• 한국동물위생학회지
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• 제14권2호
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• pp.110-120
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• 1991

28 porcine enteroviruses were isolated from 86 pig-feces of 9 swine farms located in south region, Chung-buk, from March to September 1990. Physico-chemical properties and pathogenicity of isolates were investigated. Results obtained throughout experiments are summarized as follows. According to the age, weanlings(40-90 days), sucklings(10-30 days) and adult pigs(6 months over) showed the isolation rate of 67%. 8% and 4%, respectively. By physico-chemical tests, YD-90/22, YD-90/43 and YD-90/64 strains were found to be ether, chloroform and PH stable. Nucleic acid test suggests the virus to have a DNA genome. Most of the Isolates were not evident of hemagglutinin using erythrocytes from various mammalian & avian. 22 strains among the isolates were shown CPE type I and the remainders were CPE type II. 3 strains among isolates of CPE type I strains were neutralized with high titers to serotype 2 antiserum. In the study on virus growth curve in PK-l5 cells, YD-90/22, YD-90/43 and YD-90/64 strains showed the maximum infectivity titers($10^{6.0}-l0^{6.5} TCID({50}ml$) at 4days post inoculation(PI). When 30 day-old commercial piglets were inoculated only intraoral route with the YD-90/22 strain at $10^{6.0} TCID_{50}ml,$ piglets not showed the symptoms. But piglets inoculated by intramuscle route, intraoral and intramuscle route after pretreat with dexamethasone(2.5mg /kg) for 5 days were shown the symptoms of anorexia, diarrhea, pyrexia and ataxia at 4th-6th days PI. The viral reisolation in the virus-inoculated piglets was examined from feces. The viruses were recovered intermittently from 2nd to 16th day PI and at 4th-6th day PI, all piglets excreted viruses.

• Journal of Microbiology
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• 제40권1호
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• pp.11-19
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• 2002

Mice immunized with equine herpesvirus type-1(EHV-1) L-particles skewed a significant increase (p<7.75) in serum antibody titers. Upon a booster dose four weeks lateral antibody titers increased significantly. Interestingly, immunization via intravenous or intramuscular route induced significantly higher (p<0.75) antibody titers. However, mice iummunized with UV-treated L-particles, visions or immunization via intranasal route induced lower antibody titers. Upon challenge inoculation with wildtype EHV-1, our data showed there was a poor correlation between antibody titers and protection against virus replication. Therefore, the role of cell-mediated immunity Inwards protection was investigated. As predicted, the strongest cell-mediated immunity, as measured by delayed-hypersensitivity test, was detected in mice immunized with live virus particles. The magnitude of cell-mediated immune response correlated with the efficacy of L-particles as immunizing agent. The highest efficacy, as indicated in mice immunized via intranasal routed was highly correlated with cell-mediated immunity. A similar phenomenon was also demonstrated in mice immunized intranasally with UV-treated L-particles. However, the degree of protection was reduced when mice immunized intravenously or intramuscularly with UV-treated L-particles. In conclusion, protection conferred in these animals was highly implicated by immune cells and the least by antibodies. The route of immunization and the nature of the antigen also contributed to the efficacy of L-particles as immunizing agent. In contrast to that of herpes simplex virus type 1, our data showed EHV-1 non-infectious L-particles are highly suitable for immunization of the host against EHV-1 disease.

