• YAKHAK HOEJI
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• v.34 no.4
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• pp.262-266
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• 1990

Acetylshikonine, isolated from the root of Lithospermum erythrorhizon showed a strong cytotoxic activity ($ED_{50}=0.10\;ug/ml$) against L1210 cell and T/C = 182% in ICR mice bearing S-180 at a dose of 5 mg/kg. Administrations of 10 mg/kg and 15 mg/kg reduced the T/C values to 60 and 77% respectively. Higher doses reveal toxicity. Seven naphthazarin derivatives synthesized showed good cytotoxic activities against L1210 cell. Especially, naphthazarin and hydronaphthazarin have strong activities ($ED_{50}=0.05\;ug/ml$ for both). Naphthazarin showed a severe toxic effect on ICR mice bearing S-180; no significant toxic effect was observed at a dose of 1 mg/kg or 2 mg/kg, but a severe toxicity (T/C = 23%) by administration of 5 mg/kg. Alkylation of C-2 of naphthazarin is necessary for reducing the toxic effect on ICR mice bearing S-180.

• Animal cells and systems
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• v.4 no.3
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• pp.293-297
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• 2000

The present investigation was performed to elucidate the effect of pretreatment with low dose ultraviolet radiation (UV) and ethyl methanesulfonate (EMS) on cell survival by trypan blue dye exclusion method and plasma membrane glycoconjugates by lectin-cytochemistry in sarcoma 180 (S180) cells. Pretreatment with 2 J/$m^2$ UV or 2 mM EMS increased the percentage of survival of cells subsequently treated with high dose UV (10 or 20 J/$m^2$) or EMS (10 or 20 mM), respectively. Staining intensity of concanavalin A (Con A) of the cells pretreated with 2J/$m^2$ UV or 2 mM EMS and subsequently treated with 10 or 20 mM EMS was stronger than that of the cellstreated with 10 or 20 mM EMS. These results suggest that there is an adaptive response on cell survival to EMS or UV in S180 cells. And the results show a change in mannose-containing glycoconjugates of plasma membrane in S180 cells pretreated with EMS or UV and subsequently treated with EMS.

• 한국ITS학회:학술대회논문집
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• 2002.11a
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• pp.177-180
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• 2002

• Industrial Engineering and Management Systems
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• v.4 no.2
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• pp.136-144
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• 2005

This research deals with an order picking problem in automated storage and retrieval systems (AS/RS). When retrieval requests consist of multiple items and the items are in multiple stock locations, the storage/retrieval (S/R) machine must travel to numerous storage locations to complete each order. The aim of this research is to propose algorithms for the resolution of order picking problems with multiple stock locations to minimize the total time traveled by the S/R machine. We present and compare three alternatives for solving the problem based on enumeration, ordinary heuristic and genetic algorithms. We used a set of 180 different problems that are solved by these three algorithms. The results show that our proposed genetic algorithm is more efficient than the other two.

• The Journal of The Korea Institute of Intelligent Transport Systems
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• v.6 no.2
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• pp.119-125
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• 2007

In this paper, a multi-band folded planar monopole internal antenna for mobile handset applications is proposed. The proposed antenna has multi-resonances, which is different from a conventional folded monopole antenna, and it provides a wide bandwidth at high frequency bands. The measured impedance bandwidth (VSWR < 3) is 180 MHz and 1880 MHz in lower and higher frequency bands, respectively. The proposed antenna can effectively cover most wireless communication bands including CDMA, GSM, GPS, DCS, PCS, and W-CDMA, WiBro and S-DMB.

• The Transactions of The Korean Institute of Electrical Engineers
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• v.60 no.9
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• pp.1715-1720
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• 2011

Studies suggested an increase in the competitiveness and roles of mainline railways like speed and accessibility improvement, as a fundamental direction of the National Transport Network Plan. At this point, topics presented especially for strengthening the role of human and environment centered transportation: as to the greatly improved speed competitiveness, there are an operational speed above 180km/h ~ 200km/h and traveling within 2 ~ 3 hours among big cities. As to accessibility improvement, there are accessibility to main railway stations within 30 minutes, and the improvement of accessibility, safety, eco-friendliness, amenity etc. As a part of these suggestions, field specific plans were proposed for the establishment of expressed mainline railway network in Korea such as train's, civil structures, trolley lines etc. In this paper we analyzed the conventional lines and systems to figure out whether to change details in terms of H/W of signaling system. Additionally, we reviewed the compatibility or difference of signalling system depending on train's speed. With this result, we deduced the number of virtual blocks specific to the speed of 180km/h, 200km/h and 230km/h, which were showed for the speed improvement considering each variable like blocks, braking distance etc. In this way, we suggested the railway signal system establishment plan considering safety operation.

