• Natural Product Sciences
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• 제12권3호
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• pp.144-149
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• 2006

The immediate-type allergic reaction (anaphylaxis) is involved in many allergic diseases such as asthma, allergic rhinitis, and sinusitis. The discovery of drugs for the treatment of immediate-type allergic diseases is a very important subject in human health. In this study, we investigated the effect of Rubus coreanus Miq.(Rosaceae) unripe fruits (RCF) on mast cell-mediated allergic reaction and inflammatory cytokine secretion. RCF inhibited compound 48/80-induced systemic reactions in mice. RCF attenuated immunoglobulin (Ig) E-mediated local allergic reactions. In addition, RCF dependently reduced histamine release from rat peritoneal mast cells local allergic reactions. In addition, RCF dependently reduced histamine release from rat peritoneal mast cells activated by compound 48/80 or IgE. Furthermore, RCF decreased the phorbol 12-myristate 13-acetate plus calcium ionophore A23187-stimulated tumor necrosis factor $(TNF)-{\alpha}$ and interleukin (IL)-6 secretion in human mast cells. Our findings provide evidence that RCF inhibits mast cell-derived immediate-type allergic reactions.

• 한국식품조리과학회지
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• 제31권2호
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• pp.144-152
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• 2015

The loquat (Eriobotrya japonica) is a plant belonging to the Rosaceae family, native to south-central China. It is cultivated in relatively warm areas such as Spain, Japan and South Korea. It is used commercially as an ornamental plant and for its yellow fruit, which contains much carotenoid, sugar and a little organic acid. In this study, chiffon cakes were prepared with the addition of 3%, 6%, 9% and 12% loquat fruit powder (LFP) in order to invest the mixing conditions. When more LFP was added to the dough, the pH level of the dough became lower. Specific gravity and viscosity of the dough significantly increased as higher amounts of LFP were added. In baked cakes, the weight and baking loss rate of LFP were not significantly different between samples, and the height of the risen test samples were lower than that of the controls. Moisture content was 33.58% in the 12% LFP sample (12% LFPS), which was the highest of all the samples. With respect to crust color, lightness, redness and, yellowness, these significantly decreased as the amount of LFP was increased, the 12% LFP being the lowest of all the samples. Lightness and yellowness of crumbs significantly decreased as the amount of LFP was increased, whereas redness showed the reverse effect. When looking at hardness and adhesiveness, the 12% LFPS was the highest of all the samples, nevertheless a difference in resilience was not significant among the samples. According to consumer perception, bitterness was significantly increased as amounts of LFP increased, however a difference in salty, astringency and oily tastes were not significant among the samples. The 12% LFPS showed the lowest score with respect to softness and overall acceptability. In conclusion, LFP could be considered a functional material, with the optimum amount of LFP for a chiffon cake of 3~9%.

• Asian Pacific Journal of Cancer Prevention
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• 제14권5호
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• pp.2973-2978
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• 2013

Maesil (Prunus mume Siebold & Zucc.), a member of the genus Rosaceae, has been reported to have antioxidative effects, as well as anticancer influence in many cancer lines. Thus, this present study was designed to investigate the inhibitory effect of fermented Maesil with probiotics against 7,12-dimethylbenz[a]anthracene (DMBA), 12-O-tetradecanoyl phorbol 13-acetate (TPA)-induced mouse skin carcinogenesis via its antioxidative potential. Mice were fed a diet containing fermented Maesil, containing either 1% (1% FM fed group) or 2% (2% FM fed group) along with probiotics following DMBA and TPA exposure. Continuous ingestion of the experimental feed markedly inhibited skin carcinogenesis, as evidenced by a marked decrease in papilloma numbers and epidermal hyperplasia as well as cellular proliferation and the percentage of proliferating-cell nuclear antigen positive cells. Also, the FM fed group showed an increase of total antioxidant capacity as well as an increased level of phase II detoxifying enzymes such as superoxide dismutase, concurrent with a decreased lipid peroxidation activity level. Taken together, these results suggest that fermented Maesil has the ability to suppress the development of DMBA-TPA induced skin carcinogenesis, via the reduction of lipid peroxidation, enhancing total antioxidant capacity and phase II detoxifying enzyme.

