• Title/Summary/Keyword: S109

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Effects of Ethyl Acetate Fraction from Melothria Heterophylla on Antioxidant Activity and Matrix Metalloproteinase-1 Expression in Ultraviolet A-irradiated Human Dermal Fibroblasts (백렴 에틸 아세테이트 층의 항산화 활성과 Matrix Metalloproteinase-1 발현 저해효과)

  • Cho, Young-Ho;;Sim, Gwan-Sub;Lee, Dong-Hwan;Lee, Bum-Chun;Pyo, Heong-Bae
    • Journal of the Society of Cosmetic Scientists of Korea
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    • v.31 no.1 s.49
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    • pp.103-109
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    • 2005
  • UV irradiation leads to distinct changes in skin connective tissue, which is degradation of collagen. Many of these alterations in the extracellular matrix are mediated by matrix metalloproteinases. In this study, to develop a new anti-aging agent, we screened the antioxidant activity of solvent fractions from ethanolic extract of Melothria Heterophylla. Among the four solvent fractions tested, the EtOAc fraction exhibited the highest antioxidant activity. It was investigated the inhibitory effect of the EtOAc fraction on the expression and activity of MMP-1 in UVA-irradiated human dermal fibroblasts. The EtOAc fraction inhibited the activity of MMP-1 in a dose dependent manner with the $IC_{50}$ values of $9{\mu}g/mL$. Also, UVA-induced MMP-1 expression was reduced about $90\%$ by $100{\mu}g/mL$ of the EtOAc fraction but MMP-1 mRNA expression was not inhibited. Therefore, we conclude that the EtOAc fraction significantly inhibits MMP-1 expression at the protein level. From these results, we suggest that the EtOAc fraction from M. heterophylla could be used as a new anti-aging agent for the photo-damaged skin.

A Study on the Environmental Knowledge and Skills of Middle School Students and Their Mothers -Related to 1st Grade of Middle School in Su-Won City- (환경에 대한 중학생과 중학생 어머니의 지식과 기능정도에 관한 고찰 - 수원시 중학교 1학년을 중심으로-)

  • 최미영;이무춘
    • Hwankyungkyoyuk
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    • v.13 no.1
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    • pp.133-141
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    • 2000
  • This study was designed for middle school students in Su-Won City to find out their level of hope in environmental education and who had not been introduced to environmental skills and knowledge as a separate subject in their school curriculum. Additionally, the result of the study was expected to provide basic environmental education material to teachers who are on the front line in our environmental education efforts. The mother used to be very influential on her children's thinking and behavior to a large degree. Acknowledging these facts, students and their mothers were chosen for this study The questionnaire from each of the two groups were compared and studied. The questionnaire, comprised of 23 questions, was completed during the period of time from March 6 through March 11, 2000. The schools that participated in the study were 5 junior high schools in Su-Won City and the participants were students and their mothers. The questionnaires were given to 450 students and their mothers to be completed and returned. A total of 379 student questionnaires and 323 mother questionnaires were received for examination. The results of questionnaire were analyzed by using SPSS/PC 8.0 software program with Frequencies Analysis, Mean Analysis, Reliability Analysis, Correlation Analysis, Paired Samples T-test, and $\chi$$^2$-test. The questionnaires generated the following results. The reliability coefficient was 0.847 from the students and 0.895 from the mothers. The level of interest in an environmental education curriculum was 24.3% from students and 86.0% from mothers. Interestingly, the gender difference of level of interest in an environmental education curriculum was 25.7% from male and 23.1% from female. The difference in the environmental function levels between female and male students was statistically significant(t=-4.109, p<0.001). For mathematical skills in environmental functions, the students and mothers thought trash, air pollution, and lack of forest were problems however they showed inactive support and unreasonable attitudes toward the problems that they themselves pointed to for solving the problems. Under the environmental problems solving issue, the significance between two groups was 0.014(P<0.001) and the result dictates there was no correlation. The t-test showed no difference in environmental knowledge level between student genders. The knowledge level between students and mothers was related each other. The Paired Sample t-test between students versus mothers on environmental skills and knowledge was 0.000*(*P<0.001) and it showed there was correlation between the two groups. With this study, educating mothers should be noticed as a great priority in environmental education that will lead to a more positive environmental outlook from our students.

