있다. MAIN1)은 기존 동선상에서 전화 및 데이터 서비스는 물론 광대역서비스 제공을 위해 VDSL기술을 채용하며, 망 구성방식으로는 ATM/SDH 또는 ATM/PON 기반으로 FTTx 방식의 통합 액세스망 플랫폼이다. 그러나 액세스망은 다수 망사업자와 서비스사업자 환경과 공중망과 사설망이 혼재하며, 새로운 요소기술이 복합되는 망 영역이므로 소요장치의 OAM 뿐만 아니라 망관리에 대한 체계적인 OA&M이 요구되고 있다. 액세스망의 OA&M은 비용 효과적인 액세스망 실현과 실제 망 운용비용과는 상호 상반된 관점을 가진다. 본 논문은 다양한 형태의 액세스망에 대해 통합 관점의 망 관리와 시스템 관리를 위한 체계적인 OA&M 정립을 목적으로 한다. 이를 위하여 통합 엑세스망 플랫폼에 대한 망관리 설계 접근 방법 및 고려사항에 대해 논하고, MAIN의 관리 구조 모델을 제시한다. 또한 MAIN 하드웨어 구조에서 NEL 시스템의 운용관리 및 소요기술에대한 OAM 기능과 망관리 기능 구현을 통하여 MAIN 엑세스망의 OA&M 실현 구조를 조명 함으로서 관련 액세스망 OA&M 구현 시 기본 참조 모델로 제안한다.