• Title/Summary/Keyword: Role-taking

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Post-Translational Modification of Proteins in Toxicological Research: Focus on Lysine Acylation

  • Lee, Sangkyu
    • Toxicological Research
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    • v.29 no.2
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    • pp.81-86
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    • 2013
  • Toxicoproteomics integrates the proteomic knowledge into toxicology by enabling protein quantification in biofluids and tissues, thus taking toxicological research to the next level. Post-translational modification (PTM) alters the three-dimensional (3D) structure of proteins by covalently binding small molecules to them and therefore represents a major protein function diversification mechanism. Because of the crucial roles PTM plays in biological systems, the identification of novel PTMs and study of the role of PTMs are gaining much attention in proteomics research. Of the 300 known PTMs, protein acylation, including lysine formylation, acetylation, propionylation, butyrylation, malonylation, succinylation, and crotonylation, regulates the crucial functions of many eukaryotic proteins involved in cellular metabolism, cell cycle, aging, growth, angiogenesis, and cancer. Here, I reviewed recent studies regarding novel types of lysine acylation, their biological functions, and their applicationsin toxicoproteomics research.

A Study on Increasing Durability of Concrete Curbing Block (경계블록의 내구성 향상을 위한 연구)

  • 엄태선;임채용;유재상;이종열;이근호;김응수
    • Proceedings of the Korea Concrete Institute Conference
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    • 2001.11a
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    • pp.765-770
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    • 2001
  • Concrete curbing blocks have been widely used in construction of roadways because they are easy too manufacture and cheap. But recently stone curbs are taking away the role from concrete curbs, because the durability of concrete curbs is inferior to stone curbs. Especially freeze-thaw effect on concrete is the most important cause that damages concrete curbs. The aim of this study is to increase the durability of concrete curbs. The concrete curbs that have been manufactured are extremely damaged below 60 cycles of freeze-thaw, but the ones that was manufactured with admixtures that entrains air are maintaining over 87% of relative dynamic modulus.

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Characteristic Analysis on the Induction Motor using Magnetic Wedge (자성웨지를 사용한 유도전동기의 특성해석)

  • Im, Dal-Ho;Hong, Jung-Pyo;Im, Young-Hun;Shin, Heung-Gyo;Choi, Jong-Gu
    • Proceedings of the KIEE Conference
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    • 1994.07a
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    • pp.171-173
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    • 1994
  • Magnetic wedge is proposed for improving the motor performance and to reduce the ripple of air gap flux. Carter's coefficient plays very important role when the ampere turns or exciting current is calculated. In this paper, we calculate the Carter's coe. by FEM taking into account the magnetic anisotropy of magnetic wedge in simple manner and analyze the effect of the wedge. And we analyze the slot leakage flux according to the wedge property.

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Development of an electrochemi-Iuminescenece device (전기화학형 발광소자 개발)

  • Kwon, Hyuk-Moon;Sung, YouI-Moon;Ji, Jong-Gook;Lee, Myung-Hee
    • Proceedings of the Korean Institute of IIIuminating and Electrical Installation Engineers Conference
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    • 2009.10a
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    • pp.141-144
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    • 2009
  • In this study, used simplest sandwich cells containing $Ru2^+$ liquid electrolytes in order to clarify the role of nanoporous $TiO_2$ electrodes. And, the cell structure is as follow: $F:SnO_2$ glass/ nanoporous $TiO_2$/ tris(2,2'-bipyridy)ruthenium(ll) colplex [$Ru(bpy)_3(PF_6)_2$] in acetonitrile/ $F:SnO_2$ glass. The result, we found that ECL intensities increased rapidly by use of cathodes with nanoporous $TiO_2$ layers. And, porous $TiO_2$ electrodes were confirmed to be efficient for ECL devices as well as solar cell devices. It is thought that the increases in the ECL intensities may be associated with both formation of $Ru^+$ in porous $TiO_2$ electrodes and the process taking place after reduction of $Ru^+$ which occurs in the nanoporous electrodes.

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A PC-Based System for Gear Pitch Analysis and Monitoring in Gear Manufacturing Process (기어피치분석 및 공정관측을 위한 PC기반시스템 구축)

  • 김성준;지용수
    • Journal of Korean Society for Quality Management
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    • v.30 no.3
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    • pp.111-119
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    • 2002
  • Gears are essential elements for mechanical power transmission. Geometric precision is the main factor for characterizing gear grade and qualify. Gear pitch is one of the crucial measurements, which is defined as a distance between two adjacent gear teeth. It is well-known that variability in gear pitches may causes wear-out and vibration noise. Therefore maintaining pitch errors at a low level plays a key role in assuring the gear quality to customers. This paper is concerned with a case study, which presents a computerized system for Inspecting pitch errors in a gear machining process. This system consists of a PC and window-based programs. Although the start and stop is manually accomplished, the process of measuring and analyzing pitch data is automatically conducted in this system. Our purpose lies in reducing inspection cost and time as well as Increasing test reliability. Its operation is briefly illustrated by example. Sometimes a strong autocorrelation is observed from pitch data. We also discuss a process monitoring scheme taking account of autocorrelations.

