• Journal of Sasang Constitutional Medicine
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• v.23 no.4
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• pp.471-486
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• 2011

1. Objectives The purpose of this study was to investigate the high-sensitivity C-reactive protein (hsCRP) related characteristics found in each Sasang Constitutional type. 2. Methods This cross-sectional epidemiological study was conducted using data from 2,842 men and women. After typing each participant into one of the four Sasang constitutional types, they were analyzed on various cardiovascular disease-related variables. 3. Results 1) The predictors of cardiovascular disease (metabolic syndrome, high risk FRS group, high risk hsCRP group) was found to show the highest prevalence in the Taeeum type. 2) In the group with metabolic syndrome, the mean hsCRP concentration in the Taeeum and Soyang types were higher than in the Soeum type. In the group without metabolic syndrome, the mean hsCRP concentration in the Taeeum type were higher than in the Soyang and Soeum types. 3) In the FRS low risk group, the mean hsCRP concentration were higher in order of Taeeum type > Soyang type > Soeum type. In the FRS high risk group, the mean hsCRP concentrations were not significantly different among the Sasang constitutional types. 4. Conclusions The results of this study suggest that the Taeeum constitutional type is a risk factor for high hsCRP and cardiovascular disease. These findings suggest that the prevention of cardiovascular disease is more important in the Taeeum type compared to other constitutional types. Moreover, preventive measures are warranted even in the Taeeum-type persons with low clinical cardiovascular risk.

• Journal of Sasang Constitutional Medicine
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• v.19 no.2
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• pp.11-21
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• 2007

1. Objectives The object of this thesis is to find the basis on why Jejo was assigned as a Taeumin medicine, and to understand Taeumin edema. 2. Methods ${\ulcorner}$Dongyisusebowon${\lrcorner}$ 'Shinchukbon', 'Gabobon', 'Chobonkwun', other related Sasang Constitutional Medicine(SCM) books, herbal medicine books such as ${\ulcorner}$Bonchokangmok${\lrcorner}$, and etc. were compared and researched. 3. Results & Conclusions (1) In Sasang Constitutional Medicine, edema is seen as a critical condition. The first cause of edema in Taeumin is fatigue, a condition where the flow of Qi and Fluid Qi is stagnated. Secondly, edema is caused as Taeeumin is mentally stressed(勞心焦思) and he/she is unable to accomplish his/her plans over many trials or as when they find pleasure in striving for greed. When Lungs which is Incline & Small Viscera(偏小之臟) in Taeumin decreases, it diminishes Real Count of Longevity(命脈實數) which leads to edema formation. (2) Perspective of Human Nature & Character(心性學) and Regimen(養生法) became included gradually in the treatment methods and prescription of edema in Taeumin as ${\ulcorner}$Dongyisusebowon${\lrcorner}$ was revised over time. The revisions also lead to more diversity in prescriptions. (3) Jejo didn't appear In ${\ulcorner}$Dongyisusebowon${\lrcorner}$ 'Chobonkwun' and 'Gabobon'. It was first presented in 'Shinchukbon' as a medicine to treat edema in Taeumin. (4) Jejo have effects of easing clumps. Also it has a strong radiating ability(發散力) which induces perspiration to treat diseases. Finally Jejo is used to remove Takki(濁氣) by utilizing powerful Exhale Gathering Qi contained in it.

• Journal of Sasang Constitutional Medicine
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• v.21 no.2
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• pp.48-57
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• 2009

1. Objective : The object of this thesis is to find the basis of Constitution assignment of Nogeun(蘆根, Phragmites communis Trin.) used to the medication for Taeyangin. Also, it is to recognize what kind of Constitution of Mogeun(茅根, Imperata cylindrica var. koenigii) is needed to be assigned to. 2. Methods "Dongyi Soose Bowon", 'SinchukBon', 'ChobonKwun', other related Sasang Constitutional Medicine(SCM) books, herbal medicine books such as "Boncho Kangmok", and etc. were compared and researched. 3. Results & Conclusions : 1) Nogeun(蘆根) lowers Qi and harmonizes the body. Because of the effect of lowering soar-Qi(氣), it used to treat the symptoms of Taeyangin's vomiting(噎膈反胃, Stomach reflux due to dysphagia-occlusion). Also Yuksoo Nogeun(逆水蘆恨, Reed growing near the river in low scream) is the basis of considering inhale-gathering Qi effect as a major indication of Nogeun. 2) The theory of classifying White Mogeun as a Tae-eumin Medicinal is based on the effect of Radiating while classifying White Mogeun as a Taeyangin Medicinal is based on the effect of treating stomach reflux(反胃). But both basis are not conclusive and thus requires further study. 3) In "Sasang Geumge Bibang", the first text ever to write only about separate medicinals and Classified Foods (食物類) of each constitution, there were examples of Nogeun and Mogeun's usage based on other pre-existing medical texts. 4) Because White Mogeun is classified as Tae-yangin medication in "Dongmu Yugo", but classified as a Taeeumin's medication in "Dongyi Soose Bowon" 'ChobonKwun' and "Sasang Geumge Bibang", there remains a controversy.

