Incidence and Spectrum of Chromosomal Abnormalities associated with Spontaneous Abortions in Korea: 470 Products of Conception over a Period of 6 Years (2005-2010)
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Han, Sung-Hee
(Division of Cytogenetics, Department of Laboratory Medicine, Seoul Clinical Laboratories)
An, Jeong-Wook (Division of Cytogenetics, Department of Laboratory Medicine, Seoul Clinical Laboratories) Yang, Young-Ho (Division of Cytogenetics, Department of Laboratory Medicine, Seoul Clinical Laboratories) Kim, Young-Jin (Division of Cytogenetics, Department of Laboratory Medicine, Seoul Clinical Laboratories) Cho, Han-Ik (Division of Cytogenetics, Department of Laboratory Medicine, Seoul Clinical Laboratories) Lee, Kyoung-Ryul (Division of Cytogenetics, Department of Laboratory Medicine, Seoul Clinical Laboratories) |
1 | Nagaishi M, Yamamoto T, Iinuma K, Shimomura K, Berend SA, Knops J. Chromosome abnormalities identified in 347 spontaneous abortions collected in Japan. J Obstet Gynaecol Res 2004;30:237-41. DOI ScienceOn |
2 | Kajii T, Ferrier A, Niikawa N, Takahara H, Ohama K, Avirachan S. Anatomic and chromosomal anomalies in 639 spontaneous abortuses. Hum Genet 1980;55:87-98. DOI ScienceOn |
3 | Hassold T, Chen N, Funkhouser J, Jooss T, Manuel B, Matsuura J, et al. A cytogenetic study of 1000 spontaneous abortions. Ann Hum Genet 1980;44:151-78. DOI ScienceOn |
4 | Hassold T, Abruzzo M, Adkins K, Griffin D, Merrill M, Millie E, et al. Human aneuploidy: incidence, origin, and etiology. Environ Mol Mutagen 1996;28:167-75. DOI ScienceOn |
5 | Warburton D, Kinney A. Chromosomal differences in susceptibility to meiotic aneuploidy. Environ Mol Mutagen 1996;28:237-47. DOI ScienceOn |
6 | Kalousek DK, Bamforth S. Amnion rupture sequence in previable fetuses. Am J Med Genet 1988;31:63-73. DOI ScienceOn |
7 | Gardner RJM, Sutherland GR. Chromosome abnormalities and genetic counseling. 3rd ed. New York: Oxford University Press, 2004:59-97. |
8 | Robinson WP, McFadden DE, Stephenson MD. The origin of abnormalities in recurrent aneuploidy/polyploidy. Am J Hum Genet 2001;69:1245-54. DOI ScienceOn |
9 | Hassold T, Hunt P. To err (meiotically) is human: the genesis of human aneuploidy. Nat Rev Genet 2001;2:280-91. DOI ScienceOn |
10 | Wells D, Levy B. Cytogenetics in reproductive medicine: the contribution of comparative genomic hybridization (CGH). Bioessays 2003;25:289-300. DOI ScienceOn |
11 | Eiben B, Bartels I, Bahr-Porsch S, Borgmann S, Gatz G, Gellert G, et al. Cytogenetic analysis of 750 spontaneous abortions with the direct-preparation method of chorionic villi and its implications for studying genetic causes of pregnancy wastage. Am J Hum Genet 1990;47:656-63. |
12 | Simoni G, Brambati B, Danesino C, Rossella F, Terzoli GL, Ferrari M, et al. Efficient direct chromosome analyses and enzyme determinations from chorionic villi samples in the first trimester of pregnancy. Hum Genet 1983;63:349-57. DOI ScienceOn |
13 | Lee YB, Kang KI, An KJ, Lee SJ, Jeon JS. Chromosome analyses from chorionic villi samples in early pregnancy wastages. Kor J Perinatol 1988;31:879-88. |
14 | Yang YH, Park YW, Lee MS, Park CK. Chromosome analysis of chorionic villi biopsy in the first trimester prenatal diagnosis. Kor J Obstet Gynecol 1985;28:460-7. |
