• Title/Summary/Keyword: SCOT

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Use of Coronary CT Angiography as a Screening Tool for Coronary Artery Disease in Asymptomatic Healthy Individuals or Patients (무증상 정상인 또는 환자의 관상동맥 질환 선별 검사로서 관상동맥 전산화단층촬영 혈관조영술의 유용성)

  • Gong Yong Jin
    • Journal of the Korean Society of Radiology
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    • v.83 no.1
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    • pp.54-69
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    • 2022
  • Early detection of potential asymptomatic coronary artery disease is very important, as patients with sudden cardiac death often do not show symptoms such as chest pain or motor dyspnea. Coronary CT angiography (CCTA) has long been unjustified as a screening tool for asymptomatic patients because of the risks posed by radiation exposure. However, there are still various opinions regarding the usefulness of CCTA for screening for coronary artery disease (CAD) in asymptomatic healthy individuals or patients. This review investigated the usefulness of coronary artery calcium score and CCTA as screening tests for CAD in asymptomatic healthy individuals or patients through various literature reviews. With the development of CT technology, recent studies have been conducted in asymptomatic CAD patients with a reduced radiation dose of less than 1 mSv. A total of 2.6% of asymptomatic subjects on CCTA found significant CAD over 70%, and it was concluded that screening CCTA for CAD showed prognostic power in predicting the future occurrence of CAD in asymptomatic people. However, after the completion of the current NIH SCOT-HEART 2 study, it may be possible to determine whether CCTA is appropriate as a screening tool for CAD in asymptomatic healthy individuals.

Erythrolobus australicus sp. nov. (Porphyridiophyceae, Rhodophyta): a description based on several approaches

  • Yang, Eun-Chan;Scot, Joe;West, John A.;Yoon, Hwan-Su;Yokoyama, Akiko;Karsten, Ulf;De Goer, Susan Loiseaux;Orlova, Evguenia
    • ALGAE
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    • v.26 no.2
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    • pp.167-180
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    • 2011
  • The unicellular marine red alga Erythrolobus australicus sp. nov. (Porphyridiophyceae) was isolated into laboratory culture from mangroves in Queensland and New South Wales, Australia. The single multi-lobed red to rose-red plastid has more than one pyrenoid and lacks a peripheral thylakoid. Arrays of small electron dense globules occur along the thylakoids. The nucleus is peripheral with a central to eccentric nucleolus. Each Golgi body is associated with a mitochondrion. The spherical cells are positively phototactic with slow gliding movement. The psaA + psbA phylogeny clearly showed that E. australicus is a distinct species, which is closely related to E. coxiae. The chemotaxonomically relevant and most abundant low molecular weight carbohydrate in E. australicus is floridoside with concentrations between 209 and 231 ${\mu}mol g^{-1}$ dry weight. Traces of digeneaside were also detected. These various approaches help to understand the taxonomic diversity of unicellular red algae.

Comparison of Window Functions for the Estimation of Leak Location for Underground Plastic Pipes (지하매설 플라스틱 배관의 누수지점 추정을 위한 창함수 비교 연구)

  • Lee, Young-Sup
    • Transactions of the Korean Society for Noise and Vibration Engineering
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    • v.20 no.6
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    • pp.568-576
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    • 2010
  • It is widely known that the leak locating of underground plastic pipelines is much more difficult than that of cast iron pipelines. The precision of the leak locating depends upon the speed of leak signal and the time delay estimation between the two sensors on the pipeline. In this paper, six different windowing filters are considered to improve the time delay estimation especially for the plastic pipelines. The time delay is usually estimated from the peak time of cross-correlation functions. The filtering windows including rectangle, Roth, Wiener, SCOT, PHAT and maximum likelihood are applied to derive the generalized cross-correlation function and compared each other. Experimental results for the actual plastic underground water supply pipeline show that the introduction of the filtering windows improved the precision of time delay estimation. Some window functions provide excellent leak locating capability for the plastic pipe of 98 m long, which is less than 1 % of the pipe lengths. Also a new probabilistic approach that the combinations of all results from each filtering window is suggested for the better leak locating.

A 3-DOF forced vibration system for time-domain aeroelastic parameter identification

  • Sauder, Heather Scot;Sarkar, Partha P.
    • Wind and Structures
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    • v.24 no.5
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    • pp.481-500
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    • 2017
  • A novel three-degree-of-freedom (DOF) forced vibration system has been developed for identification of aeroelastic (self-excited) load parameters used in time-domain response analysis of wind-excited flexible structures. This system is capable of forcing sinusoidal motions on a section model of a structure that is used in wind tunnel aeroelastic studies along all three degrees of freedom - along-wind, cross-wind, and torsional - simultaneously or in any combination thereof. It utilizes three linear actuators to force vibrations at a consistent frequency but varying amplitudes between the three. This system was designed to identify all the parameters, namely, aeroelastic- damping and stiffness that appear in self-excited (motion-dependent) load formulation either in time-domain (rational functions) or frequency-domain (flutter derivatives). Relatively large displacements (at low frequencies) can be generated by the system, if required. Results from three experiments, airfoil, streamlined bridge deck and a bluff-shaped bridge deck, are presented to demonstrate the functionality and robustness of the system and its applicability to multiple cross-section types. The system will allow routine identification of aeroelastic parameters through wind tunnel tests that can be used to predict response of flexible structures in extreme and transient wind conditions.