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A Study on the Usage of Investigation of Google Cloud Data (Smartphone user-oriented) (구글 클라우드 데이터의 수사활용 방안에 관한 연구 (스마트폰 사용자 중심))

  • Kim, Dongho;Lee, Sangjin
    • Journal of Digital Forensics
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    • v.12 no.3
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    • pp.109-120
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    • 2018
  • The smartphone is the communication device that is the most personal to the user, and it keeps a lot of information related to the user and makes information communication with other devices. With these characteristics, forensics on smartphones are one of the most basic methods of investigation in criminal investigations, and have actually contributed to the settlement of the case by providing many clues. However, recently, it is designed to encrypt data stored as a social issue related to the protection of user's personal information, or to delete deleted data or to delete log data together. So, any solutions? In this paper, I try to find the answer from cloud data stored by smartphone user account. Cloud forensics should approach complementary relationships rather than smartphone forensics. There are a lot of data stored in the cloud that can be meaningfully used in the investigation. Online activity information of users, such as Internet usage, YouTube view, and contents purchase information, cloud service such as e-mail, cloud drive, and location information are the most representative data. These data can be unvaluable, but here are some important clues in various types of criminal investigations. In this paper, I propose a method to extract data from the google cloud so that the data can be used for investigation, and to utilize the extracted data for investigation. And it explains the role of the extracted artifacts in the actual investigation business through virtual cases and proves its value.

Purification of Alginate Lyase from Streptomyces violaceoruber and the Growth Activity of Intestinal Bacteria by Degree of Polymerization of Alginate Hydrolysates (Streptomyces violaceoruber 유래 Alginate Lyase의 정제 및 Sodium Alginate 가수분해 올리고당의 중합도별 Bifidobacterium spp.과 Lactobacillus spp.에 대한 생육활성)

  • Yoon, Min;Park, Young-Seo;Park, Gwi-Gun
    • Food Engineering Progress
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    • v.21 no.2
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    • pp.103-109
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    • 2017
  • Alginate lyase from Streptomyces violaceoruber was purified by DEAE sephacel chromatography and SP sepharose chromatography. The specific activity of the purified enzyme was 14.6 units/mg protein, representing a 40.6-fold purification of the crude extract. The final preparation thus obtained showed a single band on Tricine-SDS polyacrylamide gel electrophoresis whose molecular weight was determined to be 23.3 kDa. The polyMG block of sodium alginate was hydrolyzed by the purified alginate lyase and then separated by activated carbon column chromatography and bio gel P-2 gel filtration. The main hydrolysates were composed of hetero type M/G-oligosaccharides with the degrees of polymerization (D.P.) being 6 and 8. To investigate the effects of hetero type M/G-oligosaccharides from the sodium alginate on the growth of some intestinal bacteria, cells were cultivated individually on the modified-MRS medium containing D.P. 6 and 8 M/G-oligosaccharides. B. longumgrew 4.25-fold and 6.44-fold more effectively by the treatment of D.P. 6 and 8 M/G-oligosaccharides compared with those of standard MRS medium. In addition, B. bifidumgrew 3.3-fold and 5.4-fold more effectively by the treatment of D.P. 6 and 8 M/G-oligosaccharides. In conclusion, D.P. 8 was more effective than D.P. 6 hetero M/G-oligosaccharides as regards the growth of Bifidobacteriumspp. and Lactobacillus spp.

