• Pediatric Infection and Vaccine
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• v.26 no.1
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• pp.11-21
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• 2019

Purpose: We aimed to investigate the epidemiological characteristics of Staphylococcus aureus bacteremia in Korean children. Methods: We retrospectively collected and analyzed data from the medical records of the patients with S. aureus bacteremia ${\leq}18years$ of age in Gil Medical Center from 2002 to 2016. Results: A total of 212 SAB cases were detected. The annual incidence of SAB from 2002 to 2016 ranged from 0.77 to 1.95 per 1,000 patients hospitalized. The neonate group (<28 days of age) and the pediatric group (28-18 years of age) were 51.4% (n=109) and 48.6% (n=103), respectively. According to the origin of infection, there were 93 cases (43.9%) of community-associated (CA)-SAB and 119 cases (56.1%) of healthcare-associated (HA)-SAB. The rates of HA-SAB among the neonate group and among the pediatric group were 64.2% and 47.6%, respectively (P=0.015). There was no difference in complications between CA-SAB and HA-SAB, but mortality was higher in HA-SAB. The proportion of methicillin-resistance S. aureus (MRSA) was the highest in neonates (88.1%), decreased with age, and was 36.4%-37.5% among children aged ${\geq}5years$. The MRSA proportion was 72.2%, showing no consistent trend over the period. Conclusions: The annual incidence of SAB and the proportion of MRSA in SAB remained constant in the recent 15 years in children. Judicious decision of antimicrobial agents for treatment considering the patient's age and the origin of infection is necessary.

• Journal of Korean Society of Transportation
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• v.18 no.6
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• pp.89-99
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• 2000

To cope with the limits of conventional O-D trip matrix collecting methods, several approaches have been developed. One of them is bilevel Programming method Proposed by Yang(1995), which uses Sensitivity Analysis Based(SAB) algorithm to solve Generalized Least Square(GLS) problem. However, the SAB a1gorithm has revealed two critical short-comings. The first is that when there exists a significant difference between target O-D matrix and true O-D matrix, SAB algorithm may not produce correct solution. This stems from the heavy dependance on the historical O-D information, in special when gravel Patterns are dramatically changed. The second is the assumption of iterative linear approximation to original Problem. Because of the approximation, SAB algorithm has difficulty in converging to Perfect Stackelberg game condition. So as to avoid the Problems. we need a more robust and stable solution method. The main purpose of this Paper is to show the problem of the dependency of Previous models and to Propose an alternative solution method to handle it. The Problem of O-D matrix estimation is intrinsically nonlinear and nonconvex. thus it has multiple solutions. Therefore it is necessary to require a method for searching globa1 solution. In this paper, we develop a solution algorithm combined with genetic algorithm(GA) , which is widely used as probabilistic global searching method To compare the efficiency of the algorithm, SAB algorithm suggested by Yang et al. (1992,1995) is used. From the results of numerical example, the Proposed algorithm is superior to SAB algorithm irrespective of travel patterns.

• Korean Journal of Environment and Ecology
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• v.29 no.3
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• pp.421-430
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• 2015

This study was carried out to understand the ecological variations of macrobenthos communities by construction dikes in the subtidal zone of Chonsu Bay. This study analyzed the distribution of benthos, the dominant species, spatial and temporal changes of benthos communities and benthic pollutions in the subtidal zone of Chonsu Bay. A total of 252 species of subtidal macrobenthos with a density of $681ind./m^2$ were studied. In all the seasons, the species diversity was found to be higher near the mouth of the bay. For all the seasons of the year, Lumbrineris japonica was found to be the most dominant species. These dominant species were found to have positive correlations with species diversity and sedimentary parameters such as organic content in sediments. Dominant species of benthos as well as species composition and diversity showed spatial and temporal distribution patterns.Benthic Pollution Index (BPI) values estimated for the stations near the embankment were in the 4~5 levels, which indicates that the organic matter has been polluted. And as for the stations near the mouth of the bay, the BPI values were in the 1~3 levels, which indicates that the organic matter has been relatively less polluted. According to the SAB-curve analysis, the number of transitional point stations became less in the mouth of the bay.

• Korean Journal of Microbiology
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• v.35 no.1
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• pp.13-17
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• 1999

Shigella sonnez is important causes of human enleric infcctions. S. sonnei KNIH104S was isolated from patient of shigellosis in Korea and previously reported. We cloned 1.7 kb BamHI fragment containing the asd gene encoding an aspartate $\beta$-semialdehyde dehydrogenase from chromosomal DNA of S. sonnei KNIH104S. This recombinant plasmid was named as pSAB17. E. coli $\chi$6097, an a d mutant, cannol grow on the LB medium without DL-$\alpha$, $\varepsilon$-diaminopimclic acid (50 pgiml) but E. coli x 6097(pSAB17) can grow on the same medium. We sequenccd the asd gene ol Shigella for the first time. The asd gcne was composed of 1,104 base pairs with ATG initiation codon and TAA termination codon. Sequence comparison of the asd gene exhibited 99.9% nucleolide sequence hornology with that of E. coli. Also, We constructed the balanced-lethal vector using pBluescrip SK(+) and asd gene of S. sonnei KNIH104S.

