• Proceedings of the Korean Institute of Navigation and Port Research Conference
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• 2011.11a
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• pp.88-90
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• 2011

The IHO(International Hydrographic Organization) has developed the S-100 standard as a universal hydrgraphic data model for consistent use and application of various hydrographic data and sources, and is developing the product specification standards. The organization modified this standard to reflect the requirements of application parts, detailed the insufficient contents for products. In this study, the trend and recent requirement of S-100 standard were analyzed. Also, a method of managing S-100 standard was completed based on the analysis of S-100 application.

• Proceedings of the Korean Institute of Information and Commucation Sciences Conference
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• 2011.10a
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• pp.178-179
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• 2011

해양 분야에서는 최근 e-navigation 실현을 위한 차세대 표준에 관한 연구가 진행 중이다. IHO(국제수로기구)를 중심으로 전자해도뿐만 아니라 해양의 지리 정보 및 관련 데이터의 교환, 공유, 활용을 위해 S-100기반 다양한 표준이 가능하다. IHO S-100 표준은 ISO 19100 시리즈 표준의 프로파일로, 응용 분야와 서비스에 따른 S-10x 표준의 기반이 된다. 프로파일링을 통해 S-101, S-102, S-10x 등 다양한 표준 프로파일이 만들어지면 각 표준에서 정의하는 데이터 모델의 요소를 일관성 있고 명확하게 해석하는 것이 필요하다. 본 논문에서는 S-10x 표준의 기반이 되는 S-100 표준을 일관된 의미 해석과 처리를 할 수 있도록 S-100 표준의 온톨로지로의 변환 방안을 제시한다.

• Biomedical Science Letters
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• v.26 no.3
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• pp.226-229
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• 2020

S100A8 functions as an essential factor in inflammatory response. Cytokine release of monocytes and regulation of neutrophil apoptosis are important steps in pathogenesis of allergy. This study aims to examine the relation between cytokine release of monocytes due to S100A8 and neutrophil apoptosis. S100A8 enhanced the release of IL-6 and IL-8 in monocytes of normal and allergic subjects. Treatment of supernatants of normal and allergic monocytes with S100A8 blocked neutrophil apoptosis by inhibition of caspase 9 and caspase 3 activation. The secretion signal induced by S100A8 is involved in TLR4, Src family protein, PKCδ, ERK1/2, p38 MAPK, JNK, and NF-κB. These findings may contribute to understanding the complex pathogenesis of allergic diseases by determining inflammatory responses associated with S100A8, monocytes, and neutrophils.

• Proceedings of the Korean Institute of Navigation and Port Research Conference
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• 2016.05a
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• pp.299-301
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• 2016

국제수로기구(IHO)는 수로데이터의 상호 운용성 확보 및 활용 증진을 위해 ISO 19100 지리공간 정보 표준을 수로분야로 확장하여 S-100(범용수로데이터모델) 표준을 개발하여 현재 2.0 버전에 이르고 있으며, S-101 차세대 전자해도 표준을 포함하여 전자서지 및 동적 수로정보 등의 다양한 표준을 개발 중이다. 한편, 국제해사기구는 e-Navigation 전략 추진을 위해 전략이행계획(SIP)를 개발하고, e-Nav 정보표준인 CMDS를 S-100 표준을 기반으로 개발하기로 결정 하였으며, 국제항로표지협회는 AtoN, IVEF, AIS-ASM, 측위 인프라에 관한 S-20X 표준개발을 진행하고 있다. 우리나라의 해양조사 및 수로도서지 간행을 담당하고 있는 국립해양조사원은 S-100 표준 기술을 확보하고 국가 수로국으로의 역할 수행을 위해 S-100 수로데이터를 구축할 계획으로 있다. 본 연구에서는 S-100/S-10X 표준개발 현황 및 우리나라의 차세대 전자해도 개발 계획을 검토하고, 해사안전, e-Navigation 및 VTS 분야 관점에서 시사점을 정리 하였다.