Extra-phase Image Generation for Its Potential Use in Dose Evaluation for a Broad Range of Respiratory Motion

  • Lee, Hyun Su;Choi, Chansoo;Kim, Chan Hyeong;Han, Min Cheol;Yeom, Yeon Soo;Nguyen, Thang Tat;Kim, Seonghoon;Choi, Sang Hyoun;Lee, Soon Sung;Kim, Jina;Hwang, JinHo;Kang, Youngnam
    • Journal of Radiation Protection and Research
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    • v.44 no.3
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    • pp.103-109
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    • 2019
  • Background: Four-dimensional computed tomographic (4DCT) images are increasingly used in clinic with the growing need to account for the respiratory motion of the patient during radiation treatment. One of the reason s that makes the dose evaluation using 4DCT inaccurate is a change of the patient respiration during the treatment session, i.e., intrafractional uncertainty. Especially, when the amplitude of the patient respiration is greater than the respiration range during the 4DCT acquisition, such an organ motion from the larger respiration is difficult to be represented with the 4DCT. In this paper, the method to generate images expecting the organ motion from a respiration with extended amplitude was proposed and examined. Materials and Methods: We propose a method to generate extra-phase images from a given set of the 4DCT images using deformable image registration (DIR) and linear extrapolation. Deformation vector fields (DVF) are calculated from the given set of images, then extrapolated according to respiratory surrogate. The extra-phase images are generated by applying the extrapolated DVFs to the existing 4DCT images. The proposed method was tested with the 4DCT of a physical 4D phantom. Results and Discussion: The tumor position in the generated extra-phase image was in a good agreement with that in the gold-standard image which is separately acquired, using the same 4DCT machine, with a larger range of respiration. It was also found that we can generate the best quality extra-phase image by using the maximum inhalation phase (T0) and maximum exhalation phase (T50) images for extrapolation. Conclusion: In the present study, a method to construct extra-phase images that represent expanded respiratory motion of the patient has been proposed and tested. The movement of organs from a larger respiration amplitude can be predicted by the proposed method. We believe the method may be utilized for realistic simulation of radiation therapy.

Field tests of indoor air cleaners for removal of PM2.5 and PM10 in elementary school's classrooms in Seoul, Korea (서울 초등학교 교실의 PM2.5 및 PM10 제거를 위한 학교용 공기청정기 실증)

  • Han, Bangwoo;Hong, Keejung;Shin, Dongho;Kim, Hakjoon;Kim, Yongjin;Kim, Sangbok;Kim, Sangwoo;Hwang, Cheongha;Noh, Kwangchul
    • Particle and aerosol research
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    • v.15 no.2
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    • pp.79-90
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    • 2019
  • It is important to control fine particles in children care centers, elementary schools, elderly care facilities and so on where vulnerable children and the aged stay during most of their time. This study has investigated $PM_{2.5}$ and $PM_{10}$ concentrations in two classrooms equipped with an air cleaner and two air cleaners, respectively and they were compared to those in a classroom without an air cleaner as well as those outdoors. Eight air cleaners which have various clean air delivery rates (CADRs) between 9.9 and $21.3m^3/min$ were tested in classrooms in two elementary schools in Seoul. Average $PM_{2.5}$ and $PM_{10}$ were $7.3{\pm}0.7$ and $45.5{\pm}4.1{\mu}g/m^3$ in classrooms equipped with an air cleaner and $4.2{\pm}0.6$ and $24.6{\pm}2.5{\mu}g/m^3$ in classrooms with two air cleaners, whereas they were $22.1{\pm}2.6$ and $109.1{\pm}9.6{\mu}g/m^3$ in classrooms without an air cleaner and $36.9{\pm}5.1$ and $74.1{\pm}10.6{\mu}g/m^3$ outdoors, respectively. $PM_{2.5}$ in classrooms could be reduced effectively by using an air cleaner or two air cleaners, because $PM_{2.5}$ was mainly infiltrated from outdoors, however $PM_{10}$ could not because $PM_{10}$ was mainly caused indoors by students' activities. Air cleaners were more effective for removal of $PM_{2.5}$ and $PM_{10}$ in classrooms with a high airtightness than those in classrooms with a relatively low one. Average $CO_2$ in classrooms was about 1500 to 2000 ppm for class hours dependent on the student number per a classroom, which was about 1.5 to 2 times higher than the standard, regardless of the use of air cleaner.