• Journal of Sasang Constitutional Medicine
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• v.16 no.2
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• pp.17-31
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• 2004

1. Objectives This research is purposed to find Lee Je-Ma's thought on Inclination of Mind(心慾) and Nature & Emotion(性情), through summarizing sentences related to Inclination of Mind(心慾) and Nature & Emotion(性情) proposed in the chief writings on Sasang Constitutional Medicine. 2. Methods It was researched bibliologically with Lee Je-Ma's chief writings such as "Gyukchigo (Draft on Inquiring the Properties of Things, 格致藁)", "Dongyi Suse Bowon Sasang Chobongyun(東醫壽世保元四象草本卷)" "Dongyi Suse Bowon (Longevity and Life Preservation in Oriental Medicine, 東醫壽世保元)". 3. Results and Conclusions (1) Lee Je-Ma's Mind(心) is the dimension of the Great Absolute(Taegeuk,太極), and is related with Benevolence-Righteousness-Propriety-Wisdom(仁義禮智) (2) Human being is classified Taeyangin(太陽人), Taeumin(太陰人), Soyangin(少陽人), Soeumin(少陰人) by SungLi(性理), and The Mean(鄙人), TheWeek(薄人), The Avaricious(貪人), The Sycophantic(懦人) by JungYok(情慾) in Sasang Constitutional Medicine. (3) Nature & Emotion(性情) of Sorrow-Anger-Joy-Pleasure(喜怒哀樂) is divided into two function. One is native function related with SungLi(性理), the other is acquired function related with JungYok(情慾). Also all two native and acquired function is related with Benevolence-Righteousness-Propriety-Wisdom(仁義禮智). (4) The Mean(鄙人), The Week(薄人), The Avaricious(貪人), The Sycophantic(懦人) may be defined as the state of Inclination of Mind(心慾) of Taeyangin(太陽人), Taeumin(太陰人), Soyangin(少陽人), Soeumin(少陰人) by function of acquired Emotion(情).

• Journal of Sasang Constitutional Medicine
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• v.24 no.2
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• pp.19-30
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• 2012

1. Objectives : The aim of this study was to survey the Original symptoms of Soyangin's and to compare the tendency of their symptoms between Soyangin Gyolhyungjeung and Soyangin Heat-related diarrhea accompanied by headache in patients of indigestion. 2. Methods : We recruited 76 Soyangin subjects in the Korean Medicine clinic and researched their original symptoms. Subjects were diagnosed by the Sasang Constitutional specialists and Sasang Constitutional Medication. Subjects were two groups, confirmed to Soyangin Gyolhyungjeung and Soyangin Heat-related diarrhea accompanied by headache. All subjects answered the questionnaire about their Original symptoms. We found the differences between 2 groups using the Mann-Whitney U Test. Analysis was conducted using SPSS 18.0 for Korean. 3. Results : In Original symptoms, there was no difference between 2 groups in sleep, appetite, digestion, eating habits, water temperature, function of bowel movement, urination, sweating, sensitivity to coldness and sensitivity to warmness. But there was difference between 2 groups in frequency of defecation & hardness of feces(p=0.027). 4. Conclusions : We found the differences of heat and cold in symptoms between two Soyangin syndromes.

