• International Journal of Computer Science & Network Security
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• 제24권5호
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• pp.135-155
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• 2024

Urban public health monitoring in smart cities focuses on the control of conditions and health challenges in urban environments. Considering the rapid spread of diseases and pandemics, it is important for health authorities to trace people carrying the virus. In smart cities, this tracing must be interoperable and intelligent, especially in indoor surfaces characterized by small distances between people. Therefore, to fight pandemics, it is necessary to start with the already-existing digital equipment of the Internet of Things, such as connected objects and smartphones. In this study, the developed system is employed to provide a social IoT network and suggest a strategy which allows reliable traceability without threatening the privacy of users. This IoT-based system allows respecting the social distance between persons sharing public services in smart cities without applying smartphone applications or severe confinement. It also permits a return to normal life in case of viral pandemic and ensures the much-desired balance between economy and health. The present study analyses previous proposed social distance systems then, unlike these studies, suggests an intelligent and distributed IoT based strategy for positioning students. Two scenarios of static and dynamic optimization-based placement of Bluetooth Low Energy devices are proposed and an experimental study shows the contribution and complementarity of the introduced contact tracing strategy with the applications on smartphones.

• Korean Journal of Radiology
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• 제20권5호
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• pp.773-780
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• 2019

Objective: To assess segmental liver stiffness (LS) with MRI before and after endovascular intervention in patients with Budd-Chiari syndrome (BCS). Materials and Methods: Twenty-three patients (13 males and 10 females; mean age, 42.6 ± 12.6 years; age range, 31-56 years) with BCS as a primary liver disease were recruited for this study. Two consecutive magnetic resonance elastography (MRE) examinations were performed before the endovascular treatment. Fifteen patients who underwent endovascular intervention treatment also had follow-up MRE scans within three days after the procedure. LS was measured in three liver segments: the right posterior, right anterior, and left medial segments. Inter-reader and inter-exam repeatability were analyzed with intraclass correlation coefficients (ICCs) and Bland-Altman analysis. Segmental LS and clinical characteristics before and after the intervention were also compared. Results: Within three days of the endovascular intervention, all three segmental LS values decreased: LS of the right posterior segment = 7.23 ± 0.88 kPa (before) vs. 4.94 ± 0.84 kPa (after), LS of the right anterior segment = 7.30 ± 1.06 kPa (before) vs. 4.77 ± 0.85 kPa (after), and LS of the left medial segment = 7.22 ± 0.87 kPa (before) vs. 4.87 ± 0.72 kPa (after) (all p = 0.001). There was a significant correlation between LS changes and venous pressure gradient changes before and after treatments (r = 0.651, p = 0.009). The clinical manifestations of all 15 patients significantly improved after therapy. The MRE repeatability was excellent, with insignificant variations (inter-reader, ICC = 0.839-0.943: inter-examination, ICC = 0.765-0.869). Bland-Altman analysis confirmed excellent agreement (limits of agreement, 13.4-19.4%). Conclusion: Segmental LS measured by MRE is a promising repeatable quantitative biomarker for monitoring the treatment response to minimally invasive endovascular intervention in patients with BCS.

• Asian Pacific Journal of Cancer Prevention
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• 제15권9호
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• pp.3997-4003
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• 2014

Background: Infection with certain human papillomavirus (HPV) genotypes is the most important risk factor related with cervical cancer. The objective of the present study was to investigate the prevalence of HPV infection, the distribution of HPV genotypes and HPV E6/E7 oncogene mRNA expression in Turkish women with different cervical cytological findings in Mersin province, Southern Turkey. Materials and Methods: A total of 476 cytological samples belonging to women with normal and abnormal cervical Pap smears were enrolled in the study. For the detection and genotyping assay, a PCR/direct cycle sequencing approach was used. E6/E7 mRNA expression of HPV-16, 18, 31, 33, and 45 was determined by type-specific real-time NASBA assay (NucliSENS EasyQ$^{(R)}$HPV v1.1). Results: Of the 476 samples, 106 (22.3%) were found to be positive for HPV DNA by PCR. The presence of HPV was significantly more common (p<0.001) in HSIL (6/8, 75%) when compared with LSIL (6/14, 42.9%), ASC-US (22/74, 29.7%) and normal cytology (72/380, 18.9%). The most prevalent genotypes were, in descending order of frequency, HPV genotype 66 (22.6%), 16 (20.8%), 6 (14.2%), 31 (11.3%), 53 (5.7%), and 83 (4.7%). HPV E6/E7 oncogene mRNA positivity (12/476, 2.5%) was lower than DNA positivity (38/476, 7.9%). Conclusions: Our data present a wide distribution of HPV genotypes in the analyzed population. HPV genotypes 66, 16, 6, 31, 53 and 83 were the predominant types and most of them were potential carcinogenic types. Because of the differences between HPV E6/E7 mRNA and DNA positivity, further studies are required to test the role of mRNA testing in the triage of women with abnormal cervical cytology or follow up of HPV DNA positive and cytology negative. These epidemiological data will be important to determine the future impact of vaccination on HPV infected women in our region.