Molecular Characterization of the Genes Encoding Acetoacetyl-Coenzyme A Transferase from Serratia marcescens KCTC 2172

  • Yoo, Ju-Soon;Kim, Hae-Sun;Lee, Young-Choon;Chung, Soo-Yeol;Choi, Yong-Lark
    • Journal of Microbiology and Biotechnology
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    • v.11 no.5
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    • pp.870-875
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    • 2001
  • A DNA fragment, pCKB13, containing two genes encoding Coenzyme a transferase, was isolated from a genomic DNA library of S. marcescens KCTC 2172. The complete nucleotide sequence of the 2,081-bp BamHI fragment on pCKB13 was determined. Sequencing of the fragment led to the identification of two open reading frames showing high homology with two Coenzyme A (CoA) transferases, Acetoacetyl-CoA transferase (Acot) and Succinyl-CoA transferase (Scot), enzymes catalyzing the reversible transfer of CoA from one carboxylic acid to another. The enzyme activity of Coenzyme A transferase increased after introducing the multicopy of the cloned gene in E. coli. The recombinant protein, overexpressed by multicopy and induction with IPTG, was a polypeptide of 42 kDa, as confirmed by SDS-PAGE. The protein was purified to homogeneity through three sequential chromatographic procedures including ion-exchanged DEAE-sepharose, CM-sepharose, and Mono Q.

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Social Contexts and Media-Historical Meaning of the Early 'Noraebang' Culture in Busan Focusing on the Relationship between Noraebang and Karaoke Culture in 1980s (초기 부산 노래방 문화 형성의 사회적 맥락과 매체사적 의미 1980년대 가라오케 문화와의 관계를 중심으로)

  • YOON, Sangkil;CHANG, Il
    • Korean journal of communication and information
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    • v.77
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    • pp.164-199
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    • 2016
  • This study analyzes the socio-economical contexts of Japan's Karaoke inflow in Busan of the 1980s, and examines the relationship between Karaoke culture of the 1980s and 'Noraebang' culture of the early 1990s in Busan from the perspective of the SCOT(social construction of technology) theory. By the end of 1970s, Japan's Karaoke was introduced under the contexts of structural transformations of a geisha tourism in the East Asian regions. Karaoke culture in Busan of the 1970s and 1980s has formulated social recognitions of the novelty of Noraebang culture in the 1990s, although it has done so through the ways of misunderstandings and Nationalism.

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Dietary Supplementation with Raspberry Extracts Modifies the Fecal Microbiota in Obese Diabetic db/db Mice

  • Garcia-Mazcorro, Jose F.;Pedreschi, Romina;Chew, Boon;Dowd, Scot E.;Kawas, Jorge R.;Noratto, Giuliana
    • Journal of Microbiology and Biotechnology
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    • v.28 no.8
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    • pp.1247-1259
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    • 2018
  • Raspberries are polyphenol-rich fruits with the potential to reduce the severity of the clinical signs associated with obesity, a phenomenon that may be related to changes in the gut microbiota. The aim of this study was to investigate the effect of raspberry supplementation on the fecal microbiota using an in vivo model of obesity. Obese diabetic db/db mice were used in this study and assigned to two experimental groups (with and without raspberry supplementation). Fecal samples were collected at the end of the supplementation period (8 weeks) and used for bacterial 16S rRNA gene profiling using a MiSeq instrument (Illumina). QIIME 1.8 was used to analyze the 16S data. Raspberry supplementation was associated with an increased abundance of Lachnospiraceae (p = 0.009), a very important group for gut health, and decreased abundances of Lactobacillus, Odoribacter, and the fiber degrader S24-7 family as well as unknown groups of Bacteroidales and Enterobacteriaceae (p < 0.05). These changes were enough to clearly differentiate bacterial communities accordingly to treatment, based on the analysis of UniFrac distance metrics. However, a predictive approach of functional profiles showed no difference between the treatment groups. Fecal metabolomic analysis provided critical information regarding the raspberry-supplemented group, whose relatively higher phytosterol concentrations may be relevant for the host health, considering the proven health benefits of these phytochemicals. Further studies are needed to investigate whether the observed differences in microbial communities (e.g., Lachnospiraceae) or metabolites relate to clinically significant differences that can prompt the use of raspberry extracts to help patients with obesity.