Fashion Paradigm of 'Slowness' on Contemporary Fashion (현대 패션에 나타난 '느림'의 패러다임)

  • Ham, Youn-Ja
    • Fashion & Textile Research Journal
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    • v.11 no.4
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    • pp.527-536
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    • 2009
  • The purpose of this study is to consider the characteristics of fashion paradigm on contemporary fashion in pursuit of social change towards 'slowness'. As for the research methodology, literature survey has been undertaken. The results of this study can be summarized as followings. First, eco-friendly ethics towards sustainability is in taking action. The concept of 'cradle-to-cradle' is realized through reuse, recycle, organic material, and no use of chemical. Second, local diversity is revolving quality and longevity. Good quality of fashion made by artisans and specificity in local area is to be kept last. Third, people are recast in roles from simple consumers to self-made producers of their clothes. Users of clothes are more active and skilled role in practice of handmade, reform, DIY, and open-source design. In Conclusion, the fashion paradigm of 'slowness' is about designing, producing, consuming and living better to combine ideas for sense of nature's time, culture's time and people's time.

Implementing Balanced Scorecard with System Dynamics Approach

  • Yoon, Joseph Y. K.
    • Proceedings of the Korean Operations and Management Science Society Conference
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    • 2000.04a
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    • pp.330-336
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    • 2000
  • This paper discusses the potential of system dynamics modelling to support balanced scorecard. The balanced scorecard is a conceptual framework for translating an organisation's strategy into a set of performance indicators. These performance indicators are distributed across the 'classic'model's four perspective: Customers, Internal Business Processes, Financial, and Learning and Growth. This balanced scorecard, whilst having significant strength, suffers from the limitation of all performance indicator systems, namely that the interrelationships between indicators are overlooked and there is no way of taking into account the impact of delayed feedback which flows from introduction of new policy and legislative changes. System Dynamics is a methodology for understanding complex problems where there is dynamic behaviour and where feedback impacts significantly on system outcomes. System dynamics provides a rigorous basis for qualitative testing of the effects of performance indicators in complex environments such as health or social security. This can be supplemented with quantitative system dynamics simulation tools that further test the validity of indicators and the business rules implicit in them. System dynamics modelling has an important role to play in extending feedback cycle in performance measurements to a full systems approach.

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The Determinants of Collective Bargaining Power in Labor-Management Relations - Focusing on the Analysis of the Economic Variables - (노사관계에 있어서 단체 교섭력의 결정요인 - 경제적 변수를 중심으로 -)

  • Baek, Gwang-Gi
    • Korean Business Review
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    • v.2
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    • pp.141-169
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    • 1989
  • Most of the theories of collective bargaining outcomes start with a set of economic variables. The economic constraints, pressures, and incentives influence the bargaining power relationship between labor union and employer. In this paper, the critical macro and micro economic variables that need to be considered in analyzing the economic context of collective bargaining power relationship is outlined. The focus is on the role that economic forces play in shaping the results of bargaining, that is the outcome of negotiations. In this study, the elasticity of the demand for labor is introduced as one of the most important economic aspects that influence bargaining power. Unions will be most successful in increasing wages when they enjoy an inelastic demand for labor. If the demand for labor is not naturally inelastic, some institutional arrangement for "taking wages out of competition" must be sought. Inflation, business cycle, and income policy are influential in shaping both parties' goals and expectations as well. In addition to the analysis of the economic variables, the nature of power is diagonized with some introductory notions about its care and feeding before proceeding to the details of the above issues.

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Performance Estimation of Tunnel Lining Concrete Reinforced Steel Fiber (강섬유 보강 터널 라이닝 콘크리트의 성능 평가)

  • Jeon, Chan-Ki;Kim, Su-Man;Lee, Myung-Soo;Lee, Jong-Eun;Jeon, Joong-Kyu
    • Proceedings of the Korea Concrete Institute Conference
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    • 2005.11a
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    • pp.579-582
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    • 2005
  • Tunnel lining is the final support of a tunnel and reflects the results of the interaction between ground and support system. Recently it is very difficult to support and manage the tunnel because the cracks on tunnel lining cause problems in supporting and managing tunnels. Therefore the analysis of the cracks is quite strongly required. The major role played by the steel fiber occurs in the post-cracking zone, in which the fibers bridge across the cracked matrix. Because of its improved ability to bridging cracks, steel fiber reinforcement concrete(SFRC) has better crack properties than that of reinforced concrete. In this study, mechanical behaviour of a tunnel lining was examined by model tests. The model tests were carried out under various conditions taking different loading shapes, thicknesses and leakage of lining, and volume content of steel fiber. From these model test, the cracking load, the failure load, defection and cracking position and type were examined and the characteristics of deformation and failure for tunnel lining were estimated and researched.

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The Effect of Sense of Community on Learner Satisfaction in Online Learning : A Meditating Model

  • Lee, Sang-Kon;Lee, Ji-Yeon
    • Journal of Information Technology Applications and Management
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    • v.15 no.3
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    • pp.153-167
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    • 2008
  • This study examines the effect of sense of community on the relationship between learner satisfaction and influencing factors related to the online learning environment. Influencing factors related to the online learning environment are derived from previous literature and classified into two groups : social dimension (leader's enthusiasm, offline activities) and system dimension (usefulness, ease of use, enjoyability). Learner satisfaction is defined as the learners' perceived learning gains from taking an online class. Study participants included 250 university students from two different institutions. The participants were divided into 43 groups and asked to complete an online TOEIC preparation module using a commercial cooperative learning system over 4 weeks. Data were collected at three points for each participant, at the beginning, 3 weeks after, and at the end of the online module. Two system factors related to the online learning environment (ease of use, usefulness) directly influenced learner satisfaction, while social factors indirectly influenced learner satisfaction through the mediating role of sense of community.

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