• Journal of Microbiology and Biotechnology
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• 제25권4호
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• pp.496-502
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• 2015

Polyketide secondary metabolites share common precursor pools, acyl-CoA. Thus, the effects of engineering strategies for heterologous and native secondary metabolite production are often determined by the measurement of pikromycin in Streptomyces venezuelae. It is hard to compare the effectiveness of engineering targets among published data owing to the different pikromycin production media used from one study to the other. To determine the most important nutritional factor and establish optimal culture conditions, medium optimization of pikromycin from Streptomyces venezuelae ATCC 15439 was studied with a statistical method, Plackett-Burman design. Nine variables (glucose, sucrose, peptone, (NH₄)₂SO₄, K₂HPO₄, KH₂PO₄, NaCl, MgSO₄·7H₂O, and CaCO₃) were analyzed for their effects on a response, pikromycin. Glucose, K₂HPO₄, and CaCO₃ were determined to be the most significant factors. The path of the steepest ascent and response surface methodology about the three selected components were performed to study interactions among the three factors, and the fine-tune concentrations for maximized product yields. The significant variables and optimal concentrations were 139 g/1 sucrose, 5.29 g/l K₂HPO₄, and 0.081 g/l CaCO₃, with the maximal pikromycin yield of 35.5 mg/l. Increases of the antibiotics production by 1.45-fold, 1.3-fold, and 1.98-fold, compared with unoptimized medium and two other pikromycin production media SCM and SGGP, respectively, were achieved.

• 사상체질의학회지
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• 제21권2호
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• pp.58-71
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• 2009

1. Objectives : The Crown Prince Sohyen(1612-1645) has been believed ro have been poisoned to death because of the political conflict with the King Injo. However, the Crown Prince Sohyen who was So-yangin(SY type) didn't be treated properly at that time. This paper is supposed to explain the reason why he died by reference. 2. Methods : The prescription which was made out to the Crown Prince Sohyen is analyzed, based on the Sasang Constitutional Medicine(SCM) through Shimyang-ilgy and Ulyudongkung-ilgy. 3. Results : 1) In the case of the prescription where So-yang medical stuffs were contained a lot or Gunyak(the main madical stuff) was So-yang one, the Crown Prince Sohyen was better, while that of Tae-eum and So-eum medical stuffs didn't work. Therefore, the Crown Prince Sohyen can be considered So-yangin. 2) The So-yang in's symptom was misunderstood as Hakjil and treated, which could lead him to be put to death 4. Conclusions : The Crown Prince Sohyen is supposed to be Soyang-in(SY type), and accordingly the So-yang in's symptom was misunderstood as Hakjil and treated, which could cause him to pass away.

• 사상체질의학회지
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• 제23권2호
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• pp.230-239
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• 2011

1. Objectives: The purpose of this study was to find out the distributional characteristics of dyspepsia according to Sasang Constitution. 2. Methods: The medical records of 108 subjects who have received prescriptions and diagnosis of Sasang constitution from June 2007 to April 2009 at a Korean Medical clinic in Seoul were reviewed. General factors and the frequency of the prescriptions according to Sasang constitution are compared and analyzed. 3. Results: Among the 108 subjects, 57(52.78%) persons were Soyangin, 27(25.00%) Taeumin, and 24(22.22%) Soeumin. The frequencies of the prescriptions of interior and exterior disease were compared. Exterior disease(89.47%) was higher than interior disease in Soyangin and interior disease was higher than exterior disease in Taeumin(88.89%) and Soeumin(91.67%). (p-value<0.001) The most common disease was Mangeum-syndrome(73.68%) of exterior disease in Soyangin, Dry-febrile symptom(88.89%) of interior disease in Taeumin and Taeum-syndrome(66.66%) of interior disease in Soeumin. 4. Conclusion: There were significant differences on the distribution of dyspepsia in interior or exterior disease according to Sasang Constitution.

