• Journal of Life Science
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• v.25 no.6
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• pp.686-692
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• 2015

Cancer is subject to dynamic interactions between contrary immune reactions that drive both tumor growth and suppression. Forkhead box p3 positive T cells (Foxp3 positive T cells) might support tumor promotion, while CD8 positive T cells might protect the host. The present study examined the distributions of CD8- and Foxp3-positive T cells and CD8 positive T cells/ Foxp3 positive T cells ratio in skin squamous cell carcinoma (SCC) and its precancerous lesions; it also compared this with data for basal cell carcinoma (BCC). Iimmunohistochemical staining for CD8 and Foxp3 was conducted in 20 cases of SCC, Bowen's disease (BD), actinic keratosis (AK) and BCC. The BD and SCC cases exhibited significantly increased numbers of both CD8- and Foxp3-positive T cells in their advancing regions compared with the AK and BCC cases, and the BD cases exhibited significantly lower CD8 positive T cells / Foxp3 positive T cells ratio in these regions than did the AK and BCC cases. There was no significant difference in both T cells and the ratio between BD and SCC. The degree of both T cells infiltration differed between the advancing and central areas in SCC and BCC. Immune micro-environments differ between cutaneous squamous cell tumors and BCC and differ as well among tumor compartments.

• The Journal of the Korea Contents Association
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• v.15 no.2
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• pp.130-138
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• 2015

Korean movies with a great variety of styles have recently succeeded in drawing people's attention Rule number one is "the more entertainment, the more audiences". On the top of box offices are always the movies that have a number of spectacular scenes, pounding sounds and big budget characters. Hong Sang Su movies, however, receive attention from the public without above noted descriptions. One of his effective methods of expression is "realism" He has illustrated the trivial episodes with his own wits and ways. Not only has his style become famous and popular but he has many followers. He enjoys using ordinary emotion and sentiment that are likely to happen to everyone. This paper uses two tools. One is the traditional analysis of realism. The other is how he can approach the public meaningfully by listing common elements he frequently uses in his movies. Nevertheless, we can't fully understand his realism by explaining how he shows our everyday life and how much his movie looks like it. Though admitting there are so many preceding papers on his works but this paper will try to look deep into his realism through the analysis of Mise-en-Sc$\grave{e}$ne.

• Journal of the Korea Concrete Institute
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• v.23 no.3
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• pp.303-310
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• 2011

To replace a steel box bridge for constructions of medium span bridges in Korea, the Hybrid Truss Bridge (HTB) is being considered as an alternative bridge type. The core technology of HTB is the connection joint that links the concrete slabs and steel truss pipes. Various construction companies in Japan have developed unique connection systems and applied to the real bridge constructions after verifying their performances through the experimental evaluation. In this study, the fatigue test of a hybrid truss girder has been performed in order to verify the newly proposed hinge type connection joint`s static and fatigue capacities. Through this fatigue test results, it is founded that the structural detail to improve the fatigue capacity should be developed. The hinge connection system with circular ribs has been proposed by means of structural finite element analyses. And then the fatigue test for this connection joint has been performed and it is proved that this connection joint has enough fatigue capacity. Finally, it is expected that the hinge connection system with circular ribs developed by in this study can be easily applied to the real bridge.

• Journal of the Korean Geotechnical Society
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• v.20 no.9
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• pp.177-189
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• 2004

The backfilled space carl have various shapes such as vertical or lateral symmetric, unsymmetric slope depending on field conditions. Kellogg (1993) suggested the different equations for the backfill earth pressure and the lateral stress ratio considering that the stresses are different between the symmetrically sloped backfilled space and the vertical one. Kellogg (1993) assumed the stress generated on sloped wall surface as the simple internal friction angle of backfilled soil. However, Moon (1997) suggested modified Kellogg equation assuming that stress behavior in the sloped wall will be varied according to the rotation angle of principal stress and the friction of sloped wall surface. This study has compared and investigated the horizontal stresss of unsymmetrical backfilled space numerically and experimentally obtained when Kellogg lateral stress ratio is appled to and when average lateral stress ratio considering unsymmetric backfill slop of left and right are applied to the modified Kellogg equation. It is shown that the horizontal stress on the sloped wall has good match numerically and experimentally in the modified Kellogg equation when Kellogg's lateral stress ratio in symmetric condition is applied to the unsymmetric condition. But the horizontal stress on the vertical wall shows disagreement numerically and experimentally. The horizontal stress results in good agreement numerically and experimentally when the average lateral stress ratio of left and right at unsymmetric slop as applied to the modified Kellogg equation. Therefore, it is estimated that the application of the average lateral stress ratio to the left and right wall should be considered when backfilled space formed unsymmetric conditions.

