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Roles of Glyceraldehyde-3-Phosphate Dehydrogenase in Edwardsiella tarda Pathogenesis (Edwardsiella tarda의 glyceraldehyde-3-phosphate dehydrogenase가 병원성에 미치는 영향)

  • Yu, Jong-Earn;Oh, Young-Eun;Lee, Tae-Ho;Kang, Ho-Young
    • Journal of Life Science
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    • v.20 no.12
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    • pp.1743-1749
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    • 2010
  • A research group demonstrated that the 37 kDA protein of Edwardsiella tarda, a causing causative agent of edwardsiellosis in fish, exhibited high antigenicity in Japanese flounder. The research group also showed that the N-terminus amino acid sequences of the 37 kDa protein were mapped to the N-terminus of GAPDH (glyceraldehyde-3-phosphate dehydrogenase). Using degenerated primer sets based on the known N-terminus sequence, the corresponding E. tarda DNA was amplified and cloned. The nucleotide sequences of the cloned gene revealed high homology with a bacterial gene for GAPDH, as we was expected. The amino acid sequence of E. tarda GAPDH (etGAPDH) revealed a <70% similarity with GAPDH proteins in other Enterobacteriaceae. With the application of artificial protein overexpression system in Escherichia coli, the recombinant etGAPDH (rGAPDH) was produced and purified. In this study, Using the purified rGAPDH, the etGAPDH specific polyclonal antibody has been was generated using the purified rGAPDHin this study. The immunoblotting analyses demonstrated that the location of the GAPDH protein is located with the association of is associated with the envelops of E. tarda. The rGAPDH was administrated into Japanese flounder via IP route for evaluation of the protective ability. Although the specific antibody titer against etGAPDH was increased about 3-fold after 4 weeks post-vaccination, the survival rates of vaccinated Japanese flounder and the control group with wild type E. tarda was were 12.5% and 0%, respectively. Our results indicated that rGAPDH is immunoreactive antigen but that it will not generate protective immunity in Japanese flounder.

A Study on the Design Improvement and Information Service of Bicycle Road Considering Environmental Factor (주변 환경요소를 고려한 자전거 도로 설계 개선 및 정보제공에 관한 연구)

  • Choi, Byoung-Gil;Park, Hong-Ki;Na, Young-Woo
    • Journal of the Korean Society of Surveying, Geodesy, Photogrammetry and Cartography
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    • v.29 no.1
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    • pp.11-20
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    • 2011
  • This study aimed to devise the method to construct safe and convenient bicycle road by considering the peripheral environmental factor related to using bicycle. Analyzing the existing design of bicycle road and construction case, this study established the method to design bicycle road that reflects site condition and presented the optimal design method for each type of bicycle road to construct safe and convenient bicycle road by analyzing the type of traffic accident for each type of bicycle road, surveying present situation and local survey. It was found that the optimum design of bicycle road for specification, width, curve radius, ascending slope, etc in consideration of peripheral environment and separating traffic between users of traffic means should be done by installing safety sign, safe facilities and separation facilities to design safe bicycle road. Further, the minimum traffic space of bicycle users and connection between bicycle roads should be ensured to design safe bicycle road. It is judged that information related to safety and convenience of bicycle road such as slope, route information, location of convenience facilities, information to the public traffic should be provided so as to activate the users of bicycle.

Ultrasonographic Findings and Usefulness in Ulnar Neuropathy at the Elbow (주관절부 척골 신경병증에서의 초음파 소견 및 유용성)

  • Kim, Dong-Hu;Cho, Chul-Hyun;Lee, Kyung-Rak
    • Clinics in Shoulder and Elbow
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    • v.15 no.2
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    • pp.109-116
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    • 2012
  • Purpose: The aim of this study was to evaluate preoperative ultrasonographic findings and usefulness in ulnar neuropathy around elbow. Materials and Methods: Twenty-two patients with ulnar neuropathy were performed preoperative ultrasonogram. The route, location, thickness of the ulnar nerve and space occupying lesion through longitudinal scan were evaluated. Cross-sectional areas of the ulnar nerve were measured at the level of medial epicondyle and 3 cm proximal and distal to the medial epicondyle through axial scan. Correlations between swelling ratio of ulnar nerve and eletrophysiologic study and preoperative Dellon's assessment were checked. Results: In 21 cases (95.6%) of total 22 cases, diffuse swelling of the ulnar nerve around elbow were identified. 4 cases had space occupying lesions including 3 ganglionic cysts and 1 heterotopic ossification. Cross sectional areas at the level of medial epicondyle were significantly larger than at the level of 3 cm proximal and distal to the medial epicondyle (p<0.05). There were no statistically significant correlations between swelling ratio of ulnar nerve and eletrophysiologic study and preoperative clinical assessment (p>0.05). Conclusion: This study showed that ultrasonography was helpful to detect etiology of ulnar neuropathy around elbow such as space occupying lesion, morphological change or dislocation of ulnar nerve. It could be useful tool for diagnosis and treatment in patients with ulnar neuropathy at elbow.