• International journal of advanced smart convergence
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• 제12권4호
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• pp.386-394
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• 2023

This study investigated changes in salivary cortisol, lactic acid, and heart rate along the route during walking exercise in a forest environment for the purpose of reducing stress. Walking exercise in a forest environment was conducted on a Hill Type (Distance: 800m, Average slope 25°, Altitude 112m) and Step Type (Distance: 800m, Average slope 25°, Altitude 114m) routes for 10 female college students in their 20s. The subjects were asked to walk at a speed of 60 bpm. The resulting changes in salivary cortisol, lactate, and average heart rate during exercise were compared and analyzed using Repeated Measurement two-way ANOVA, and the maximum heart rate during exercise and average heart rate at rest were compared and analyzed using paired t-test, and the following results were obtained. First, there was no significant difference in salivary cortisol depending on the type and period of the forest, but it tended to gradually decrease. Second, there was a significant difference in lactic acid depending on the type and period, and it was higher in Step Type. Third, there was a significant difference in the average heart rate during exercise, and it was higher in Step Type. Fourth, there was a significant difference in maximum heart rate during exercise, and it was higher in Step Type. Fifth, there was no significant difference in average heart rate during rest. In summary, walking exercise in a forest environment can be effective for stress reduction for female college students in their 20s, but it appears that forest routes should be selected according to physical strength level, and walking exercise in a forest environment for long periods of time is not recommended. For this purpose, it is suggested that it is appropriate to select the Hill Type route.

• 한국통신학회논문지
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• 제27권6C호
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• pp.544-561
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• 2002

본 논문에서는 이동 ad-hoc 네트워크(Mobile Ad-hoc Networks)에서 인접 단말(node)간에만 경로 설정 정보를 교환하는 협의의 네트워크인 가상 클러스터(Virtual Cluster)를 정의하고, 이를 기반으로 하는 새로운 형태의 혼합 방식 경로 설정 프로토콜(Virtual Cluster-based Routing Protocol. VCRP)을 제안한다. 이는 단말이 전체 네트워크의 구성 및 비용 정보를 알고 즉시 경로를 설정할 수 있는 Proactive Routing Protocol (PRP)이 갖는 짧은 전송 지연시간의 장점과 모든 단말이 자신을 제외한 어떠한 단말과도 정보를 교환하지 않고 단지 경로탐색 패킷(Route Query Packet)에 의존하여 동작하는 Reactive Routing Protocol (RRP)이 갖는 우수한 오버헤드 효율성의 장점을 동시에 만족하도록 설계된 방식이다. 이는 경로탐색 패킷이 가상 클러스터가 갖는 장점을 이용하여 적은 오버헤드로 신속하게 네트워크 토폴로지 정보의 수집이 가능한 형태로 수정된 전파(flooding) 기법에 기인한 것이다. 또한, 제안 방식은 수집된 정보를 기반으로 최적 경로뿐만 아니라 부수적으로 백업 경로를 동시에 파악할 수 있기 때문에 이를 이용하는 프로토콜(Virtual Cluster-based Routing Protocol with Backup Route: VCBRP)도 고려하였다. VCRP와 VCBRP 방식은 네트워크 토폴로지 변화에 대해 강인한 특성을 지니며, 동시에 패킷 전송 지연(Packet Transfer Delay), 링크 단절률(Link Failure Ratio), 그리고 무선 자원 수율(Throughput) 및 오버헤드 효율성의 성능이 기존의 경로 설정 프로토콜들에 비해 우수함을 모의 실험을 통해 검증했다.

• Nuclear Engineering and Technology
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• 제55권6호
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• pp.2139-2146
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• 2023