• Applied Chemistry for Engineering
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• v.28 no.4
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• pp.460-466
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• 2017

The common petroleum can make precipitation such as a wax in a polar region due to severely cold weather condition, which can cause problems to fuel supply system. The petroleum product used in the polar region has thus been manufactured and sold suitable for the cold environment. However it is difficult to supply such petroleum products on time since these were mainly supplied abroad. In this article, the original fuel properties were first analyzed in order to find alternative fuel products for polar region. Jet fuel which is excellent cold characteristics was chosen and the fuel properties was tested by adding a constant concentration of lubricant additives to the jet fuel. As a result, the lubricant additive R621 showed the best lubricity, and adding 1000 mg/L of R621 content to the jet fuel was sufficient to enhance the lubricity. We envision that the jet fuel added 1000 mg/L of R621A can be suitable for alternative special antarctic blend diesel (SAB) in an severe polar environment.

• Korean Journal of Fisheries and Aquatic Sciences
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• v.30 no.5
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• pp.771-781
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• 1997

In order to select an effective and appropriate evaluation method for the marine environmental protection and management, it is necessary to evaluate the present status of environmental conditions and to monitor and regulate the harzadous waste continuously. Among the evaluation methods that use benthic fauna, some graphical methods and biological index methods such as species abundance-biomass (SAB), Rank-frequency diagram (RFD), Abundance-Biomass comparison (ABC), log-normal distribution (LND), and Benthic Pollution Index (BPI) modified by Infaunal Trophic Index were used for the assessments of marine environment in the Inchon coastal area. Even though the graphic methods are convenient for easy glimpse of general trend of environmental condition but because they require sufficient ecological data, those methods do not fit for analysis or comparison of regional and detailed environmental condition. On the other hand, when BPI was applied, it was able to compare the spatial benthic conditions. Through considering the functional aspects of benthic fauna which can not be obtained in the cluster analysis, BPI was made it possible to measure or trace down the source of pollution. In the case of the environmental assessment result analyzed in Inchon coastal area, the north eastern part of Yongjongdo was more influenced by the pollution than the outer area of Inchon. The research indicates that especially Inchon harbor has been greatly affected.

• Journal of Genetic Medicine
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• v.8 no.1
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• pp.44-52
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• 2011

Purpose: Cytogenetic analysis of spontaneous abortions (SABs) provides valuable information to establish the causes of fetal loss, information that is essential to provide accurate reproductive and genetic counseling couples. Such analysis also provides information on the frequencies and types of chromosomal abnormalities and associated risks of recurrence. However, there have only been a few reports of chromosomal abnormalities in small samples of SABs in the Korean population. Here, we report the incidence and spectrum of chromosomal abnormalities for cases of 470 SAB in Korea. Material and Methods: Between 2005 and 2010, a total of 470 products of conception (POC) resulting from SABs were submitted to our laboratory for cytogenetic analysis from various medical sites in Korea. The incidences and types of specific chromosomal abnormalities were determined. The abnormalities were distinguished by gestational age at the time of SAB and by maternal age. Results: The frequency of chromosomal abnormalities in POCs was 54.3% (255/470), including 228 (89.3%) numerical and 27 (10.7%: 3 balanced and 24 unbalanced) structural abnormalities. Among the numerical abnormalities, trisomy was predominant (67.0%), followed by monosomy X (12.5%), polyploidy (8.2%), triple X (0.8%), and autosomal monosomy (0.8%). The overall sex ratio (male: female) among the 470 POCs with normal and abnormal karyotypes were 0.58 and 0.65, respectively. Trisomies were identified for each autosome, with the exceptions of 1, 3, and 19. Among the 171 autosomal trisomies, trisomy 16 was the most common (19.9%), followed by trisomy 22 (13.5%), trisomy 21 (12.3 %), trisomy 15 (9.9%), and trisomies 18 and 13 (5.3%). The frequency of chromosomal abnormalities decreased with gestational age and increased with maternal age, but only because of increases in trisomies and complex abnormalities. Conclusions: We have presented a large collection of cytogenetic data for SABs collected during the past 6 years and provided a database for prenatal genetic counseling of parents who have experienced SABs in Korea.

