• ETRI Journal
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• v.42 no.5
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• pp.643-657
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• 2020

Sixth generation will exploit satellite, aerial, and terrestrial platforms jointly to improve radio access capability and unlock the support of on-demand edge cloud services in three-dimensional (3D) space, by incorporating mobile edge computing (MEC) functionalities on aerial platforms and low-orbit satellites. This will extend the MEC support to devices and network elements in the sky and forge a space-borne MEC, enabling intelligent, personalized, and distributed on-demand services. End users will experience the impression of being surrounded by a distributed computer, fulfilling their requests with apparently zero latency. In this paper, we consider an architecture that provides communication, computation, and caching (C3) services on demand, anytime, and everywhere in 3D space, integrating conventional ground (terrestrial) base stations and flying (non-terrestrial) nodes. Given the complexity of the overall network, the C3 resources and management of aerial devices need to be jointly orchestrated via artificial intelligence-based algorithms, exploiting virtualized network functions dynamically deployed in a distributed manner across terrestrial and non-terrestrial nodes.

• Journal of Communications and Networks
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• v.13 no.3
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• pp.277-285
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• 2011

Real-time multimedia streaming over the Internet is rapidly increasing with the popularity of user-created contents, Web 2.0 trends, and P2P (peer-to-peer) delivery support. While many homes today are broadband-enabled, the quality of experience (QoE) of a user is still limited due to frequent interruption of media playout. The vulnerability of TCP (transmission control protocol), the popular transport-layer protocol for streaming in practice, to the packet losses, retransmissions, and timeouts makes it hard to deliver a timely and persistent flow of packets for online multimedia contents. This paper presents TCP-real-time online multimedia environment (ROME), a novel transport-layer framework that allows the establishment and coordination of multiple many-to-one TCP connections. Between one client with multiple home addresses and multiple co-located or distributed servers, TCP-ROME increases the total throughput by aggregating the resources of multiple TCP connections. It also overcomes the bandwidth fluctuations of network bottlenecks by dynamically coordinating the streams of contents from multiple servers and by adapting the streaming rate of all connections to match the bandwidth requirement of the target video.

• Advances in aircraft and spacecraft science
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• v.9 no.5
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• pp.479-491
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• 2022

This work concerns the investigation of a Q1D methodology employed to study pressure oscillations in solid rocket motors driven by hydrodynamic instabilities. A laboratory-scale solid motor designed to develop vortex-shedding phenomena is analyzed for the whole firing time. The comparison between numerical results and experimental data shows good agreement regarding pressure oscillations signature, especially in the flute-mode behavior, the typical oscillations frequency trend present in any motor liable to hydrodynamic instabilities. Such result ensures the model capability to cope with this particular kind of pressure oscillations source, allowing the investigation of the phenomenon with a lighter and cost savings methodology than CFD simulations.

• Asian Pacific Journal of Cancer Prevention
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• v.16 no.9
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• pp.3635-3638
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• 2015

Several improvements in ovarian cancer treatment have been achieved in recent years, both in surgery and in combination chemotherapy with targeting. However, ovarian tumors remain the women's cancers with highest mortality rates. In this scenario, a pivotal role has been endorsed to the immunological environment and to the immunological mechanisms involved in ovarian cancer behavior. Recent evidence suggests a loss of the critical balance between immune-activating and immune-suppressing mechanisms when oncogenesis and cancer progression occur. Ovarian cancer generates a mechanism to escape the immune system by producing a highly suppressive environment. Immune-activated tumor infiltrating lymphocytes (TILs) in ovarian tumor tissue testify that the immune system is the trigger in this neoplasm. The TIL mileau has been demonstrated to be associated with better prognosis, more chemosensitivity, and more cases of optimal residual tumor achieved during primary cytoreduction. Nowadays, scientists are focusing attention on new immunologically effective tumor biomarkers in order to optimize selection of patients for recruitment in clinical trials and to identify relationships of these biomarkers with responses to immunotherapeutics. Assessing this point of view, TILs might be considered as a potent predictive immunotherapy biomarker.

• Journal of Industrial Technology
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• v.29 no.A
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• pp.27-36
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• 2009

Reliability plays a pivotal role in products safety and quality. DoD RIAC recently developed a new reliability prediction methodology, $217Plus^{TM}$, for electronic systems. It officially replaces the well-known MIL-HDBK-217 and is expected to be widely used. Although theoretic study about $217Plus^{TM}$ and its application towards field systems seem to be attractive, it is also desirable to understand the general background of its development. In this paper, we performed a historical review of the arenas related to reliability prediction. Due to the vast of materials, our scope was limited to the development of $217Plus^{TM}$. We first reviewed Rome Laboratory and RIAC. We then explained the development course of reliability methods, MIL-HDBK-217, PRISM, and 217-Plus. This review will form not only a good understanding of the methodology but a basis for future study. We conclude this study with provision of future research areas.