• Journal of Sasang Constitutional Medicine
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• v.19 no.3
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• pp.51-61
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• 2007

1. Objectives The Face is an important standard for the classification of Sasang Constitutions. We are developing 3D Automatic Face Recognition Apparatus(3D-AFRA) to analyse the facial characteristics. This apparatus show us 3D image and data of man's face and measure facial figure data. So We should examine the Measurement of Facial Figure data error of 3D Automatic Face Recognition Apparatus(3D-AFRA) in Software Error Analysis. 2. Methods We scanned face status by using 3D Automatic Face Recognition Apparatus(3D-AFRA). And we measured lengths Between Facial Definition Parameters of facial figure data by Facial Measurement program. 2.1 Repeatability test We measured lengths Between Facial Definition Parameters of facial figure data restored by 3D-AFRA by Facial Measurement program 10 times. Then we compared 10 results each other for repeatability test. 2.2 Measurement error test We measured lengths Between Facial Definition Parameters of facial figure data by two different measurement program that are Facial Measurement program and Rapidform2006. At measuring lengths Between Facial Definition Parameters, we uses two measurement way. The one is straight line measurement, the other is curved line measurement. Then we compared results measured by Facial Measurement program with results measured by Rapidform2006. 3. Results and Conclusions In repeatability test, standard deviation of results is 0.084-0.450mm. And in straight line measurement error test, the average error 0.0582mm, and the maximum error was 0.28mm. In curved line measurement error test, the average error 0.413mm, and the maximum error was 1.53mm. In conclusion, we assessed that the accuracy and repeatability of Facial Measurement program is considerably good. From now on we complement accuracy of 3D-AFRA in Hardware and Software.

• Proceedings of the Korean Society of Postharvest Science and Technology of Agricultural Products Conference
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• 1994.07a
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• pp.7-8
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• 1994

한국산 표고버섯 균사체를 액체배양하여 천연항암물질로 알려진 단백다당체를 추출한 후 그 물질의 특성에 대하여 검토하였다. 균사체의 최적 재양조건을 TGY배지로 조사한 바 온도 $25^{\circ}C$, 배양초기 pH4.0, 교반속도 300rpm, 균사배지 접종량을 10.0%로 하고 산소 통기량을 1.0volume of ait/volume of medium/mimute으로 하였을때 가장 양호한 조건이였으며, 대량생산 하기 위한 SCM배지에서 최적의 C/N비는 13.1오써 7일간 배양하였을때 18.8g/L의 균사령을 얻었으며, 이때 생산수율은 0.46으로 나타났다. 발효가 끝난 배양액에서 균사, 여액 그리고 배양액의 전체에서 단백다당체를 분리한 결과 각 분획에서 단백다당체가 각각 0.55%, 0.12%, 0.69%가 회수되어 배양액 전체에서 단백다당체를 추출하는 것이 바람직하며, 추출방법으로 열수추출, glass bead추출 및 cellulasa처리를 하여 단백다당체의 수율을 비교한 결과 0.25-0.5mm glass nead로 30분간 균사체를 분쇄한 다음 열수추출을 1시간을 하였을때 990mg/100ml의 단백다당체를 얻을 수 있었다. 고단백다당체를 1차 단백질 가수분해 효소로 분해하고, EDAE cellulose 및 Sepadex G-100 column chromatography로 정제한 후, TLC/FLD, ultracentrifugation한 결과 순수한 물질임을 알 수 있었다. 단백다당체의 항암효과 조사중 in vitro배양에서 $P_{388}$과 $L_{1210}$에 대한 단백다당체의 활성단위 1 unit는 1mg정도였으며, 인체의 장암세포인 HCT-48, HRT-18, HT-29 밀 간암세포인 Hep G2 대한 생육저해 단위는 각각 4.4, 3.6, 6.6, 2.6mg이었다. HCT-48과 Hep G2 세포의 크기 분포도는 대조군에 비하여 시간이 경과함에 따라, 그리고 단백다당체의 농도가 증가함에 따라 peak가 작은 size 쪽으로 이동하였다. 또, 단백다당체를 첨가 배양한 HCT-48과 Hep G2세포의 현미경 관찰에서 본래의 암세포 형태가 변형되고 크기가 감소하며 세포사이의 경계막이 흐트러지면서 세포수가 감소하고 사멸하였다. In vivo실험에서는 대조군보다 단백다당체를 첨가한 군에서 항체 형성능력이 대조군에 비하여 형질세포가 2배로 증가하였다. 단백다당체의 화학적 성분 분석에서 다당함량은 46.1%이면 구성다당류는 glucose, galactose, mannose, xylose로 구성되었고 단백질의 함량은 7.28%이며, 구성아미노산은 15종의 아미노산으로 되었다. 또 무기물은 Na, K, Zn, Ca등의 순으로 이루어 짐을 알 수 있었다.

