• Molecules and Cells
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• v.42 no.12
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• pp.840-849
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• 2019

The spatiotemporal mitotic processes are controlled qualitatively by phosphorylation and qualitatively by ubiquitination. Although the SKP1-CUL1-F-box protein (SCF) complex and the anaphase-promoting complex/cyclosome (APC/C) mainly mediate ubiquitin-dependent proteolysis of mitotic regulators, the E3 ligase for a large portion of mitotic proteins has yet to be identified. Here, we report c-Cbl as an E3 ligase that degrades DDA3, a protein involved in spindle dynamics. Depletion of c-Cbl led to increased DDA3 protein levels, resulting in increased recruitment of Kif2a to the mitotic spindle, a concomitant reduction in spindle formation, and chromosome alignment defects. Furthermore, c-Cbl depletion induced centrosome over-duplication and centriole amplification. Therefore, we concluded that c-Cbl controls spindle dynamics and centriole duplication through its E3 ligase activity against DDA3.

• Proceedings of the KWS Conference
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• 2002.05a
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• pp.178-181
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• 2002

This is a partial report of the investigation of fatigue behaviour of hollow section T-joints with circular brace members and rectangular chord members (CRHS). Hot spot stresses and the stress concentration factors (SCFs) were determined experimentally. Fatigue testing was carried out under constant amplitude loading in air. The experimental SCF values for CRHS joints were found to be below those of circular-to-circular (CCHS) and rectangular-to-rectangular (RRHS) hollow section joints. The fatigue strength referred to experimental hot spot stress was in reasonably good agreement with current fatigue design codes for tubular joints.

• Proceedings of the Safety Management and Science Conference
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• 2013.11a
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• pp.209-219
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• 2013

The research is to evaluate the statistical difference between K-GAAP(Generally Accepted Account Principles) in 2008 year and K-IFRS(International Financial Reporting Standards) in 2012 year. H Motor Company, S Electronics and L Electronics are the three representative firms adopting K-GAAP and K-IFRS in Korea. The ${\chi}^2$ homogeneous test are used to identify the reduction of the number of account items of four financial statements such as Statement of Financial Position(SFP), Statement of Comprehensive Income(SCI), Statement of Cash Flow(SCF), and Statement of Change in Equity(SCE) between K-GAAP and K-IFRS.

• Journal of Ocean Engineering and Technology
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• v.2 no.1
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• pp.106-115
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• 1988

반잠수식 시추선의 설계에 있어서 구조의 피로수명을 정확하게 추정하는 것은 매우 중요하며, 또한 어려운 일이다. 본 논문에서는 이미 실용화된 Aker H-3모델에 대하여 Palmgren-Miner 가정에 의하여 시추선의 hot-point인 수평 및 수직 K-brace 멤버에 대하여 피로수명을 로이드 선급의 커브에 따라 계산한 결과 북해의 해성환경 조건에서는 16년 동안 계속 작업을 할 수 있다는 결론을 얻었으나 응력 집중계수 (SCF)를 선정하는데 불확실성으로 인하여 사용하는데 주위를 요한다.

• Journal of the Korean Society of Safety
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• v.7 no.1
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• pp.13-19
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• 1992

Supercritical fluid technology was applied to the regeneration of industrial catalyst contaminated with toxic materials. The regeneration process of activated loaded with phenol was proposed, then the adsorphon tower was packed with the activated carbon-bed. Phenol diffuses into supercritical carbon dioxide(SCC) through the micro-pore and voldge of the activated carbon. The saturated solubility of phenol in SCC depended on the density of SCC varing with temperature and pressure conditions. Therefore, the fasile phase equilibrium calculation model of dxpanded liquid One was proposed, and equilibrium solubility of phenol in SCC was calculated using the model theoretically. The regeneration mechanism of activated carbon was analysed by degree of saturation of phenol and diffusion in SCC. The solubility prediction was more satisfactory for the wide range of SCC density than the dense gas model and the desorption of phenol depended on the degree of saturation of phenol in SCC.

• Computational Structural Engineering
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• v.10 no.1
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• pp.159-171
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• 1997

This study investigates the stress distribution in a transversely isotropic medium containing a spheroidal cavity where the medium is under uniaxial tension in z-direction in one case and pure shear in the plane of isotropy in another case. The technical approach used in this study combines exact analytical and numerical methods. The exact analytical method is based upon three potential functions taken in terms of the Legendre associated functions of the first and second kind. The numerical method is based upon the finite difference approach. Numerical results concerning the two loading conditions with five anisotropic materials are presented.

• Proceedings of the KWS Conference
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• 2001.10a
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• pp.281-284
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• 2001

Fatigue behaviour of eight different hollow section T-joints was investigated experimentally using scaled steel models. The joints had circular brace members and rectangular chords (CRHS). Hot spot stresses and the stress concentration factors (SCFs) were determined experimentally. Fatigue testing was carried out under constant amplitude loading in air. The experimental SCF values for CRHS joints were found to be between those of circular-to-circular (CCHS) and rectangular-to-rectangular (RRHS) hollow section joints. The fatigue strength referred to experimental hot spot stress was in reasonably good agreement with current fatigue design codes for tubular joints.

• Bulletin of the Korean Chemical Society
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• v.3 no.1
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• pp.30-33
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• 1982

Photochemical and thermal solvolysis of 2,3,4-picolyl chlorides (2,3,4-PC) were studied in amine solvents and the results were correlated with the electronic structures calculated by PPP-SCF-MO CI method. Activation parameters show that the thermal solvolysis of PC is $S_N2$ type rcaction. The rates of thermal reaction in pyridine or t-butylamine solvent decrease in the order of 2-PC > 3-PC > 4-PC. These results are consistent with the predictions based on the electron densities of picolyl chlorides. In photosolvolysis, the same products as those of thermal reactions were obtained. The results indicate that photochemical solvolysis undergoes through heterolytic cleavage. Relative quantum yields of photosolvolysis of 2,3,4-picolyl chlorides in t-butylamine solvent were determined to be 0.73, 1, and 0.50 respectively. These results are in good agreement with the electron densities of the excited triplet state of picolyl chlorides.

• Bulletin of the Korean Chemical Society
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• v.6 no.1
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• pp.3-7
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• 1985

The general formulas for SCF atomic orbitals |5s > and |6p > have been derived separately by expressing the spherical harmonics part in terms of the coordinate($r_1,\;$r_2$) of the reference point, and by translating the exponential part, $r^4\;exp\;(-{\beta}r)$), in terms of $r_1,\;and\;r_2$ and the modified Bessel functions. Master formulas for overlap and dipole moment matrix elements are derived. The computed values of overlap and dipole moment matrix elements for hypothetical NO molecule are exactly in agreement with those for the previous methods.

• Bulletin of the Korean Chemical Society
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• v.12 no.6
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• pp.699-705
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• 1991

Procedures to perform reliable relativistic self-consistent-field (RSCF) calculations are described. Using light atoms and molecules, it is demonstrated that the present method always yields correct nonrelativistic limit by employing a sufficiently large value for the speed of light in RSCF calculations. Many problems associated with analytic expansions of the Dirac equations can be computationally avoided by kinetically balancing the basis sets for large and small component spinors. Results of RSCF calculations for Ne, Kr, $H_2$, and LiH indicate very small relativistic effects for these systems as expected. Trends found is these molecules, however, may be useful in understanding relativistic effects for molecules with similar valence electronic structures and heavier atoms.