Research Perspectives and Research Issues on the Origins of Korean Technology Culture: Focusing on Amateur Radio

  • Sangkil Yoon
    • Journal of the Korea Society of Computer and Information
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    • v.29 no.10
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    • pp.197-205
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    • 2024
  • Starting with the problem that the origin of Korean technology culture lies in the technology culture of amateur radio lovers in the 1950s and 1960s, the purpose of this study is to explore the research perspective and research issues necessary for the historical study of Korean amateur radio, which has remained a blind spot. More specifically, the main contents of the 'social constructivism of technology' theory, which is a perspective that is mainly interested in the early history phase and a theoretical resource that views the relationship between technology and culture, were examined, and technology culture of amateur radio lovers was examined. And based on this, major research issues were derived. The main research issues derived are to determine the historical composition of amateur radio in the 1950s and 1960s, to explain the Cold War transformation of Korean amateur radio (technology) culture, and to examine the relationship between radio electronics market and amateur radio hobby market growth.

Identifying the Usefulness of Weblog Genre Analysis in Organizational knowledge Creation: A Social Construction of Technology Perspective (조직내 지식창출을 위한 웹블로그 장르분석의 유용성 발굴: 기술의 사회구성론적 관점)

  • Park, Ji-Hong
    • Journal of the Korean Society for information Management
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    • v.25 no.1
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    • pp.5-17
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    • 2008
  • The purpose of this paper is to identify the usefulness of Weblog genre analysis in knowledge creation within an organization where communications are occurred frequently among the employees with information and communication technologies (ICTs). Knowledge creation is essential to achieve competitive advantage in today's knowledge-oriented working environments. There has been huge investment on knowledge management systems to achieve such advantages. It is, however, widely recognized that distributed knowledge management systems often fail due to the different social contexts across the sub-organizations where the local information systems are deployed. It is important to coordinate such social gaps across the sub-organizations to achieve better advantages. Given that Weblogs users often feel a shared social norm. Weblogs playa positive role of narrowing the social gaps. This paper argues that the genre analysis of Web logs could provide important clues to narrow the social gaps existed across the sub-organizations within an organization. Hence, such taxonomical practice may be a solution for the high rate of failure in knowledge management system implementations in an organization. This paper uses the theory of organizational knowledge creation (Nonaka & Takeuchi. 1995) and social construction of technology (SCOT) approach (Bijker, 1995) to compare the socialized with the non-socialized integration of distributed information systems. The findings of this research provide a useful framework for better implementing knowledge management practices especially in distributed working environments.

A clinical study on the effects of myocardial protection during open heart surgery (개심술에서 술중 심근보호효과에 관한 임상적연구)

  • 김근호
    • Journal of Chest Surgery
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    • v.20 no.2
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    • pp.230-240
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    • 1987
  • Cardioplegia and myocardial protection were performed under cardiopulmonary bypass during open-heart surgery with the use of cold St. Thomas Hospital cardioplegic solution [4=C] for the coronary artery perfusion and normal saline solution [4- C] for the topical cardiac cooling. To maintain the state of myocardial protection, coronary artery reperfusion was carried out using St. Thomas Hospital cardioplegic solution at the interval of 30 minutes. A total number of patients studied were 57 cases, including 37 cases of correction for congenital cardiac anomalies and 20 cases for acquired heart valvular diseases. Cardiopulmonary bypass time during the surgery was observed to be average of 87.89*47.55 hours, aortic cross-clamping time to be average of 76.68~44.27 hours raging from 30 to 191 minutes. In order to evaluate the effects of myocardial protection in the surgery, serum enzyme levels were determined. To observe the relationship between aortic cross-clamping time and myocardial protection effects, patients studied were divided into the following 3 groups. I group: aortic cross-clamping time, 60 minutes, II group: aortic cross-clamping time, 90 minutes, III group: aortic cross-clamping time, over 91 minutes. 1. Changes in serum enzyme levels in postoperative period. [1] SCOT; The postoperative value [increased over 200 units] for ischemic myocardial injury during operation was observed in 11 cases [19.3% of the total] of the total patients studied, of which 4 cases [13.3%] in I group, 1 case [10.0%] in II group, and 6 cases [35.3%] in III group. [2] LDH; The positive value [increased over 900 units] for ischemic myocardial injury during operation was observed in 9 cases [15.7% of the total] of the total patients studied, of which 2 cases [6.6%] in I group, 1 case [10.0%] in II group, and 6 cases [35.3%] in III group. [3] CPK; The positive value [increased over 800 units] for ischemic myocardial injury during operation was observed in 10 cases [17. 5% of the total] of the total patients studied, including 4 cases [13. 3%] in I group, 1 case [10.0%] in II group, and 5 cases [29.4%] in III group. 2. The myocardial protection method used in the present study was demonstrated to be effective for the myocardial protection in the surgery with aortic cross-clamping time of up to 90 minutes. A few ischemic myocardial injury were observed in the surgery with aortic cross-clamping time over 91 minutes, but no significant cardiac dysfunction was noted. The surgery with aortic cross-clamping time of up to 191 minutes did not appear to give rise any significant interference with postoperative recovery.

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