• Proceedings of the KOR-KST Conference
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• 2002.02a
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• pp.17-42
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• 2002

전통적인 OD조사에 의한 OD추정의 여러 문제점들로 인해 링크관측교통량과 기존OD를 결합해 OD를 추정하고자 하는 연구들이 제시되고 있다. Yang(1995)은 일반화최소자승법을 풀기 위한 IEA와 SAB 알고리즘을 제시하였다. 그러나 두 알고리즘의 문제점은 첫째 실제 OD를 알기가 어렵기 때문에 기존 OD를 중요한 추정기준으로 설정한다는 것으로, 이러한 추정의 종속성으로 인해, 기존 OD와 실제 OD의 차이가 큰 경우 정확한 해를 도출하지 못한다. 두 번째 문제는 통행패턴 추정시 선형근사화를 가정하기 때문에 게임이론적 측면에서 전제로 설정한 완전한 Stackelberg 상황을 구현하지 못한다는 것이다. 이러한 문제점을 피하기 위해서는 기존 OD나 관측교통량의 오차에 일관적인 해도출 기법이 필요하다. OD추정 문제는 본질적으로 비선형이고 비볼록하여 전역해 탐색기법이 필요하기 때문에 전역최적화가 가능한 유전알고리즘을 이용한 OD추정모형(GAM)을 개발하였다. 사례네트워크 분석결과, GAM은 기존 OD의 오차에 대해 크게 종속적이지 않으며 OD구조가 변하는 경우에도 추정이 가능하여, 일반적으로 실제 OD를 알 수 없는(기존OD의 오차가 어느 정도인지를 알 수 없는) 도시부 네트워크에서 신뢰성있는 추정력을 보였다. 또한 기존 OD 추정모형은 비교적 용이하게 차종별로 관측할 수 있는 링크교통량을 차종구분 없이 단일차종으로 이용함으로써, 정보의 손실을 초래하여 결과적으로 모형의 추정력을 저하시켰다. 그렇지만 다차종 링크관측교통량으로부터 다차종 OD 추정연구는 거의 없었으며, 그 결과가 단일차종에 대한 추정결과와 어떻게 다른지에 대한 연구도 전무하였다. 본 연구에서는 유전알고리즘을 이용한 OD 추정모형을 다수단 OD 추정모형(GAMUC)으로 확대하였다. 사례 분석 결과 단일차종 OD추정기법은 심각한 추정오류를 범할 수 있으며, 그 적용성도 낮다는 것을 보였다. 다차종 OD 추정기법이 단일차종 OD 추정기법보다 양호한 추정력을 보였으며, 다차종 기법 중에서는 GAMUC가 IEAMUC보다 우수한 추정력을 보였다.

• Journal of Food Hygiene and Safety
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• v.26 no.3
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• pp.198-202
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• 2011

Rice has been the most important staple food in everyday meals of Korean people for thousands of years. Nowadays, it is getting increasingly used as flour ingredients in a variety of processed foods, so that it is consumed in more diversified ways. As a consequence, production volume of rice flour to manufacture rice cakes, noodles, breads, or confectioneries is recently getting increased in Korea. But there are not sufficient research outcomes to guarantee Korean consumers microbiological qualities of rice flour as well as rice. As a preliminary experiment, therefore, the microbiological profiles (aerobic mesophilic bacteria (AMB), spore-forming aerobic bacteria (SAB), lactic acid bacteria (LAB), yeasts and molds (YM), and Escherichia coli and coliforms) have been monitored for nine retailed white rice samples in this study. AMB counts ranged $10^2-10^6$ CFU/g for all the nine white rice samples. All the nine rice samples have SAB counts within a narrow range $(1.0{\times}10^2-2.5{\times}10^3$ CFU/g). LAB was detected in two white rice samples ($4.0{\times}10^2$ and $3.7{\times}10^3$ CFU/g), YM was detected in one white rice sample ($2.0{\times}10^2$ CFU/g) only. E. coli was not detected from all the nine samples. Coliforms were detected in one white rice sample ($4.1{\times}10$ CFU/g) only. All the rice samples were conclusively considered to have various microorganisms, though most of them are harmless and some, such as coliforms, may be harmful.

• The Journal of Korean Obstetrics and Gynecology
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• v.27 no.1
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• pp.120-139
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• 2014

Objectives: The tendency of experimental studies on the male infertility was analyzed through focusing on domestic theses for a degree to indicate the hereafter direction for its study in oriental herbal medicine. Methods: 35 domestic theses for a degree published after 2003 were analyzed. And theses were classified by year, study design, degree and subjects. Results: The followings are the results of this study. 1. 35 theses were reviewed. 11 master dissertations and 24 doctorate dissertations 2. In the annual publishing tendency, the number of theses began to increase from 2003 and the theses have been published actively from 2005. 3. Classified by study design, 19 in vitro & in vivo and 16 in vitro experimental studies were performed. 4. In the medication and prescription, the studies with single medication were 32, and prescription were 3. In the studies with single medication, four studies on Ginseng Radix (人蔘) were the most. 5. In theses related to single medication, BoYang-Yak was most prefered, followed BoYeum-Yak, BoKi-Yak, SabJung-ChukNyo-JiDae-Yak. 6. Analysed 35 theses by subject, concentrational experiments were 23, periodical experiment were 3, concentrational & periodical experiment was 1. 7. In theses related to herb medication, the themes were Body & testicular weight, sperm parameters, testosterone level, CREM mRNA level & CREM protein, seminiferous tubule and antioxidant activity. 8. Related to herb medication's antioxidant activity efficacy were 7 theses. Conclusions: If there are more diverse studies on medication, prescription, external treatment methods and experiment methods in the future, this will be very helpful for the clinical treatment of male infertility.