• Journal of Korean Neurosurgical Society
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• v.44 no.5
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• pp.308-313
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• 2008

Objective: The serum S100 protein has been known to reflect the severity of neuronal damage. The purpose of this study was to assess the prognostic value of the serum S100 protein by Elecsys S100 immunoassay in patients with subarachnoid hemorrhage (SAH) and intracerebral hemorrhage (ICH) and to establish reference value for this new method. Methods: Serum S100 protein value was measured at admission, day 3 and 7 after bleeding in 42 consecutive patients (SAH : 20, ICH : 22) and 74 healthy controls, prospectively. Admission Glasgow coma scale (GCS) score, Hunt & Hess grade and Fisher grade for SAH, presence of intraventricular hemorrhage, ICH volume, and outcome at discharge were evaluated. Degrees of serum S100 elevation and their effect on outcomes were compared between two groups. Results: Median S100 levels in SAH and ICH groups were elevated at admission (0.092 versus $0.283{\mu}g/L$) and at day 3 (0.110 versus $0.099{\mu}g/L$) compared to healthy controls ($0.05{\mu}g/L;$ p<0001). At day 7, however, these levels were normalized in both groups. Time course of S100 level in SAH patient was relatively steady at least during the first 3 days, whereas in ICH patient it showed abrupt S100 surge on admission and then decreased rapidly during the next 7 days, suggesting severe brain damage at the time of bleeding. In ICH patient, S100 level on admission correlated well with GCS score (r=-0.859; p=0.0001) and ICH volume (r=0.663; p=0.001). A baseline S100 level more than $0.199{\mu}g/L$ predicted poor outcome with 92% sensitivity and 90% specificity. Logistic regression analyses showed Ln (S100) on admission as the only independent predictor of poor outcome (odd ratio 36.1; 95% CI, 1.98 to 656.3) Conclusion: Brain damage in ICH patient seems to develop immediately after bleeding, whereas in SAH patients it seems to be sustained for few days. Degree of brain damage is more severe in ICH compared to SAH group based on the S100 level. S100 level is considered an independent predictor of poor outcome in patient with spontaneous ICH, but not in SAH. Further study with large population is required to confirm this result.

• Proceedings of the Korean Institute of Navigation and Port Research Conference
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• 2015.07a
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• pp.121-123
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• 2015

해사안전과 해양환경 보호를 위해 국제해사기구가 추진하고 있는 e-Navigation 정보의 종류는 해상교통 정보, 수로도서지 정보, 동적해역 정보 등 다양하며, 국제해사기구가 e-Nav 정보 표준 개발에 S-100 표준을 적용하기로 결정함에 따라 일관된 기준에 따른 e-Nav DB 구축이 요구되고 있다. S-100 표준에는 DB 구축 지침 문서인 DCEG(Data Classification Encoding Guide) 양식을 정의한 바 있는데 본 문서는 타 표준 문서와 일관성있게 작성되어야 하나, S-100 표준 개발과정에서 휴먼 에러나 오류에 문제점이 발생되고 있다. 본 연구에서는 이를 위하여 S-100 기반 e-Nav DB 구축문서 지원을 위한 S/W 개발 방안에 대해 연구 하였는데, S-100 표준 체계에서 등록소의 FCD와 피쳐 카탈로그 DB가 운영된다는 점에 착안하여, 피쳐 카탈로그 DB와 연계할 수 있는 DCEG DB과 DCEG Editor 개발방안을 제안 하였다. 본 연구에서 제안하는 방안은 향후 일관적인 e-Navigation DB 구축에 도움이 될 것으로 사료된다.