A Historical Geography of the Castles in the Sacheon Bay Region (사천만 연안에 축성된 성(城)의 유형과 기능에 관한 역사지리적 연구)

  • Lee, Jeon
    • Journal of the Korean association of regional geographers
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    • v.6 no.1
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    • pp.51-68
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    • 2000
  • The Sacheon bay region functioned as a strategic place as the bay provided a major sea-route leading to the Kyungnam province. So it is no wonder that a number of castles and walls were located in such an outlying post of strategic importance. In the bay region there are found Sacheon, Gonyang and Seonghwangdang town castles, Yeegu, Seongbangri, Shinbyukdong, Duckgockri, Baekcheondong and Gaksan miltary castles, Seonjinri and Sadung Japanese castles, Kumseonri and Wueolseongri mud walls, Gaksan, Anjeom, Chimzi and Usan beacon-post walls, and Tongyang, Gasan and Jangam warehouse walls(사천읍성, 곤양읍성, 성황당산성, 이구산성, 성방리산성, 신벽동산성, 덕곡리산성, 백천동산성, 각산산성, 사등산성지, 선진리성, 금성리 토성, 월성리 토성지, 각산봉수대성, 안점봉수대성, 침지봉수대성지, 우산봉수대성, 통양창성지, 가산창성지, 장암창성). Castles are, according to their functions, classified into two: town castles and military castles. In the former castles people live permanently, but in the latter people do not. Military castles are occupied only in time of emergence. Beside the two types, two Japanese castles, two old mud walls, four beacon-post walls, and three warehouse-post walls are found in the Sacheon bay region. Castles are also classified into plain castles and mountain castles according to their location. Mud, stone, wood, and brick materials were used for castle and wall building. As the castles and walls of the bay region are precious cultural assets, they should be preserved and protected with much attention. It should be remembered that in the future they can be the most valuable tourist attractions all around.

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The Decision Criteria on the Transshipment Container Ports (컨테이너항만의 환적항 결정요인 분석)

  • Park, Byung-In;Sung, Souk-Kyung
    • Journal of Korea Port Economic Association
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    • v.24 no.1
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    • pp.41-60
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    • 2008
  • Korea has been doing a two-port system as a main port development policy and developing the port of Busan and Gwangyang as the transshipment hubs in the northeast Asia. However, the growth rate of the transshipment container volume of the Gwangyang port in 2007 was sharply dropping more than 31.4%. The reasons why reduced the growth rate of transshipment cargo were from the port development in north China and the direct callings of ships. Therefore, it is time to evaluate the transshipment hub port policy of Korea. This study would recognize the decision criteria of shipping companies as customers for the transshipment hub in the northeast Asia by the AHP methodology based on Lirn et al. (2004). It has been known the costs of shipping companies and port location as the main first tier criteria for transshipment ports, and container handling charges, closeness to the main navigation route, carriers' strategy, and nearness to the feeder ports as the important second tier factors. Finally, the domestic terminal operating companies would focus on only a few attributes including the terminal cost factor, but the international shipping companies would be considering more several factors than they do. Therefore, the transshipment port strategy should be enriched in the near future.

