• 대한불안의학회지
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• 제3권1호
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• pp.20-25
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• 2007

The definite causes of obsessive-compulsive disorder (OCD) are still unknown. OCD has been suggested to be related to many neurotransmitters in brain, such as serotonin, dopamine and glutamate. It has been shown that serotonergic neurons play a crucial role in the pathophysiology of OCD. Recently, it is known that neurotransmitters other than serotonin also play a role in the pathophysiology of OCD, and a series of studies have provided a few evidence that glutamate may be involved in some OCD patients. The purpose of this article was to review the literatures on glutamatergic dysfunction in OCD. We suggest that glutamatergic dysfunction may be implicated in the pathophysiology of OCD.

• Asian Pacific Journal of Cancer Prevention
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• 제16권18호
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• pp.8041-8045
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• 2016

Cervical cancer is one of the most common cancers in women worldwide. During their life time the vast majority of women become infected with human papillomavirus (HPV), but interestingly only a small portion develop cervical cancer and in the remainder infection regresses to a normal healthy state. Beyond HPV status, associated molecular characterization of disease has to be established. However, initial work suggests the existence of several different molecular classes, based on the biological features of differentially expressed genes in each subtype. This suggests that additional risk factors play an important role in the outcome of infection. Host genomic factors play an important role in the outcome of such complex or multifactor diseases such as cervical cancer and are also known to regulate the rate of disease progression. The aim of this review was to compile advances in the field of host genomics of HPV positive and negative cervical cancer and their association with clinical response.

• Clinical and Experimental Reproductive Medicine
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• 제18권2호
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• pp.143-151
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• 1991

An embryo-derived platelet activating factor (PAF) has been demonstrated to play an important role in reproduction. This report examined the effect of PAF on ovulation, fertilization, embryo development, implantation and fetal viability by using murine model. PAF had no stimulatory effect on ovulation and fertilization. But PAF had stimulatory effect on embryo development in in-vitro test, in spite of no effect on implantation and fetal viability. These results demonstrate that exogenous PAF could enhance embryo development and implantation and give suggestion that PAF may play an role in human IVF program.

• IMMUNE NETWORK
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• 제10권4호
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• pp.109-114
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• 2010

The molecular mechanisms involved in the pathogenesis of chronic obstructive pulmonary disease (COPD) are poorly defined. Accumulating evidences indicate that chronic inflammatory responses and adaptive immunity play important roles in the development and progression of the disease. Recently, it has been shown that IL-17 producing CD4 T cells, named Th17 cells, which have been implicated in the pathogenesis of several inflammatory and autoimmune diseases, are involved in airway inflammation and COPD. In addition, we and others suggest that autoimmunity may play a critical role in the pathogenesis of COPD. Here, we will review the current understanding of roles of Th17 cells and autoimmune responses in COPD.

• 대한음성학회:학술대회논문집
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• 대한음성학회 2006년도 춘계 학술대회 발표논문집
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• pp.117-120
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• 2006

This paper examined two hypotheses. Firstly, if the first syllable of word play an important role in visual word recognition, it may be the unit of word neighbor. Secondly, if the first syllable is the unit of lexical access, the neighborhood size effect and the neighborhood frequency effect would appear in a lexical decision task and a form primed lexical decision task. We conducted two experiments. Experiment 1 showed that words had large neighbors made a inhibitory effect in the LDT(lexical decision task). Experiment 2 showed the interaction between the neighborhood frequency effectand the word form similarity in the form primed LDT. We concluded that the first syllable in Korean words might be the unit of word neighborhood and play a central role in a lexical access.