• Journal of Sasang Constitutional Medicine
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• v.23 no.2
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• pp.240-253
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• 2011

1. Objectives: The purpose of this study was to survey the Original symptoms(素證) of Soyangin's and to compare the tendency of their symptoms between Soyangin Heat-related diarrhea accompanied by headache(身熱頭痛亡陰證) and Soyangin Cold-related diarrhea accompanied by abdominal pain(身寒腹痛亡陰證). 2. Methods: We recruited 56 Soyangin subjects in the Korean Medicine clinic and researched their original symptoms. Subjects were diagnosed by the Sasang Constitutional specialists and Sasang Constitutional Medication. Subjects were two groups, confirmed to Soyangin Heat-related diarrhea accompanied by headache and Soyangin Cold-related diarrhea accompanied by abdominal pain. All subjects answered the questionnaire about their Original symptoms. We found the differences between 2 groups using the Independent-Samples T-test. Analysis was conducted using SPSS 12.0 for Korean. 3. Results and Conclusions: In Original symptoms, Tendency of overeating(p=0.01), Condition of digestion(p=0.04), Perspiration after exercise (p=0.02), Usual perspiration(p=0.00), Tiredness after perspiration(p=0.05) Cold intolerance on extremities(p=0.04), General edema(p=0.01) etc. are different between 2 groups. We found the differences of heat and cold in symptoms between two Soyangin syndromes.

• Journal of Sasang Constitutional Medicine
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• v.20 no.1
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• pp.67-88
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• 2008

1. Objectives The aim of this study was to find out clinical characteristics of atopic dermatitis according to Sasang Constitutions and to help on Sasang Constitutional management and treatment of atopic dermatitis 2. Methods 108patients with atopic dermatitis were involved in the study. The patients had visited C Oriental Clinic from January 2007 to September 2007 and had taken oriental herbal medicine for over one month. They were divided into four groups by Sasang Constitutions and were evaluated the clinical features of atopic dermatitis according to Sasang Constitutions. 3. Results and Conclusions The clinical characteristics for 108 patients with atopic dermatitis was surveyed 1. Soyangin with atopic dermatitis had significantly more Allergic conjunctivitis than other Constitutions, and Taeumin with atopic dermatitis had significantly less Allergic conjunctivitis than other Constitutions. 2. Soyangin with atopic dermatitis had significantly more 'Sleep loss' than other Constitutions. 3. Emotion was significantly more aggravating factor of atopic dermatitis in Soyangin than in other Constitutions. 4. Soeumin with atopic dermatitis had significantly more 'Orbital darkening' than other Constitution. 5. 'Tuna' was significantly more aggravating factor of atopic dermatitis in Soeumin than in other Constitution. The treatment progress for 57 patients with atopic dermatitis was surveyed 6. Soyangin with atopic dermatitis had significantly more improvement than other Constitution and Soeumin with atopic dermatitis had significantly less improvement than other Constitution in Sasang Constitutional Medicine treatment.

• Journal of Sasang Constitutional Medicine
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• v.18 no.3
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• pp.155-165
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• 2006

1. Objectives The purpose of this research is to find out the Constitutional difference of Oxidative stress by Free oxygen radicals. 2. Methods We enrolled 55 patients who visited our hospital for medical examination from February 1, 2006 to May 31, 2006. This research investigated the Constitutional difference of Oxidative stress by Free oxygen radicals. 3. Results and Conclusions l) The Sasang Constitutional distribution of patients have oxidatative stress by Free oxygen radicals was Taeunmin 30%(8persons of total 27persons), Soeumin 56%(9persons of total 16persons), Soyangin 33%(4persons of total 12persons). The rate of patients have oxidatate stress was high in Soeumin. The Sasang Constitution had significance relation with oxidatative stress by Free oxygen radicals. 2) Triglyceride on the average of Taeumin patients have oxidatative stress by Free oxygen radicals is ststistical significantly higher than Triglyceride on the average of controlled normal persons in Taeumin(p-value=0.010) and Soyangin(p-value=0.015). Blood uric acid level on the average of patients have oxidatate stress by Free oxygen radicals is ststistical significantly lower than Blood uric acid level on the average of controlled normal persons in Taeumin(p-value=0.004) and Soyangin(p-value=0.037). This research has shown that there is a statistical significance between the Triglyceride level, Blood uric acid level and oxidatate stress by Free oxygen radicals.