• Applied Biological Chemistry
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• 제18권1호
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• pp.52-55
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• 1975

1) 본실험조건(本實驗條件)에서 GLC에 의하여 AsA의 최저(最低)농도(濃度) 1mg%까지 정량가능(定量可能)하였다. 2) TMS 반응조건(反應條件)으로서 동결건조시료(凍結乾燥試料)에는 반드시 TMS 혼합시액중(混合試液中)에서 추출(抽出)과 TMS 화(化)를 동시(同時)에 시켜야만 98% 이상(以上)의 회수율(回收率)을 얻을 수 있다. 3) AsA 농도(濃度)가 1mg%이상(以上)인 시료(試料)에 대(對)하여 GLC에 의한 미량정량(微量定豊)을 확립(確立)하여 특(特)히 방해물질(妨害物質)이 많은 일반식품(一般食品)의 정량(定量)에 적용(適用)이 가능(可能)하도록 하였다. 4) 본실험(本實驗)에 사용(便用)한 일본전자(日本電子)의 750형(型)의 eletron meter의 성능(性能)보다 감도(感度)가 300배(倍)인 20K 형(型)을 사용(使用) 한다면 혈청중(血淸中) AsA의 정량(定量) 및 그 이하(以下)의 농도(濃度)인 미량정량(微量定量)도 충분(充分)히 가능(可能)하리라 생각된다.

• 한국환경농학회지
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• 제30권2호
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• pp.196-201
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• 2011

BACKGROUND: Bioavailability enhancement by solubilization of lipophilic drugs in nano-emulsion has been reported and it may be useful in pharmaceutical and nutraceutical products. This study was performed to compare in vivo bioavailability of nano-emulsion formulation with that of the general product as control. METHODS AND RESULTS: The pharmacokinetics assessment of Vitamin A, D and E complex of nanoemulsion formulation (LaVita), in comparison to the general product, was performed in the male rat plasma by a single oral dose at 20 mL/kg body weight (n=3/group). For nano-emulsion formulation (LaVita), $C_{max}$ of vitamin A and E in plasma were much higher and the area under the curve (AUC) of vitamin A, D and E were 14-63% higher, and the half-life of vitamin E was 2-fold longer than the general product. According to statistical analysis, each $C_{max}$ of vitamin A, D & E was significantly higher (p<0.01, 0.05 and 0.01, respectively) than that of general product. Half-life of vitamin A was significantly higher (p<0.01) and AUC of vitamin A and D were also significantly higher than the general product. CONCLUSION(s): Considering significant increment of $C_{max}$ and AUC, LaVita made of nano-emulsion could be more effective the absorption rate and extent for bioavailability of vitamin A, D & E than those of general product.

• 한국수소및신에너지학회논문집
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• 제18권1호
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• pp.52-59
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• 2007

We investigated the effects of the addition of Mn and $AB_5$ type alloy on the electrochemical characteristics of Ti-Cr-V BCC type alloys as anode materials for Ni-MH battery. The activation behavior and discharge capacity of the BCC type alloys were significantly improved by ball-milling with the $LmNi_{4.1}Al_{0.25}Mn_{0.3}Co_{0.65}$ alloy, because the $AB_5$ type alloy acted as hydrogen path on the surface of the BCC type alloy. Among the Mn substituted alloys($Mn=0.03%{\sim}0.08%$), the $Ti_{0.32}Cr_{0.38}Mn_{0.05}V_{0.25}$ alloy ball-milled with $AB_5$ type alloy exhibited the greatest discharge capacity of $336\;mAh{\cdot}g^{-1}$. In addition, Mn substituted alloys exhibited the lower plateau pressure in P-C- T curve, the better hydrogen storage capacity and faster surface activation compared with the alloy without Mn.