A Study on Satisfaction Survey for the Revitalization of the Ancient Capital Cities in Korea (고도(古都)보존육성에 관한 만족도 조사 분석)

  • Lee, Wang-Kee;Jeon, Chil-Soo
    • Korean Journal of Heritage: History & Science
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    • v.48 no.4
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    • pp.94-109
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    • 2015
  • This study examines Korea's revitalization policy on the ancient capital cities, which has been set out for preserving and improving living quality of the local communities. Since it was established, the policy has faced with constant challenges such as the lack of funding for preservation and revitalization of local communities. This study aims at providing a set of recommendation on the problems on the policy. In order for the study, it takes objective and empirical analysis on the problems of the policy by executing survey on the satisfaction level of the stakeholders and policy-makers on the present policy. The survey has displayed that the government needs to 1. subsidize more budget, 2. set out a policy to reduce the inconvenience of local communities 3. establish a supportive program to help the present promotion policy. In addition, the survey analysis has proved that the elements of revitalization policy affect to the increase of satisfaction. It concludes with a set of recommendation, 1. to secure sufficient budget to implement the policy; 2. to reduce a restriction of individual rights; 3. to promote the supporting program of local community; 4. to establish governance system with officers, experts, residents, and research institutes.

Introduction To A New Created Scientific Discipline: Management Of allSelves' Enlightenment and Empowerment(MOSEE) with 5th Dimension Spirit Paradigm shift will conciliate the modern Management Philosophies(3rd Issue)-Creating Shared Value(CSV) of Michael Porter, Strategic Intent(SI) of Gary Hamel and Complexity Economics(CE) of W. Brian Arthur (새로운 과학적 학문분야를 창시 소개함: 깨달음경영학의 5차원 인간의식(영성)의 자원 자산화를 통한 현대 경영철학들의 통섭을 위한 고찰(3회)-마이클 포터의 공유가치론(CSV)과 게리 함멜의 전략적 의도(S I)와 브라이언 아서의 복잡계 경제연구(CE))

  • Lee, Jae-Yun;Lee, Jae-Ho
    • Proceedings of the Korea Contents Association Conference
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    • 2019.05a
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    • pp.109-110
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    • 2019
  • 자본주의 사회에서 기업은 이윤의 극대화라는 목표를 이루기 위해, 인간을 하나의 자원으로 간주하여 도구화 하는 경향이 있다. 그 결과 인간소외(alienation) 및 부의 양극화 현상이 심각한 사회적 문제로 거론되고 있다. 오늘날 경제성장에 따른 물질적 풍요와 번영이 인류사회에 행복을 가져다 줄 것이라는 통념은 '물질적 풍요 속의 정신적 빈곤'이라는 문제제기에 의해 그 위상이 흔들리고 있다. 자본주의가 인류사회의 행복과 공동번영에 기여하는 경제체제로서 역할을 다하려면, 자본주의 역시 시대의 변화에 맞추어 진화해야 한다. 본 논문에서는 새 시대에 걸 맞는 자본주의의 대안을 논의하고자, 저자 이재윤이 창시한 깨달음경영학(MOSEE;Management Of allSelves' Enlightenment and Empowerment)의 새로운 과학적 학문연구를 통해 새로운 실현성 영역을 추구하는 동시에, 깨달음경영의 새로운 5차원 요소인 의식(영성) 자원 및 자산(SRA:Spirit Resource and Asset)과 본질적으로 무(無)에서 유(有)를 창조하는 진성 창조경영(MOC:Management Of Creation)의 연구 및 인간의식 성장 방법론에 대하여 발표 하고자 한다. 이로써 현대의 주요한 여러 경영철학들 예컨대 CSV(마이클 포터) SI(개리 함멜) 복잡계 철학 美德경영 등의 내재된 구조적 제약들을 분석 평가하고 한계를 극복하는 방안들을 제시함으로써 21세기 우주 인류 신문명 창달을 위한 5차원의 깨달음경영 혁명을 성취 하고자 한다. 즉 2040년 전에 지구 인류의 고도 영성 초 과학기술 문명을 넘어서 우주 인류의 초 영성 초 과학기술 문명 창달을 선도하는 학문연구 교육 인류 사회활동을 지속적으로 해갈 것이다. 위와 같이 21세기 우주 인류의 영원한 평화 자유 지속적 번영을 이루고자 한다. 본 연구는 통섭 고찰 제2회로 미국의 마이클 포토와 막 클램머의 공유가치(CSV)와 영국의 게리 함멜과 프라할라드의 전략적 의도와 브라이언 아서의 복잡계 경영경제 이론을 통섭을 고찰한다.