During reactor operation, the divertor must withstand unprecedented simultaneous high heat fluxes and high-energy neutron irradiation. The extremely severe service environment of the divertor imposes a huge challenge to the bonding quality of divertor joints, i.e., the joints must withstand thermal, mechanical and neutron loads, as well as cyclic mode of operation. In this paper, potassium-doped tungsten (KW) is selected as the plasma facing material (PFM), oxygen-free copper (OFC) as the interlayer, oxide dispersion strengthened copper (ODS-Cu) alloy as the heat sink material, and reduced activation ferritic/martensitic (RAFM) steel as the structural material. In this study, a vacuum brazing technology is proposed and optimized to bond Cu and ODS-Cu alloy with the silver-free brazing material CuSnTi. The most appropriate brazing parameters are a brazing temperature of 940 ℃ and a holding time of 15 min. High-quality bonding interfaces have been successfully obtained by vacuum brazing technology, and the average shear strength of the as-obtained KW/Cu and ODS-Cu alloy joints is ~268 MPa. And a fabrication route for manufacturing the flat-type divertor target based on brazing technology is set. For evaluating the reliability of the fabrication technologies under the reactor relevant condition, the high heat flux test at 20 MW/m² for the as-manufactured flat-type KW/Cu/ODS-Cu/RAFM mockup is carried out by using the Electron-beam Material testing Scenario (EMS-60) with water cooling. This paper reports the improved vacuum brazing technology to connect Cu to ODS-Cu alloy and summarizes the production route, high heat flux (HHF) test, the pre and post non-destructive examination, and the surface results of the flat-type KW/Cu/ODS-Cu/RAFM mockup after the HHF test. The test results demonstrate that the mockup manufactured according to the fabrication route still have structural and interfacial integrity under cyclic high heat loads.

• 한국재료학회지
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• 제12권8호
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• pp.595-599
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• 2002

A homogeneous and stable, amorphous-type, anorthite (CaO $Al_2$$O_3$ $2SiO_2$)powder was synthesized by an organic-inorganic steric entrapment route. Polyvinyl alcohol ( PVA) was used as an organic carrier for the precursor ceramic gel. The PVA content, its degree of polymerization and type of silica sol had a significant influence on the calcination and crystallization behavior of the precursors. For densifiction and crystallization at low temperature, porous and soft, amorphous-type anorthite powder was planetary milled for 20h. The milled powder crystallized to stable anorthite phase and densified to a relative density of 94% below $1000^{\circ}C$. In the development of crystalline phases of the planetary milled powder, omisteinbergite phase was unusually observed at $900^{\circ}C$, and then anorthite was observed at $950^{\circ}C$. The sintered anorthite had a thermal expansion coefficient of $4.6$\times$10^{-6}$ /$^{\circ}C$ and a dielectric constant of 7.5 at 1 MHz. Finally, the anorthite synthesized by the new process is expected to be an useful material for low-firing ceramic substrate.

• 한국ITS학회 논문지
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• 제20권1호
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• pp.193-202
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• 2021

고정밀 지도의 갱신은 정사영상 또는 점군 데이터 등을 원천 자료로 하여 기하 정보를 우선적으로 수정한 이후 지도를 구성하는 공간객체들 간의 연관관계를 재정립하는 방식으로 진행된다. 이러한 일련의 과정들은 기하 정보를 처리하는 데에 많은 시간을 소요하므로 차량의 실시간 경로 계획(Real-time route planning)에 빠르게 적용되기 어렵다. 따라서 이 연구에서는 그래프 구조를 활용하여 경로 계획을 위한 도로 연결구조를 우선적으로 업데이트 하는 방식 및 도로 네트워크의 특징을 고려한 그래프 구조의 저장 유형을 제안하였다. 또한 제안된 방법을 실제 도로 자료에 적용해 봄으로써 실시간 경로 정보 전송 시의 활용 가능성에 대해 검토하였다.

• Advances in nano research
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• 제10권2호
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• pp.191-210
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• 2021