• Journal of Communications and Networks
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• 제17권5호
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• pp.453-462
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• 2015

Body area networks (BANs) have emerged as an enabling technique for e-healthcare systems, which can be used to continuously and remotely monitor patients' health. In BANs, the data of a patient's vital body functions and movements can be collected by small wearable or implantable sensors and sent using shortrange wireless communication techniques. Due to the shared wireless medium between the sensors in BANs, it may be possible to have malicious attacks on e-healthcare systems. The security and privacy issues of BANs are becoming more and more important. To provide secure and correct association of a group of sensors with a patient and satisfy the requirements of data confidentiality and integrity in BANs, we propose a novel enhanced secure sensor association and key management protocol based on elliptic curve cryptography and hash chains. The authentication procedure and group key generation are very simple and efficient. Therefore, our protocol can be easily implemented in the power and resource constrained sensor nodes in BANs. From a comparison of results, furthermore, we can conclude that the proposed protocol dramatically reduces the computation and communication cost for the authentication and key derivation compared with previous protocols. We believe that our protocol is attractive in the application of BANs.

• Journal of Welding and Joining
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• 제24권3호
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• pp.27-33
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• 2006

Structural stress approach is well known as a mesh-size insensitive fatigue assessment method by using finite element analyses. It is, however, difficult to estimate the structural stress (SS) at weld end points due to stress singularities when shell elements are used. In this study, fatigue evaluations with longitudinal load carrying box fillet weldment under out-of-plane bending load have been performed by using virtual node method (VNM) in order to avoid the problem, which is called the weld end effect. Various combinations of virtual node parameters, such as reference point and virtual node locations, are investigated for the estimation of proper structural stress values applying VNM in a systematic manner. The appropriate guidance of virtual node parameter has been offered for the fillet weldment considered in the study. The structural stress values obtained by VNM have also been validated by comparing the result with finite element model including weld bead. Moreover, the fatigue strength of the fillet weldment based on the equivalent structural stress is shown to be consistent with the master S-N curve.

• 대한기계학회논문집B
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• 제21권5호
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• pp.615-627
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• 1997

An experiment was performed to local heat transfer coefficient and Nusselt number in the circular duct of 180.deg. bend for Re=6*10$^{4}$, 8*10$^{4}$ and 1*10$^{5}$ at swirling flow and non-swirling flow conditions. The test tube with circular section was made by stainless which has curvature ratio 9.4. The wall of test tube was heated directly by electrical power to 3.51 kw and swirling motion of air was produced by a tangential inlet to the pipe axis at the 180 degree. Measurements of local wall temperatures and bulk mean temperature of air are made at four circumferential positions in the 16 stations. The wall temperatures show particularly reduced distribution curve at bend for non-swirling flow but this effect does not appear for swirling flow. Nusselt number distributions for swirling flow which was calculated from the measured wall and bulk temperatures were higher than that of non-swirling flow. Average Nusselt number of swirling flow increased about 90 ~ 100% than that of non-swirling flow whole through the test tube. The Nu/N $u_{DB}$ values at the station of 90.deg. for non-swirling flow and swirling flow are respectively about 2.5 and 4.8 at Re=6*10$^{4}$. Also that is good agreement with Said's result for non-swirling flow. flow.

• 한국방재학회 논문집
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• 제9권5호
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• pp.15-21
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• 2009

AASHTO LRFD 설계 기준에 따른 합성형 교량 전단연결재 설계는 주로 강도보다는 피로에 의해 지배되는 것으로 알려져 있다. 이 피로 설계는 1966년 Slutter와 Fisher의 연구에 근거하고 있다. 당시의 시험은 1면으로 수행되었기 때문에 편심이 작용하였고, 이로 인하여 전단연결재에 별도의 인장력이 가해지게 되어 피로 강도가 감소되는 결과를 낳은 것으로 보인다. 또한, 피로 S-N 곡선은 응력변동폭과 하중반복 횟수 각각의 로그 스케일에 대하여 선형 관계를 보이는 것으로 Fisher에 의해 후에 밝혀졌으나, 전단연결재의 경우에 대해서만은 아직도 응력변동폭에 로그를 취하지 않고 있다. 이 연구는 현재 미국, 영국, 유럽, 일본에서 사용 중인 피로 설계 곡선을 비교 검토한 결과 미국 설계 기준이 비교적 보수적인 설계를 하고 있음을 확인하였다. 나아가, 당시의 실험 세팅과 데이터를 재분석하고 최근까지 전 세계에 공개된 피로 실험 데이터를 수집하여 분석 비교하고, 이를 바탕으로 적절한 설계식을 추천하고자 한다.