• Tribology and Lubricants
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• 제34권3호
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• pp.84-92
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• 2018

Bearings are essential for reducing vibration and wear, in order to achieve high durability and increase longevity. White metal treatment of tilting pads via centrifugal casting method has the possibility of increasing durability. However, this manufacturing method has drawbacks such as long processing time, high defect rate, and harmful health effects. Laser cladding deposition technique is a powerful method that can address these issues by decreasing the processing time and providing good adhesion. In this study, we suggest optimum conditions for laser cladding deposition that can be used in industrial applications. We deposited a soft white metal layer on SCM440 that is primarily used in shafts to minimize wear of bearing pads. During the laser deposition process, we controlled factors such as laser power, powder feed rate, and laser head speed to determine the optimum conditions. In addition, we measured the hardness using micro Vickers, and performed field emission scanning electron microscopy, energy dispersive X-ray spectroscopy, X-ray diffraction, and friction tests to investigate the mechanical properties and surface characteristics for different parameters. Based on the experimental results, we suggest that laser power, powder feed rate, and laser head speed of 1.3 kW, 2.5 rpm, and 10 mm/s, respectively, constitute the optimum conditions for producing white metals using laser cladding.

• 무역학회지
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• 제48권3호
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• pp.1-22
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• 2023

최근 주요국들의 공급망 실사 규제는 공급망 전반에서 발생할 수 있는 인권과 환경적 위험에 대한 실사를 의무화하기 때문에 공급망 ESG라는 통합적 차원에서 접근할 필요가 있다. 이에 본 연구는 국가 신성장동력산업 중 하나인 이차전지 산업의 글로벌 공급망 ESG 전략 수립에 있어 한국 중소기업에 맞춤화된 공급망 ESG 환경평가지표를 제시하고자 한다. 실증 분석은 AHP 방법론을 활용하여 가중치 분석을 실시하였다. 본 연구는 이를 통해 글로벌 이차전지 공급망 ESG 실사에 대비한 환경평가지표의 우선순위를 평가할 수 있었다. 분석 결과, 1위 온실가스 감축, 2위 환경영향평가, 3위 지속 가능한 조달 등의 순으로 가중치 순위를 보여주었다. 이에 본 연구는 다양한 공정이 요구되는 글로벌 이차전지 공급망에서 국내 중소기업이 공급망 내 지속가능성을 확보하기 위해서는 제조공정의 온실가스 감축 및 화학물질에 대한 환경영향평가와 환경 및 사회적 위험을 최소화한 원자재 조달을 가장 최우선으로 고려해야 할 필요성에 대한 함의를 제시할 수 있다.

• 사상체질의학회지
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• 제18권2호
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• pp.34-40
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• 2006

1. Objectives We are going to develope 3D Face Recognition Apparatus to analyse the facial characteristics of the Sasangin. In the process, we should identify the recognition rate of the three dimensional position using this Apparatus. 2. Methods We took a photograph of calibrator($280{\times}400mm$) with interval of 20mm longitudinal direction of 10 times using 3D Face Recognition Apparatus. In the practice, we obtained 967 point to the exclusion of points deviating from the visual field of dual camera. And we made a comparison between measurement values and three dimensional standard values to calculate the errors. 3. Results and Conclusions In this test, the average error rate of X axis values was 0.019% and the maximum error rate of X axis values was 0.033%, the average error rate of Y axis values was 0.025% and the maximum error rate of Y axis values was 0.044%, the average error rate of Z axis values was 0.158% and the maximum error rate of Z axis values was 0.269%. This results exhibit much improvement upon the average error rate 1% and the maximum error rate 2.242% of the existing 3D Recognition Apparatus. In conclusion, we assessed that this apparatus was adaptable to abstract the facial characteristic point from three dimensional face shape in the mechanical aspects.

• 한국재료학회지
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• 제16권11호
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• pp.681-686
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• 2006

Plasma nitrocarburising and plasma post oxidation were performed to improve the wear and corrosion resistance of S45C and SCM440 steel by a plasma ion nitriding system. Plasma nitrocarburizing was conducted for 3h at $570^{\circ}C$ in the nitrogen, hydrogen and methane atmosphere to produce the ${\varepsilon}-Fe_{2-3}$(N, C) phase. Plasma post oxidation was performed on the nitrocarburized samples with various oxygen/hydrogen ratio at constant temperature of $500^{\circ}C$ for 1 hour. The very thin magnetite ($Fe_3O_4$) layer $1-2{\mu}m$ in thickness on top of the $15{\sim}25{\mu}m$ ${\varepsilon}-Fe_{2-3}$(N, C) compound layer was obtained by plasma post oxidation. A salt spray test and electrochemical testing revealed that in the tested 5% NaCl solution, the corrosion characteristics of the nitrocarburized compound layer could be further improved by the application of the superficial magnetite layer. Throttle valve shafts were treated under optimum plasma processing conditions. Accelerated life time test results, using throttle body assembled with shaft treated by plasma nitrocarburising and post oxidation, showed that plasma nitrocarburizing and plasma post oxidation processes could be a viable technology in the very near future which can replace $Cr^{6+}$ plating.