• 생약학회지
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• 제36권4호통권143호
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• pp.324-331
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• 2005

The roots of Rosa rugosa have been used to treat diabetes mellitus in the folkloric society of Korea. To demonstrate the active component for the rat obesity induced by high fat diet for 6 weeks, the phytochemical fractionation and the pharmacological activity test were performed on this crude drug. It was shown that the methanolic extract and its EtOAc fraction inhibited the weight increase of the rat body, abdominal fat pad and hyperlipidemia at 200 mg/kg dose. Further, the triterpenoids, euscaphic acid and tormentic acid, isolated from R. rugosa roots were active at 30 mg/kg in the same assay. The two components shifted serum total-, HDL, and LDL-cholesterol levels toward the values of the unteated group, suggesting that the active compounds has hypolipidemic effects. The rats fad euscaphic acid and tormentic acid also reduced thiobarbituric acid-reactive substance (TBARS) and hydroxyl radical in the rat blood and increased superoxide dismutase activity compared to the control. TBARS values and carbonyl contest of the hepatic protein were reduced by treatment with the two triterpenoids. Antioxidative enzyme (SOD, glutathione peroxidase, and catalase) activities in hepatic were increased by treatment of rats with the triterpenoids, which suggests that triterpenoids inhibited the reduction of hepatic antioxidative activity caused by high fat diet. Taken together, these results support that euscaphic acid and tormentic acid improve a high fat diet-induced hyperlipidemia via the activation of antioxidative mechanism.

• 생약학회지
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• 제49권1호
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• pp.40-46
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• 2018

Chaenomeles sinensis (Thouin) Koehne fruit (Rosaceae) has been used as a traditional medicine in Korea, Japan and China to treat sore throat, diarrhea and inflammation. The ethanol extract of C. sinensis fruit was successively partitioned as methylene chloride, ethyl acetate, n-butanol and $H_2O$ soluble fractions. Among those fractions, the n-butanol fraction showed the most potent DPPH radical scavenging and superoxide quenching activities. To verify antioxidant activities, the n-butanol fraction was checked the activities of superoxide dismutase (SOD) and catalase activities, and intracellular ROS levels and oxidative stress tolerance in Caenorhabditis elegans. Furthermore, to see if increased stress tolerance of worms by treating of the n-butanol fraction was due to regulation of stress-response gene, we quantified SOD-3 expression using transgenic strain. Consequently, the n-butanol fraction elevated SOD and catalase activities of C. elegans, and reduced intracellular ROS accumulation in a dose-dependent manner. Moreover, the n-butanol fraction-treated CF1553 worms exhibited significantly higher SOD-3::GFP intensity.

• 한국잡초학회지
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• 제13권2호
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• pp.164-172
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• 1993

1992년(年) 6월(月)과 9월(月)에 경북지방(慶北地方)의 묘지에 분포하는 잡초(雜草)를 조사하여 얻어진 결과는 다음과 같다. 1. 묘지에서 조사된 잡초종(雜草種)은 53과 196종으로 그 중 일년생(一年生) 31종, 울년생(越年生) 38종, 다년생(多年生) 127종이었다. 2. 묘지에서 조사된 잡초종(雜草種)을 과별(科別)로 보면 국화과 34종, 벼과 27종, 콩과 17종, 장미과 10종, 백합 미나리아재비과 8종, 석죽 배추과 7종, 꿀풀 마디풀과 6종, 돌나물 사초과 4종 그리고 나머지 41과에서 1~3종의 잡초(雜草)가 조사되었다. 3. 경북지방(慶北地方)의 묘지에서 우점(優占)하는 초종은 띠, 쑥, 제비꽃, 개망초, 망초, 산딸기, 꿀풀 등이었다.

