• 제목/요약/키워드: SDA

검색결과 114건 처리시간 0.027초

악성간암환자의 유전체자료 심볼릭 나무구조 모형연구 (Symbolic tree based model for HCC using SNP data)

  • 이태림
    • Journal of the Korean Data and Information Science Society
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    • 제25권5호
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    • pp.1095-1106
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    • 2014
  • 본 연구에서는 악성간암환자의 생존기간에 영향을 주는 인자를 찾기 위하여 반응변수를 악성간암 환자의 생존을 임상변수의 정보와 SNP유전인자를 통합한 자료를 대상으로 이해하기 쉬운 나무구조 생존모형과 심볼릭자료분석을 실시하여 영향을 주는 유의한 인자 뿐 아니라 그 임계치를 구하여 임상적으로 유용한 결과를 찾아 임상에 적용하는 것이 목적이다. 악성간암환자의 임상자료를 계량화하여 통계적 예후진단 모형을 구함으로써 임상변수 간 숨겨진 변수간의 관계를 규명하고 생존기간 군에 따른 예측 분류모형을 구하여 현시적으로 진단후 예후에 영향을 주는 중요 임상변수와 유전체변수 그 임계치를 구하여 임상에서의 치료계획에 중요한 근거를 제시했다. 심볼릭데이터 분석 결과 정상, 만성 간염, 간염, 악성간염 등의 4개 군으로 구성된 1840명의 대상자를 분석 5 유전체의 20개 SNP가 밝혀진 바 있다. 즉 IL10-ht2가 악성간암의 발병에 매위 강한 관련이 있고 TGFB L10P-Prosms가 만성 간염 환자 중 악성간암 발생 위험을 줄여주는 유전체로 밝혀졌다. SNP변수와 질병군의 컴셉트 변수에 따라 상관정도를 원의 반지름 길이로 상대적으로 나타내 줌으로써 가장 판별력 있는 심볼릭변수를 상대적으로 비교할 수 있었다. 임상자료와 유전체자료를 통합하여 심볼릭 나무구조 생존모형을 구하여 생존기간을 군으로 한 나무구조모형을 유의한 변수와 기준치와 함께 구할 수 있었다.

YIG박막-GGG층 구조를 갖는 마이크로스트립 선로의 전파특성 해석 (Analysis of Propagation Characteristics of Microstrip Lines with a Composite YIG Film-GGG Structure)

  • 박기동;임영석
    • 한국전자파학회논문지
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    • 제11권7호
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    • pp.1168-1175
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    • 2000
  • YIG 박막상의 마이크로스트립 선로에 대한 전파특성을 살펴버기 위해 FDTD을 적용하였다. GGG층과 YIG필름의 두께 변화에 따른 분산 곡선 및 차단 대역 특성을 계산하고, 도테 선로 바로 및의 횡단면 전계 성문의 분포를 상.하한 차단 주파수 부근에서 구하였다. 상한 차단 주파수에 대한 2차원 및 3차원 FDTD의 결과를 SDA와 비교하여 상대 오차가 6% 이내로 잘 일치함을 확인하였다.

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Symbolic Cluster Analysis for Distribution Valued Dissimilarity

  • Matsui, Yusuke;Minami, Hiroyuki;Misuta, Masahiro
    • Communications for Statistical Applications and Methods
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    • 제21권3호
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    • pp.225-234
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    • 2014
  • We propose a novel hierarchical clustering for distribution valued dissimilarities. Analysis of large and complex data has attracted significant interest. Symbolic Data Analysis (SDA) was proposed by Diday in 1980's, which provides a new framework for statistical analysis. In SDA, we analyze an object with internal variation, including an interval, a histogram and a distribution, called a symbolic object. In the study, we focus on a cluster analysis for distribution valued dissimilarities, one of the symbolic objects. A hierarchical clustering has two steps in general: find out step and update step. In the find out step, we find the nearest pair of clusters. We extend it for distribution valued dissimilarities, introducing a measure on their order relations. In the update step, dissimilarities between clusters are redefined by mixture of distributions with a mixing ratio. We show an actual example of the proposed method and a simulation study.