• 사상체질의학회지
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• 제19권1호
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• pp.90-97
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• 2007

1. Objectives and Methods This study was done to investigate the relationships of Sound parameters between Liver Heat Symptom and Esophagus Symptom of Taeumin using PSSC(Phonetic System of Sasang Constitution) in a sentence. Experimental Participants were 20 Korean adult males including, each 10 Liver Heat Symptom and Esophagus Symptom of Taeumin. 2. Results In Pitch segment, APQ segment and Shimmer segment, there were no significant differences between Liver Heat Symptom and Esophagus Symptom of Taeumin. In Octave segment, there were significant differences in Octave 1, Octave 3, Octave 4, Octave 6 of Liver Heat Symptom of Taeumin were significantly high compared with Esophagus Symptom of Taeumin. In Energy segment, FreQ Domain Total Sum / cnt(0), 0k-2k Total Sum,0k-2k sum dev., 2k-4k Total Sum, 2k-4k sum dev., A# Tot E, B__TOT_E, C__TOT_E, C# Tot E, D__TOT_E, A sum dev., A# sum dev., B sum dev., C sum dev., C# sum dev., Dsum dev., D# sum dev., E sum dev., F sum dev., F# sum dev., G sum dev., G# sum dev. of Liver Heat Symptom of Taeumin were significantly high compared with Esophagus Symptom of Taeumin. In Voice Recording time segment, Total Voice Recording Time, Voice Recording Time, Divide By Time3, Divide By Energy10, Total Unit, Max Unit Position, U_0 TO 3 of Liver Heat Symptom of Taeumin were significantly high compared with Esophagus Symptom of Taeumin. 3. Conclusion From above result, there is the postbility of efficiency quide constitutional sx. of Taeumin by Voice characteristics. More Soeumin, Soyangin and Taeyangin Symptoms are needed to determine Sasang Constitution using PSSC and to make PSSC effective.

• 열처리공학회지
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• 제5권4호
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• pp.195-200
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• 1992

SCM 415 has been vacuum carburized in the carburizing pressure of 60-65kpa and the carburizing temperature of 1233k and 1273k after varied to 0-20 in the ratio of $N_2/C_3H_8$ and then diffusion treated for various times at 1123k. The results obtained from the experiment are as follows. 1. With increasing from 0 to 20 in ratio of $N_2/C_3H_8$ the sooting formation of surface after carburizing considerably decreased. 2. The hardness control and surface carbon content of carburizing surface has been modified by the addition of nitrogen to the propan. 3. The appoximate value of k is indirectry calculated at 1123k which results are obtained to $0.58{\times}10^{-2}(wt.%.S^{-1/2})$. 4. A great deal of propan by addition of nitrogen gas in carburizing gas was possible to saving without considerable change in case hardening depth. 5. The effective carburizing depth range is obtained to 0.8-1.1mm by diffusion temperature of 1123k after carburization at 1273k-3.6ks, and the surface hardness is increased as the increasing of $T_D/T_c$ in our experimental condition, and the maximum hardness as reachin distance from surface is decreased.

• 사상체질의학회지
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• 제19권3호
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• pp.176-187
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• 2007

1. Objectives The purpose of this research is to find out the Sasang Constitutional difference in Heart Rate Variability. 2. Methods We enrolled 8498 workers who tested for Heart Rate Variability(HRV) from September 1, 2005 to November 28, 2005 except works whose body constitusions were undetermined according to QSCCII. 3. Results & Conclusions The result of HRV of autonomic activity and stress resistance were arranged in the order of Soeumin, Soyangin and Taeumin. On the other hand Stress Index and Fatigue Index were arranged in the order of Taeumin, Soyangin and Soeumin. But autonomic balance was no significance relationship between Sasang Constitutions. This research has shown that there is a statistical significance between the HRV and Sasang Constitutions. The findings indicated that HRV could be useful mean to make a diagnosis of Sasang Constitution or apprehended Constitutional differences.