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http://dx.doi.org/10.7314/APJCP.2013.14.11.6669

Luteolin, a Bioflavonoid, Attenuates Azoxymethane-Induced Effects on Mitochondrial Enzymes in Balb/c Mice  

Pandurangan, Ashok Kumar (Department of Biochemistry, University of Madras, Guindy Campus)
Sadagopan, Suresh Kumar Ananda (Department of Biochemistry, University of Madras, Guindy Campus)
Dharmalingam, Prakash (Department of Biochemistry, University of Madras, Guindy Campus)
Ganapasam, Sudhandiran (Department of Biochemistry, University of Madras, Guindy Campus)
Publication Information
Asian Pacific Journal of Cancer Prevention / v.14, no.11, 2013 , pp. 6669-6672 More about this Journal
Abstract
Colon cancer (CRC) is a serious health problem throughout the world. Development of novel drugs without side effects for this cancer is crucial. Luteolin (LUT), a bioflavonoid, has many beneficial effects such as antioxidant, anti-inflammatory and anti-proliferative potential. was a potent chemical carcinogen used for the induction of colon cancer. Colon carcinogenesis was initiated by intraperitoneal injection of azoxymethane (AOM) to mice at the dose of 15 mg/body kg weight in Balb/C mice for 3 weeks. Mice were treated with LUT at the dose of 1.2 mg/body kg weight orally. Mitochondrial enzymes such as isocitrate dehydrogenase (ICDH), ${\alpha}$-keto dehydrogenase (${\alpha}$-KDH), succinate dehydrogenase (SDH) and the activities of respiratory chain enzymes NADH dehydrogenase and cytochrome c oxidase were found to be elevated in AOM-treated animals. Treatment with LUT decreased the activities of all the parameters significantly. Hence, LUT might be a potent anticancer agent against colorectal cancer.
Keywords
Colon cancer; luteolin; azoxymethane; chemoprevention; mitochondrial enzymes;
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