• 동의생리병리학회지
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• 제22권2호
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• pp.385-389
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• 2008

Nitric oxide (NO) has been suggested to play an important role in endotoxin-mediated shock and inflammation. In this study, we investigated the effect of Rosa laevigata Michx. (Rosaceae) on the production of NO and the molecular mechanism of its action. Rosa laevigata inhibited NO generation and iNOS expression in LPS-stimulated murine macrophages. Activity of nuclear $factor{-\kappa}B\;(NF{-\kappa}B)$ and the degradation of $I{\kappa}B-{\alpha}$ were suppressed by Rosa laevigata. Furthermore, extracellular signal-stimulated kinase (ERK), which is known to be involved in $NF{-\kappa}B$ activation, is inhibited by Rosa laevigata. These results suggest that Rosa laevigata could exert its anti-inflammatory actions by suppressing the synthesis of NO through inhibition of $NF{-\kappa}B$ activity.

• 생명과학회지
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• 제16권6호
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• pp.898-903
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• 2006

한국내 분포하는 장미과의 솜양지꽃(Potentilla discolor Bunge) 15집단에 대한 19 알로자임 대립유전자좌위에서 유전적 다양성과 집단구조를 분석하였다. 조사한 좌위에 대해 약 73.7%가 다형성을 나타내었다. 종과 집단 수준에서 유전적 다양도는 각각 0.215, 0.196이었으며, 집단간 분화정도는 낮았다$(G_{ST}\;=\;0.069)$. 전체 유전적 다양성은 0${\sim}$0.656이며 평균 0.292였다. 유전적 다양도 중 집단내 변이는 높았다$(H_{S}\;=\;0.274)$. 전체 유전적 변이에서 집단간 차이는 Pgm-2에서 0.010, Pgd-2에서 0.261로 평균 0.069였다. 이는 전체 알로자임 변이 중 약 6.9%가 집단간에 있음을 의미한다. 솜양지꽃의 특성으로 광범위한 분포, 다년생 초본, 여러 세대의 존재 등이 높은 유전적 다양성을 나타내는데 기여하는 것으로 설명된다. 조사한 솜양지꽃 집단에서 세대당 이주하는 개체수는 3.36으로 평가되었다.

• 아시안잔디학회지
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• 제22권2호
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• pp.179-184
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• 2008

경기도 가평의 골프장에서 주황긴다리풍뎅이의 기주식물을 조사한 결과 7과 10종의 미기록 기주가 추가되어 주황긴다리풍뎅이의 기주식물은 30과 94종이 된다. 노박덩굴과의 회잎나무와 진달래과의 영산홍, 황철쭉, 느릅나무과의 혹느릅나무, 장미과의 사과나무와 야광나무, 인동과의 삼색병꽃나무, 버드나무과의 키버들, 참나무과의 바늘참나무가 주황긴다리 풍뎅이의 새로운 기주가 되었고, 자작나무와 사과나무, 핀참나무의 피해도가 높았다.

• 한국정보통신학회:학술대회논문집
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• 한국정보통신학회 2017년도 춘계학술대회
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• pp.149-152
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• 2017

빅데이터 분석은 데이터베이스에 잘 정리된 정형 데이터뿐 아니라 인터넷, 소셜 네트워크 서비스, 모바일 환경에서 생성되는 웹 문서, 이메일, 소셜 데이터 등 비정형 데이터를 효과적으로 분석하는 기술을 말한다. 메타분석은 여러 실증연구의 정량적인 결과를 통합과 분석을 통해 전체 결과를 조망할 수 있는 기회를 제공하는 통계적 통합 방법이다. 오늘날 성별과 나이와 상관없이 어떻게 하면 더 젊고 건강한 삶을 영위할 수 있을지에 대한 관심이 높아지고 있다. 아로니아는 블랙 초크베리 라고 불리는 장미과에 속하는 베리류의 식물열매로 원래는 북부 아메리카 지역에서 자생한다. 본 연구는 아로니아 추출물의 항산화 활성과 관련 요인을 분석한 연구에서 2000년부터 2017년까지 우리나라 학회지에 게재된 연구를 대상으로 하였다. 개념모델에서 제시된 총당, 산도, 폴리페놀, 안토시아닌 그리고 항산화 활성 요인을 대상으로 하였다. 결과를 바탕으로 학문적 실무적 의의를 논의하고자 한다.