• Proceedings of the Korean Institute of Information and Commucation Sciences Conference
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• 2002.11a
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• pp.701-705
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• 2002

This paper describes implementation of IPv6-IPv4 transition toolbox named as 6TALK(IPv6 TrAansLator of Krv6) and some scenarios using 6TALK which enables IPv6 island to connect other IPv6 island or IPv4 island seamlessly. 6TALK implements some transition mechanisms suggested in NGTrans Working Group of IETF. Those mechanisms are composed of basic mechanism, tunneling, and applied mechanism such as DSTM. 6TALK provides functions which enable IPv6 network at the edge of existing network to communicate with IPv4 network by using these transition mechanisms. As major transition mechanisms in 6TALK we adopt NAT-PT/SIIT and DSTM/DSTM options and as implementation environment we use Linux Kernel 2.4.18 and Netfilter framework. Software modules implemented in Linux kernel was ported to hardware box using Motorola MPC 8260 processor. The transition mechanisms used in 6TALK are the ones predicted to be used in initial transition step to IPv6.

• Journal of the Korea Institute of Information and Communication Engineering
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• v.22 no.8
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• pp.1123-1132
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• 2018

In this paper, we design and implement a public bicycle sharing system based on smart phone application capable of distributing access codes via internet connection. When smartphone user uses the application to request a bicycle unlock code, server receives the request and sends an encrypted code, which is used to unlock the bicycle at the station and the same code is used to return the bicycle. The station's hardware prototypes were built on top of Internet devices such as raspberry pi, arduino, keypad, and motor driver, and smartphone application basically includes shared bike rental and return functionality. It also includes an additional feature of reservation for a certain time period. We tested the implemented system, and found that it is efficient because it shows the average of 3-4 seconds delay. The system can be implemented to manage multiple bikes with a single control box, and as the user can use a smartphone application, this makes the system more cost effective.

• Journal of the Korea Society of Computer and Information
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• v.15 no.7
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• pp.57-66
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• 2010

Due to the advancement of IPTV technologies, open IPTV services are a step closer to becoming reality. In such service environment, users are able to enjoy IPTV services using a variety of devices available at their home domain. However, it is impossible to get such flexible services at their convenience unless each of devices is individually connected to Set-Top-Box (STB) because of Conditional Access System (CAS) or service providers otherwise allow STB to freely distribute decoded contents to every user devices attached to STB. In this paper, we propose a key management scheme for securely distributing contents from STB to multiple user devices at home domain. The proposed scheme also makes the service providers be able to control the access rights to each of user devices without installing individual STBs. It is achieved by computationally dividing a private key of RSA signature scheme into three parts and thus makes possible to distribute the contents scrambled through a underlying CAS mechanism without re-encrypting them that the existing scheme should employ. It improves significantly computation and communication complexities, maintaining it as secure as the existing schemes. Additionally, it prevents misbehaving users from illegally distributing the contents from STB to their devices available at home domain.