• The Journal of The Korea Institute of Intelligent Transport Systems
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• v.16 no.2
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• pp.180-189
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• 2017

Some people who take a driver's license test retake it again because of license cancellation, but most of them take the test for the first time to drive the car. Driving a car is directly linked to life, and the initial correct driving habits are more important than anything else. In particular, it is very important to obtain a license by evaluating the correct driving ability based on objective and fair standards when learning the first driving, because many people acquire a driving license while entering the society for the first time. In this paper, we propose the S / W design and its main functions that can emit high quality drivers through efficient, fair and accurate automated scoring. Through this, it is proposed to improve the automatic grading driver's license system, to prevent traffic accidents, and to reduce traffic accidents through proper driving.

• IE interfaces
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• v.19 no.3
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• pp.174-180
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• 2006

This paper deals with the robot system of recognizing human's expression from a detected human's face and then showing human's emotion. A face detection method is as follows. First, change RGB color space to CIElab color space. Second, extract skin candidate territory. Third, detect a face through facial geometrical interrelation by face filter. Then, the position of eyes, a nose and a mouth which are used as the preliminary data of expression, he uses eyebrows, eyes and a mouth. In this paper, the change of eyebrows and are sent to a robot through serial communication. Then the robot operates a motor that is installed and shows human's expression. Experimental results on 10 Persons show 78.15% accuracy.

• The Journal of The Korea Institute of Intelligent Transport Systems
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• v.7 no.6
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• pp.63-69
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• 2008

Reconfigurable RF one-chip solutions have been researched with the objective of designing for smaller-sized and more economical RF transceiver and it can be applied to a vehicular wireless terminal. The proposed voltage-controlled oscillator satisfies the targeted frequency range ($4.2{\sim}5.4\;GHz$) and the frequency planning which correspond to the standards such as CDMA(IS-95), PCS, GSM850, EGSM, WCDMA, WLAN, Bluetooth, WiBro, S-DMB, DSRC, GPS, and DVB-H/DMB-H/L(L Band). In order to improve phase noise performance, PMOS is adopted in the cross-coupled pair, the tail current source and MOS varactor in this VCO and differential-typed switching is proposed in capacitor array. Based on the measurement results, a total power dissipation is $5.3{\sim}6.0\;mW$ at 1.8 V power supply voltage. The oscillator is tuned from 4.05 to 5.62 GHz; The tuning range is 33%. The phase noise is -117.16 dBc/Hz at 1 MHz offset frequency and the FOM (Figure Of Merit) is $-180.84{\sim}-180.5$.

• Journal of Korean Institute of Industrial Engineers
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• v.37 no.3
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• pp.180-190
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• 2011

Efficient energy consumption is a critical factor for deployment and operation of wireless sensor networks (WSNs). To achieve energy efficiency there have been several hierarchical routing protocols that organize sensors into clusters where one sensor is a cluster-head to forward messages received from its cluster-member sensors to the base station of the WSN. In this paper, we propose a self-organized clustering method for cluster-head selection and cluster based routing for a WSN. To select cluster-heads and organize clustermembers for each cluster, every sensor uses only local information and simple decision mechanisms which are aimed at configuring a self-organized system. By these self-organized interactions among sensors and selforganized selection of cluster-heads, the suggested method can form clusters for a WSN and decide routing paths energy efficiently. We compare our clustering method with a clustering method that is a well known routing protocol for the WSNs. In our computational experiments, we show that the energy consumptions and the lifetimes of our method are better than those of the compared method. The experiments also shows that the suggested method demonstrate properly some self-organized properties such as robustness and adaptability against uncertainty for WSN's.