• Asian Pacific Journal of Cancer Prevention
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• v.16 no.7
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• pp.2883-2887
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• 2015

Background: The calcium-binding S100A4 protein is involved in epithelial to mesenchymal transition, oncogenic transformation, angiogenesis, cytoskeletal integrity, mobility and metastasis of cancer cells. This study aimed to clarify the roles of S100A4 in genesis and progression of glioma. Materials and Methods: S100A4 expression was examined by real-time RT-CPR and Western blot in glioma and paired normal brain tissue (n=69), and compared with clinicopathological parameters of tumors. In addition, glioma U251 cells transfected with an S100A4-expressing plasmid were examined for proliferation by MTT, apoptosis by Annexin V-FITC, and migration and invasion with Transwell chambers. Results: Increased S100A4 mRNA expression was found in gliomas, compared with paired non-tumor tissue (p<0.001). Gradual elevation of overexpression of S100A4 was observed with increasing glioma grade (p<0.001). Astrocytoma showed lower S100A4 mRNA expression than oligodendrogliomas, with glioblastomas having highest values (p<0.001). Similar results were obtained for S100A4 protein, a positive link being found between mRNA and protein expression in gliomas (p<0.001). There was higher growth, lower apoptosis, stronger migration and invasion of S100A4 transfectants than control and mock transfected cells (p<0.001). Conclusions: These findings indicate that up-regulated S100A4 expression is positively linked to pathogenesis, progression and histogenesis of glioma by modulating proliferation, apoptosis, migration and invasion.

• Asian-Australasian Journal of Animal Sciences
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• v.32 no.9
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• pp.1355-1362
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• 2019

Objective: S100A7A, a member of the S100 protein family, is involved in various biological processes, including innate immunity, antimicrobial function, and epithelial tumorigenesis. However, the expression and function of S100A7A in the endometrium during the estrous cycle and pregnancy are not well understood in pigs. Therefore, this study determined the expression and regulation of S100A7A at the maternal-conceptus interface in pigs. Methods: We obtained endometrial tissues from pigs throughout the estrous cycle and pregnancy, conceptus tissues during early pregnancy, and chorioallantoic tissues during midto late pregnancy and analyzed the expression of S100A7A in these tissues. We also determined the effects of steroid hormones, estradiol-$17{\beta}$ ($E_2$) and progesterone, and interleukin-$1{\beta}$ (IL1B) on S100A7A expression in endometrial tissues. Results: We found that S100A7A was expressed in the endometrium during the estrous cycle and pregnancy in a pregnancy status- and stage-dependent manner and was localized to endometrial luminal epithelial (LE) and superficial glandular epithelial cells with strong intensity in LE cells on day 12 of pregnancy. Early stage conceptuses and chorioallantoic tissues from day 30 to term pregnancy also expressed S100A7A. The expression of S100A7A was increased by $E_2$ and IL1B in endometrial tissues. Conclusion: S100A7A was expressed at the maternal-conceptus interface at the initiation of implantation in response to conceptus-derived estrogen and IL1B and could be a unique endometrial epithelial marker for conceptus implantation in pigs. These findings provide an important insight into the understanding of conceptus-endometrial interactions for the successful establishment of pregnancy in pigs.

• Journal of Digital Contents Society
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• v.19 no.7
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• pp.1289-1296
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• 2018

The e-Navigation promoted by the International Maritime Organization is a technology that provides marine-related information necessary for ship and shore side by electronic means for marine safety, security and protecting marine environment. The IHO S-100 standard is a geospatial standard that can express various hydrographic information. Various specifications including S-101 for electronic charts are being developed. In this paper, to help developers who are interested in implementing the technology of S-100, we not only analyze the process to portray the S-100 based data but also implement a case study on S-129 under keel clearance management. The portrayal process consists of data encoding and portrayal engine. Data encoding includes generation of application schema and data set. Portrayal engine is performed by the reform of the generated data set, the XSLT processing, and then the generation of drawing instructions.

• Proceedings of the Korean Institute of Navigation and Port Research Conference
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• 2012.06a
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• pp.507-509
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• 2012

IHO has established S-100 Standard profiled from ISO 19100 GIS standards for standardization and improvement of hydrographic data and are developing S-10X Standards. IMO is implementing the e-Navigation strategy for maritime safety and marine environment protection and has established the CMDS as information standard framework which will be developed from the S-100 standard. The development domain of e-Navigation can be divided into onboard, communication network, onshore and VTS is a core actor in onshore system. In this study, we analyzed the effects of S-100 standard development on VTS through e-Navigation strategy of IMO and suggested the cooperation between hydrographic fields and VTS fields under e-Navigation strategy.