• ETRI Journal
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• v.42 no.5
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• pp.669-685
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• 2020

5G AgiLe and fLexible integration of SaTellite And cellulaR (5G-ALLSTAR) is a Korea-Europe (KR-EU) collaborative project for developing multi-connectivity (MC) technologies that integrate cellular and satellite networks to provide seamless, reliable, and ubiquitous broadband communication services and improve service continuity for 5G and beyond. The main scope of this project entails the prototype development of a millimeter-wave 5G New Radio (NR)-based cellular system, an investigation of the feasibility of an NR-based satellite system and its integration with cellular systems, and a study of spectrum sharing and interference management techniques for MC. This article reviews recent research activities and presents preliminary results and a plan for the proof of concept (PoC) of three representative use cases (UCs) and one joint KR-EU UC. The feasibility of each UC and superiority of the developed technologies will be validated with key performance indicators using corresponding PoC platforms. The final achievements of the project are expected to eventually contribute to the technical evolution of 5G, which will pave the road for next-generation communications.

• Proceedings of the Korean Society for Language and Information Conference
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• 1996.02a
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• pp.137-146
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• 1996

Our research goal has been the development of a domain independent natural language processing (NLP) system suitable for information retrieval. As part of that research, we have investigated ways to automatically extend the semantics of a lexicon derived from machine-readable lexical sources. This paper details the extraction of thematic roles derived from lexical patterns in a machine-readable dictionary.

• Asian Pacific Journal of Cancer Prevention
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• v.15 no.8
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• pp.3359-3362
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• 2014

Increasing attention is being devoted to the mechanisms by which cells receive signals and then translate these into decisions for growth, death, or migration. Recent findings have presented significant breakthroughs in developing a deeper understanding of the activation or repression of target genes and proteins in response to various stimuli and of how they are assembled during signal transduction in cancer cells. Detailed mechanistic insights have unveiled new maps of linear and integrated signal transduction cascades, but the multifaceted nature of the pathways remains unclear. Although new layers of information are being added regarding mechanisms underlying ovarian cancer and how polymorphisms in VDR gene influence its development, the findings of this research must be sequentially collected and re-interpreted. We divide this multi-component review into different segments: how vitamin D modulates molecular network in ovarian cancer cells, how ovarian cancer is controlled by tumor suppressors and oncogenic miRNAs and finally how vitamin D signaling regulates miRNA expression. Intra/inter-population variability is insufficiently studied and a better understanding of genetics of population will be helpful in getting a step closer to personalized medicine.

• International Journal of High-Rise Buildings
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• v.7 no.4
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• pp.265-285
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• 2018

This paper presents a state-of-the-art review on the design, research and education aspects of fire safety engineering (FSE) with a particular concern on high-rise buildings. FSE finds its root after Great Fire of Rome in 64 AD, followed by Great London Fire in 1666. The development of modern FSE is continuously driven by industry revolution, insurance community and government regulations. Now FSE has become a unique engineering discipline and is moving towards performance-based design since 1990s. The performance-based fire safety design (PBFSD) involves identification of fire safety goals, design objectives, establishment of performance criteria, and selection of proper solutions for fire safety. The determination of fire scenarios and design fires have now become major contents for PBFSD. To experience a rapid and positive evolution in design and research consistent with other engineering disciplines, it is important for fire safety engineering as a profession to set up a special educational system to deliver the next-generation fire safety engineers. High-rise buildings have their unique fire safety issues such as rapid fire and smoke spread, extended evacuation time, longer fire duration, mixed occupancies, etc., bringing more difficulties in ensuring life safety and protection of property and environment. A list of recommendations is proposed to improve the fire safety of high-rise buildings. In addition, some source information for specific knowledge and information on FSE is provided in Appendix.

• International Journal of Aeronautical and Space Sciences
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• v.14 no.1
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• pp.30-45
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• 2013

The present work focuses on the unsteady aerodynamics and aeroelastic properties of a small-medium sized wind-turbine blade operating under ideal conditions. A tapered/twisted blade representative of commercial blades used in an experiment setup at the National Renewable Energy Laboratory is considered. The aerodynamic loads are computed using Computational Fluid Dynamics (CFD) techniques. For this purpose, FLUENT$^{(R)}$, a commercial finite-volume code that solves the Navier-Stokes and the Reynolds-Averaged Navier-Stokes (RANS) equations, is used. Turbulence effects in the 2D simulations are modeled using the Wilcox k-w model for validation of the CFD approach. For the 3D aerodynamic simulations, in a first approximation, and considering that the intent is to present a methodology and workflow philosophy more than highly accurate turbulent simulations, the unsteady laminar Navier-Stokes equations were used to determine the unsteady loads acting on the blades. Five different blade pitch angles were considered and their aerodynamic performance compared. The structural dynamics of the flexible wind-turbine blade undergoing significant elastic displacements has been described by a nonlinear flap-lag-torsion slender-beam differential model. The aerodynamic quasi-steady forcing terms needed for the aeroelastic governing equations have been predicted through a strip-theory based on a simple 2D model, and the pertinent aerodynamic coefficients and the distribution over the blade span of the induced velocity derived using CFD. The resulting unsteady hub loads are achieved by a first space integration of the aeroelastic equations by applying the Galerkin's approach and by a time integration using a harmonic balance scheme. Comparison among two- and three- dimensional computations for the unsteady aerodynamic load, the flap, lag and torsional deflections, forces and moments are presented in the paper. Results, discussions and pertinent conclusions are outlined.