• 한국축산식품학회지
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• 제31권3호
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• pp.381-388
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• 2011

Dietary conjugated linoleic acid (CLA) play key roles in lipid metabolism. Here, we investigated the effect of CLA on the transcriptional activity of TR4, an orphan nuclear receptor that plays an important role in lipid homeostasis. CLA increased TR4 gene mRNA level in 3T3-L1 adipocytes, but inhibited TR4 transcriptional activity in a dose-dependent manner. TR4 induced perilipin expression in 3T3-L1 adipocytes by activating perilipin promoter activity. In a gel shift assay, TR4 bound direct to the putative TR4 response element in the perilipin promoter. Interestingly, CLA reduced the interaction between TR4 and consensus DR1, a well-known TR4 binding site. Additionally, CLA inhibited TR4-induced perilipin promoter activity in a dose-dependent manner. Together, our results suggest that CLA may play a role in lipid homeostasis in adipocytes by functionally regulating TR4.

• 한국디지털건축인테리어학회논문집
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• 제9권1호
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• pp.41-48
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• 2009

Entering the 21st century, countries throughout the world are turning the direction of their education to be consumer-oriented and reinforcing lifelong education in preparation for the rapid advance of science and technology and the globalization, opening and informatization of the world. With the reinforcement of consumer-oriented education and lifelong education, the role of school is emphasized as a ground for lifelong education in community and efforts are being made to use schools and community facilities compositely so that schools may play the role of central facilities in community. Accordingly, the objective of this study is to analyze the relation between lifelong education and school facilities in the educational aspect, and to suggest a basic architectural direction so that schools may play central roles for social, cultural, educational, welfare, and sport activities in community.

• BMB Reports
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• 제50권4호
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• pp.158-159
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• 2017

MicroRNAs (miRNAs) regulate gene expression by guiding the Argonaute (Ago)-containing RNA-induced silencing complex (RISC) to specific target mRNA molecules. It is well established that miRNAs are stabilized by Ago proteins, but the molecular features that trigger miRNA destabilization from Ago proteins remain largely unknown. To explore the molecular mechanisms of how targets affect the stability of miRNAs in human Ago (hAgo) proteins, we employed an in vitro system that consisted of a minimal hAgo2-RISC in HEK293T cell lysates. Surprisingly, we found that miRNAs are drastically destabilized by binding to seedless, non-canonical targets. We showed that miRNAs are destabilized at their 3' ends during this process, which is largely attributed to the conformational flexibility of the L1-PAZ domain. Based on these results, we propose that non-canonical targets may play an important regulatory role in controlling the stability of miRNAs, instead of being regulated by miRNAs.

• 생물정신의학
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• 제18권4호
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• pp.169-175
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• 2011

Stress, a risk factor of major depression induces cytokine mediated inflammation and decreased neurogenesis. In patients with major depression, significant increases of pro-inflammatory cytokines have been consistently reported. The pro-inflammatory cytokines can stimulate the hypothalamic-pituitary-adrenal (HPA) axis to release glucocorticoids. In the brain, microglia and play a role of immune activation in response to stress. Increased pro-inflammatory cytokine play a role in restricting neurogenesis in the brain. Although neurogenesis may not be essential for the development of depression, it may be required for clinically effective antidepressant treatment. Hence, stimulation of neurogenesis is regarded as a promising strategy for new antidepressant targets. This review introduces changes in neurotransmitter, cytokine and neurogenesis in major depression and explores the possible relationship between pro-inflammatory cytokines and neurogenesis related to stress in major depression.

• 패션비즈니스
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• 제19권4호
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• pp.75-91
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• 2015

There is an increased interest in having beauty regardless of ages and sex with improvement of the national income level and increase in social activities. Competition within the beauty service industry is increasing rapidly because of global impact within Korea wave. Thus, active public relations and offering distinguished service in the beauty service industry are important. Also, uniforms play an important role in providing an image differentiated from other brands and presents professionalism to the customer. Therefore, we determined function and design of uniforms required in beauty service industry by researching wearing realities, satisfaction, preferred designs and functions of uniforms from hair shop staff. Functional and aesthetic uniforms play an important role to enhance the staffs' sense of belonging. In addition, it is good for the image of hair shop. Special design mirroring job characteristics with expression of differentiated personalities is needed. However, the research was conducted only in the hair shop in Seoul, Daejeon, and Gyeonggi-do. Further studies on much wider areas will be needed.