• Journal of Life Science
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• v.27 no.12
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• pp.1479-1485
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• 2017

Muscle atrophy due to aging, starvation, and various chronic diseases leads to a decrease in muscle fiber area and density due to reduced muscle protein synthesis and increased protein breakdown. This study investigated the effect of dexamethasone and hydrogen peroxide on the induction of muscle atrophy and expression of atrophy-related genes in differentiated C2C12 myotubes. C2C12 myoblasts were differentiated into myotubes in differentiation medium. During myoblast differentiation, muscle-specific transcription factors, such as myogenin, and MyoD expression increased. Differentiated C2C12 myotubes exposed to noncytotoxic levels of dexamethasone and hydrogen peroxide showed a decrease in myotube diameter, which was associated with up-regulation of muscle-specific ubiquitin ligases, such as muscle atrophy F-box (MAFbx)/atrogin-1 and muscle RING finger-1 (MuRF1), and down-regulation of myogenin and MyoD. These results demonstrated that dexamethasone and hydrogen peroxide induced atrophy through regulation of muscle-specific ubiquitin ligases and muscle-specific transcription factors in C2C12 myotubes. In this study, we confirmed the process of differentiation of C2C12 myoblasts into myotubes in in vitro experiments in the presence of atrophy. This muscle atrophy model of C2C12 cells induced by dexamethasone or hydrogen peroxide seems suited to studies of the mechanism of muscle atrophy suppression and to exploit the experiment for excavating new muscle atrophy.

• Journal of Bio-Environment Control
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• v.21 no.4
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• pp.404-410
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• 2012

This study was conducted to examine effects of harvest time (09:00 vs. 14:00), precooling at $4^{\circ}C$ vs. no precooling, and storage temperature (4 vs. $8^{\circ}C$) on the storage life of 'Maehyang' strawberry fruits for export. Fruits at a 60% ripe stage were harvested from a commercial greenhouse in Gyeongsangnamdo, Jinju on May 4, 2010. Fruits were precooled by a forced draft cooling for three hours, transported for about 30 minutes and then stored, immediately. Small precoolers set in the farm were used for precooling. Fruits were placed in constant temperature chamber (4 or $8^{\circ}C$) after packaging using PVC wrap and a cardboard box. Fruits were examined for their changes in weight, hardness, Hunter color values, soluble solids content (SSC), and incidence of gray mold (Botrytis cinerea) during storage at a two days interval from May 6 to May 14, 2010. Hardness and SSC decreased as the ripening stage progressed. The Hunter's 'L' and 'a' value of fruit color decreased as time passed. Also, fresh weight decreased during storage at all temperatures. Soft rot appeared on epidermal tissues and followed by gray mold. Incidence of gray mold was greater at $8^{\circ}C$ storage temperature than in $4^{\circ}C$ storage temperature. However, no difference by the harvested time and precooling. The results indicate that effectiveness for keeping the freshness was best achieved by precooling at $4^{\circ}C$ and storage at $4^{\circ}C$, respectively.

• Journal of Embryo Transfer
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• v.32 no.1
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• pp.25-31
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• 2017

This study was conducted to investigate the effect of activation method on the endoplasmic reticulum (ER) stress induction, apoptosis and in vitro development of porcine parthenogenetic embryos. Porcine in vitro matured oocytes were activated by four activation methods; 1) electric stimulus (ES) (E), 2) $ES+10{\mu}M$ Ca-ionophore (A23187) treatment (EC), 3) ES+2 mM 6-dimethylaminopurine (6-DMAP) treatment (ED), or 4) ES+A23187 and 6-DMAP treatments (ECD). Parthenogenetic embryos were sampled to analyze x-box binding protein 1 (Xbp1) mRNA, ER stress-associated genes and apoptosis genes at 3 h after ES and the 1-cell and blastocyst stages. In the EC group, the band intensity of spliced Xbp1 (Xbp1s) mRNA was higher than those of the other groups at the 3 h and 1-cell stage, and higher than that of the E group at the blastocyst stage. Four ER stress-associated genes were expressed at the highest level in the EC group and weakly expressed in the ED group at 3 h after activation. However, most of the genes were highly expressed at the 1-cell and blastocyst stages with some variation in the EC and ECD groups. Expression of Bcl-2-associated X protein (Bax) and caspase-3 mRNA was significantly higher in the EC group than in the other groups at all development stages. The developmental rates to the blastocyst stage were higher in the ED and ECD groups than in the E and EC groups. These results suggest that the intracellular ER stress of parthenogenetic porcine embryos is affected by the activation method and subsequently lead to the apoptosis of embryos.