Korean Journal of Radiology

The Korean Society of Radiology (대한영상의학회)
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Segmental Liver Stiffness Evaluated with Magnetic Resonance Elastography Is Responsive to Endovascular Intervention in Patients with Budd-Chiari Syndrome

  • Peng Xu (Department of Radiology, Affiliated Hospital of Xuzhou Medical University) ;
  • Lulu Lyu (Department of CT and MRI, Xuzhou Central Hospital) ;
  • HaitaoGe (Department of Radiology, Affiliated Hospital of Xuzhou Medical University) ;
  • Muhammad Umair Sami (Department of Radiology, Affiliated Hospital of Xuzhou Medical University) ;
  • Panpan Liu (Department of Radiology, Affiliated Hospital of Xuzhou Medical University) ;
  • Chunfeng Hu (Department of Radiology, Affiliated Hospital of Xuzhou Medical University) ;
  • Kai Xu (Department of Radiology, Affiliated Hospital of Xuzhou Medical University)
  • Received : 2018.11.09
  • Accepted : 2019.01.18
  • Published : 2019.05.01
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Abstract

Objective: To assess segmental liver stiffness (LS) with MRI before and after endovascular intervention in patients with Budd-Chiari syndrome (BCS). Materials and Methods: Twenty-three patients (13 males and 10 females; mean age, 42.6 ± 12.6 years; age range, 31-56 years) with BCS as a primary liver disease were recruited for this study. Two consecutive magnetic resonance elastography (MRE) examinations were performed before the endovascular treatment. Fifteen patients who underwent endovascular intervention treatment also had follow-up MRE scans within three days after the procedure. LS was measured in three liver segments: the right posterior, right anterior, and left medial segments. Inter-reader and inter-exam repeatability were analyzed with intraclass correlation coefficients (ICCs) and Bland-Altman analysis. Segmental LS and clinical characteristics before and after the intervention were also compared. Results: Within three days of the endovascular intervention, all three segmental LS values decreased: LS of the right posterior segment = 7.23 ± 0.88 kPa (before) vs. 4.94 ± 0.84 kPa (after), LS of the right anterior segment = 7.30 ± 1.06 kPa (before) vs. 4.77 ± 0.85 kPa (after), and LS of the left medial segment = 7.22 ± 0.87 kPa (before) vs. 4.87 ± 0.72 kPa (after) (all p = 0.001). There was a significant correlation between LS changes and venous pressure gradient changes before and after treatments (r = 0.651, p = 0.009). The clinical manifestations of all 15 patients significantly improved after therapy. The MRE repeatability was excellent, with insignificant variations (inter-reader, ICC = 0.839-0.943: inter-examination, ICC = 0.765-0.869). Bland-Altman analysis confirmed excellent agreement (limits of agreement, 13.4-19.4%). Conclusion: Segmental LS measured by MRE is a promising repeatable quantitative biomarker for monitoring the treatment response to minimally invasive endovascular intervention in patients with BCS.

Keywords

Acknowledgement

Authors gratitude to Mr. Weiqiang Dou (GE Healthcare, MR Research China) for optimization of MRI scanning parameters.

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