• 한국지반신소재학회논문집
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• 제16권3호
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• pp.1-10
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• 2017

최근 발생하고 있는 자연재해 중 산사태와 관련된 재해는 막대한 인명과 재산피해를 발생시키고 있다. 지속적으로 발생하고 있는 산사태로 인한 피해를 최소화하기 위해서는 계측, 모니터링 시스템 등 관련 기술에 대한 과학적 관리체계가 필요하다. 본 연구는 사면붕괴 예측을 통한 산사태 피해저감을 위한 관리체계 확립을 목적으로 하고 있다. 이를 위해 산사태 발생시 지반거동을 예측하기 위한 표층지반변형률 봉을 제작하고, 사면 붕괴전조로서 변형률 증가를 관측하였다. 그 결과, 사면 붕괴시 지반의 변형은 붕괴 전조 구간, 변형 가속 구간, 변형 급가속 구간을 거친 후 붕괴에 이르는 것으로 나타나, 붕괴 전조 예측과 상관관계가 있는 것으로 판단된다. 모든 조건에서 사면붕괴 전조로서 시간에 따른 변위량의 증가가 공통적으로 관측되었으며, 이는 붕괴위험 사면의 계측 및 유지관리 관점에서 대단히 중요한 현상으로 판단된다. 산사태 발생에 따른 지반변위는 향후 지속적 연구를 통해 사면붕괴예측 및 계측관리기준의 기초자료로 활용될 수 있을 것으로 사료되며, 산사태 피해저감 및 계측산업 활성화에 기여할 수 있을 것으로 판단된다.

• 한국지반신소재학회논문집
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• 제16권3호
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• pp.21-30
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• 2017

노후저수지 제체 보강을 목적으로 시멘트 그라우팅공법이 일반적으로 적용되고 있으나, 주입재의 재료적 한계로 인해 여러 문제점이 제기되어 왔다. 이를 극복하기 위하여 국내에서도 다양한 그라우트 재료들을 개발하고 현장에 적용하고 있으나 실제 현장에서 침투주입시 원지반 교란으로 인한 문제가 야기되는 경우가 많다. 본 연구에서는 이와 같은 문제점을 개선하기 위하여 원지반에의 이상적인 침투주입이 가능하도록 고분말, 고점도의 특성을 가지며 실트질 모래층까지 침투주입을 확장시키고 복합조건의 지반에서도 적용할 수 있는 하이브리드형 그라우트재의 물리적 특성을 분석하였으며, 최적의 팽창제를 선정하여 그라우트재와 혼합한 후 부피팽창에 따른 압력과 다짐효과를 검토하여 실효성을 검증하고자 하였다. 팽창율, 일축압축강도, 팽창압력 및 다짐효과확인시험 결과, HI-E(2%) 시료는 팽창제에 의한 개선효과가 탁월한 것으로 나타나 이를 혼합한 하이브리드형 그라우트재는 노후저수지, 방조제 등의 차수 및 보강공법에 효과적으로 적용이 가능할 것으로 판단된다.

• Asian Pacific Journal of Cancer Prevention
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• 제16권17호
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• pp.7485-7489
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• 2015

Background: Breast cancer is the most common type of cancer in women throughout the world. However, in comparison with Western women, it presents relatively early in women of Asian ethnicity. Early menarche, late menopause, use of OCP's, family history of benign or malignant breast disease, exposure to radiation and BMI in the under-weight range are well known risk factors for the development of breast cancer in premenopausal women. Early detection with the use of breast self-examination (BSE) and breast cancer screening programs can lead to a reduction in the mortality rates due to breast cancer. The aim of our study was to assess the risk factors for breast cancer among young women and to emphasize the importance of early screening among them. Materials and Methods: We conducted a cross-sectional study among women aged 18 to 25 using a self-administered questionnaire. Data was collected over a period of 6 months from June to December, 2014. A total of 300 young women selected randomly from Dow Medical College and various departments of Karachi University successfully completed the survey. Results: Respondents were 18-25 years of age (mean age=21.5). Out of the 300 young females, 90 (30%) had at least one risk factor, 90 (30%) had two, 40 (13%) had three, 8 (2.7%) had four, 2 (0.7%) had five while one female was found to have six positive risk factors for breast cancer. Some 66 women (22%) experienced symptoms of breast cancer such as non-cyclical pain and lumps. While 222 women (74%) had never performed breast self-examination, 22 (7.3%) had had a breast examination done by a health professional while 32 (10.7%) had participated in breast screening programs. A total of 223 (74.3%) women considered breast cancer screening important for young women. Conclusions: The percentage of young women with risk factors for breast cancer was found to be alarmingly high. Therefore, screening for breast cancer should start at an early age especially in high risk groups. Awareness about breast self-examination should be emphasized. Moreover, screening programs should be started to ensure early detection and reduction of mortality rates caused by breast cancer also in young Pakistani females.