To compare the antifungal effect of two nanomaterials (NMs), nanoparticles of zinc oxide were synthesized by a chemical route and zinc oxide-based nanobiohybrids were obtained using green synthesis in an extract of garlic (Allium sativum). The techniques of X-Ray Diffraction (XRD), Infrared (IR) and Ultraviolet Visible (UV-Vis) absorption spectroscopies and Scanning (SEM) and Transmission Electron Microscopies (TEM) were used to determine the characteristics of the nanomaterials synthesized. The results showed that the samples obtained were of nanometric size (< 100 nm). To compare their antifungal capacity, their effect on Cercospora sp. was evaluated. Test results showed that both nanomaterials had an antifungal capacity. The nanobiohybrids (green route) gave an inhibition of fungal growth of ~72.4% while with the ZnO-NPs (chemical route), inhibition was ~87.1%. Microstructural studies using High Resolution Optical Microscopy (HROM) and ultra-structural analysis using TEM carried out on the treated strains demonstrated the effect of the nanofungicides on the vegetative and reproductive structures, as well as on their cell wall. To account for the antifungal effect presented by ZnO-NPs and ZnO nanobiohybrids on the fungi tested, effects reported in the literature related to the action of nanomaterials on biological entities were considered. Specifically, we discuss the electrical interaction of the ZnO-NPs with the cell membrane and the biomolecules (proteins) present in the fungi, taking into account the n-type nature of the ZnO semiconductor and the electrical behavior of the fungal cell membrane and that of the proteins that make up the protein crown.

• 한국ITS학회 논문지
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• 제13권3호
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• pp.47-65
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• 2014

도형식 가변안내표지판은 운전자들의 경로선택에 대한 의사결정을 지원하는 역할을 하며 운전자의 이해도와 시인성이 높아 도심부 도로 및 고속도로에 설치가 확대되고 있다. 그러나 도형식 가변안내표지판에 대한 운영방안이나 지침 등이 전무한 실정이다. 이에 본 연구는 도형식 가변안내표지판 표출면 구성에 따른 운전자의 선호도를 평가하는 모형을 개발하기 위하여 차량 시뮬레이터를 활용한 실험 및 설문조사를 수행하였다. 연구 결과 표출면의 구성요소 중 도로선형, 외곽선, 문자체 등의 디자인적인 요소보다는 문자높이, 노드수 등의 정보 제공 량이나 시인성과 관련된 부분이 운전자의 감성요인과 선호도에 큰 영향을 미치는 것으로 나타났다. 또한 도형식 가변안내표지판의 제공 정보 단위 수는 11단위 또는 12단위가 적절한 것으로 나타났으며, 이는 통행시간을 제공할 경우 3개의 노드, 통행시간을 제공하지 않을 경우 5개 노드의 정보를 제공하는 것이 적정한 수준임을 의미한다. 따라서 가변안내표지판을 설치할 때 운전자의 감성요인과 선호도를 높일 수 있는 구성요소를 고려하여 표출면을 설계하여야 한다.

• 헤리티지:역사와 과학
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• 제55권4호
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• pp.6-22
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• 2022

본고에서는 서·남해안에서 출수된 닻돌 228점의 유형을 분류하고, 유형별 결합 방식 상정, 출수 위치를 통한 항로 및 묘박지 추정 등을 시도하였다. 유형 분류에 앞서 닻돌의 무게, 두께, 너비, 길이를 측정하였는데, 묘박(錨泊)에서 가장 큰 영향을 끼치는 무게를 I~V군으로, 닻돌의 형태는 1~6형으로 구분하였다. 이러한 무게와 형태의 상관 관계를 통해 모두 17개의 유형으로 분류하였다. 유형별 결합 방식은 출수된 닻돌의 기준값 형태적 특징에 따라 무게가 180kg 이하이면서, 형태가 1·2형인 것은 닻장에 결합하여 사용하는 닻으로, 무게가 180kg 이상이며 형태가 3~6형인 것은 닻채에 결합하여 사용하는 닻으로 상정하였다. 이와 함께 과거 기록과 지역 주민의 증언을 통해 항로와 묘박지(錨泊地)를 파악하고 이를 실물자료와 대조하였다. 항로는 대체로 과거 기록과 그 위치가 일치했지만, 새로운 항로가 섬 인근이나 내륙 인접 해역에서 확인되기도 하였다. 묘박지의 경우 닻돌 집중 분포지인 태안 마도 해역과 진도 벽파진 해역(珍島 碧波津 海域)에서 소형, 대형 닻돌들이 출수되는 양상을 볼 때, 여러 크기의 선박이 두 해역에 묘박하였다는 증언과 일치하였다.