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A Study on the Movement of Street-based Urban Morphology Using Analysis of Integrated Land Use-Transportation (토지이용-교통 통합적 분석을 통한 도로 기반 도시 형태학적 변화에 관한 연구)

  • Joo, Yong-Jin
    • Spatial Information Research
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    • v.19 no.3
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    • pp.63-72
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    • 2011
  • Urban space structure tends to have a significant change in accordance with maintenance of urban infrastructure such as a traffic route. For this reason, quantitative analysis has been needed to establish spatial distribution and location patterns by considering change of both road accessibility and urban infrastructure level, which can have the most pervasive influence in urban development process. Therefore, this paper aims to analyze spatio-temporal urban morphology through considering distribution patterns of road among transportation infrastructures, population, and spatial structure of metropolitan areas, focusing on Seoul where population growth and the size of urban area have been dramatically increased. For this, we firstly developed and constructed time-series GIS database by using satellite images and topographic maps of the last 70 years to analyze variables which affect urban growth and transportation. In particular, we analyzed the transform of the system of the street by Space Syntax which is able to grasp hierarchical spatial structure through visibility of space and spatial cognition in terms of accessibility. What's more, we analyzed and visualized the relationship urban morphology and road according the regions of Seoul through IPA(Importance Performance Analysis). In terms of the integration land-use and transportation, Space Syntax approach is expected to contribute to efficient urban planning through understanding the influence which various transportation phenomena has an effect on urban development patterns.

Designing the Optimal Urban Distribution Network using GIS : Case of Milk Industry in Ulaanbaatar Mongolia (GIS를 이용한 최적 도심 유통 네트워크 설계 : 몽골 울란바타르 내 우유 산업 사례)

  • Enkhtuya, Daariimaa;Shin, KwangSup
    • The Journal of Bigdata
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    • v.4 no.2
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    • pp.159-173
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    • 2019
  • Last-Mile delivery optimization plays a key role in the urban supply chain operation, which is the most expensive and time-consuming and most complicated part of the whole delivery process. The urban consolidation center (UCC) is regarded as a significant asset for supporting customer demand in the last-mile delivery service. It is the key benefit of UCC to improve the load balance of vehicles and to reduce the total traveling distance by finding the better route with the well-organized multi-leg vehicle journey in the urban area. This paper presents the model using multiple scenario analysis integrated with mathematical optimization techniques using Geographic Information System (GIS). The model aims to find the best solution for the distribution network consisted of DC and UCC, which is applied to the case of Ulaanbaatar Mongolia. The proposed methodology integrates two sub-models, location-allocation model and vehicle routing problem. The multiple scenarios devised by selecting locations of UCC are compared considering the general performance and delivery patterns together. It has been adopted to make better decisions the quantitative metrics such as the economic value of capital cost, operating cost, and balance of using available resources. The result of this research may help the manager or public authorities who should design the distribution network for the last mile delivery service optimization using UCC within the urban area.

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Development of Video Work Manual for Rock-Drill Data In Fire Service (소방에서의 도상훈련 기초자료 영상화작업 매뉴얼 개발)

  • Cho, Jae-Kwan;Park, Hee-Jin;Hwang, Inn;Kwon, Hayrran
    • The Korean Journal of Emergency Medical Services
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    • v.6 no.1
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    • pp.103-128
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    • 2002
  • As a result of trying the various manufacturing methods considering the reality of manpower and equipments with this manual, the following standardized procedures and contents can be suggested. (1) Since tools presenting Rock-Drill data must formalize the order of explanation although explainers are different, it will be valid that it is configured by existing power point method rather than by web document type. Composition of contents are selected on the basis of defence card and survey and then 8 items including initial screen, peripheral conditions, mobilization route, general conditions, use and structure by floor, department of vehicle consideration in activities and end screen are included. (2) Making methods and cautions of data included and used in power point are as follows ; - It was most effective that objects of fire fighting and location of neighboring fire fighting water were expressed by electronic map and drawing of inner building was made by scanning it after paining general architecture drawing(plan by each floor) rather than using drawing tools of EXCEL program or CAD drawing. And it was helpful to simplify contents of architecture drawing to wall, stairs and gate in understanding them. - Photographing of video data should be taken to show available fire fighting facilities in fire, use of planned space and the whole inner structure of each floor from the inside of fire fighting buildings and to display play time between 10 sec. and 1 min, for obstacles to distance from adjacent buildings or passage of special vehicles and fire fighting water from the outside of the building. - File format of video data taken in this way is most suitable to use wmv(window media video) or asf(advanced streaming format) type in consideration of time required for export, screen quality, file capacity and play type in Rock-Drill through network. - Still screen(photo) is more effective to express the department of fire fighting vehicles or other equipments than using video. (3) In configuration work of power point, hyper link was used most and configured to see any part at any situation like web document and then uniformity of presentation order of power point was complemented. (4) In case of sales facilities with the area of $35.557m^2$, the time of 22 hours and 30 minutes for five days was taken with five persons. Therefore, when eight-hour works a day were calculated, the whole process of video work for Rock-Drill can be finished with three day works.