• 한국가스학회지
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• 제7권4호
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• pp.61-66
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• 2003

본 연구에서는 화학설비의 취약점을 파악하여 안전성을 경제적으로 확보할 수 있는 대안에 대한 설비별 안전투자비용과 그에 따른 편익을 산출하고, 분석함으로써 경제적인 안전 투자 대안을 제시할 수 있는 시스템을 개발하였다. 이를 위해 화학설비의 위험성을 정량적으로 평가하기 위한 사고 빈도 분석 모듈과 사고 피해 예측 모듈을 개발하고, 중대산업사고 사례 및 선진국(네덜란드, 호주, 미국, 영국, 독일 등)의 사회적 위험성을 비교 $\cdot$ 분석하여 국내 현실에 반영할 수 있는 사회적 위험성(societal risk : F-N Curve) 기준을 제시하였다. 또한, 현장 방문을 통하여 공정에 대한 투자비용과 그에 따른 편익 항목을 분석$\cdot$선정하여 앞의 결과들을 통하여 화학설비에서 발생하는 비용$\cdot$편익에 대한 안전투자대안의 순현재가치(NVP, Net Present Value)를 도출하여 안전성을 향상시킬 수 있는 대안들을 분석하고 비교할 수 있는 시스템을 개발하였다.

• Archives of Pharmacal Research
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• 제29권4호
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• pp.310-317
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• 2006

We investigated the effects of trinitrobenzene sulfonic acid (TNBS), an amino-group reagent, on the human ether-a-go-go-related gene (HERG) $K^+$ channels expressed in Xenopus oocytes. TNBS neutralizes the positively charged amino-groups of peptide N-terminal and lysine residues. External application of TNBS at 10 mM for 5 min irreversibly shifted the curves for currents at the end of the pulse and tail currents of HERG to a more negative potential and decreased the maximal amplitude of the $I_{tail}$ curve $(I_{tail,max})$. TNBS had little effect on either the activated current-voltage relationship or the reversal potential of HERG current, indicating that TNBS did not change ion selectivity properties. TNBS shifted the time constant curves of both activation and deactivation of the HERG current to a more hyperpolarized potential; TNBS's effect was greater on channel opening than channel closing. External $H^+$ is known to inhibit HERG current by shifting $V_{1/2}$ to the right and decreasing $I_{tail,max}$. TNBS enhanced the blockade of external $H^+$ by exaggerating the effect of $H^+$ on $I_{tail,max}$, not on $V_{1/2}$. Our data provide evidence for the presence of essential amino-groups that are associated with the normal functioning of the HERG channel and evidence that these groups modify the blocking effect of external $H^+$ on the current.

• Hip & pelvis
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• 제30권4호
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• pp.219-225
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• 2018

Purpose: Ischiofemoral impingement (IFI)-primarily diagnosed by magnetic resonance imaging (MRI)-is an easily overlooked disease due to its low incidence. The purpose of this study was to evaluate the usefulness of false profile view as a screening test for IFI. Materials and Methods: Fifty-eight patients diagnosed with IFI between June 2013 and July 2017 were enrolled in this retrospective study. A control group (n=58) with matching propensity scores (age, gender, and body mass index) were also included. Ischiofemoral space (IFS) was measured as the shortest distance between the lateral cortex of the ischium and the medial cortex of lesser trochanter in weight bearing hip anteroposterior (AP) view and false profile view. MRI was used to measure IFS and quadratus femoris space (QFS). The receiver operating characteristics (ROC), area under the ROC curve (AUC) and cutoff point of the IFS were measured by false profile images, and the correlation between the IFS and QFS was analyzed using the MRI scans. Results: In the false profile view and hip AP view, patients with IFI had significantly decreased IFS (P<0.01). In the false profile view, ROC AUC (0.967) was higher than in the hip AP view (0.841). Cutoff value for differential diagnosis of IFI in the false profile view was 10.3 mm (sensitivity, 88.2%; specificity, 88.4%). IFS correlated with IFS (r=0.744) QFS (0.740) in MRI and IFS (0.621) in hip AP view (P<0.01). Conclusion: IFS on false profile view can be used as a screening tool for potential IFI.