유전체 덮개층을 갖는 비대칭 결합선로를 이용한 90$^{\circ}$ 위상천이기의 광대역 특성 (Broadband Characteristics of Asymmetirc Coupled-Line 90$^{\circ}$Phase Shifter with Dielectric Overlay)

  • 윤남일;강창훈;이용국;박한규
    • 한국통신학회논문지
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    • 제24권6B호
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    • pp.1142-1148
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    • 1999
  • 본 논문에서는 Ku-밴드의 마이크로파 대역에서 위상배열 안테나에 사용 가능한 결합선로를 이용하여 위상천이기에서 기존에 고려하지 않았던 주파수에 따른 분산특성을 전파(Full-wave) 해석방법인 SDA(Spectral Domain Approach)를 사용하여 정확히 해석하였다. 또한 비대칭 결합선로를 사용하는 위상천이와 유전치 덮개층이 부가된 위상천이기의 설계를 제안하였다. 현재 사용되고 있는 대칭 결합선로를 이용한 쉬프만 위상천이기와 비교하여, 이에 대한 위상응답의 특성변화에서 통과대역의 위상편차가 줄고 대역폭이 확대되어 광대역 특성이 개선되는 것을 이론적으로 해석하고 실험을 통하여 검증하였다.

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Mechanical strengths of self compacting concrete containing sawdust-ash and naphthalene sulfonate

  • Elinwa, Augustine U.;Mamuda, Mamuda;Ahmed, M.
    • Advances in concrete construction
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    • 제2권4호
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    • pp.301-308
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    • 2014
  • The present research work is on the effect of sawdust ash (SDA) on the mechanical strengths of self compacting concrete (SCC) using naphthalene sulfonate (NS) as a plasticizer. Experiments on compressive, flexural and splitting tensile strengths are conducted and the data analyzed using the Minitab 15 software. The results showed that SDA can defer the reaction of cement hydration and prolong the setting times of cement paste. This was very much pronounced on the flexural and splitting tensile strengths at 90 days of curing which are 36 % and 33 % higher than the control strengths, respectively. The study has proposed strength relations of mortar compressive strength with the flexural and splitting tensile strengths and these are, 5 and 7 times respectively. The flexural strength is 1.5 times that of the splitting tensile. Finally, linear models were developed on these relationships.

Genetic Similarity between Cotton Leafroll Dwarf Virus and Chickpea Stunt Disease Associated Virus in India

  • Mukherjee, Arup Kumar;Mukherjee, Prasun Kumar;Kranthi, Sandhya
    • The Plant Pathology Journal
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    • 제32권6호
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    • pp.580-583
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    • 2016
  • The cotton leafroll dwarf virus (CLRDV) is one of the most devastating pathogens of cotton. This malady, known as cotton blue disease, is widespread in South America where it causes huge crop losses. Recently the disease has been reported from India. We noticed occurrence of cotton blue disease and chickpea stunt disease in adjoining cotton and chickpea fields and got interested in knowing if these two viral diseases have some association. By genetic studies, we have shown here that CLRDV is very close to chickpea stunt disease associated virus (CpSDaV). We were successful in transmitting the CLRDV from cotton to chickpea. Our studies indicate that CpSDaV and CLRDV in India are possibly two different strains of the same virus. These findings would be helpful in managing these serious diseases by altering the cropping patterns.

A New Characterizing Method for Recycled Paper and the Application of Image Segmentation on the Measurement Sub-visible Dirt

  • Dong, Shijin;Zhang, Haitao;Cui, Xuejun;Li, Junfeng;Wang, Hongyan
    • 펄프종이기술
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    • 제40권5호
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    • pp.11-19
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    • 2008
  • The paper established a new method for fast measurement and characterizing of sub-visible dirt of recycled paper which is too small to be seen with naked eye. This method provided a new way for the evaluation of recycled paper that is hard to be characterized by the conventional method. Two effective thresholding algorithms HA and SDA were compared and their applicable conditions were discussed. Results showed that the HA could be used for un-printed paper while SDA is suited for recycled papers. The gloss of paper samples was measured and the relation between gloss and sub-visible dirt was investigated. The significant effect of this method for characterizing and comparing paper was exhibited. The experiment results indicated that sub-visible dirt measuring method could be a complementariness of the conventional methods.

Schizophrenia : Changing Concepts and the Development of Novel Antipsychotics

  • Remington, Gary
    • 생물정신의학
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    • 제3권1호
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    • pp.22-29
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    • 1996
  • The introduction of chlorpromazine in the 1950's revolutionized the treatment of schizophrenia and ultimately led to the development of selective $D_2$ antagonists such as haloperidol, a goal in keeping with the prevalent theories at that time. However, limitations in the efficacy of these agents, a growing awareness of their side effects, and theoretical shifts in our understanding of schizophrenia have encouraged ongoing efforts to develop better 'atypical' antipsychotics. Clozapine, and subsequently risperidone, represent examples of these novel compounds, both of which incorporate shared serotonin-dopamine antagonism(SDA). The next years will be dominated by further development of SDA compounds, although a number of other lines of investigation are also being pursued.

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