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An Object Recognition Performance Improvement of Automatic Door using Ultrasonic Sensor (초음파 센서를 이용한 자동문의 물체인식 성능개선)

  • Kim, Gi-Doo;Won, Seo-Yeon;Kim, Hie-Sik
    • Journal of the Institute of Electronics and Information Engineers
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    • v.54 no.3
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    • pp.97-107
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    • 2017
  • In the field of automatic door, the infrared rays and microwave sensor are much used as the important components in charge of the motor's operation control of open and close through the incoming signal of object recognition. In case of existing system that the sensor of the infrared rays and microwave are applied to the automatic door, there are many malfunctions by the infrared rays and visible rays of the sun. Because the automatic doors are usually installed outside of building in state of exposure. The environmental change by temperature difference occurs the noise of object recognition detection signal. With this problem, the hardware fault that the detection sensor is unable to follow the object moving rapidly within detection area makes the sensing blind spot. This fault should be improved as soon as possible. Because It influences safety of passengers who use the automatic doors. This paper conducted an experiment to improve the detection area by installing extra ultrasonic sensor besides existing detection sensor. So, this paper realize the computing circuit and detection algorithm which can correctly and rapidly process the access route of objects moving fast and the location area of fixed obstacles by applying detection and advantages of ultrasonic signal to the automatic doors. With this, It is proved that the automatic door applying ultrasonic sensor is improved detection area of blind spot sensing through field test and improvement plan is proposed.

A Study on the Block Planning Characteristics of the Tribute Granary Castle at Asan Cape Gongse in the Joseon Dynasty (조선시대 아산 공세곶창성의 배치 특성에 관한 연구)

  • Lee, Wang-Kee;Lee, Jeong-Soo;Lim, Cho-Long
    • Journal of architectural history
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    • v.16 no.3
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    • pp.75-94
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    • 2007
  • There were many researches on marine transportation and granaries, most of which focused on the historical establishment and organization of the marine transportation. However, a few researches were conducted on the architectural aspects. Hence the purposes of this study are to investigate the following matters: first, documents and relics concerning the tribute granary castle at Cape Gongse in Asan, a typical granary during the Joseon Dynasty, were investigated to academically understand the castle's establishment and historical background; second, the dispositional characteristics of the granary and the castle, including its adjacent facilities, were investigated to review its archaeological value; finally, basic materials were provided for systematical preservation and management these relics. As for the research method, the author referred to and analyzed sundry records and old maps, and ascertained in detail historical evidence through residential testimonies and the on-the-spot surveys. In addition, the author investigated the dispositional characteristics of the tribute granary castle at Cape Gongse by analyzing its exact size and shape, based on the old documents and an actual survey of the castle remains. The characteristics of the tribute granary castle at Cape Gongse may be summarized as follows. First, tribute granary at cape Gongse is a only tribute granary which has a granary and castle. second, the tribute granary castle at Cape Gongse has a curvilinear shape, like a gourd dipper; a large circle surrounding the village and a small circle surrounding the area of Mt. Shinpoong both meet up with it. Third, the construction type of the tribute granary castle at Cape Gongse is in a style similar to a town castle or a battle camp castle located in the coastal regions. As for its locational conditions, however, the east gate, presumably an incoming and outgoing route to the granary for vessels, was a feature unique to the marine granary castle. Fourth, the tribute granary at Cape Gongse had a granary of eighty kan in 1523 and, in addition, there were also Bongsang-cheong, Sa-chang, Joseon-sobakcheo, Chimhae-dang, and more, not to mention many privates houses in the castle. The granary is located in the center of the tribute granary castle, where Gongse Nonghyub is currently located. The location of the government offices seemed to be on the northern ridge. Fifth, the tribute granary castle at Cape Gongse is a valuable relic that offers insight into marine transportation, tribute granaries, and tribute granary castles during the Joseon Dynasty. It has special archaeological value because it was one of only a few tribute granary castles that served to protect the tribute granaries.

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