• 한국건축시공학회지
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• 제18권5호
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• pp.447-453
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• 2018

인공투수관을 혼입한 폴리머 투수블록은 폴리머를 치환할 경우 강도, 공극률, 투수계수 등의 'KS F 4419'(보차도용 콘크리트 인터록킹 블록)의 기준보다 높은 결과 값이 측정되었으며, 제품의 경량화가 가능할 것으로 판단된다. 폴리머 재료의 단가 문제로 인해 경제성을 고려하여 시멘트와의 치환율을 14%로 선정하는 것이 효과적이라고 판단된다. 또한, 인공투수관의 혼입율의 3가지 수준 중 2.0%가 가장 적당하다고 판단되며, 3가지 수준에 대한 측정 값이 큰 차이를 보이지 않는 것으로 나타났다. 공극률과 투수계수의 경우 2%에서 개선된 값이 측정되었기 때문에 인공투수관 혼입율 2%의가 효과적일 것으로 판단된다. 투수블록 제품화를 하기 위해선 경제성을 고려해야 하며, 본 연구에서 사용된 폴리머 VAE 경제성이 떨어지기 때문에 다른 폴리머의 재료와 비교 실험을 진행하여 문제점을 개선 한다면 투수블록 제품화가 가능할 것이라 판단된다. 본 연구의 결과는 추후 폴리머 및 인공투수관을 활용한 연구의 기초적인 자료로 사용 가능 할 경우 효율적인 데이터로 활용이 가능할 것으로 판단된다.

• 생태와환경
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• 제48권1호
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• pp.38-50
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• 2015

서부 DMZ 인접지역의 담수어류 출현양상을 밝히기 위하여 2014년 조사를 실시하였다. 조사기간 동안 채집된 어류는 14과 61종이었고, 우점종은 피라미 (Zacco platypus, 상대풍부도 20.3%), 아우점종은 참갈겨니 (Z. koreanus, 12.6%)였고, 그 밖에 밀어 (Rhinogobius brunneus, 9.2%), 돌고기 (Pungtungia herzi, 4%), 줄납자루 (Acheilognathus yamatsutae, 4.4%), 모래무지 (Pseudogobio esocinus, 4.0%) 등의 순으로 우세하게 출현하였다. 출현종 중 고유종은 25종(40.1%)이었고, 외래어종은 떡붕어 (Carassius cuvieri) 1종이었다. 천연기념물은 어름치 (Hemibarbus mylodon) 1종이었고, 멸종위기야생생물은 I급의 흰수마자 (Gobiobotia naktongensis)와 II급의 다묵장어 (Lethenteron reissneri), 묵납자루 (A. signifer), 가는돌고기 (Pseudopungtungia tenuicorpa), 돌상어 (G. brevibarba), 꾸구리 (G. macrocephala) 6종이었으며, 회유성 어종은 뱀장어 (Anguilla japonica, 강하성)와 은어 (Plecoglossus altivelis, 양측회유성) 2종이 채집되었다. 조사지역 중 사미천 하류부(St. 5, 6)와 군남댐 인근(St. 11, 14)은 서식지가 다양하고 인위적 교란이 적어 33~42종의 많은 종이 서식하고 있었는데, 특히 천연기념물 1종과 멸종위기야생생물 3~5종이 집단으로 서식하고 있어 보전가치가 매우 높았다.

• The Korean Journal of Physiology and Pharmacology
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• 제26권4호
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• pp.263-275
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• 2022

There is a paucity of detailed data related to the effect of senescence on the mitochondrial antioxidant capacity and redox state of senescent human cells. Activities of TCA cycle enzymes, respiratory chain complexes, hydrogen peroxide (H₂O₂), superoxide anions (SA), lipid peroxides (LPO), protein carbonyl content (PCC), thioredoxin reductase 2 (TrxR2), superoxide dismutase 2 (SOD2), glutathione peroxidase 1 (GPx1), glutathione reductase (GR), reduced glutathione (GSH), and oxidized glutathione (GSSG), along with levels of nicotinamide cofactors and ATP content were measured in young and senescent human foreskin fibroblasts. Primary and senescent cultures were biochemically identified by monitoring the augmented cellular activities of key glycolytic enzymes including phosphofructokinase, lactate dehydrogenase, and glycogen phosphorylase, and accumulation of H₂O₂, SA, LPO, PCC, and GSSG. Citrate synthase, aconitase, α-ketoglutarate dehydrogenase, succinate dehydrogenase, malate dehydrogenase, isocitrate dehydrogenase, and complex I-III, II-III, and IV activities were significantly diminished in P25 and P35 cells compared to P5 cells. This was accompanied by significant accumulation of mitochondrial H₂O₂, SA, LPO, and PCC, along with increased transcriptional and enzymatic activities of TrxR2, SOD2, GPx1, and GR. Notably, the GSH/GSSG ratio was significantly reduced whereas NAD⁺/NADH and NADP⁺/NADPH ratios were significantly elevated. Metabolic exhaustion was also evident in senescent cells underscored by the severely diminished ATP/ADP ratio. Profound oxidative stress may contribute, at least in part, to senescence pointing at a potential protective role of antioxidants in aging-associated disease.