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The Solidarity Networking between Labor and Civil Society Movements: the Case Study of Hope Bus (시민사회의 연대운동 네트워킹 사례연구: 희망버스를 중심으로)

  • Lee, Byoung-Hoon;Kim, Jindu
    • Korean Journal of Labor Studies
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    • v.23 no.2
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    • pp.109-139
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    • 2017
  • In light that solidarity movements become significant under the situation of 'labor and labor movement' crisis, our study pays attention to the fact that the Hope Bus campaigns made remarkable achievements, and aims to figure out how those campaigns were successful, by focusing on their solidarity networking. The successful operating conditions of solidarity networking in the Hope Bus campaigns are examined in three aspects - the conditions of triggering, forming, and activating. The solidarity networking of Hope Bus campaigns were mainly triggered by the injustice of layoffs by Hanjin Heavy Industry, aerial protest by Jin-sook Kim, and the tragic symbol of the protest site (Crane no. 85). The solidarity movement of Hope Bus could be formed by the mutual trust and cohesive team-building of key network brokers, their utilization and expansion of social movement networks, and massive ripple effect of SNS-mediated communication. The solidarity networking of Hope Bus was effectively activated by open and de-hierarchical operations of the central planning group, active solidarity activities of participant groups, and the provision of 'heuristic experience' for developing the sensibility to labor solidarity. The virtuous combination of those three operating conditions leads to the building of unified forces among social movements, massive civil participation, and meaningful movement outcomes, through the solidarity networking of Hope Bus campaigns.

The mediation effect of grip strength trajectory on the association between exercise participation and life satisfaction among couples (중노년기 부부의 운동참여가 삶의 만족도에 미치는 영향에 관한 악력 궤적의 매개효과)

  • Joo, Susanna;Jun, Hey Jung
    • 한국노년학
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    • v.40 no.1
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    • pp.91-109
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    • 2020
  • This study aims to investigate the interdependence of Korean middle and old-aged couples in the association between exercise and life satisfaction through grip strength trajectory. Data were drawn from the nationally representative Korea Longitudinal Study of Aging (KLoSA) collected from 2006 to 2016. The sample included couples over 45 years of age in the first wave and participated in all six waves of the survey (Ncouple=1,997). There were three steps for analyses: correlation, parallel latent growth curve model, tests of indirect effects of the mediation paths. Covariates included in the models were husbands and wives' characteristics (age, education, work status, chronic diseases, marital satisfaction, contact frequency with friends or neighbors) and couple's household income. Results showed husbands' and wives' life satisfaction and grip strength were interdependent upon each other. Also, exercise participation of both husbands and wives was associated with both husbands' and wives' life satisfaction via the initial level of grip strength of husbands. Moreover, exercise participation of only husbands was associated with wives' life satisfaction through the initial grip strength of husbands. These results suggest the aging processes of middle and old-aged couples need to be understood in the context of gender dynamics and couple interdependence.