15 | Choi SK, Park SY, Hwang JH, Ryu HM, Jun JY. Cytogenetic studies from chorionic villi of 573 spontanous abortion. Kor J Obstet Gynecol 1995;38:2271-7. |
16 | Kim KY, Yun DJ, Yang JS, Hahn S. Cytogenetic analysis of conceptus material of Korean women at first trimester. Yonsei Med J 1979;20:113-26. DOI |
17 | Jin SJ, Seo SS, Kim KS, Kim NK, Kim JD. A cytogenetic study of abortuses with recurrent spontaneous abortion. Kor J Perinatol 1994;37:2328-34. |
18 | Yoo TW, Hwang JH, Park MI, Chung SR, Hwang YY, Shin SH, at al. Chromosome analysis from chorionic villi samples in recurrent spontaneous abortion. Kor J Perinatol 1997;18:408-13. |
19 | Choi YY, Kim HM, Son YS, Kim JI. Chromosomal analysis of abortus chorionic villi in missed abortion. Kor J Obstet Gynecol 1998;41:2097-101. |
20 | Ko HS, Kim YH, Ahn HY, Park IY, Lee Y, Kim SJ, et al. Cytogenetic analysis in spontaneous abortion. Kor J Perinatol 2005;8-14. |
21 | Hwang SM, Kwon KH, Yoon KA, Oh SK. A cytogenetic analysis of abortus with spontaneous abortion. J Genet Med 2009:6;62-6. |
22 | Jamieson ME, Coutts JRT, Connor JM. The chromosome constiturtion of human preimplantation embryos fertilized in vitro. Hum Reprod 1994;9:709-15. DOI |
23 | Sanchez JM, Franzi L, Collia F, De Diaz SL, Panal M, Dubner M. Cytogenetic study of spontaneous abortions by transabdominal villus sampling and direct analysis of villi. Prenat Diagn 1999;19:601-3. DOI ScienceOn |
24 | Rock JA, Zacur HA. The clinical management of repeated early pregnancy wastage. Fertil Steril 1983;39:123-40. DOI |
25 | Kim JS, Choung TB, Park JW, Kim JR, Kang JB, Kim HB, et al. Cytogenetic study of abortuses with spontaneous abortion. Kor J Obstet Gynecol 1999;42:1408-15. |
26 | Harlap S, Shiono PH. Alcohol, smoking, and incidence of spontaneous abortions in the first and second trimester. Lancet 1980;2:173-6. |
27 | Pezeshki K, Feldman J, Stein DE, Lobel SM, Grazi RV. Bleeding and spontaneous abortion after therapy for infertility. Fertil Steril 2000;74:504-8. DOI ScienceOn |
28 | Simpson JL. Genes, chromosomes, and reproductive failure. Fertil Steril 1980;33:107-16. DOI |
29 | De la Chapelle A, Schro der J, Kokkonen J. Cytogenetics of recurrent abortion or unsuccessful pregnancy. Int J Fertil 1973;18:215-9. |
30 | Hassold TJ, Jacobs PA. Trisomy in man. Annu Rev Genet 1984;18:69-97. DOI ScienceOn |
31 | Morton NE, Chiu D, Holland C, Jacobs PA, Pettay D. Chromosome anomalies as predictors of recurrence risk for spontaneous abortion. Am J Med Genet 1987;28:353-60. DOI ScienceOn |
32 | Warburton D. Genetic factors influencing aneuploidy frequency. Basic Life Sci 1985;36:133-48. |
33 | Yamamoto M, Ito T, Watanabe M, Watanabe G. Causes of chromosome anomalies suggested by cytogenetic epidemiology of induced abortions. Hum Genet 1982;60:360-4. DOI ScienceOn |
34 | Bowen P, Lee CS. Spontaneous abortion. Chromosome studies on 41 cases and an analysis of maternal age and duration of pregnancy in relation to karyotype. Am J Obstet Gynecol 1969;104:973-83. DOI |
35 | Menasha J, Levy B, Hirschhorn K, Kardon NB. Incidence and spectrum of chromosome abnormalities in spontaneous abortions: new insights from a 12-y ear study. Genet Med 2005;7:251-63. DOI ScienceOn |
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